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	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Cacabelos 2016 Neurobiol Dis	2016	Cacabelos D, Ayala V, Granado-Serrano AB, Jové M, Torres P, Boada J, Cabré R, Ramírez-Núñez O, Gonzalo H, Soler-Cantero A, Serrano JC, Bellmunt MJ, Romero MP, Motilva MJ, Nonaka T, Hasegawa M, Ferrer I, Pamplona R, Portero-Otín M (2016) Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis. Neurobiol Dis 88:148-60.	ROUTINE		Intact cells	Rat	Nervous system
Bynum 2016 Transfusion	2016	Bynum JA, Adam Meledeo M, Getz TM, Rodriguez AC, Aden JK, Cap AP, Pidcoke HF (2016) Bioenergetic profiling of platelet mitochondria during storage: 4°C storage extends platelet mitochondrial function and viability. Transfusion 56 Suppl 1:S76-84.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Platelet
Kawalec 2016 Praca doktorska	2016	Kawalec MM (2016) Badanie komórkowych skutków mutacji w genie mitofuzyny 2. Próba zaproponowania testu patogenności mutacji. Praca doktorska p86.	LEAK ROUTINE ET		Intact cells	Mouse	Fibroblast
Ferguson 2016 J Bioenerg Biomembr	2016	Ferguson MA, Sutton RM, Karlsson M, Sjövall F, Becker LB, Berg RA, Margulies SS, Kilbaugh TJ (2016) Increased platelet mitochondrial respiration after cardiac arrest and resuscitation as a potential peripheral biosignature of cerebral bioenergetic dysfunction. J Bioenerg Biomembr 48:269-79.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Homogenate Intact cells	Pig	Nervous system Platelet
Watala 2016 Int J Pharm	2016	Watala C, Karolczak K, Kassassir H, Siewiera K, Maczynska K, Pieniazek A, Labieniec-Watala M (2016) How do the full-generation poly(amido)amine (PAMAM) dendrimers activate blood platelets? Platelet membrane zeta potential and other membrane-associated phenomena. Int J Pharm 500:379-89.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Platelet
Lukasiak 2016 Eur J Pharmacol	2016	Łukasiak A, Skup A, Chlopicki S, Łomnicka M, Kaczara P, Proniewski B, Szewczyk A, Wrzosek A (2016) SERCA, complex I of the respiratory chain and ATP-synthase inhibition are involved in pleiotropic effects of NS1619 on endothelial cells. Eur J Pharmacol 786:137-47.	ROUTINE ET	Other combinations	Intact cells	Human	Other cell lines Endothelial;epithelial;mesothelial cell
Birkenmeier 2016 Int J Cancer	2016	Birkenmeier Katrin, Droese Stefan, Wittig Ilka, Winkelmann Ria, Kaefer Viktoria, Doering Claudia, Hartmann Sylvia, Wenz Tina, Reichert Andreas S, Brandt Ulrich, Hansmann Martin‐Leo (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines HeLa Macrophage-derived
Lores-Arnaiz 2016 Neurochem Res	2016	Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63.	LEAK ROUTINE OXPHOS ET	N S	Isolated mitochondria Intact cells	Mouse	Nervous system
Berschneider 2016 Thesis	2016	Berschneider K (2016) Connecting the functions of the proteasome and mitochondria in the lung. Dissertation p161.	LEAK ROUTINE ET	ROX	Permeabilized cells	Mouse	Lung;gill
Barison 2016 J Bioenerg Biomembr	2016	Barisón MJ, Damasceno FS, Mantilla BS, Silber AM (2016) The active transport of histidine and its role in ATP production in Trypanosoma cruzi. J Bioenerg Biomembr 48:437-49.	LEAK ROUTINE ET		Intact cells	Protists
Sengupta 2016 Free Radic Biol Med	2016	Sengupta S, Yang G, O'Donnell JC, Hinson MD, McCormack SE, Falk MJ, La P, Robinson MB, Williams ML, Yohannes MT, Polyak E, Nakamaru-Ogiso E, Dennery PA (2016) The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med 93:177-89.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Lung;gill Fibroblast
Moll 2016 bioRxiv	2016	Moll CWI, Lindtner RA, Vogel GF, Brunner M, Gutleben K, Blauth M, Krumschnabel G, Ebner HL (2016) Bone marrow mesenchymal stem cells from osteoporotic patients do not show altered mitochondrial energetics or ultrastructure. bioRxiv doi.org/10.1101/046300.	LEAK ROUTINE OXPHOS ET	N S ROX	Intact cells Permeabilized cells	Human	Stem cells
