- high-resolution terminology - matching measurements at high-resolution
Oxoglutarate dehydrogenase
Description
Oxoglutarate dehydrogenase (Ξ±-ketoglutarate dehydrogenase) is a highly regulated enzyme of the tricarboxylic acid cycle. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD+ to NADH and thus links to Complex I in the electron transfer system.
Abbreviation: OgDH
Reference: Tretter 2005 Philos Trans R Soc Lond B Biol Sci
MitoPedia topics: Enzyme
The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).
The reaction catalyzed by OgDH is: oxoglutarate (Ξ±-ketoglutarate) + NAD+ + CoA β Succinyl CoA + CO2 + NADH + H+
