Difference between revisions of "Oxoglutarate dehydrogenase"
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|abbr=OgDH | |abbr=OgDH | ||
|description='''Oxoglutarate dehydrogenase''' (Ξ±-ketoglutarate dehydrogenase) is | |description='''Oxoglutarate dehydrogenase''' (Ξ±-ketoglutarate dehydrogenase) is a highly regulated enzyme of the [[tricarboxylic acid cycle]]. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD+ to [[NADH]] and thus links to [[Complex I]] in the electron transfer system. | ||
|info=[[Tretter 2005 Philos Trans R Soc Lond B Biol Sci]] | |||
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{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Enzyme | |mitopedia topic=Enzyme | ||
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The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD). | The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD). | ||
The reaction catalyzed by | The reaction catalyzed by OgDH is: | ||
Ξ±-ketoglutarate + NAD<sup>+</sup> + CoA β Succinyl CoA + CO<sub>2</sub> + NADH | oxoglutarate (Ξ±-ketoglutarate) + NAD<sup>+</sup> + CoA β Succinyl CoA + CO<sub>2</sub> + NADH + H+ | ||
Revision as of 10:36, 3 August 2014
- high-resolution terminology - matching measurements at high-resolution
Oxoglutarate dehydrogenase
Description
Oxoglutarate dehydrogenase (Ξ±-ketoglutarate dehydrogenase) is a highly regulated enzyme of the tricarboxylic acid cycle. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD+ to NADH and thus links to Complex I in the electron transfer system.
Abbreviation: OgDH
Reference: Tretter 2005 Philos Trans R Soc Lond B Biol Sci
MitoPedia topics: Enzyme
The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).
The reaction catalyzed by OgDH is: oxoglutarate (Ξ±-ketoglutarate) + NAD+ + CoA β Succinyl CoA + CO2 + NADH + H+