Reynolds 2016 Am J Physiol Endocrinol Metab	2016	Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS (2016) β-cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. Am J Physiol Endocrinol Metab 311:E186-201.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Intact cells	Rat	Islet cell;pancreas;thymus
Stier 2016 Methods Ecol Evol	2016	Stier A, Romestaing C, Schull Q, Lefol E, Robin JP, Roussel D, Bize P (2016) How to measure mitochondrial function in birds using red blood cells: a case study in the king penguin and perspectives in ecology and evolution. Methods Ecol Evol doi:10.1111/2041-210X.12724.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized tissue Intact cells	Birds	Skeletal muscle Blood cells
Lesage 2016 Am J Hum Genet	2016	Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T, Maurage CA, Sahbatou M, Liebau S, Ding J, Bilgic B, Emre M, Erginel-Unaltuna N, Guven G, Tison F, Tranchant C, Vidailhet M, Corvol JC, Krack P, Leutenegger AL, Nalls MA, Hernandez DG, Heutink P, Gibbs JR, Hardy J, Wood NW, Gasser T, Durr A, Deleuze JF, Tazir M, Destée A, Lohmann E, Kabashi E, Singleton A, Corti O, Brice A (2016) Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-Dependent Mitophagy. Am J Hum Genet 98:500-13.	LEAK ROUTINE ET	ROX	Intact cells	Other mammals	Kidney Other cell lines
Svenkrtova 2016 Biogerontology	2016	Svenkrtova A, Belicova L, Volejnikova A, Sigler K, Jazwinski SM, Pichova A (2016) Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality. Biogerontology 17:395-408.	ROUTINE	CIV ROX	Intact cells	Saccharomyces cerevisiae
Fonseca-Berzal 2016 Parasitology	2016	Fonseca-Berzal C, DA Silva CF, Menna-Barreto RF, Batista MM, Escario JA, Arán VJ, Gómez-Barrio A, Soeiro Mde N (2016) Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes. Parasitology 143:1469-78.	ROUTINE	ROX	Intact organism	Protists
Barth 2016 Thesis	2016	Barth C (2016) Effekte einer intermittierenden Hyperoxie auf die mitochondriale Atmung in Alveolarmakrophagen. Dissertation p69.	LEAK ROUTINE OXPHOS	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse	Lung;gill Macrophage-derived
Alvarez-Mora 2016 Mol Neurobiol	2016	Alvarez-Mora MI, Rodriguez-Revenga L, Madrigal I, Guitart-Mampel M, Garrabou G, Milà M (2016) Impaired mitochondrial function and dynamics in the pathogenesis of FXTAS. Mol Neurobiol 54:6896-902.	ROUTINE	N S NS	Intact cells	Human	Fibroblast
Liu 2016 Apoptosis	2016	Liu X, Gao RW, Li M, Si CF, He YP, Wang M, Yang Y, Zheng QY, Wang CY (2016) The ROS derived mitochondrial respiration not from NADPH oxidase plays key role in Celastrol against angiotensin II-mediated HepG2 cell proliferation. Apoptosis 21:1315-26.	ROUTINE		Intact cells	Human	Liver Other cell lines
Nauta 2016 Thesis	2016	Nauta TD (2016) HIF-2α regulates in vitro neovascularization during hypoxia. Doctoral Dissertation p206.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Davuluri 2016 J Physiol	2016	Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Skeletal muscle Other cell lines
Zhunussova 2016 PLOS ONE	2016	Zhunussova A, Vitol EA, Polyak B, Tuleukhanov S, Brooks AD, Sensenig R, Friedman G, Orynbayeva Z (2016) Mitochondria-mediated anticancer effects of non-thermal atmospheric plasma. PLOS ONE 11:e0156818.	LEAK ROUTINE ET		Intact cells	Human	Genital Other cell lines
Anand 2016 PLOS ONE	2016	Anand R, Strecker V, Urbach J, Wittig I, Reichert AS (2016) Mic13 is essential for formation of crista junctions in mammalian cells. PLOS ONE 11:e0160258.	LEAK ROUTINE OXPHOS ET	N CIV NS Other combinations ROX	Permeabilized cells Intact cells		HEK
Bastow 2016 J Cell Sci	2016	Bastow EL, Peswani AR, Tarrant DS, Pentland DR, Chen X, Morgan A, Staniforth GL, Tullet JM, Rowe ML, Howard MJ, Tuite MF, Gourlay CW (2016) New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis. J Cell Sci 129:4118-29.	LEAK ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
