Difference between revisions of "DeLuca 1961 Proc Natl Acad Sci USA"
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|journal=Proc Natl Acad Sci USA | |journal=Proc Natl Acad Sci USA | ||
|abstract=Rat kidney mitochondria take up large quantities of calcium by a process requiring ATP, magnesium ions, and an oxidizable substrate. Although the process requires ATP, it is not directly dependent upon oxidative phosphorylation or upon the operation of the entire electron transport chain. The rate of calcium uptake is not enhanced by vitamin D. It is inhibited strongly by dicumarol, antimycin A and 2,3-dimercaptopropanol and less strongly by phloridzin and p-chloromercuribenzoate, but not by dinitrophenol, azide, cyanide, oligomycin, and iodoacetate at the concentrations tested. The mitochondria apparently can bind about 15 calcium ions per molecule of ATP utilized. | |abstract=Rat kidney mitochondria take up large quantities of calcium by a process requiring ATP, magnesium ions, and an oxidizable substrate. Although the process requires ATP, it is not directly dependent upon oxidative phosphorylation or upon the operation of the entire electron transport chain. The rate of calcium uptake is not enhanced by vitamin D. It is inhibited strongly by dicumarol, antimycin A and 2,3-dimercaptopropanol and less strongly by phloridzin and p-chloromercuribenzoate, but not by dinitrophenol, azide, cyanide, oligomycin, and iodoacetate at the concentrations tested. The mitochondria apparently can bind about 15 calcium ions per molecule of ATP utilized. | ||
|keywords= | |keywords=Calcium, Mitochondria | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|organism= | |organism=Rat | ||
|tissues=Kidney | |tissues=Kidney | ||
|preparations=Isolated Mitochondria | |preparations=Isolated Mitochondria | ||
Revision as of 15:34, 13 February 2013
| DeLuca HF, Engstrom GW (1961) Calcium uptake by rat kidney mitochondria. Proc Natl Acad Sci USA 47: 1744-1750. |
DeLuca HF, Engstrom GW (1961) Proc Natl Acad Sci USA
Abstract: Rat kidney mitochondria take up large quantities of calcium by a process requiring ATP, magnesium ions, and an oxidizable substrate. Although the process requires ATP, it is not directly dependent upon oxidative phosphorylation or upon the operation of the entire electron transport chain. The rate of calcium uptake is not enhanced by vitamin D. It is inhibited strongly by dicumarol, antimycin A and 2,3-dimercaptopropanol and less strongly by phloridzin and p-chloromercuribenzoate, but not by dinitrophenol, azide, cyanide, oligomycin, and iodoacetate at the concentrations tested. The mitochondria apparently can bind about 15 calcium ions per molecule of ATP utilized. • Keywords: Calcium, Mitochondria
Labels:
Organism: Rat
Tissue;cell: Kidney
Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
Regulation: Ion Homeostasis"Ion Homeostasis" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., ATP; ADP; AMP; PCr"ATP; ADP; AMP; PCr" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
Made history
