|
|
| Line 17: |
Line 17: |
|
| |
|
| Diagnosis of mitochondrial function has advanced to a new technological level by the introduction of high-resolution respirometry, and on a scientific level of innovation by multiple substrate-uncoupler-inhibitor titration protocols with permeabilized fibres from small muscle biopsies. Nevertheless, compared to the small needle biopsy, functional mt-diagnosis on far less invasive blood samples (thrombocytes) might provide a '''new perspective for large-scale screening''' of individual athletes, extended cohorts in clinical studies, and application for individual patients. Simultaneous measurement of mitochondrial respiration and additional parameters (mt-membrane potential by ion selective electrodes, hydrogen peroxide production by spectrofluorimetry coupled to the O2k) requires the development of new diagnostic protocols that can be applied to permeabilized muscle fibres and/or intact and permeabilized thrombocytes. Although conventional cardiopulmonary exercise testing (CPX) provides insights into the coupling of external to cellular respiration, it mirrors insufficiently the metabolic processes in the contracting and recovering muscle. Thus, combining CPX and techniques assessing bioenergetic processes in the working muscles will undoubtedly increase the conclusiveness of exercise testing in athletes and patients. These diagnostic MultiSensor protocols in combination with comprehensive exercise testing and genetic fingerprinting will generate an '''innovative repertoire of diagnostic tests''' that can be offered in the context of sports and mitochondrial diseases. | | Diagnosis of mitochondrial function has advanced to a new technological level by the introduction of high-resolution respirometry, and on a scientific level of innovation by multiple substrate-uncoupler-inhibitor titration protocols with permeabilized fibres from small muscle biopsies. Nevertheless, compared to the small needle biopsy, functional mt-diagnosis on far less invasive blood samples (thrombocytes) might provide a '''new perspective for large-scale screening''' of individual athletes, extended cohorts in clinical studies, and application for individual patients. Simultaneous measurement of mitochondrial respiration and additional parameters (mt-membrane potential by ion selective electrodes, hydrogen peroxide production by spectrofluorimetry coupled to the O2k) requires the development of new diagnostic protocols that can be applied to permeabilized muscle fibres and/or intact and permeabilized thrombocytes. Although conventional cardiopulmonary exercise testing (CPX) provides insights into the coupling of external to cellular respiration, it mirrors insufficiently the metabolic processes in the contracting and recovering muscle. Thus, combining CPX and techniques assessing bioenergetic processes in the working muscles will undoubtedly increase the conclusiveness of exercise testing in athletes and patients. These diagnostic MultiSensor protocols in combination with comprehensive exercise testing and genetic fingerprinting will generate an '''innovative repertoire of diagnostic tests''' that can be offered in the context of sports and mitochondrial diseases. |
|
| |
| ==Workshops: Mitochondrial Competence Tyrol==
| |
|
| |
| ===5th MitoCom Workshop===
| |
|
| |
| '''Mitochondrial Competence Tyrol - Ankündigung'''
| |
|
| |
| Zeit: Jänner oder März 2012; wird angekündigt
| |
|
| |
| Ort: Standortagentur Tirol, Ing.-Etzel-Straße 17, Innsbruck
| |
|
| |
| Wir wollen mit diesem Treffen an die im Dezember 2010 begonnene Serie von MitoCom Workshops anschließen.
