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 Was published in yearHas titleTissue and cellMammal and model
Liepinsh 2024 Br J Pharmacol2024Liepinsh E, Zvejniece L, Clemensson L, Ozola M, Vavers E, Cirule H, Korzh S, Skuja S, Groma V, Briviba M, Grinberga S, Liu W, Olszewski P, Gentreau M, Fredriksson R, Dambrova M, Schiöth HB (2024) Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver. Br J Pharmacol [Epub ahead of print]. https://doi.org/10.1111/bph.16363LiverMouse
Dong 2024 Nat Commun2024Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H (2024) Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease. https://doi.org/10.1038/s41467-023-44057-6LiverMouse
Visker 2024 Exp Physiol2024Visker JR, Leszczynski EC, Wellette-Hunsucker AG, McPeek AC, Quinn MA, Kim SH, Bazil JN, Ferguson DP (2024) Postnatal growth restriction alters myocardial mitochondrial energetics in mice. https://doi.org/10.1113/ep091304HeartMouse
Balmaceda 2024 Biochim Biophys Acta Mol Basis Dis2024Balmaceda V, Komlodi T, Szibor M, Gnaiger E, Moore AL, Fernandez-Vizarra E, Viscomi C (2024) The striking differences in the bioenergetics of brain and liver mitochondria are enhanced in mitochondrial disease. Biochim Biophys Acta Mol Basis Dis 1870:167033. https://doi.org/10.1016/j.bbadis.2024.167033Nervous system
Liver
Mouse
Ravasz 2024 Sci Rep2024Ravasz D, Bui D, Nazarian S, Pallag G, Karnok N, Roberts J, Marzullo BP, Tennant DA, Greenwood B, Kitayev A, Hill C, Komlódi T, Doerrier C, Cunatova K, Fernandez-Vizarra E, Gnaiger E, Kiebish Michael A, Raska A, Kolev K, Czumbel B, Narain NR, Seyfried TN, Chinopoulos C (2024) Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia. Sci Rep 14:1729. https://doi.org/10.1038/s41598-024-51365-4Heart
Liver
Mouse
Fitzgerald 2024 J Cachexia Sarcopenia Muscle2024Fitzgerald LF, Lackey J, Moussa A, Shah SV, Castellanos AM, Khan S, Schonk M, Thome T, Salyers ZR, Jakkidi N, Kim K, Yang Q, Hepple RT, Ryan TE (2024) Chronic aryl hydrocarbon receptor activity impairs muscle mitochondrial function with tobacco smoking. https://doi.org/10.1002/jcsm.13439Skeletal muscleMouse
Hu 2024 Front Endocrinol (Lausanne)2024Hu Y, Fang B, Tian X, Wang H, Tian X, Yu F, Li T, Yang Z, Shi R (2024) Passive exercise is an effective alternative to HRT for restoring OVX induced mitochondrial dysfunction in skeletal muscle. Front Endocrinol (Lausanne) 15:1356312. https://doi.org/10.3389/fendo.2024.1356312Skeletal muscleMouse
Donnelly 2024 Redox Biol2024Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion A-C, Matera A, Tavernari D, Campiche O, Paolicelli RC, Zanou N, Kayser B, Gnaiger E, Place N (2024) Functional hypoxia reduces mitochondrial calcium uptake. Redox Biol 71:103037. https://doi.org/10.1016/j.redox.2024.103037Heart
Skeletal muscle
Human
Mouse
Cefis 2024 Acta Physiol (Oxf)2024Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, Gouspillou G (2024) MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission. Acta Physiol (Oxf) [Epub ahead of print]. https://doi.org/10.1111/apha.14119Skeletal muscleMouse
Xiao 2024 Sci Adv2024Xiao L, Yin Y, Sun Z, Liu J, Jia Y, Yang L, Mao Y, Peng S, Xie Z, Fang L, Li J, Xie X, Gan Z (2024) AMPK phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise. Sci Adv 10:eadj2752. https://doi.org/10.1126/sciadv.adj2752Skeletal muscleMouse
Tsouka 2024 Commun Med (Lond)2024Tsouka S, Kumar P, Seubnooch P, Freiburghaus K, St-Pierre M, Dufour JF, Masoodi M (2024) Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human. Commun Med (Lond) 4:39. https://doi.org/10.1038/s43856-024-00465-3LiverMouse
Shi 2024 Clin Sci (Lond)2024Shi L, Yang J, Tao Z, Zheng L, Bui TF, Alonso RL, Yue F, Cheng Z (2024) Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning. Clin Sci (Lond) 138:371-85. https://doi.org/10.1042/cs20230973FibroblastMouse
Queiroz 2024 Ecotoxicol Environ Saf2024Queiroz MIC, Lazaro CM, Dos Santos LMB, Rentz T, Virgilio-da-Silva JV, Moraes-Vieira PMM, Cunha FAS, Santos JCC, Vercesi AE, Leite ACR, Oliveira HCF (2024) In vivo chronic exposure to inorganic mercury worsens hypercholesterolemia, oxidative stress and atherosclerosis in the LDL receptor knockout mice. Ecotoxicol Environ Saf 275:116254. https://doi.org/10.1016/j.ecoenv.2024.116254LiverMouse
Kim 2024 J Exerc Rehabil2024Kim TW, Park SS, Kim SH, Kim MK, Shin MS, Kim SH (2024) Exercise before pregnancy exerts protective effect on prenatal stress-induced impairment of memory, neurogenesis, and mitochondrial function in offspring. J Exerc Rehabil 20:2-10. https://doi.org/10.12965/jer.2448068.034Nervous systemMouse
