Difference between revisions of "Kosenko 2010 Biology Bull"
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{{Publication | {{Publication | ||
|title=Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology | |title=Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull 37:346-50. | ||
|info=[http://www. | |info=[http://www.ncbi.nlm.nih.gov/pubmed?term=The%20drug%20hypoxen%3A%20A%20new%20inhibitor%20of%20mitochondrial%20respiration%20and%20dehydrogenases%20 PMID: 20799641] | ||
|authors=Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG | |authors=Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG | ||
|year=2010 | |year=2010 | ||
|journal= | |journal=Biology Bull | ||
|abstract=The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with | |abstract=The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with | ||
succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. | succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. | ||
|keywords=Hypoxen (Oliphen, Moscow), | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
|organism=Rat | |||
|tissues=Liver | |||
|preparations=Isolated mitochondria | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
| | |additional=Pharmacology; Biotechnology | ||
}} | }} | ||
Latest revision as of 15:50, 26 May 2015
| Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull 37:346-50. |
Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) Biology Bull
Abstract: The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. • Keywords: Hypoxen (Oliphen, Moscow)
Labels:
Organism: Rat
Tissue;cell: Liver
Preparation: Isolated mitochondria
HRR: Oxygraph-2k
Pharmacology; Biotechnology