| |
|
| |
| Zum Programm:
| |
| * Kurzbericht über das ''MitoCom'' K-Regio Projekt
| |
| * Erweiterung der regionalen ''MitoCom'' Kontakte
| |
| | |
|
| |
|
| |
| ===4th MitoCom Workshop===
| |
|
| |
| '''Mitochondrial Competence Tyrol: Healthcare and Comprehensive Exercise Testing'''
| |
|
| |
| 2011, Mar 10, 15:30-18:00
| |
|
| |
| ''Sektion für Hygiene und Medizinische Mikrobiologie (MUI), HMM''
| |
|
| |
|
| |
|
| |
| ===3rd MitoCom Workshop===
| |
|
| |
| '''Mitochondrial Competence Tyrol: Sports and Disease'''
| |
|
| |
| 2011, Feb 03, 15:30-18:00
| |
|
| |
| ''Universitätssportinstitut (USI), LFU''
| |
|
| |
|
| |
| ===2nd ''MitoCom'' Workshop===
| |
|
| |
| '''[[Talk:MitoCom#Gespraechsnotiz_2nd_MitoCom_Workshop|Mitochondrial Competence Tyrol: Sports and Disease]]'''
| |
|
| |
| 2011, Jan 18, 15:30-18:00
| |
|
| |
| ''Seminarraum 6-G-050 Psychiatrische Klinik, Med. Univ. Innsbruck''
| |
|
| |
| '''Programm - Projektantrag K-Regio''': Focus on a K-Regio project application (K-Regio consortium)
| |
|
| |
| 15:30 '''Petra Stöckl''' (Standortagentur Tirol, Cluster Life Sciences Tirol), '''Erich Gnaiger''' (OROBOROS INSTRUMENTS): Begrüßung
| |
|
| |
| 15:45 '''Heribert Insam''' (Inst. Mikrobiologie, Univ. Innsbruck): K-Regio Projekt BioTreat, Renewable energy through Biological Treatment and Recycling Technologies: Projekterfahrung seit 01.07.2008.
| |
|
| |
| 16:10 '''Thomas Hugl''' (Ergospect), '''Erich Gnaiger''' (OROBOROS INSTRUMENTS): Projektantrag K-Regio aus der Sicht zweier Firmen in enger Vernetzung mit der Medizinischen Universität Innsbruck und internationalen Beziehungen.
| |
|
| |
| 16:30 Diskussion zum Projektantrag K-Regio: ''MitoCom Tyrol: Sports and Disease'' – Mitochondrial Diagnostic Competence in Life Style Diagnostics to Mitochondrial Diseases (Projektantrag engl.)
| |
|
| |
| • Gemeinsames Ziel
| |
|
| |
| • Projektpartner
| |
|
| |
| • Zeitplan zur Einreichung (bis 15. März 2011)
| |
| Diskussionsleitung '''Petra Stöckl''' (Cluster Life Sciences Tirol)
| |
| Teilnehmer
| |
|
| |
| '''Burtscher Martin''', Inst. Sportwissenschaften, Univ. Innsbruck.
| |
|
| |
| '''Dietrich Hermann''', Zentrale Versuchstieranlage, Medizinische Universität Innsbruck.
| |
|
| |
| '''Fasching Mario''', OROBOROS INSTRUMENTS, Innsbruck.
| |
|
| |
| '''Galvan Oliver''', HNO, Medizinische Universität Innsbruck.
| |
|
| |
| '''Gatterer Hannes''', Inst. Sportwissenschaften, Univ. Innsbruck.
| |
|
| |
| '''Gnaiger Erich''', D. Swarovski Res. Lab., Dept. Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck; and OROBOROS INSTRUMENTS, Innsbruck.
| |
|
| |
| '''Göbel Georg''', Medizinische Universität Innsbruck.
| |
|
| |
| '''Hansel Armin''', Ionimed Analytik, Innsbruck.
| |
|
| |
| '''Harrison David''', Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; and OROBOROS INSTRUMENTS, Innsbruck.
| |
|
| |
| '''Hugl Thomas''', Ergospect Mecial Technology, Innsbruck.
| |
|
| |
| '''Insam Heribert''', Inst. Mikrobiologie, Univ. Innsbruck.
| |
|
| |
| '''Jansen-Dürr Pidder''', Inst. Biomedical Ageing Research, Austrian Academy of Sciences, Innsbruck.
| |
|
| |
| '''Kohl Ingrid''', Ionimed Analytik, Innsbruck.
| |
|
| |
| '''Parson Walther''', Institut für Gerichtliche Medizin, Medizinische Universität Innsbruck.
| |
|
| |
| '''Pesta Dominik''', Department of Radiology, Medical University of Innsbruck.
