Prosthetic group: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|description=A '''prosthetic group''' is 'a tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity' (IUPAC definition).. | |description=A '''prosthetic group''' is a [[cofactor]] that is attached permanently and tightly or even covalently to an enzyme and that is regenerated in each enzymatic turnover. Thus a prostethic group is distinguished from a [[coenzyme]] or cosubstrate that is attached loosely and transiently. Like a coenzyme, the prosthetic group is required by an enzyme for its activity. A prosthetic group is 'a tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity' (IUPAC definition). | ||
FMN/FMNH<sub>2</sub> and FAD/FADH<sub>2</sub> are prosthetic groups of [[Complex I]] and [[Complex II]], respectively. | |||
|info=https://www.ebi.ac.uk/chebi/searchId.do?chebiId=26348 | |info=https://www.ebi.ac.uk/chebi/searchId.do?chebiId=26348 | ||
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{{ | {{Template:Keywords: Substrates and cofactors}} | ||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Enzyme, Substrate and metabolite | |mitopedia topic=Enzyme, Substrate and metabolite | ||
}} | }} | ||
Latest revision as of 22:01, 7 May 2023
- high-resolution terminology - matching measurements at high-resolution
Prosthetic group
Description
A prosthetic group is a cofactor that is attached permanently and tightly or even covalently to an enzyme and that is regenerated in each enzymatic turnover. Thus a prostethic group is distinguished from a coenzyme or cosubstrate that is attached loosely and transiently. Like a coenzyme, the prosthetic group is required by an enzyme for its activity. A prosthetic group is 'a tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity' (IUPAC definition).
FMN/FMNH2 and FAD/FADH2 are prosthetic groups of Complex I and Complex II, respectively.
Reference: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=26348
- Bioblast links: Substrates and cofactors - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Cofactor
- » Cofactor
- » Coenzyme, cosubstrate
- » Nicotinamide adenine dinucleotide
- » Coenzyme Q2
- » Prosthetic group
- » Flavin adenine dinucleotide
- Cofactor
- Referennces
- » Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. MitoFit Preprints 2023.3.v6. https://doi.org/10.26124/mitofit:2023-0003.v6
- Referennces
MitoPedia topics: Enzyme, Substrate and metabolite
