Desler 2017 Abstract MITOEAGLE Barcelona

Bioenergetic changes of differentiating human embryonic cells.

Link: MITOEAGLE

Desler C, M. Hopkinson B, Kalisz M, Siig Vestentoft P, Bisgaard HC, Juel Rasmussen L (2017)

Event: MITOEAGLE Barcelona 2017

Mitochondrial dysfunction has been demonstrated to result in premature aging due to its effects on stem cells. Nevertheless, a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking. We show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage. Our study reveals especially the transition between hepatic specification and hepatic maturation, as dependent of mitochondrial respiration and demonstrates that even though differentiating cells are primarily dependent on glycolysis until induction of hepatocyte maturation, oxidative phosphorylation is essential at all stages of differentiation.

• Bioblast editor: Bitschnaub B

Labels: MiParea: Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style  Pathology: Aging;senescence, Neurodegenerative, Parkinson's  Stress:Oxidative stress;RONS  Organism: Mouse, Drosophila, Caenorhabditis elegans, Nematodes  Tissue;cell: Nervous system 

Enzyme: Complex I 

Event: A3 

Affiliations

Desler(1,2) , M. Hopkinson(1), Kalisz(3) , Siig Vestentoft(1) , Bisgaard(1), Juel Rasmussen(1,2)

1. Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark
2. Center for Healthy Aging, University of Copenhagen, Denmark
3. The Danish Stem Cell Center, Faculty of Health Sciences, University of Copenhagen, Denmark