| |
|
| |
| '''Pototschnig Claus''', HNO, Medizinische Universität Innsbruck.
| |
|
| |
| '''Schneider Rainer''', Institut für Biochemie, Universität Innsbruck.
| |
|
| |
| '''Stecher Katrin''', OROBOROS INSTRUMENTS, Innsbruck.
| |
|
| |
| '''Stöckl Petra''', Tiroler Zukunftsstiftung, Cluster Life Sciences Tirol, Innsbruck.
| |
|
| |
| '''Stoffner Rudolf''', Tiroler Zukunftsstiftung.
| |
|
| |
| '''Widmann Gerlig''', Department of Radiology, Medical University of Innsbruck.
| |
|
| |
| '''Wiethüchter Anita''', OROBOROS INSTRUMENTS, Innsbruck.
| |
|
| |
|
| |
| ''* 18:18 Reception: ''MiPArt Exhibition'' '''ODRA NOEL''' and '''RICHARD AGREITER'''
| |
| OROBOROS INSTRUMENTS and ''MiPArt Gallery'', Schöpfstr. 18, Innsbruck, AT''
| |
|
| |
| ===1st ''MitoCom'' Workshop===
| |
|
| |
| '''[[Talk:MitoCom#Gespraechsnotiz_1st_MitoCom_Workshop|Innsbruck, 2010, December 7]]'''
| |
|
| |
| Time: 15:30-19:00 pm
| |
|
| |
| Location: [http://www.dibk.at/index.php?portal=13 Haus der Begegnung], Rennweg 12, A-6020 Innsbruck
| |
|
| |
| The '''Tiroler Zukunftsstiftung''' / [http://www.zukunftsstiftung.at/page.cfm?vpath=cluster/life_sciences_tirol Cluster Life Science] offers a seminar in the series of 'Impulsgespräche', as a meeting of experts and interested parties.
| |
|
| |
| In addition to short presentations on current projects in the fields of mitochondrial physiology, pathology and biotechnology, the discussion will also focus on a potential application (K-Regio Project) to become a Regional Centre of Excellence (Kompetenzzentrum). General information will be provided on K-Regio Projects.
| |
|
| |
| '''Programme 2010-Dec-07'''
| |
|
| |
| 15:30 '''Petra Stöckl''' (Tiroler Zukunftsstiftung, Cluster Life Sciences Tirol, Innsbruck, AT)
| |
| '''Welcome'''.
| |
| 15:35 '''Erich Gnaiger''' (D. Swarovski Research Laboratory, Department of Visceral, Transplant
| |
| and Thoracic Surgery, Medical University of Innsbruck, AT; and OROBOROS INSTRUMENTS,
| |
| Innsbruck, AT)
| |
| '''A perspective of MitoCom Tyrol'''.
| |
|
| |
| ''Hotspots in Mitochondrial Research''
| |
|
| |
| 15:50 '''Matallo J''', Calzia E (Division APV, Dept. Anesthesiology, University Hospital, Ulm, DE)
| |
| '''Interactions between sulfide and mitochondrial respiration in cultured murine'''
| |
| '''alveolar macrophages'''.
| |
| 16:00 '''Pesta D''', Faulhaber M, Burtscher M, Gnaiger E, Schocke M (Departments of Radiology and
| |
| Visceral, Transplant and Thoracic Surgery Medical University of Innsbruck; and
| |
| Inst. Sportwissenschaften, Univ. Innsbruck, AT)
| |
| '''Mitochondrial adaptations to endurance training'''.
| |
| 16:10 '''Perkhofer S''', Lass-Flörl C (Department für Hygiene, Mikrobiologie und
| |
| Sozialmedizin, Medical University of Innsbruck, AT)
| |
| '''Interaction between platelets and ''Aspergillus fumigatus'': possible role in the'''
| |
| '''inhibition of the fungal respiratory system'''.
