Huetter 2002 Mol Biol Rep: Difference between revisions
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{{Publication | {{Publication | ||
|title=Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29: 83- | |title=Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/12241081 PMID: 12241081] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/12241081 PMID: 12241081] | ||
|authors=Huetter E, Renner K, Jansen-Duerr P, Gnaiger | |authors=Huetter E, Renner K, Jansen-Duerr P, Gnaiger Erich | ||
|year=2002 | |year=2002 | ||
|journal=Mol Biol Rep | |journal=Mol Biol Rep | ||
|abstract=Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an increased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia. | |abstract=Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an increased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia. | ||
|mipnetlab= | |mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck Jansen-Duerr P, AT Innsbruck Oroboros , DE Regensburg Renner-Sattler K | ||
}} | }} | ||
== Cited by == | |||
::* 8 articles in PubMed (2024-01-11) https://pubmed.ncbi.nlm.nih.gov/12241081/ | |||
{{Template:Cited by Komlodi 2021 MitoFit AmR}} | |||
{{Labeling | {{Labeling | ||
|area=Respiration | |||
|organism=Human | |||
|tissues=Fibroblast | |||
|preparations=Intact cells | |||
|topics=Oxygen kinetics | |||
|couplingstates=ROUTINE | |||
|pathways=ROX | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
| | |additional=MitoFit 2021 AmR | ||
}} | }} | ||
Latest revision as of 08:12, 11 January 2024
| Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7. |
Huetter E, Renner K, Jansen-Duerr P, Gnaiger Erich (2002) Mol Biol Rep
Abstract: Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an increased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia.
• O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck Jansen-Duerr P, AT Innsbruck Oroboros, DE Regensburg Renner-Sattler K
Cited by
- 8 articles in PubMed (2024-01-11) https://pubmed.ncbi.nlm.nih.gov/12241081/
- Komlódi T, Schmitt S, Zdrazilova L, Donnelly C, Zischka H, Gnaiger E. Oxygen dependence of hydrogen peroxide production in isolated mitochondria and permeabilized cells. MitoFit Preprints (in prep).
Labels: MiParea: Respiration
Organism: Human
Tissue;cell: Fibroblast
Preparation: Intact cells
Regulation: Oxygen kinetics Coupling state: ROUTINE Pathway: ROX HRR: Oxygraph-2k
MitoFit 2021 AmR