Puskarich 2016 J Crit Care	2016	Puskarich MA, Kline JA, Watts JA, Shirey K, Hosler J, Jones AE (2016) Early alterations in platelet mitochondrial function are associated with survival and organ failure in patients with septic shock. J Crit Care 31:63-7.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Platelet
Holandino 2016 Bioelectrochemistry	2016	Holandino C, Teixeira CA, de Oliveira FA, Barbosa GM, Siqueira CM, Messeder DJ, de Aguiar FS, da Veiga VF, Girard-Dias W, Miranda K, Galina A, Capella MA, Morales MM (2016) Direct electric current treatment modifies mitochondrial function and lipid body content in the A549 cancer cell line. Bioelectrochemistry 111:83-92.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lung;gill Other cell lines
Heimer 2016 Am J Hum Genet	2016	Heimer G, Kerätär JM, Riley LG, Balasubramaniam S, Eyal E, Pietikäinen LP, Hiltunen JK, Marek-Yagel D, Hamada J, Gregory A, Rogers C, Hogarth P, Nance MA, Shalva N, Veber A, Tzadok M, Nissenkorn A, Tonduti D, Renaldo F, Kraoua I, Panteghini C, Valletta L, Garavaglia B, Cowley MJ, Gayevskiy V, Roscioli T, Silberstein JM, Hoffmann C, Raas-Rothschild A, Tiranti V, Anikster Y, Christodoulou J, Kastaniotis AJ, Ben-Zeev B, Hayflick SJ (2016) MECR mutations cause childhood-onset dystonia and optic atrophy, a mitochondrial fatty acid synthesis disorder. Am J Hum Genet 99:1229-44.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Jang 2016 Clin Toxicol (Phila)	2016	Jang DH, Shofer FS, Weiss SL, Becker LB (2016) Impairment of mitochondrial respiration following ex vivo cyanide exposure in peripheral blood mononuclear cells. Clin Toxicol (Phila) 54:303-7.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Sanchez-Calvo 2016 PLOS ONE	2016	Sánchez-Calvo B, Cassina A, Rios N, Peluffo G, Boggia J, Radi R, Rubbo H, Trostchansky A (2016) Nitro-arachidonic acid prevents Angiotensin II-induced mitochondrial dysfunction in a cell line of kidney proximal tubular cells. PLOS ONE 11:e0150459.	LEAK ROUTINE ET	ROX	Intact cells	Human	Kidney Other cell lines
Wos 2016 Arch Biochem Biophys	2016	Woś M, Szczepanowska J, Pikuła S, Tylki-Szymańska A, Zabłocki K, Bandorowicz-Pikuła J (2016) Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease. Arch Biochem Biophys 593:50-9.	LEAK ROUTINE ET		Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Raturi 2016 J Cell Biol	2016	Raturi A, Gutiérrez T, Ortiz-Sandoval C, Ruangkittisakul A, Herrera-Cruz MS, Rockley JP, Gesson K, Ourdev D, Lou PH, Lucchinetti E, Tahbaz N, Zaugg M, Baksh S, Ballanyi K, Simmen T (2016) TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca²⁺ flux. J Cell Biol 214:433-44.	LEAK ET ROUTINE		Permeabilized cells Intact cells	Mouse Human	HeLa Other cell lines
Oliveira 2016 PLOS ONE	2016	Oliveira MP, Correa Soares JB, Oliveira MF (2016) Sexual preferences in nutrient utilization regulate oxygen consumption and reactive oxygen species generation in Schistosoma mansoni: potential implications for parasite redox biology. PLOS ONE 11:e0158429.	LEAK ROUTINE	F ROX	Intact organism	Other invertebrates
McFarlane 2016 Thesis	2016	McFarlane SV (2016) Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Dissertation p74.	LEAK ROUTINE OXPHOS ET	F N	Isolated mitochondria Intact cells	Other mammals	Fat
Ehinger 2016 Mov Disord	2016	Ehinger JK, Morota S, Hansson MJ, Gesine P, Elmér E (2016) Mitochondrial respiratory function in peripheral blood cells from Huntington’s disease patients. Mov Disord doi:10.1002/mdc3.12308.	LEAK ROUTINE OXPHOS ET	N S CIV NS Other combinations ROX	Permeabilized cells Intact cells	Human	Blood cells Lymphocyte Platelet
Jang 2016 J Intensive Care Med	2016	Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med 32:86-94.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Peruzzo 2016 Cell Cycle	2016	Peruzzo P, Comelli M, Di Giorgio E, Franforte E, Mavelli I, Brancolini C (2016) Transformation by different oncogenes relies on specific metabolic adaptations. Cell Cycle 15:2656-68.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fibroblast