| |
| 16:20 '''Zschocke J''', Amberger A (Divisions of Human Genetics and Clinical Genetics,
| |
| Medical University Innsbruck, AT)
| |
| '''17β-hydroxysteroid dehydrogenase type 10 deficiency – the first inborn error'''
| |
| '''of mitochondrial transcript processing?'''
| |
|
| |
| ''Förderinformation Tiroler Zukunftsstiftung''
| |
|
| |
| 16:30 '''Rudolf Stoffner''' ([http://www.zukunftsstiftung.at/page.cfmvpath=foerderungen/k_regio Projekt Manager Forschungsprogramme], Tiroler Zukunftsstiftung)
| |
| '''Alps Bio Cluster'''.
| |
| 16:45 '''Georg Göbel''' (Tiroler Zukunftsstiftung)
| |
|
| |
| 16:45 Pause
| |
|
| |
| ''Round Table''
| |
|
| |
| 17:20 Who is who (5 min)
| |
|
| |
| * [[Dietrich H|'''Dietrich Hermann''']], Zentrale Versuchstieranlage der Medizinischen Universität Innsbruck, AT
| |
| * [[Gatterer H|'''Gatterer Hannes''']], Inst. Sportwissenschaften, Univ. Innsbruck, AT
| |
| * [[Griesser U|'''Griesser Ulrich''']], Institut für Pharmazie, Univ. Innsbruck, AT
| |
| * [[Harrison DK|'''Harrison David''']], Institute of Cellular Medicine, Newcastle University,
| |
| Newcastle upon Tyne, UK; and [http://www.oroboros.at OROBOROS INSTRUMENTS], Innsbruck, AT
| |
| * [[Huettenhofer A|'''Hüttenhofer Alexander''']], Division of Genomics & RNomics, Biocenter,
| |
| Innsbruck Medical University, AT
| |
| * [[JansenDuerr P|'''Jansen-Dürr Pidder''']], Institute for Biomedical Ageing Research,
| |
| Austrian Academy of Sciences, Innsbruck, AT
| |
| * [[Klocker H|'''Klocker Helmut''']], Universitätsklinik für Urologie, Medical University of Innsbruck, AT
| |
| * [[Kofler K|'''Kofler Kurt''']], [http://www.cemit.at CEMIT] - Center of Excellence in
| |
| Medicine and IT GmbH, Innsbruck, AT
| |
| * [[Koller A|'''Koller Arnold''']], Institut für Sport-, Alpinmedizin und Gesundheitstourismus
| |
| (ISAG), Innsbruck, AT
| |
| * [[Rieneck W|'''Rieneck Wolfram''']], [http://www.bep.at BEP], Büro für Europäische Programme, Innsbruck, AT
| |
| * [[Schobersberger W|'''Schobersberger Wolfgang''']], Institut für Sport-, Alpinmedizin
| |
| und Gesundheitstourismus (ISAG), Innsbruck, AT
| |
| * [[Schocke M|'''Schocke Michael''']], Department of Radiology, Medical University of Innsbruck, AT; and
| |
| [http://www.ergospect.com Ergospect Mecial Technology], Innsbruck, AT
| |
| * [[Troppmair J|'''Troppmair Jakob''']], D. Swarovski Research Laboratory, Department of Visceral,
| |
| Transplant and Thoracic Surgery, Innsbruck Medical University, AT
| |
| * [[Weiss G|'''Weiss Günter''']], Universtätsklinik für Innere Medizin I, Innsbruck Medical University, AT
| |
| * [[Wenning GK|'''Wenning Gregor K''']], Abt. f. klinische Neurobiologie, Parkinson-Zentrum,
| |
| Medical University of Innsbruck, AT
| |
|
| |
|
| |
| Companies
| |
|
| |
| * [[Fasching M|'''Fasching Mario''']], [[Renner K|'''Renner-Sattler Kathrin''']], [[Sumbalova Z|'''Sumbalová Zuzana''']], [[Wiethuechter A|'''Wiethüchter Anita''']], [[Gnaiger E|'''Gnaiger Erich''']],
| |
| [http://www.oroboros.at OROBOROS INSTRUMENTS], Innsbruck, AT
| |
| * [[Hansel A|'''Hansel Armin''']], [http://ionimed.com Ionimed Analytik], Innsbruck, AT.
