Difference between revisions of "Cheng 2010 FEBS Lett"
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{{Publication | {{Publication | ||
|title=Cheng Y, Debska-Vielhaber G, Siemen D (2010) Interaction of mitochondrial potassium channels with the permeability transition pore. FEBS | |title=Cheng Y, Debska-Vielhaber G, Siemen D (2010) Interaction of mitochondrial potassium channels with the permeability transition pore. FEBS Lett 584:2005–12. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/20036666 PMID: 20036666 Open Access] | |||
|authors=Cheng Y, Debska-Vielhaber G, Siemen D | |authors=Cheng Y, Debska-Vielhaber G, Siemen D | ||
|year=2010 | |year=2010 | ||
|journal=FEBS Lett | |journal=FEBS Lett | ||
|abstract=Three types of potassium channels cooperate with the permeability transition pore (PTP) in the | |abstract=Three types of potassium channels cooperate with the permeability transition pore (PTP) in the inner mitochondrial membranes of various tissues, mtK(ATP), mtBK, and mtKv1.3. While the latter two share similarities with their plasma membrane counterparts, mtK(ATP) exhibits considerable differences | ||
inner mitochondrial membranes of various tissues, mtK(ATP), mtBK, and mtKv1.3. While the latter | with the plasma membrane K<sub>(ATP)</sub>-channel. One important function seems to be suppression of release of proapototic substances from mitochondria through the PTP. Open potassium channels tend to keep the PTP closed thus acting as antiapoptotic. Nevertheless, in their mode of action there are considerable differences among them. This review introduces three K<sup>+</sup>-channels and the PTP, and discusses known facts about their interaction. | ||
two share similarities with their plasma membrane counterparts, mtK(ATP) exhibits considerable differences | |keywords=Mitochondria Ion channel, Permeability transition pore, Apoptosis, Mitochondrial potassium channel | ||
with the plasma membrane K(ATP)-channel. One important function seems to be suppression | |mipnetlab=DE Magdeburg Siemen D, DE Magdeburg Klinik Neurologie | ||
of release of proapototic substances from mitochondria through the PTP. Open potassium | |discipline=Biomedicine | ||
channels tend to keep the PTP closed thus acting as antiapoptotic. Nevertheless, in their mode of | |||
action there are considerable differences among them. This review introduces three K+-channels | |||
and the PTP, and discusses known facts about their interaction. | |||
|keywords=Mitochondria Ion channel, | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
|injuries=Cell death | |||
|discipline=Biomedicine | |discipline=Biomedicine | ||
}} | }} | ||
Latest revision as of 14:26, 27 March 2015
| Cheng Y, Debska-Vielhaber G, Siemen D (2010) Interaction of mitochondrial potassium channels with the permeability transition pore. FEBS Lett 584:2005–12. |
Cheng Y, Debska-Vielhaber G, Siemen D (2010) FEBS Lett
Abstract: Three types of potassium channels cooperate with the permeability transition pore (PTP) in the inner mitochondrial membranes of various tissues, mtK(ATP), mtBK, and mtKv1.3. While the latter two share similarities with their plasma membrane counterparts, mtK(ATP) exhibits considerable differences with the plasma membrane K(ATP)-channel. One important function seems to be suppression of release of proapototic substances from mitochondria through the PTP. Open potassium channels tend to keep the PTP closed thus acting as antiapoptotic. Nevertheless, in their mode of action there are considerable differences among them. This review introduces three K+-channels and the PTP, and discusses known facts about their interaction. • Keywords: Mitochondria Ion channel, Permeability transition pore, Apoptosis, Mitochondrial potassium channel
• O2k-Network Lab: DE Magdeburg Siemen D, DE Magdeburg Klinik Neurologie
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