Difference between revisions of "Oxoglutarate dehydrogenase"

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Oxoglutarate dehydrogenase

Description

Oxoglutarate dehydrogenase (α-ketoglutarate dehydrogenase) is a highly regulated enzyme of the tricarboxylic acid cycle. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD⁺ to NADH and thus links to Complex I in the Electron transfer-pathway. OgDH is activated by low Ca²⁺ (<20 µM) but inactivated by high Ca²⁺ (>100 µM). OgDH is an important source of ROS.

Abbreviation: OgDH

Reference: Tretter 2005 Philos Trans R Soc Lond B Biol Sci

MitoPedia topics: Enzyme

The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).

The reaction catalyzed by OgDH is:

Oxoglutarate (α-ketoglutarate) + NAD⁺ + CoA → Succinyl CoA + CO₂ + NADH + H⁺

@@ Line 1: / Line 1: @@
 {{MitoPedia
 |abbr=OgDH
-|description='''Oxoglutarate dehydrogenase''' (NADP<sup>+</sup>) is part of the oxoglutarate dehydrogenase complex (OGDC)/
+|description='''Oxoglutarate dehydrogenase''' (α-ketoglutarate dehydrogenase) is a highly regulated enzyme of the [[tricarboxylic acid cycle]]. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD<sup>+</sup> to [[NADH]] and thus links to [[Complex I]] in the Electron transfer-pathway. OgDH is activated by low Ca<sup>2+</sup> (<20 µM) but inactivated by high Ca<sup>2+</sup> (>100 µM). OgDH is an important source of ROS.
-α-ketoglutarate dehydrogenase complex which plays a role in the [[TCA cycle]].
+|info=[[Tretter 2005 Philos Trans R Soc Lond B Biol Sci]]
-|info=[http://en.wikipedia.org/wiki/Oxoglutarate_dehydrogenase_%28NADP%2B%29 Wikipedia]
 }}
+{{MitoPedia methods}}
 {{MitoPedia topics
 |mitopedia topic=Enzyme
 }}
-{{Labeling
+:::: The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).
-|enzymes=TCA Cycle
-|type=Enzyme
-}}
-The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).
-''The reaction catalyzed by this enzyme in the citric acid cycle is:''
+:::: The reaction catalyzed by OgDH is:
-α-ketoglutarate + NAD<sup>+</sup> + CoA → Succinyl CoA + CO<sub>2</sub> + NADH
+::::::::Oxoglutarate (α-ketoglutarate) + NAD<sup>+</sup> + CoA → Succinyl CoA + CO<sub>2</sub> + NADH + H<sup>+</sup>