| |
| * [[Hugl T|'''Hugl Thomas''']], [[Schocke M|'''Schocke Michael''']],[http://www.ergospect.com Ergospect Mecial Technology], Innsbruck, AT
| |
|
| |
|
| |
| 18:30-19:00 Discussion – Summary
| |
|
| |
| ''Participants''
| |
|
| |
| * [[Amberger A|'''Amberger Albert''']], Divisions of Human Genetics and Clinical Genetics, Medical University Innsbruck, AT
| |
| * [[Calzia E|'''Calzia Enrico''']], Division APV, Dept. Anesthesiology, University Hospital, Ulm, DE
| |
| * [[Dietrich H|'''Dietrich Hermann''']], Zentrale Versuchstieranlage der Medizinischen Universität Innsbruck, AT
| |
| * [[Fasching M|'''Fasching Mario''']], [http://www.oroboros.at OROBOROS INSTRUMENTS], Innsbruck, AT
| |
| * [[Gatterer H|'''Gatterer Hannes''']], Inst. Sportwissenschaften, Univ. Innsbruck, AT
| |
| * [[Gnaiger E|'''Gnaiger Erich''']], D. Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, AT; and [http://www.oroboros.at OROBOROS INSTRUMENTS], Innsbruck, AT
| |
| * [[Goebel G|'''Göbel Georg''']], Tiroler Zukunftsstiftung, AT
| |
| * [[Griesser U|'''Griesser Ulrich''']], Institut für Pharmazie, Univ. Innsbruck, AT
| |
| * [[Grubeck-Loebenstein B|'''Grubeck-Loebenstein Beatrix''']], Institute for Biomedical Ageing Research, Austrian Academy of Sciences, Innsbruck, AT
| |
| * [[Hansel A|'''Hansel Armin''']], [http://ionimed.com Ionimed Analytik], Innsbruck, AT.
| |
| * [[Harrison DK|'''Harrison David''']], Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; and [http://www.oroboros.at OROBOROS INSTRUMENTS], Innsbruck, AT
| |
| * [[Hugl T|'''Hugl Thomas''']], [http://www.ergospect.com Ergospect Mecial Technology], Innsbruck, AT
| |
| * [[Huettenhofer A|'''Hüttenhofer Alexander''']], Division of Genomics & RNomics, Biocenter, Innsbruck Medical University, AT
| |
| * [[JansenDuerr P|'''Jansen-Dürr Pidder''']], Institute for Biomedical Ageing Research, Austrian Academy of Sciences, Innsbruck, AT
| |
| * [[Kofler K|'''Kofler Kurt''']], [http://www.cemit.at CEMIT - Center of Excellence in Medicine and IT GmbH], Innsbruck, AT
| |
| * [[Koller A|'''Koller Arnold''']], Institut für Sport-, Alpinmedizin und Gesundheitstourismus (ISAG), Innsbruck, AT
| |
| * [[Lass-Floerl C|'''Lass-Floerl Cornelia''']], Department für Hygiene, Mikrobiologie und Sozialmedizin, Medical University of Innsbruck, AT
| |
| * [[Matallo J|'''Matallo Jose''']], Division APV, Dept. Anesthesiology, University Hospital, Ulm, DE
| |
| * [[Perkhofer S|'''Perkhofer Susanne''']], Department für Hygiene, Mikrobiologie und Sozialmedizin, Medical University of Innsbruck, AT
| |
| * [[Pesta D|'''Pesta Dominik''']], Department of Radiology, Medical University of Innsbruck, AT
| |
| * [[Rieneck W|'''Rieneck Wolfram''']], [http://www.bep.at BEP], Büro für Europäische Programme, Innsbruck, AT
| |
| * [[Schocke M|'''Schocke Michael''']], Department of Radiology, Medical University of Innsbruck, AT; and [http://www.ergospect.com Ergospect Mecial Technology], Innsbruck, AT
| |
| * [[Stoeckl P|'''Stöckl Petra''']], [http://www.zukunftsstiftung.at Tiroler Zukunftsstiftung], [http://www.zukunftsstiftung.at/page.cfm?vpath=cluster/life_sciences_tirol Cluster Life Sciences Tirol], Innsbruck, AT
| |
| * [[Stoffner R|'''Stoffner Rudolf''']], [http://www.zukunftsstiftung.at Tiroler Zukunftsstiftung], AT
| |
| * [[Stolz C|'''Stolz Claudia''']], [http://www.zukunftsstiftung.at Tiroler Zukunftsstiftung], [http://www.zukunftsstiftung.at/page.cfm?vpath=cluster/life_sciences_tirol Cluster Life Sciences Tirol], Innsbruck, AT
