Difference between revisions of "Oxoglutarate dehydrogenase"
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{{MitoPedia | {{MitoPedia | ||
|abbr=OgDH | |abbr=OgDH | ||
|description='''Oxoglutarate dehydrogenase''' ( | |description='''Oxoglutarate dehydrogenase''' (α-ketoglutarate dehydrogenase) is a highly regulated enzyme of the [[tricarboxylic acid cycle]]. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD<sup>+</sup> to [[NADH]] and thus links to [[Complex I]] in the Electron transfer-pathway. OgDH is activated by low Ca<sup>2+</sup> (<20 µM) but inactivated by high Ca<sup>2+</sup> (>100 µM). OgDH is an important source of ROS. | ||
|info=[ | |info=[[Tretter 2005 Philos Trans R Soc Lond B Biol Sci]] | ||
}} | }} | ||
{{MitoPedia methods}} | |||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Enzyme | |mitopedia topic=Enzyme | ||
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:::: The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD). | |||
:::: The reaction catalyzed by OgDH is: | |||
::::::::Oxoglutarate (α-ketoglutarate) + NAD<sup>+</sup> + CoA → Succinyl CoA + CO<sub>2</sub> + NADH + H<sup>+</sup> | |||
Latest revision as of 15:03, 20 October 2017
- high-resolution terminology - matching measurements at high-resolution
Oxoglutarate dehydrogenase
Description
Oxoglutarate dehydrogenase (α-ketoglutarate dehydrogenase) is a highly regulated enzyme of the tricarboxylic acid cycle. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD+ to NADH and thus links to Complex I in the Electron transfer-pathway. OgDH is activated by low Ca2+ (<20 µM) but inactivated by high Ca2+ (>100 µM). OgDH is an important source of ROS.
Abbreviation: OgDH
Reference: Tretter 2005 Philos Trans R Soc Lond B Biol Sci
MitoPedia topics: Enzyme
- The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).
- The reaction catalyzed by OgDH is:
- Oxoglutarate (α-ketoglutarate) + NAD+ + CoA → Succinyl CoA + CO2 + NADH + H+
- The reaction catalyzed by OgDH is:
