From Bioblast
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
- high-resolution terminology - matching measurements at high-resolution
Malate-aspartate shuttle
Description
The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate2- for 2-oxoglutarate2-. Cytosolic and mitochondrial malate dehydrogenase and transaminase complete the shuttle for the transport of cytosolic NADH into the mitochondrial matrix. It is most important in heart, liver and kidney.
Reference: Gnaiger 2020 BEC MitoPathways
- Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - »Bioblast link«
MitoPedia methods:
Respirometry
MitoPedia topics:
Enzyme
