Difference between revisions of "Scott 2013 Abstract MiP2013"
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{{Abstract | {{Abstract | ||
|title=Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08. | |title=Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08. | ||
|info=[[File:Logo MiP2013.jpg|150px|right|MiPsociety]] [ | |info=[[File:Logo MiP2013.jpg|150px|right|MiPsociety]] [[MiP2013]], [[Laner 2013 Mitochondr Physiol Network MiP2013|Book of Abstracts Open Access]] | ||
|authors=Scott GR, Mahalingam S, McClelland GB | |authors=Scott GR, Mahalingam S, McClelland GB | ||
|year=2013 | |year=2013 | ||
| Line 10: | Line 10: | ||
{{Labeling | {{Labeling | ||
|area=Respiration, Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style | |area=Respiration, Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style | ||
|organism=Other mammals | |organism=Other mammals, Birds | ||
|tissues=Skeletal muscle | |tissues=Skeletal muscle | ||
|preparations=Isolated mitochondria, Enzyme | |preparations=Isolated mitochondria, Enzyme | ||
|topics= | |topics=Oxygen kinetics | ||
|couplingstates=LEAK, OXPHOS | |couplingstates=LEAK, OXPHOS | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
Latest revision as of 11:23, 28 April 2017
| Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08. |
Link:
MiP2013, Book of Abstracts Open Access
Scott GR, Mahalingam S, McClelland GB (2013)
Event: MiPNet18.08_MiP2013
The hypoxic and cold environment at high altitudes requires endothermic animals to sustain high rates of O2 consumption for both locomotion and thermogenesis while facing a diminished O2 supply. We are examining the mitochondrial mechanisms of genotypic adaptation and phenotypic plasticity that help maintain ATP supply during hypoxia in high-altitude birds and mammals. Respiratory capacity, cytochrome oxidase activity, phosphorylation efficiency, oxygen kinetics, and several other variables were measured in mitochondria isolated from the flight muscle of bar-headed geese and the hindlimb muscle of highland deer mice, and each were compared to closely-related lowland taxa. Our results suggest that several mitochondrial adaptations, coupled with enhanced mitochondrial O2 supply, contribute to performance in hypoxia.
• O2k-Network Lab: CA Hamilton Scott GR
Labels: MiParea: Respiration, Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style
Organism: Other mammals, Birds
Tissue;cell: Skeletal muscle
Preparation: Isolated mitochondria, Enzyme
Regulation: Oxygen kinetics Coupling state: LEAK, OXPHOS
HRR: Oxygraph-2k
MiP2013
Affiliations and support
Department of Biology, McMaster University, Hamilton, Ontario, Canada
Email: [email protected]
Supported by NSERC of Canada.
