Difference between revisions of "Oxalomalic acid"
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|description='''Oxalomalic acid''' is an inhibitor of aconitase (and of cytoplasmic NADP-dependent isocitrate dehydrogenase). Aconitase mediates the isomerization of citrate to isocitrate as the first step in the [[TCA_cycle| TCA cycle]]. Oxalomalic acid has been used at 1 mM concentration and after 45 min of pre-incubation to inhibit aconitase in permeabilized rat Soleus muscle fibres, inhibiting the enzyme by 24% [Osiki 2016 FASEB J]. | |description='''Oxalomalic acid''' is an inhibitor of aconitase (and of cytoplasmic NADP-dependent isocitrate dehydrogenase). Aconitase mediates the isomerization of citrate to isocitrate as the first step in the [[TCA_cycle| TCA cycle]]. Oxalomalic acid has been used at 1 mM concentration and after 45 min of pre-incubation to inhibit aconitase in permeabilized rat Soleus muscle fibres, inhibiting the enzyme by 24% ([[Osiki 2016 FASEB J]]). | ||
|info=[http://bioblast.at/index.php/Osiki_2016_FASEB_J Osiki 2016 FASEB J] | |info=[http://bioblast.at/index.php/Osiki_2016_FASEB_J Osiki 2016 FASEB J] | ||
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Latest revision as of 11:18, 2 June 2016
- high-resolution terminology - matching measurements at high-resolution
Oxalomalic acid
Description
Oxalomalic acid is an inhibitor of aconitase (and of cytoplasmic NADP-dependent isocitrate dehydrogenase). Aconitase mediates the isomerization of citrate to isocitrate as the first step in the TCA cycle. Oxalomalic acid has been used at 1 mM concentration and after 45 min of pre-incubation to inhibit aconitase in permeabilized rat Soleus muscle fibres, inhibiting the enzyme by 24% (Osiki 2016 FASEB J).
Reference: Osiki 2016 FASEB J
MitoPedia topics: Inhibitor
