Difference between revisions of "Kuzelova 2008 Gen Physiol Biophys"
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antioxidant/oxidant balance in a rat model of diabetes mellitus and | antioxidant/oxidant balance in a rat model of diabetes mellitus and | ||
hypercholesterolaemia was studied. In the diabetic-hypercholesterolaemic rats the | hypercholesterolaemia was studied. In the diabetic-hypercholesterolaemic rats the | ||
signs of oxidative stress-decreased alpha-tocopherol/cholesterol in the plasma (p | signs of oxidative stress-decreased alpha-tocopherol/cholesterol in the plasma (''p'' | ||
< 0.01) and alpha-tocopherol in liver (p < 0.001) together with increased lipid | < 0.01) and alpha-tocopherol in liver (''p'' < 0.001) together with increased lipid | ||
peroxidation in the liver (TBARS, p < 0.05) were found. Increased coenzyme Q9 | peroxidation in the liver (TBARS, ''p'' < 0.05) were found. Increased coenzyme Q9 | ||
concentrations in the plasma (p < 0.05) and liver (p < 0.01), coenzyme Q10 in the | concentrations in the plasma (''p'' < 0.05) and liver (''p'' < 0.01), coenzyme Q10 in the | ||
myocardium (p < 0.05) and in the liver (p < 0.01) may indicate adaptation to | myocardium (''p'' < 0.05) and in the liver (''p'' < 0.01) may indicate adaptation to | ||
oxidative stress. Administration of simvastatin (10 mg/kg) to the | oxidative stress. Administration of simvastatin (10 mg/kg) to the | ||
diabetic-hypercholesterolaemic rats counteracted increased myocardial (coenzyme | diabetic-hypercholesterolaemic rats counteracted increased myocardial (coenzyme | ||
Q10, p < 0.05) and liver (total coenzyme Q9, p < 0.05) coenzyme Q concentrations | Q10, ''p'' < 0.05) and liver (total coenzyme Q9, ''p'' < 0.05) coenzyme Q concentrations | ||
but did not improve alpha-tocopherol depletion and increased formation of TBARS | but did not improve alpha-tocopherol depletion and increased formation of TBARS | ||
in the liver. Even though simvastatin treatment did not induce coenzyme Q | in the liver. Even though simvastatin treatment did not induce coenzyme Q | ||
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effect of statins on the coenzyme Q levels in the animal models of pathological | effect of statins on the coenzyme Q levels in the animal models of pathological | ||
conditions known to change the initial antioxidant defence system. | conditions known to change the initial antioxidant defence system. | ||
|keywords= | |keywords=Hypercholesterolaemia, Diabetes, Coenzyme Q, a-tocopherol, Simvastatin, Rat, Liver | ||
|mipnetlab=SK Bratislava Sumbalova Z | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
|diseases=Diabetes | |||
|injuries=Oxidative stress;RONS, Mitochondrial disease | |||
|organism=Rat | |organism=Rat | ||
|tissues=Heart, Liver | |tissues=Heart, Liver | ||
|additional=daibetes | |additional=daibetes | ||
}} | }} | ||
Latest revision as of 15:42, 27 March 2018
| Kuzelova M, Adameova A, Sumbalova Z, Paulikova I, Harcarová A, Svec P, Kucharska J. (2008) The effect of simvastatin on coenzyme Q and antioxidant/oxidant balance in diabetic-hypercholesterolaemic rats. Gen Physiol Biophys. 27:291-8. |
Kuzelova M, Adameova A, Sumbalova Z, Paulikova I, Harcarova A, Svec P, Kucharska (2008) Gen Physiol Biophys
Abstract: The effect of simvastatin administered for 10 days on coenzyme Q and antioxidant/oxidant balance in a rat model of diabetes mellitus and hypercholesterolaemia was studied. In the diabetic-hypercholesterolaemic rats the signs of oxidative stress-decreased alpha-tocopherol/cholesterol in the plasma (p < 0.01) and alpha-tocopherol in liver (p < 0.001) together with increased lipid peroxidation in the liver (TBARS, p < 0.05) were found. Increased coenzyme Q9 concentrations in the plasma (p < 0.05) and liver (p < 0.01), coenzyme Q10 in the myocardium (p < 0.05) and in the liver (p < 0.01) may indicate adaptation to oxidative stress. Administration of simvastatin (10 mg/kg) to the diabetic-hypercholesterolaemic rats counteracted increased myocardial (coenzyme Q10, p < 0.05) and liver (total coenzyme Q9, p < 0.05) coenzyme Q concentrations but did not improve alpha-tocopherol depletion and increased formation of TBARS in the liver. Even though simvastatin treatment did not induce coenzyme Q deficiency in plasma, heart and liver of the diabetic-hypercholesterolaemic rats as compared to the control levels, it was not able to prevent completely the changes in antioxidant/oxidant balance induced by diabetes and hypercholesterolaemia. The results highlight the importance of studying the effect of statins on the coenzyme Q levels in the animal models of pathological conditions known to change the initial antioxidant defence system. • Keywords: Hypercholesterolaemia, Diabetes, Coenzyme Q, a-tocopherol, Simvastatin, Rat, Liver
• O2k-Network Lab: SK Bratislava Sumbalova Z
Labels:
Pathology: Diabetes
Stress:Oxidative stress;RONS, Mitochondrial disease
Organism: Rat
Tissue;cell: Heart, Liver
daibetes