Chubanov 2016 Elife	2016	Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T (2016) Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife 5. pii: e20914.	ROUTINE ET	ROX	Intact cells	Human	Fibroblast Other cell lines
Mesquita 2016 Thesis	2016	Mesquita Rodrigues C (2016) Efeito da depleção de ferro sobre Leishmania (Viannia) braziliensisuma análise ultraestrutural, proteômica e interação com matrizes de colágeno sintéticas. Doctoral Dissertation p210.	ROUTINE	ROX	Intact cells	Protists
Siewiera 2016 Life Sci	2016	Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2016) Higher mitochondrial potential and elevated mitochondrial respiration are associated with excessive activation of blood platelets in diabetic rats. Life Sci 148:293-304.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Blood cells Platelet
Gerber 2016 J Med Genet	2016	Gerber S, Ding MG, Gérard X, Zwicker K, Zanlonghi X, Rio M, Serre V, Hanein S, Munnich A, Rotig A, Bianchi L, Amati-Bonneau P, Elpeleg O, Kaplan J, Brandt U, Rozet JM (2016) Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy. J Med Genet 54:346-56.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Scrima 2016 Biochim Biophys Acta	2016	Scrima R, Cela O, Merla G, Augello B, Rubino R, Quarato G, Fugetto S, Menga M, Fuhr L, Relógio A, Piccoli C, Mazzoccoli G, Capitanio N (2016) Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay. Biochim Biophys Acta 1857:1344-51.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver Endothelial;epithelial;mesothelial cell Other cell lines Fibroblast
Frey 2016 Biochim Biophys Acta	2016	Frey S, Geffroy G, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Amati-Bonneau P, Chevrollier A, Barth M, Henrion D, Lenaers G, Bonneau D, Reynier P, Procaccio V (2016) The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model. Biochim Biophys Acta 1863:284-91.	ROUTINE LEAK ET	N S NS	Permeabilized cells Intact cells	Human	Nervous system
Gdynia 2016 Nat Commun	2016	Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T, Miller M, Pahl J, Cerwenka A, Enders M, Mairbäurl H, Kamiński MM, Penzel R, Zhang C, Fuller JC, Wade RC, Benner A, Chang-Claude J, Brenner H, Hoffmeister M, Zentgraf H, Schirmacher P, Roth W (2016) The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun 7:10764.	ROUTINE	ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Vevera 2016 Physiol Res	2016	Vevera J, Fišar Z, Nekovářová T, Vrablík M, Zlatohlávek L, Hroudová J, Singh N, Raboch J, Valeš K (2016) Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia. Physiol Res 65:777-88.	LEAK ROUTINE OXPHOS ET	N S NS Other combinations ROX	Intact cells Permeabilized cells	Human Rat	Blood cells Platelet
Drehmer 2016 Stem Cell Res	2016	Drehmer DL, de Aguiar AM, Brandt AP, Petiz L, Cadena SM, Rebelatto CK, Brofman PR, Filipak Neto F, Dallagiovanna B, Abud AP (2016) Metabolic switches during the first steps of adipogenic stem cells differentiation. Stem Cell Res 17:413-421.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fat Stem cells
Shao 2016 Cell Res	2016	Shao LW, Niu R, Liu Y (2016) Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Res 26:1182-96.	ROUTINE		Intact organism	Caenorhabditis elegans
Cacabelos 2016 Acta Neuropathol Commun	2016	Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized tissue Intact cells	Mouse	Nervous system Other cell lines
Salvi 2016 Oxid Med Cell Longev	2016	Salvi A, Patki G, Khan E, Asghar M, Salim S (2016) Protective effect of tempol on buthionine sulfoximine (BSO)-induced mitochondrial impairment in hippocampal derived HT22 cells. Oxid Med Cell Longev 2016:5059043.	ROUTINE		Intact cells	Mouse	Nervous system Other cell lines
