Difference between revisions of "Malate-aspartate shuttle"

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Malate-aspartate shuttle

Description

The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate^2- for 2-oxoglutarate^2-. Cytosolic and mitochondrial malate dehydrogenase and transaminase complete the shuttle for the transport of cytosolic NADH into the mitochondrial matrix. It is most important in heart, liver and kidney.

Reference: Gnaiger 2020 BEC MitoPathways

Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - »Bioblast link«

MitoPedia methods: Respirometry

MitoPedia topics: Enzyme

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 {{MitoPedia
 |description=The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate<sup>2-</sup> for 2-oxoglutarate<sup>2-</sup>. Cytosolic and mitochondrial malate dehydrogenase and transaminase complete the shuttle for the transport of cytosolic NADH into the mitochondrial matrix. It is most important in heart, liver and kidney.
-|info=[[MiPNet11.04]]
+|info=[[Gnaiger 2020 BEC MitoPathways]]
-|type=Enzyme
 }}
-{{Labeling
-|topics=Respiration; OXPHOS; ETS Capacity
+::::* Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - [[Scaduto 1994 Eur J Biochem |»Bioblast link«]]
-|enzymes=TCA Cycle and Matrix Dehydrogenases
+{{MitoPedia methods
+|mitopedia method=Respirometry
+}}
+{{MitoPedia topics
+|mitopedia topic=Enzyme
 }}