| |
| * [[Sumbalova Z|'''Sumbalová Zuzana''']], [http://www.oroboros.at OROBOROS INSTRUMENTS], Innsbruck, AT
| |
| * [[Troppmair J|'''Troppmair Jakob''']], D. Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, AT
| |
| * [[Wiethuechter A|'''Wiethüchter Anita''']], [http://www.oroboros.at OROBOROS INSTRUMENTS], Innsbruck, AT
| |
| * [[Zschocke J|'''Zschocke Johannes''']], Divisions of Human Genetics and Clinical Genetics, Medical University Innsbruck, AT
| |
|
| |
| ''Further contacts''
| |
|
| |
| * [[Braun A|'''Braun Andreas''']], D. Swarovski Tourism Services GmbH, Kristallwelten, Wattens, AT
| |
| * [[Burtscher M|'''Burtscher Martin''']], Inst. Sportwissenschaften, Univ. Innsbruck, AT
| |
| * [[Galvan O|'''Galvan Oliver''']], HNO, Medizinische Universität Innsbruck, AT
| |
| * [[Gradl P|'''Gradl Philipp''']], [http://[email protected] WGT-Elektronik GmbH & Co KG], Kolsass, AT | |
| * [[Kohl I|'''Kohl Ingrid''']], Ionimed Analytik, Innsbruck, AT
| |
| * [[Skladal D|'''Karall Daniela''']], Neonatologie, Neuropädiatrie und angeborene Stoffwechselstörungen, Department für Kinder- und Jugendheilkunde, Universitätsklinik für Pädiatrie IV, Medizinische Universität Innsbruck, AT
| |
| * [[Parson W|'''Parson Walther''']], [http://gerichtsmedizin.at/parson_walther.html Institut für Gerichtliche Medizin], Medizinische Universität Innsbruck, AT
| |
| * [[Pototschnig C|'''Pototschnig Claus''']], HNO, Medizinische Universität Innsbruck, AT
| |
| * [[Schneider R|'''Schneider Rainer''']], Institut für Biochemie, Universität Innsbruck, AT
| |
| * [[Schobersberger W|'''Schobersberger Wolfgang''']], Institut für Sport-, Alpinmedizin und Gesundheitstourismus (ISAG), Innsbruck, AT
| |
| * [[Stecher K|'''Stecher Katrin''']], OROBOROS INSTRUMENTS, Innsbruck, AT
| |
| * [[Weiss G|'''Weiss Günter''']], Universtätsklinik für Innere Medizin I, Innsbruck Medical University, AT
| |
| * [[Wenning GK|'''Wenning Gregor K''']], [http://www.i-med.ac.at/neurologie/forschung/cnbu/ Abt. f. klinische Neurobiologie], [http://www.emsa-sg.org Parkinson-Zentrum], Medical University of Innsbruck, AT
| |
| * [[Widmann G|'''Widmann Gerlig''']], Department of Radiology, Medical University of Innsbruck, AT
| |
|
| |
| ==''MitoCom Tyrol: Healthcare and Sport''==
| |
|
| |
| ===Centre of Excellence===
| |
|
| |
| A research and diagnostic laboratory should be established to form a '''Centre of Excellence and Service Centre for Clinical Mitochondrial Physiology and Pathology'''. In a laboratory equipped with state-of-the-art instrumentation in mitochondrial respiratory physiology and bioenergetics, with model systems from cultured cells to human blood samples and biopsies, linked to ergometric and P-NMR exercise testing and cardiovascular monitoring, highly trained technical and scientific staff will provide a basis for
| |
|
| |
| * carrying out measurements in the context of '''interdisciplinary pilot projects''', supported by the expertise for experimental design, analysis and interpretation of data in terms of specific mitochondrial function/dysfunction,
| |
|
| |
| * for the operation of a '''Centre for Functional Mitochondrial Diagnostics''' as an institution unique in Europe (in cooperation with other specialized centres, e.g. Salzburg, AT; Bordeaux, FR; Copenhagen, DK; Nijmegen, NL; Newcastle, UK), which will
| |
|
| |
| * attract '''international cooperations''' in the field of mitochondrial physiology to Innsbruck.