Dutra 2016 Acta Trop	2016	Dutra FL, Oliveira MM, Santos RS, Silva WS, Alviano DS, Vieira DP, Lopes AH (2016) Effects of linalool and eugenol on the survival of Leishmania (L.) infantum chagasi within macrophages. Acta Trop 164:69-76.	ROUTINE	ROX	Intact organism Intact cells	Protists
Zelenka 2016 Oxid Med Cell Longev	2016	Zelenka J, Dvořák A, Alán L, Zadinová M, Haluzík M, Vítek L (2016) Hyperbilirubinemia protects against aging-associated inflammation and metabolic deterioration. Oxid Med Cell Longev ID 6190609:10p.	ROUTINE		Intact cells Isolated mitochondria	Rat	Liver Kidney Fibroblast
Maarman 2016 J Appl Physiol (1985)	2016	Maarman GJ, Andrew BM, Blackhurst DM, Ojuka EO (2016) Melatonin protects against uric acid-induced mitochondrial dysfunction, oxidative stress, and triglyceride accumulation in C₂C₁₂ myotubes. J Appl Physiol (1985) 122:1003-10.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle
Tsai 2016 Sci Rep	2016	Tsai HH, Chang SC, Chou CH, Weng TP, Hsu CC, Wang JS (2016) Exercise training alleviates hypoxia-induced mitochondrial dysfunction in the lymphocytes of sedentary males. Sci Rep 6:35170.	LEAK ROUTINE OXPHOS ET	F N S NS Other combinations ROX	Permeabilized cells Intact cells	Human	Lymphocyte Blood cells
Schaefer 2016 PLOS ONE	2016	Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA (2016) Metabolic characterization of intact cells reveals intracellular amyloid beta but not its precursor protein to reduce mitochondrial respiration. PLOS ONE 11:e0168157.	LEAK ROUTINE ET	CIV ROX	Intact cells	Human Mouse	Nervous system HEK
Safiedeen 2016 Antioxid Redox Signal	2016	Safiedeen Z, Rodríguez-Gómez I, Vergori L, Soleti R, Vaithilingam D, Douma I, Agouni A, Leiber D, Dubois S, Simard G, Zibara K, Andriantsitohaina R, Martínez MC (2016) Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction. Antioxid Redox Signal 26:15-27.	LEAK ET ROUTINE	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Castellano-Gonzalez 2016 Oncotarget	2016	Castellano-González G, Pichaud N, Ballard JW, Bessede A, Marcal H, Guillemin GJ (2016) Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes. Oncotarget 7:7426-40	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Strecker 2016 Biochim Biophys Acta	2016	Strecker V, Kadeer Z, Heidler J, Cruciat CM, Angerer H, Giese H, Pfeiffer K, Stuart RA, Wittig I (2016) Supercomplex-associated Cox26 protein binds to cytochrome c oxidase. Biochim Biophys Acta 1863:1643-52.	ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
Sheremet 2016 Biochemistry (Moscow)	2016	Sheremet NL, Nevinitsyna TA, Zhorzholadze NV, Ronzina IA, Itkis YS, Krylova TD, Tsygankova PG, Malakhova VA, Zakharova EY, Tokarchuk AV, Panteleeva AA, Karger EM, Lyamzaev KG, Avetisov SE (2016) Previously unclassified mutation of mtDNA m.3472T>C: evidence of pathogenicity in Leber’s hereditary optic neuropathy. Biochemistry (Moscow) BM16-078.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast Platelet
Boeck 2016 Mitochondrion	2016	Boeck C, Koenig AM, Schury K, Geiger ML, Karabatsiakis A, Wilker S, Waller C, Gündel H, Fegert JM, Calzia E, Kolassa IT (2016) Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress. Mitochondrion 30:197-207.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Torres 2016 Redox Biol	2016	Torres S, Matías N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-Rovés P, Balboa E, Zanlungo S, Fabrías G, Casas J, Enrich C, Garcia-Ruiz C, Fernández-Checa JC (2016) Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72.	LEAK ROUTINE OXPHOS ET	N S ROX	Homogenate Intact cells	Human Mouse	Nervous system Liver Endothelial;epithelial;mesothelial cell Fibroblast
Giraldos Jimenez 2016 Thesis	2016	Giraldos Jiménez D (2016) Oxidative phosphorylation system’s role in adipogenic differentiation. Thesis p25.	LEAK ROUTINE	ROX
Schiffer 2016 Am J Physiol Cell Physiol	2016	Schiffer TA, Peleli M, Sundqvist ML, Ekblom B, Lundberg JO, Weitzberg E, Larsen FJ (2016) Control of human energy expenditure by cytochrome c oxidase subunit IV-2. Am J Physiol Cell Physiol 311:C452-61.	LEAK OXPHOS ET ROUTINE	N NS	Permeabilized cells Isolated mitochondria Intact cells	Human	Skeletal muscle HEK
