- high-resolution terminology - matching measurements at high-resolution
Glycerophosphate
Description
Glycerophosphate (synonym: α-glycerophosphate; glycerol-3-phosphate; C3H9O6P) is an organophosphate and it is a component of glycerophospholipids. Due to an ambiguity in the D, L nomenclature based on the Fisher projection the biologically active enantiomer can be labeled either D-Glycerol 1-phosphate or L-Glycerol 3-phosphate. An alternative is sn-Glycerol 3-phosphate. Following the Cahn–Ingold–Prelog priority rules the biologically active substance is the (R) enantiomer.
Abbreviation: Gp
MitoPedia topics: Substrate and metabolite
Glycerophosphate feeds electrons directly to ubiquinone and glycerophosphate dehydrogenase oxidizes glycerophosphate to dihydroxyacetone phosphate. See also glycerol phosphate shuttle.
Comment:
Sigma does not sell DL-alpha-glycerophosphate disodium salt hexahydrate (FW = 324.1; Sigma G-2138) any more (personal communication with Dr. Zdenek Drahota, Dept. of Bioenergetics, Institute of Physiology, Academy of Sciences of the Czech Rep.)!
[In Dr. Drahota's lab a 1 M stock solution is used and the final concentration in the O2k-chamber is 10 mM.]
Search for an adequate replacement is underway.
Alternatives:
- enatiomerically pure lithium salt: Sigma: 94124
