Difference between revisions of "Roskams T Falk Workshop Inflammation & Cancer"
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{{Abstract | {{Abstract | ||
|title=Roskams T (2012) Stem cells and liver cancer | |title=Roskams T (2012) Stem cells and liver cancer | ||
|info=[http://www.drfalkpharma.ru/FW_Hamburg_2012_Abstractband_05.pdf#page=36] | |info=[http://www.drfalkpharma.ru/FW_Hamburg_2012_Abstractband_05.pdf#page=36 PDF] | ||
|authors=Roskams T | |authors=Roskams T | ||
|year=2012 | |year=2012 | ||
Revision as of 17:08, 16 April 2012
| Roskams T (2012) Stem cells and liver cancer |
Link: PDF
Roskams T (2012)
Event: Falk Workshop Inflammation & Cancer
According to the cancer stem cell concept, hepatocellular carcinoma (HCC) consists of a hierarchy of cell populations, of which the very small cancer stem cell population is the one that has the growth and metastatic potential of the tumour. The other neoplastic cells are offspring of the cancer stem cells and each can differentiate a little differently, according to the local microenvironment in each part of the tumor, hence explaining the enormous phenotypic heterogeneity of a neoplasm.
Current therapeutic strategies mostly target rapidly growing differentiated tumour cells. However the results are often unsatisfactory because of the chemoresistance of HCC. New therapies targeting cancer stem cells should therefore be developed. A prerequisite is a good understanding of the mechanisms of activation and differentiation of normal stem/progenitor cells in normal and diseased liver. Hepatocytes and cholangiocytes have stem cell features, but also progenitor cells, located in the smallest branches of the biliary tree. These cells are especially activated in the cirrhotic stage of chronic liver diseases, the stage in which HCC develops. HCC with progenitor cell features, possibly reflecting a progenitor cell origin, have a very bad prognosis and therefore should be recognized and treated accordingly.
• Keywords: liver stem cells, liver progenitor cells, hepatocellular carcinoma, cholangiocarcinoma, chemoresistance, cancer stem cells, side population
Labels:
Stress:Cancer; Apoptosis; Cytochrome c"Cancer; Apoptosis; Cytochrome c" is not in the list (Cell death, Cryopreservation, Ischemia-reperfusion, Permeability transition, Oxidative stress;RONS, Temperature, Hypoxia, Mitochondrial disease) of allowed values for the "Stress" property.
Tissue;cell: Hepatocyte; Liver"Hepatocyte; Liver" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property.