Xiong 2016 Hypertension	2016	Xiong S, Wang P, Ma L, Gao P, Gong L, Li L, Li Q, Sun F, Zhou X, He H, Chen J, Yan Z, Liu D, Zhu Z (2016) Ameliorating endothelial mitochondrial dysfunction restores coronary function via transient receptor potential vanilloid 1-mediated protein kinase A/uncoupling protein 2 pathway. Hypertension 67:451-60.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Larsen 2016 FASEB J	2016	Larsen FJ, Schiffer TA, Ørtenblad N, Zinner C, Morales-Alamo D, Willis SJ, Calbet JA, Holmberg HC, Boushel R (2016) High-intensity sprint training inhibits mitochondrial respiration through aconitase inactivation. FASEB J 30:417-27.	LEAK ROUTINE OXPHOS	N NS	Permeabilized cells Isolated mitochondria Intact cells	Human	Skeletal muscle
Schinagl 2016 PLoS One	2016	Schinagl CW, Vrabl P, Burgstaller W (2016) Adapting high-resolution respirometry to glucose-limited steady state mycelium of the filamentous fungus Penicillium ochrochloron: method development and standardisation. PLoS One 11:e0146878.	ROUTINE ET		Intact cells	Fungi
Yao 2016 Biochem Biophys Res Commun	2016	Yao K, Zhang WW, Yao L, Yang S, Nie W, Huang F (2016) Carvedilol promotes mitochondrial biogenesis by regulating the PGC-1/TFAM pathway in human umbilical vein endothelial cells (HUVECs). Biochem Biophys Res Commun 470:961-6.	ROUTINE		Intact cells	Human	Endothelial;epithelial;mesothelial cell HUVEC
Camacho-Pereira 2016 Cell Metab	2016	Camacho-Pereira J, Tarragó MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN (2016) CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab 23:1127-39.	LEAK ROUTINE OXPHOS ET	S ROX	Isolated mitochondria Intact cells	Human Mouse	Liver Lung;gill Other cell lines
Silva 2016 Thesis	2016	Silva Luana Caroline Schüeler da (2016) Fucoxantina inibe a oxidação de LDL e ativação de macrófagos in vitro. PhD Thesis:93 pp.	LEAK ROUTINE ET	ROX	Intact cells	Human
Brandt 2016 Chem Biol Interact	2016	Brandt AP, Gozzi GJ, Pires Ado R, Martinez GR, Dos Santos Canuto AV, Echevarria A, Di Pietro A, Cadena SM (2016) Impairment of oxidative phosphorylation increases the toxicity of SYD-1 on hepatocarcinoma cells (HepG2). Chem Biol Interact 256:154-60.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver Other cell lines
Bueno 2016 Thesis	2016	Bueno e Silva MM (2016) Alterações mitocondriais e reprogramação metabólica em células de glioblastoma após tratamento com temozolomida. Dissertation p71.	LEAK ROUTINE ET		Intact cells	Human	Nervous system Other cell lines
Chakraborty 2016 Pancreatology	2016	Chakraborty M, Hickey AJ, Petrov MS, Macdonald JR, Thompson N, Newby L, Sim D, Windsor JA, Phillips AR (2016) Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis. Pancreatology 16:739-47.	LEAK OXPHOS ROUTINE ET	N Gp CIV NS ROX S	Permeabilized cells	Human Rat	Blood cells
Rohlenova 2016 Antioxid Redox Signal	2016	Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2^high breast cancer. Antioxid Redox Signal 26:84-103.	LEAK ROUTINE ET	N S Other combinations	Permeabilized cells Homogenate	Human Mouse	Liver Genital Other cell lines
Rodrigues 2015 J Cell Biochem	2015	Rodrigues MF, Carvalho É, Pezzuto P, Rumjanek FD, Amoêdo ND (2015) Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin a on the energy metabolism of breast cancer cells. Int J Biochem Cell Biol 116:797-808.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Falabella 2015 Oxid Med Cell Longev	2015	Falabella M, Forte E, Magnifico MC, Santini P, Arese M, Giuffrè A, Radić K, Chessa L, Coarelli G, Buscarinu MC, Mechelli R, Salvetti M, Sarti P (2015) Evidence for detrimental cross interactions between reactive oxygen and nitrogen species in Leber’s hereditary optic neuropathy cells. Oxid Med Cell Longev 3187560.	ROUTINE	ROX	Intact cells	Human	Blood cells Lymphocyte