| |
|
| |
| The combined expertise of both '''local SMEs''' (small and medium enterprises) '''and scientific institutions''' will make it possible to quickly establish a laboratory under international technological leadership, in particular, based on
| |
|
| |
| (i) [[high-resolution respirometry]] ([http://www.oroboros.at OROBOROS INSTRUMENTS]), coupled with spectrophotometry (Harrison; cytochrome redox spectra) and spectrofluorimety,
| |
|
| |
| (ii) the reputation of the [http://www.mitophysiology.org International Mitochondrial Physiology Society], which has its base in Innsbruck (Gnaiger; Chairperson; www.mitophysiology.org).
| |
|
| |
| In combination with clinical diagnostic in vivo techniques (Schocke; P-NMR; ergometry; Ergospect) and expertise in genetics and molecular biology (Zschocke, Hüttenhofer; Genomics, RNomics; ..), '''MitoCom Innsbruck''' will open up the perspective of establishing a world-leading, unique Centre of Excellence in clinical mitochondrial physiology. The relationship between sports, health and disease (Burtscher, Schobersberger; altitude medicine, hypoxia, endurance training, sports therapy, competitive sports) will be integral to interdisciplinary projects at MitoCom Tyrol and will extend the reputation of '''"Tyrol - a Heart for Sports"'''.
| |
|
| |
| === Stichworte ===
| |
|
| |
| * Aerobe Fitness vom Kind bis ins hohe Alter – Lebensqualität mit gesunden Mitochondrien
| |
| * Mitochondrien und Leistung vom Muskel bis zum Hirn und Immunsystem
| |
| * Höhe und Hypoxie – Eustress/Dysstress/Synstress: Sauerstoffversorgung und körperliche Aktivität
| |
| * Höhenaufenthalt, mitochondrielle und physiologische Fitness
| |
| * Mitochondrielle Präventivmedizin: die kostengünstigste Vorsorge – Krebs (Kooperation Oncotyrol), Diabetes 2 und 3, Alzheimer, Parkinson - alle degenerative Krankheiten
| |
| * Mitochondrielle Therapie: Inaktivität macht krank – körperliche Bewegung ist Medizin
| |
| * Mitochondrielle Funktion und Leistungssport
| |
| * Genetische Disposition, mt-Haplotypen, Heteroplasmie und mitochondrielle Funktion
| |
| * Mitochondrielle Funktion, Evolution und ökologische Anpassung
| |
| * Qualitätskontrolle in der funktionellen mt-Diagnostik – siehe QA-Workshop Innsbruck, Dez. 2009; MiPNet14.12: http://www.oroboros.at/index.php?qa-in-respirometry
| |
|
| |
| ==MitoCom News==
| |
|
| |
| ===Cluster Life Sciences Award 2010===
| |
| [[File:2010-11 OROBOROS-Cluster-Award.jpg|400px|thumb|right]]
| |
|
| |
| '''Cluster Life Sciences Award 2010''' (23. November 2010, Tiroler Innovationstag):
| |
|
| |
| * [http://www.oroboros.at OROBOROS INSTRUMENTS]
| |
|
| |
| "Punktegleichstand gab es im Cluster Life Sciences Tirol. Deshalb erging der Cluster Award in dieser Kategorie gleich an zwei Unternehmen. Einmal an die Ergospect GmbH für ihr „Diagnostic Pedal“, mit dem Muskeln im Magnetresonanztomographen dynamisch belastet werden können. Sowie ein weiteres Mal an Oroboros Instruments für den Oxygraphen-2k als hochauflösendes Gerät zur Bestimmung der Zell- und Gewebeatmung."
