Krumschnabel 1994 Experientia: Difference between revisions

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Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-485.

» http://link.springer.com/article/10.1007%2FBF01920752

Krumschnabel G, Wieser W (1994) Experientia

Abstract: In isolated goldfish hepatocytes underaerobic conditions the energy requirement for the sodium pump (calculated from Rb+ flux) is closely matched by the ouabain-sensitive fraction of oxygen consumption, whereas during in vitroanoxia (cyanide inhibition of the electron transport chain) the measured ATP demand of the sodium pump clearly exceeds ouabain-sensitive ATP production by anaerobic glycolysis. We conclude that when the energy status of cells is low, part or all of the ATP spared by the inhibition of a particular function may be used for fuelling other ATP-consuming functions. • Keywords: goldfish, hepatocyte, sodium pump, protein synthesis, membrane-metabolic coupling, lactate, ouabain

• O2k-Network Lab: AT Innsbruck OROBOROS

Labels:

Tissue;cell: Liver Preparation: Intact cells

Coupling state: ROUTINE

HRR: Oxygraph-2k

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 |title=Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-485.
 |info=http://link.springer.com/article/10.1007%2FBF01920752
 |authors=Krumschnabel G, Wieser W
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-|instruments=Oxygraph-2k
 |taxonomic group=Fishes
 |tissues=Liver
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