Luevano-Martinez 2015 Biochim Biophys Acta	2015	Luévano-Martínez LA, Forni MF, Dos Santos VT, Souza-Pinto NC, Kowaltowski AJ (2015) Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress. Biochim Biophys Acta 1847:587-98.	ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae Fungi
Du 2015 J Biol Chem	2015	Du J, Rountree A, Cleghorn WM, Contreras L, Lindsay KJ, Sadilek M, Gu H, Djukovic D, Raftery D, Satrustegui J, Kanow M, Chan L, Tsang SH, Sweet IR, Hurley JB (2015) Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina. J Biol Chem 291:4698-710.	LEAK ROUTINE OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Nervous system Islet cell;pancreas;thymus
Duskova 2015 Mol Microbiol	2015	Dušková M, Ferreira C, Lucas C, Sychrová H (2015) Two glycerol uptake systems contribute to the high osmotolerance of Zygosaccharomyces rouxii. Mol Microbiol 97:541-59.	ROUTINE		Intact cells	Fungi
Lehtola 2015 Master's Thesis	2015	Lehtola A (2015) Main protein component of high density lipoprotein, apolipoprotein A1, modulates leukocyte cell respiration. Master's Thesis 1-44.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Blood cells Other cell lines Lymphocyte
Bernhardt 2015 Sci Rep	2015	Bernhardt D, Müller M, Reichert AS, Osiewacz HD (2015) Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan. Sci Rep 5:7885.	ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
Renner 2015 Eur J Immunol	2015	Renner K, Geiselhöringer AL, Fante M, Bruss C, Färber S, Schönhammer G, Peter K, Singer K, Andreesen R, Hoffmann P, Oefner P, Herr W, Kreutz M (2015) Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions. Eur J Immunol 45:2504-16.	LEAK ROUTINE ET		Intact cells	Human	Blood cells Lymphocyte
Li 2015 Sci Rep	2015	Li P, Wang B, Sun F, Li Y, Li Q, Lang H, Zhao Z, Gao P, Zhao Y, Shang Q, Liu D, Zhu Z (2015) Mitochondrial respiratory dysfunctions of blood mononuclear cells link with cardiac disturbance in patients with early-stage heart failure. Sci Rep 5:10229.	LEAK ROUTINE OXPHOS ET	N S NS	Intact cells	Human	Blood cells Lymphocyte
Ofer 2015 Mol Endocrinol	2015	Ofer P, Heidegger I, Eder IE, Schöpf B, Neuwirt H, Geley S, Klocker H, Massoner P (2015) Both IGF1R and INSR knockdown exert anti-tumorigenic effects in prostate cancer in vitro and in vivo. Mol Endocrinol 29:1694-707.	ROUTINE OXPHOS ET	F N NS	Permeabilized cells Intact cells	Human	Genital Other cell lines
Lee 2015 Methods Mol Biol	2015	Lee W, Kelly RD, Yeung KY, Cagnone G, McKenzie M, John JC (2015) Analysis of mitochondrial DNA in induced pluripotent and embryonic stem cells. Methods Mol Biol 1330:219-52.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Stem cells
Smolkova 2015 Int J Biochem Cell Biol	2015	Smolková K, Dvořák A, Zelenka J, Vítek L, Ježek P (2015) Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. Int J Biochem Cell Biol 65:125-33.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Sjoevall 2015 US Patent	2015	Sjövall F, Ehinger J, Hansson M, Elmer E, Batcheller DG (2018) Mitochondrial toxicity test. US Patent US20150253306 A1.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Blood cells Macrophage-derived Platelet
Dueregger 2015 PLoS One	2015	Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704.	LEAK ROUTINE OXPHOS ET	F N NS ROX	Permeabilized cells Permeabilized tissue	Human	Genital Other cell lines
Hendricks 2015 Thesis	2015	Hendricks EW (2015) The impact of aging and estrogen therapy on synaptic mitochondrial bioenergetics in an Alzheimer's mouse model. Master Thesis 1-67.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Mouse	Nervous system
Negmadjanov 2015 PLOS ONE	2015	Negmadjanov U, Godic Z, Rizvi F, Emelyanova L, Ross G, Richards J, Holmuhamedov EL, Jahangir A (2015) TGF-β1-mediated differentiation of fibroblasts is associated with increased mitochondrial content and cellular respiration. PLOS ONE 10:e0123046. doi: 10.1371/journal.pone.0123046.	LEAK ROUTINE ET	ROX		Mouse	Fibroblast
