Difference between revisions of "Jesina 2004 Physiol Res"
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{{Publication | {{Publication | ||
|title=Jesina P, Kholova D, Bolehovska R, Cervinkova Z, Drahota Z, Houstek J (2004) Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria. Physiol | |title=Jesina P, Kholova D, Bolehovska R, Cervinkova Z, Drahota Z, Houstek J (2004) Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria. Physiol Res 53:305-10. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/15209538 PMID: 15209538 Open Access] | |||
|authors=Jesina P, Kholova D, Bolehovska R, Cervinkova Z, Drahota Z, Houstek J | |authors=Jesina P, Kholova D, Bolehovska R, Cervinkova Z, Drahota Z, Houstek J | ||
|year=2004 | |year=2004 | ||
|journal=Physiol. Res. | |journal=Physiol. Res. | ||
|abstract=We studied the extent to which hormonally-induced mitochondrial glycerophosphate dehydrogenase (mGPDH) activity contributes to the supply of reducing equivalents to the mitochondrial respiratory chain in the rat liver. The activity of glycerophosphate oxidase was compared with those of NADH oxidase and/or succinate oxidase. It was found that triiodothyronine-activated mGPDH represents almost the same capacity for the saturation of the respiratory chain as Complex II. Furthermore, the increase of mGPDH activity induced by triiodothyronine correlated with an increase of capacity for glycerophosphate-dependent hydrogen peroxide production. As a result of hormonal treatment, a 3-fold increase in glycerophosphate-dependent hydrogen peroxide production by liver mitochondria was detected by polarographic and luminometric measurements. | |abstract=We studied the extent to which hormonally-induced mitochondrial glycerophosphate dehydrogenase (mGPDH) activity contributes to the supply of reducing equivalents to the mitochondrial respiratory chain in the rat liver. The activity of glycerophosphate oxidase was compared with those of NADH oxidase and/or succinate oxidase. It was found that triiodothyronine-activated mGPDH represents almost the same capacity for the saturation of the respiratory chain as Complex II. Furthermore, the increase of mGPDH activity induced by triiodothyronine correlated with an increase of capacity for glycerophosphate-dependent hydrogen peroxide production. As a result of hormonal treatment, a 3-fold increase in glycerophosphate-dependent hydrogen peroxide production by liver mitochondria was detected by polarographic and luminometric measurements. | ||
|keywords=Rat liver mitochondria, Mitochondrial glycerophosphate dehydrogenase, Triiodothyronine, Hydrogen peroxide | |keywords=Rat liver mitochondria, Mitochondrial glycerophosphate dehydrogenase, Triiodothyronine, Hydrogen peroxide | ||
| | |mipnetlab=CZ Hradec Kralove Cervinkova Z, CZ Prague Houstek J | ||
|discipline=Mitochondrial Physiology, Biomedicine | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
|injuries=Oxidative stress;RONS | |||
|organism=Rat | |||
|tissues=Liver | |||
|preparations=Isolated mitochondria | |||
|instruments=Oxygraph-2k | |||
|discipline=Mitochondrial Physiology, Biomedicine | |discipline=Mitochondrial Physiology, Biomedicine | ||
}} | }} | ||
Latest revision as of 14:31, 26 March 2018
| Jesina P, Kholova D, Bolehovska R, Cervinkova Z, Drahota Z, Houstek J (2004) Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria. Physiol Res 53:305-10. |
Jesina P, Kholova D, Bolehovska R, Cervinkova Z, Drahota Z, Houstek J (2004) Physiol. Res.
Abstract: We studied the extent to which hormonally-induced mitochondrial glycerophosphate dehydrogenase (mGPDH) activity contributes to the supply of reducing equivalents to the mitochondrial respiratory chain in the rat liver. The activity of glycerophosphate oxidase was compared with those of NADH oxidase and/or succinate oxidase. It was found that triiodothyronine-activated mGPDH represents almost the same capacity for the saturation of the respiratory chain as Complex II. Furthermore, the increase of mGPDH activity induced by triiodothyronine correlated with an increase of capacity for glycerophosphate-dependent hydrogen peroxide production. As a result of hormonal treatment, a 3-fold increase in glycerophosphate-dependent hydrogen peroxide production by liver mitochondria was detected by polarographic and luminometric measurements. • Keywords: Rat liver mitochondria, Mitochondrial glycerophosphate dehydrogenase, Triiodothyronine, Hydrogen peroxide
• O2k-Network Lab: CZ Hradec Kralove Cervinkova Z, CZ Prague Houstek J
Labels:
Stress:Oxidative stress;RONS Organism: Rat Tissue;cell: Liver Preparation: Isolated mitochondria
HRR: Oxygraph-2k
