Jansen 2017 MiP2017: Difference between revisions
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{{Abstract | {{Abstract | ||
|title=[[Image:MiPsocietyLOGO.JPG|left|90px|Mitochondrial Physiology Society|MiPsociety]] | |title=[[Image:MiPsocietyLOGO.JPG|left|90px|Mitochondrial Physiology Society|MiPsociety]] | ||
Dietary and pharmacological anti-obesogenic treatments improve myocardial metabolism in diet-induced obese mice. | |||
|info=[[MiP2017]] | |info=[[MiP2017]] | ||
|authors=Jansen KM, Larsen TS | |||
|year=2017 | |year=2017 | ||
|event=MiP2017 | |event=MiP2017 | ||
|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] | |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] | ||
|editor=[[ | Calanus oil (a novel marine oil), as well exenatide (GLP-1 agonist), reduce deposition of intra-abdominal fat in adipose tissue during high-fat feeding. To test the hypothesis that targeted reduction of intra-abdominal fat can recover metabolic flexibility of the heart, which is otherwise lost in obesity. | ||
Female C57bl/6J ''mice'' received high-fat diet (HFD) or normal chow for 12 wks in order to induce obesity. Thereafter, the HFD ''mice'' were treated for 8 wks with Calanus oil (2%), exenatide (10 µg/kg/day), or the two treatments combined. Non-treated chow- and HFD-fed ''mice'' served as lean and obese controls, respectively. At the end of the treatment period, substrate oxidation (radioisotope technique) and tolerance to ischemia-reperfusion were examined, using Langendorff-perfused hearts. | |||
Both Calanus oil and exenatide had a clear anti-obesogenic effect, as demonstrated by significantly reduced intra-abdominal fat stores at the end of the treatment period. This was associated with improved myocardial glucose oxidation, relative to non-treated obese controls. Pre-ischemic left ventricular (LV) function was not different between the groups, but hearts from Calanus oil-treated obese ''mice'' showed increased post-ischemic functional recovery relative to hearts from non-treated obese ''mice''. No synergism between Calanus oil and exenatide treatment was observed. | |||
In conclusion, obesity-related loss of myocardial metabolic flexibility was counteracted both by Calanus oil and exenatide treatment. In Calanus oil-treated ''mice'', this was associated with increased post-ischemic recovery of LV function. | |||
|editor=[[Beno M]] | |||
|mipnetlab=NO Tromsoe Larsen TS | |||
}} | }} | ||
{{Labeling}} | {{Labeling}} | ||
== Affiliations == | == Affiliations == | ||
:::: Dept Medical Biol, Fac Health Sc, UiT The Arctic Univ Norway | |||
Revision as of 14:09, 23 October 2017
 Dietary and pharmacological anti-obesogenic treatments improve myocardial metabolism in diet-induced obese mice. |
Link: MiP2017
Event: MiP2017
Calanus oil (a novel marine oil), as well exenatide (GLP-1 agonist), reduce deposition of intra-abdominal fat in adipose tissue during high-fat feeding. To test the hypothesis that targeted reduction of intra-abdominal fat can recover metabolic flexibility of the heart, which is otherwise lost in obesity.
Female C57bl/6J mice received high-fat diet (HFD) or normal chow for 12 wks in order to induce obesity. Thereafter, the HFD mice were treated for 8 wks with Calanus oil (2%), exenatide (10 µg/kg/day), or the two treatments combined. Non-treated chow- and HFD-fed mice served as lean and obese controls, respectively. At the end of the treatment period, substrate oxidation (radioisotope technique) and tolerance to ischemia-reperfusion were examined, using Langendorff-perfused hearts.
Both Calanus oil and exenatide had a clear anti-obesogenic effect, as demonstrated by significantly reduced intra-abdominal fat stores at the end of the treatment period. This was associated with improved myocardial glucose oxidation, relative to non-treated obese controls. Pre-ischemic left ventricular (LV) function was not different between the groups, but hearts from Calanus oil-treated obese mice showed increased post-ischemic functional recovery relative to hearts from non-treated obese mice. No synergism between Calanus oil and exenatide treatment was observed.
In conclusion, obesity-related loss of myocardial metabolic flexibility was counteracted both by Calanus oil and exenatide treatment. In Calanus oil-treated mice, this was associated with increased post-ischemic recovery of LV function.
• Bioblast editor: Beno M
• O2k-Network Lab: NO Tromsoe Larsen TS
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Affiliations
- Dept Medical Biol, Fac Health Sc, UiT The Arctic Univ Norway