Ehinger 2015 J Neurol	2015	Ehinger JK, Morota S, Hansson MJ, Paul G, Elmér E (2015) Mitochondrial dysfunction in blood cells from amyotrophic lateral sclerosis patients. J Neurol 262:1493-503.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Blood cells Lymphocyte Platelet
Tesori 2015 Sci Rep	2015	Tesori V, Piscaglia AC, Samengo D, Barba M, Bernardini C, Scatena R, Pontoglio A, Castellini L, Spelbrink JN, Maulucci G, Puglisi MA, Pani G, Gasbarrini A (2015) The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing. Sci Rep 5:9149.	LEAK ROUTINE ET		Intact cells	Rat	Liver Other cell lines Stem cells
Gupta 2015 PLoS Genet	2015	Gupta S, Radhakrishnan A, Raharja-Liu P, Lin G, Steinmetz LM, Gagneur J, Sinha H (2015) Temporal expression profiling identifies pathways mediating effect of causal variant on phenotype. PLoS Genet 11:e1005195.	ROUTINE		Intact cells	Fungi
Jeger 2015 BioMed Res Internat	2015	Jeger V, Brandt S, Porta F, Jakob SM, Takala J, Djafarzadeh S (2015) Dose response of Endotoxin on hepatocyte and muscle mitochondrial respiration in vitro. BioMed Res Internat Article ID 353074:1-13.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human	Skeletal muscle Liver Other cell lines
Taferner 2015 PLoS One	2015	Taferner A, Pircher H, Koziel R, von Grafenstein S, Baraldo G, Palikaras K, Liedl KR, Tavernarakis N, Jansen-Dürr P (2015) FAH domain containing protein 1 (FAHD-1) is required for mitochondrial function and locomotion activity in C. elegans. PLoS One 10(8):e0134161.	ROUTINE		Intact organism	Caenorhabditis elegans Nematodes
Plecita-Hlavata 2015 J Bioenerg Biomembr	2015	Plecitá-Hlavatá L, Ježek J, Ježek P (2015) Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells. J Bioenerg Biomembr 47(6):467-76.	LEAK ROUTINE ET		Intact cells	Human	Liver
Seillier 2015 EMBO Mol Med	2015	Seillier M, Pouyet L, N'Guessan P, Nollet M, Capo F, Guillaumond F, Peyta L, Dumas JF, Varrault A, Bertrand G, Bonnafous S, Tran A, Meur G, Marchetti P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A (2015) Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med 7:802-18.	LEAK ROUTINE OXPHOS ET	F CIV NS ROX	Permeabilized cells Intact cells	Human Mouse	Fibroblast
Mallick 2015 Cell Calcium	2015	Mallick RL, Kumari S, Singh N, Sonkar VK, Dash D (2015) Prion protein fragment (106-126) induces prothrombotic state by raising platelet intracellular calcium and microparticle release. Cell Calcium 57:300-11.	ROUTINE	ROX	Intact cells	Human	Blood cells Platelet
Garama 2015 Mol Cell Biol	2015	Garama DJ, Harris TJ, White CL, Rossello FJ, Abdul-Hay M, Gough DJ, Levy DE (2015) A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3. Mol Cell Biol 35:3646-56.	LEAK ROUTINE ET		Intact cells	Mouse	Endothelial;epithelial;mesothelial cell Fibroblast
Schoettl 2015 Endocrinology	2015	Schöttl T, Kappler L, Braun K, Fromme T, Klingenspor M (2015) Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice. Endocrinology 156:923-33.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Isolated mitochondria Intact cells	Mouse	Fat
Peyta 2015 Biochim Biophys Acta	2015	Peyta L, Jarnouen K, Pinault M, Coulouarn C, Guimaraes C, Goupille C, de Barros JP, Chevalier S, Dumas JF, Maillot F, Hatch GM, Loyer P, Servais S (2015) Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia. Biochim Biophys Acta 1851:1490-500.	LEAK ROUTINE OXPHOS ET	NS	Permeabilized cells Intact cells	Rat	Liver Other cell lines
Venter 2015 J Clin Cell Immunol	2015	Venter G, Wijers M, Oerlemans FTJJ, Manjeri G, Fransen JAM, Wieringa B (2015) Glycolytic metabolism is differentially coupled to proliferative potential and morphodynamic capacity in RAW 264.7 and Mafb/C-Maf deficient macrophage lineages. J Clin Cell Immunol 6:1-11.	LEAK ROUTINE ET	ROX		Mouse	Blood cells Macrophage-derived

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