Difference between revisions of "Bioblast alert 2015"
From Bioblast
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*O2k-Publication: '''Heart failure and mitochondrial dysfunction'''. Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism. | *O2k-Publication: '''Heart failure and mitochondrial dysfunction'''. Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism. | ||
::[[Lemieux 2011 Int. J. Biochem. Cell Biol.|Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int. J. Biochem. Cell Biol. 43: 1729–1738]]. | ::[[Lemieux 2011 Int. J. Biochem. Cell Biol.|Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int. J. Biochem. Cell Biol. 43: 1729–1738]]. >>> [[Talk:Lemieux 2011 Int. J. Biochem. Cell Biol.|Discussion: Complementary results on the PGC-1a pathway]]. | ||
*'''[[Scientific service]]''': '''[[Tissue storage]]''' on ice is possible for limited periods of time (several hours) with preservation of mitochondrial respiratory function, as evaluated with [[SUIT protocol]]s. | *'''[[Scientific service]]''': '''[[Tissue storage]]''' on ice is possible for limited periods of time (several hours) with preservation of mitochondrial respiratory function, as evaluated with [[SUIT protocol]]s. | ||
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*Term of the week: '''[[Uncoupled]], [[non-coupled]], [[dyscoupled]]''' - a hallmark of high-resolution respirometry is a matching '''high-resolution terminology'''. | *Term of the week: '''[[Uncoupled]], [[non-coupled]], [[dyscoupled]]''' - a hallmark of high-resolution respirometry is a matching '''high-resolution terminology'''. | ||
::[[Talk:Uncoupled respiration|Evaluate an example of low-resolution terminology]]: '''''[[Dyscoupled respiration|Uncoupling]]''' was studied in stressed cells by measurement of coupled respiration, evaluation of '''[[LEAK|uncoupled]]''' respiration after inhibition with oligomycin, and FCCP titration to quantify '''[[non-coupled|uncoupled]]''' respiration''. | ::[[Talk:Uncoupled respiration|Evaluate an example of low-resolution terminology]]: '''''[[Dyscoupled respiration|Uncoupling]]''' was studied in stressed cells by measurement of coupled respiration, evaluation of '''[[LEAK|uncoupled]]''' respiration after inhibition with oligomycin, and FCCP titration to quantify '''[[non-coupled|uncoupled]]''' respiration''. | ||
=== Bioblast alert 2011(01): 2011-11-11 === | === Bioblast alert 2011(01): 2011-11-11 === | ||
Revision as of 06:49, 17 November 2011
Bioblast alert
Bioblast alert messages draw attention to specific topics on the Bioblast wiki.
Bioblast alert - previous issues
Bioblast alert 2011(02): 2011-11-17
- O2k-Publication: Heart failure and mitochondrial dysfunction. Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism.
- Scientific service: Tissue storage on ice is possible for limited periods of time (several hours) with preservation of mitochondrial respiratory function, as evaluated with SUIT protocols.
- Term of the week: Uncoupled, non-coupled, dyscoupled - a hallmark of high-resolution respirometry is a matching high-resolution terminology.
- Evaluate an example of low-resolution terminology: Uncoupling was studied in stressed cells by measurement of coupled respiration, evaluation of uncoupled respiration after inhibition with oligomycin, and FCCP titration to quantify uncoupled respiration.
Bioblast alert 2011(01): 2011-11-11
- O2k-Fluorimetry Workshop IOC66: 2012-03-15 to 16. OROBOROS INSTRUMENTS, Innsbruck, Austria. The first series of the O2k-Fluorescence Module will be delivered in April 2012, for orders received by end of January 2012.
- O2k-Publication: A key question on the separation of qualitative versus quantitative change of mitochondrial function is addressed in a new O2k-Publication. Does training induce mild uncoupling? Are sedentary humans healthy controls?
- Scientific service: ETS capacity plays a key role in such analyses, which cannot be achieved quantitatively without careful uncoupler titrations.
- Term of the month: Basal respiration - a hallmark of high-resolution respirometry is a matching high-resolution terminology.
