Hunte 2010 Science: Difference between revisions
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{{Publication | {{Publication | ||
|title=Hunte C, Zickermann V, Brandt U (2010) Functional modules and structural basis of conformational coupling in mitochondrial complex I. https://doi.org/10.1126/science.1191046 | |title=Hunte C, Zickermann V, Brandt U (2010) Functional modules and structural basis of conformational coupling in mitochondrial complex I. https://doi.org/10.1126/science.1191046 | ||
|info=Science 329:448-51. [https://pubmed.ncbi.nlm.nih.gov/20595580 PMID: 20595580 | |info=Science 329:448-51. [https://pubmed.ncbi.nlm.nih.gov/20595580 PMID: 20595580] | ||
|authors=Hunte Carola, Zickermann Volker, Brandt Ulrich | |authors=Hunte Carola, Zickermann Volker, Brandt Ulrich | ||
|year=2010 | |year=2010 | ||
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|editor=[[Plangger M]] | |editor=[[Plangger M]] | ||
}} | }} | ||
{{Labeling}} | {{Labeling | ||
|area=mt-Structure;fission;fusion | |||
|enzymes=Complex I | |||
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Latest revision as of 14:10, 29 March 2023
| Hunte C, Zickermann V, Brandt U (2010) Functional modules and structural basis of conformational coupling in mitochondrial complex I. https://doi.org/10.1126/science.1191046 |
» Science 329:448-51. PMID: 20595580
Hunte Carola, Zickermann Volker, Brandt Ulrich (2010) Science
Abstract: Proton-pumping respiratory complex I is one of the largest and most complicated membrane protein complexes. Its function is critical for efficient energy supply in aerobic cells, and malfunctions are implicated in many neurodegenerative disorders. Here, we report an x-ray crystallographic analysis of mitochondrial complex I. The positions of all iron-sulfur clusters relative to the membrane arm were determined in the complete enzyme complex. The ubiquinone reduction site resides close to 30 angstroms above the membrane domain. The arrangement of functional modules suggests conformational coupling of redox chemistry with proton pumping and essentially excludes direct mechanisms. We suggest that a approximately 60-angstrom-long helical transmission element is critical for transducing conformational energy to proton-pumping elements in the distal module of the membrane arm.
• Bioblast editor: Plangger M
Labels: MiParea: mt-Structure;fission;fusion
Enzyme: Complex I
