Difference between revisions of "Oxoglutarate dehydrogenase"
From Bioblast
Beno Marija (talk | contribs) Β |
|||
(10 intermediate revisions by 2 users not shown) | |||
Line 1: | Line 1: | ||
{{MitoPedia | {{MitoPedia | ||
|abbr=OgDH | |abbr=OgDH | ||
|description='''Oxoglutarate dehydrogenase''' ( | |description='''Oxoglutarate dehydrogenase''' (Ξ±-ketoglutarate dehydrogenase) is a highly regulated enzyme of the [[tricarboxylic acid cycle]]. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD<sup>+</sup> to [[NADH]] and thus links to [[Complex I]] in the Electron transfer-pathway. OgDH is activated by low Ca<sup>2+</sup> (<20 Β΅M) but inactivated by high Ca<sup>2+</sup> (>100 Β΅M). OgDH is an important source of ROS. | ||
|info=[[Tretter 2005 Philos Trans R Soc Lond B Biol Sci]] | |||
|info=[ | |||
}} | }} | ||
{{MitoPedia methods}} | |||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Enzyme | |mitopedia topic=Enzyme | ||
}} | }} | ||
:::: The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD). | |||
Β | |||
Β | |||
The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD). | |||
The reaction catalyzed by | :::: The reaction catalyzed by OgDH is: | ||
Ξ±-ketoglutarate + NAD<sup>+</sup> + CoA β Succinyl CoA + CO<sub>2</sub> + NADH | ::::::::Oxoglutarate (Ξ±-ketoglutarate) + NAD<sup>+</sup> + CoA β Succinyl CoA + CO<sub>2</sub> + NADH + H<sup>+</sup> |
Latest revision as of 15:03, 20 October 2017
Description
Oxoglutarate dehydrogenase (Ξ±-ketoglutarate dehydrogenase) is a highly regulated enzyme of the tricarboxylic acid cycle. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD+ to NADH and thus links to Complex I in the Electron transfer-pathway. OgDH is activated by low Ca2+ (<20 Β΅M) but inactivated by high Ca2+ (>100 Β΅M). OgDH is an important source of ROS.
Abbreviation: OgDH
Reference: Tretter 2005 Philos Trans R Soc Lond B Biol Sci
MitoPedia topics: Enzyme
- The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).
- The reaction catalyzed by OgDH is:
- Oxoglutarate (Ξ±-ketoglutarate) + NAD+ + CoA β Succinyl CoA + CO2 + NADH + H+
- The reaction catalyzed by OgDH is: