View source for Kuzelova 2008 Gen Physiol Biophys

{{Publication
|title=Kuzelova M, Adameova A, Sumbalova Z, Paulikova I, Harcarová A, Svec P, Kucharska J. (2008) The effect of simvastatin on coenzyme Q and antioxidant/oxidant balance in diabetic-hypercholesterolaemic rats. Gen Physiol Biophys. 27(4):291-8.
|info=http://www.ncbi.nlm.nih.gov/pubmed/19202203
|authors=Kuzelova M, Adameova A, Sumbalova Z, Paulikova I, Harcarova A, Svec P, Kucharska
|year=2008
|journal=Gen Physiol Biophys
|abstract=The effect of simvastatin administered for 10 days on coenzyme Q and
antioxidant/oxidant balance in a rat model of diabetes mellitus and
hypercholesterolaemia was studied. In the diabetic-hypercholesterolaemic rats the
signs of oxidative stress-decreased alpha-tocopherol/cholesterol in the plasma (p
< 0.01) and alpha-tocopherol in liver (p < 0.001) together with increased lipid
peroxidation in the liver (TBARS, p < 0.05) were found. Increased coenzyme Q9
concentrations in the plasma (p < 0.05) and liver (p < 0.01), coenzyme Q10 in the
myocardium (p < 0.05) and in the liver (p < 0.01) may indicate adaptation to
oxidative stress. Administration of simvastatin (10 mg/kg) to the
diabetic-hypercholesterolaemic rats counteracted increased myocardial (coenzyme
Q10, p < 0.05) and liver (total coenzyme Q9, p < 0.05) coenzyme Q concentrations 
but did not improve alpha-tocopherol depletion and increased formation of TBARS
in the liver. Even though simvastatin treatment did not induce coenzyme Q
deficiency in plasma, heart and liver of the diabetic-hypercholesterolaemic rats 
as compared to the control levels, it was not able to prevent completely the
changes in antioxidant/oxidant balance induced by diabetes and
hypercholesterolaemia. The results highlight the importance of studying the
effect of statins on the coenzyme Q levels in the animal models of pathological
conditions known to change the initial antioxidant defence system.
|keywords=hypercholesterolaemia, diabetes, coenzyme Q, a-tocopherol, simvastatin, rat, liver
}}
{{Labeling
|injuries=RONS; Oxidative Stress, Mitochondrial Disease; Degenerative Disease and Defect
|organism=Rat
|tissues=Cardiac muscle, Liver
|additional=daibetes
}}