Kaspar 2021 Sci Adv: Difference between revisions
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<small>Copyright ยฉ 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).</small> | <small>Copyright ยฉ 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).</small> | ||
|editor=[[Reiswig R]] | |editor=[[Reiswig R]] | ||
|mipnetlab=DE Cologne Trifunovic A | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration, nDNA;cell genetics, Genetic knockout;overexpression | |area=Respiration, nDNA;cell genetics, Genetic knockout;overexpression | ||
|organism=Mouse | |organism=Mouse | ||
|tissues=Heart | |tissues=Heart | ||
Latest revision as of 09:13, 5 August 2021
| Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, Trifunovic A (2021) Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Sci Adv 7:0971. |
Kaspar Sophie, Oertlin Christian, Szczepanowska Karolina, Kukat Alexandra, Senft Katharina, Lucas Christina, Brodesser Susanne, Hatzoglou Maria, Larsson Ola, Topisirovic Ivan, Trifunovic Aleksandra (2021) Sci Adv
Abstract: In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive transcriptional response sharing a signature of the integrated stress response (ISR) is activated. We report an intricate interplay between three transcription factors regulating the mitochondrial stress response: CHOP, C/EBPฮฒ, and ATF4. We show that CHOP acts as a rheostat that attenuates prolonged ISR, prevents unfavorable metabolic alterations, and postpones the onset of mitochondrial cardiomyopathy. Upon mitochondrial dysfunction, CHOP interaction with C/EBPฮฒ is needed to adjust ATF4 levels, thus preventing overactivation of the ATF4-regulated transcriptional program. Failure of this interaction switches ISR from an acute to a chronic state, leading to early respiratory chain deficiency, energy crisis, and premature death. Therefore, contrary to its previously proposed role as a transcriptional activator of mitochondrial unfolded protein response, our results highlight a role of CHOP in the fine-tuning of mitochondrial ISR in mammals.
Copyright ยฉ 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
โข Bioblast editor: Reiswig R โข O2k-Network Lab: DE Cologne Trifunovic A
Labels: MiParea: Respiration, nDNA;cell genetics, Genetic knockout;overexpression
Organism: Mouse
Tissue;cell: Heart
Preparation: Isolated mitochondria
Coupling state: LEAK, OXPHOS, ET
Pathway: N, S, NS, ROX
HRR: Oxygraph-2k
2021-08