| |
|
| |
|
| |
|
| |
| Erich Gnaiger nimmt die Auszeichnung für OROBOROS INSTRUMENTS entgegen. Die Jurymitglieder (von links) Sebastian Huber (ITG Salzburg) und Hubert Hofer (TIS Bozen) gratulieren gemeinsam mit Landesrätin Patrizia Zoller-Frischauf und Harald Gohm.
| |
|
| |
| ===News - Publications===
| |
|
| |
| * Boushel R, Gnaiger E, Calbet JA, Gonzalez-Alonso J, Wright-Paradis C, Sondergaard H, Ara I, Helge JW, Saltin B (2011) Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans. Mitochondrion 11: 303-307. - [[Talk:Boushel_2011_Mitochondrion|Selected: Faculty 1000 with comments]]
| |
|
| |
| * science2business award 2011
| |
| Am science2business-Award beteiligen sich die besten Kooperationspartner aus Wirtschaft und Wissenschaft.
| |
| Dotation: EUR 12.000,00 - bereitgestellt vom BM für Wirtschaft, Familie und Jugend
| |
| Deadline: 10. Februar 2011
| |
| Naehere Infos: http://www.life-science.at/career2/index.php
| |
|
| |
| * 26.04.2011 [http://www.oroboros.at/index.php?nextcourse 61st O2k-Workshop on High-Resolution Respirometry]
| |
| * 10.12.2010 [[Talk:MitoCom|Call-for-Papers on Sedentary Lifestyle]]
| |
| * 06.12.2010 [http://www.wirtschaftsblatt.at/archiv/oroboros-baut-an-kompetenzzentrum-450147/print.do Wirtschaftsblatt]
| |
| * [http://www.bioblast.at/index.php/Special:BrowseData/Publications?Instruments_and_Methods=Oxygraph-2k Oxygraph-2k applications]
| |
| * 26.11.2010 [http://www.uibk.ac.at/public-relations/presse/archiv/2010/112602/ Diabetes-Medikament ist neue Hoffnung im Kampf gegen Alzheimer]
| |
| * 23.11.2010 [http://regionaut.meinbezirk.at/nassereith/wirtschaft/standort-tirol-blickt-in-die-zukunft-d37369.html Standort Tirol blickt in die Zukunft - Kategorie Life Sciences: Oxygraph-2k als hochauflösendes Gerät zur Bestimmung der Zell- und Gewebeatmung]
| |
|
| |
| ===OROBOROS MiPNet Reference Laboratories in Innsbruck===
| |
|
| |
| * [[AT_Innsbruck_Burgstaller W]]
| |
| * [[AT_Innsbruck_Burtscher M]]
| |
| * [[AT_Innsbruck_Gnaiger E]]
| |
| * [[AT_Innsbruck_Jansen Duerr P]]
| |
| * [[AT_Innsbruck_OROBOROS]]
| |
|
| |
|
| |
| ===Conference on Crystals in Mitochondrial Competence===
| |
|
| |
| * 2012-12-12
| |
|
| |
| * A welcome in Crystal World Swarovski - Tyrol with a heart for sports
| |
| * Crystals and science - history of science - the roots of innovation
| |
| * Mitochondrial life style - from evolution to preventive medicine
| |
| * Mitochondria at the top of life - their big role in sports
| |
| * Mitochondrial science without borders - Health and disease - MitoCom World-Wide
| |
