Moisoi 2018 MiP2018a: Difference between revisions
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{{Abstract | {{Abstract | ||
|title=[[Image: | |title=[[Image:MoisoiN.jpg|left|90px|Nicoleta Moisoi]] Mitochondria-nucleus communication: Who talks first? Who talks louder? | ||
|info=[[MiP2018]] | |info=[[MiP2018]] | ||
|authors=Moisoi N | |authors=Moisoi N | ||
|year=2018 | |year=2018 | ||
|event=MiP2018 | |event=MiP2018 | ||
|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action | |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MitoEAGLE]] | ||
Mitochondrial dysfunction and DNA damage accumulation are recognised hallmarks of age related diseases. Mitochondrial dysfunction initiates protective signalling mechanisms coordinated at nuclear level particularly by modulating transcription of stress signalling factors. In turn, the cellular response to DNA lesions comprises a series of interconnected complex protective pathways, which require the energetic and metabolic support of the mitochondria. Here I will discuss how mitochondria-nucleus communication operates in physiologically relevant stress conditions to protect against neurodegeneration. Thus in mammalian cells and Drosophila subjected to both mitochondrial and genotoxic stress, mitochondrial activity slows down while maintaining the DNA integrity takes priority. Depending on the site of the initiating stress, mitochondria or the nucleus can take the lead in stress response initiation - βtalks firstβ. In most situations the nucleus and its integrity appear to be a priority - βtalks louderβ. These communication phenomena have a protective role against neurodegenerative processes. | Mitochondrial dysfunction and DNA damage accumulation are recognised hallmarks of age related diseases. Mitochondrial dysfunction initiates protective signalling mechanisms coordinated at nuclear level particularly by modulating transcription of stress signalling factors. In turn, the cellular response to DNA lesions comprises a series of interconnected complex protective pathways, which require the energetic and metabolic support of the mitochondria. Here I will discuss how mitochondria-nucleus communication operates in physiologically relevant stress conditions to protect against neurodegeneration. Thus in mammalian cells and Drosophila subjected to both mitochondrial and genotoxic stress, mitochondrial activity slows down while maintaining the DNA integrity takes priority. Depending on the site of the initiating stress, mitochondria or the nucleus can take the lead in stress response initiation - βtalks firstβ. In most situations the nucleus and its integrity appear to be a priority - βtalks louderβ. These communication phenomena have a protective role against neurodegenerative processes. | ||
|editor=[[Plangger M]], [[Kandolf G]], | |editor=[[Plangger M]], [[Kandolf G]], |
Latest revision as of 08:09, 13 September 2018
Mitochondria-nucleus communication: Who talks first? Who talks louder? |
Link: MiP2018
Moisoi N (2018)
Event: MiP2018
Mitochondrial dysfunction and DNA damage accumulation are recognised hallmarks of age related diseases. Mitochondrial dysfunction initiates protective signalling mechanisms coordinated at nuclear level particularly by modulating transcription of stress signalling factors. In turn, the cellular response to DNA lesions comprises a series of interconnected complex protective pathways, which require the energetic and metabolic support of the mitochondria. Here I will discuss how mitochondria-nucleus communication operates in physiologically relevant stress conditions to protect against neurodegeneration. Thus in mammalian cells and Drosophila subjected to both mitochondrial and genotoxic stress, mitochondrial activity slows down while maintaining the DNA integrity takes priority. Depending on the site of the initiating stress, mitochondria or the nucleus can take the lead in stress response initiation - βtalks firstβ. In most situations the nucleus and its integrity appear to be a priority - βtalks louderβ. These communication phenomena have a protective role against neurodegenerative processes.
β’ Bioblast editor: Plangger M, Kandolf G
Labels: MiParea: nDNA;cell genetics Pathology: Aging;senescence, Neurodegenerative
Organism: Other mammals, Drosophila
Affiliations
- Leicester School Pharmacy, De Montfort Univ, United Kingdom. - [email protected]