Difference between revisions of "Malate-aspartate shuttle"

Revision as of 07:54, 17 December 2018

high-resolution terminology - matching measurements at high-resolution

Malate-aspartate shuttle

Description

The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate^2- for 2-oxoglutarate^2-. Cytosolic and mitochondrial malate dehydrogenase and transaminase complete the shuttle for the transport of cytosolic NADH into the mitochondrial matrix. It is most important in heart, liver and kidney.

Reference: Gnaiger 2014 MitoPathways

MitoPedia methods: Respirometry

MitoPedia topics: Enzyme

Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - »Bioblast link«

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 {{MitoPedia
 |description=The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate<sup>2-</sup> for 2-oxoglutarate<sup>2-</sup>. Cytosolic and mitochondrial malate dehydrogenase and transaminase complete the shuttle for the transport of cytosolic NADH into the mitochondrial matrix. It is most important in heart, liver and kidney.
-|info=[http://www.oroboros.at/?Gnaiger_2012_MitoPathways Gnaiger 2012 MitoPathways]
+|info=[[Gnaiger 2014 MitoPathways]]
-|type=Enzyme
-}}
-{{MitoPedia concepts|type=Enzyme
 }}
 {{MitoPedia methods
 |mitopedia method=Respirometry
-|type=Enzyme
-}}
-{{MitoPedia O2k and high-resolution respirometry|type=Enzyme
 }}
 {{MitoPedia topics
 |mitopedia topic=Enzyme
-|type=Enzyme
 }}
+::::* Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - [[Scaduto 1994 Eur J Biochem |»Bioblast link«]]