Jiang 2024 Nat Metab2024Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG (2024) Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nat Metab [Epub ahead of print]. https://doi.org/10.1038/s42255-024-01038-3LiverMouse
Hu 2024 Ecotoxicol Environ Saf2024Hu R, Fan W, Li S, Zhang G, Zang L, Qin L, Li R, Chen R, Zhang L, Gu W, Zhang Y, Rajagopalan S, Sun Q, Liu C (2024) PM2.5-induced cellular senescence drives brown adipose tissue impairment in middle-aged mice. Ecotoxicol Environ Saf 278:116423. https://doi.org/10.1016/j.ecoenv.2024.116423FatMouse
Lhuissier 2024 iScience2024Lhuissier C, Desquiret-Dumas V, Girona A, Alban J, Faure J, Cassereau J, Codron P, Lenaers G, Baris OR, Gueguen N, Chevrollier A (2024) Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission. iScience 27:109808. https://doi.org/10.1016/j.isci.2024.109808FibroblastMouse
Thome 2024 JCI Insight2024Thome T, Vugman NA, Stone LE, Wimberly K, Scali ST, Ryan TE (2024) A tryptophan-derived uremic metabolite-Ahr-Pdk4 axis governs skeletal muscle mitochondrial energetics in chronic kidney disease. JCI Insight [Epub ahead of print]. https://doi.org/10.1172/jci.insight.178372Skeletal muscleHuman
Mouse
Zhang 2023 J Cachexia Sarcopenia Muscle2023Zhang S, Yan H, Ding J, Wang R, Feng Y, Zhang X, Kong X, Gong H, Lu X, Ma A, Hua Y, Liu H, Guo J, Gao H, Zhou Z, Wang R, Chen P, Liu T, Kong X (2023) Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy. https://doi.org/10.1002/jcsm.13290Skeletal muscleMouse
Ebanks 2023 PLoS One2023Ebanks B, Kwiecinska P, Moisoi N, Chakrabarti L (2023) A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer. https://doi.org/10.1371/journal.pone.0276147Skeletal muscleMouse
Drosophila
Dewidar 2023 EBioMedicine2023Dewidar B, Mastrototaro L, Englisch C, Ress C, Granata C, Rohbeck E, Pesta D, Heilmann G, Wolkersdorfer M, Esposito I, Reina Do Fundo M, Zivehe F, Yavas A, Roden M (2023) Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases. https://doi.org/10.1016/j.ebiom.2023.104714Skeletal muscle
Liver
Mouse
Mayayo-Vallverdu 2023 Redox Biol2023Mayayo-Vallverdú C, López de Heredia M, Prat E, González L, Espino Guarch M, Vilches C, Muñoz L, Asensi MA, Serra C, Llebaria A, Casado M, Artuch R, Garrabou G, Garcia-Roves PM, Pallardó FV, Nunes V (2023) The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9-/- mouse model of cystinuria. https://doi.org/10.1016/j.redox.2023.102801KidneyMouse
Fletcher 2023 Transl Res2023Fletcher E, Miserlis D, Sorokolet K, Wilburn D, Bradley C, Papoutsi E, Wilkinson T, Ring A, Ferrer L, Haynatzki G, Smith RS, Bohannon WT, Koutakis P (2023) Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease. https://doi.org/10.1016/j.trsl.2023.05.002Skeletal muscleMouse
Wang 2023 Nature2023Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, Paré G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, Jørgensen SB, Steinberg GR (2023) GDF15 promotes weight loss by enhancing energy expenditure in muscle. https://doi.org/10.1038/s41586-023-06249-4Skeletal muscleMouse
Peixoto 2023 J Physiol Biochem2023Peixoto ÁS, Moreno MF, Castro É, Perandini LA, Belchior T, Oliveira TE, Vieira TS, Gilio GR, Tomazelli CA, Leonardi BF, Ortiz-Silva M, Silva Junior LP, Moretti EH, Steiner AA, Festuccia WT (2023) Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning. https://doi.org/10.1007/s13105-023-00970-4Liver
Fat
Mouse
Som 2023 Am J Physiol Cell Physiol2023Som R, Fink BD, Yu L, Sivitz WI (2023) Oxaloacetate regulates complex II respiration in brown fat: dependence on UCP1 expression. Am J Physiol Cell Physiol 324:C1236-48. doi: 10.1152/ajpcell.00565.2022FatMouse
Gonnot 2023 Nat Commun2023Gonnot F, Boulogne L, Brun C, Dia M, Gouriou Y, Bidaux G, Chouabe C, Crola Da Silva C, Ducreux S, Pillot B, Kaczmarczyk A, Leon C, Chanon S, Perret C, Sciandra F, Dargar T, Gache V, Farhat F, Sebbag L, Bochaton T, Thibault H, Ovize M, Paillard M, Gomez L (2023) SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases. https://doi.org/10.1038/s41467-023-39027-xHeartMouse
Czyzowska 2023 Redox Biol2023Czyżowska A, Brown J, Xu H, Sataranatarajan K, Kinter M, Tyrell VJ, O'Donnell VB, Van Remmen H (2023) Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness. https://doi.org/10.1016/j.redox.2023.102761Skeletal muscleMouse
Pharaoh 2023 Geroscience2023Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martín-Pérez M, Qian WJ, MacCoss MJ, Villén J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ (2023) The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT). https://doi.org/10.1007/s11357-023-00861-ySkeletal muscleMouse
Pereyra 2023 Am J Physiol Gastrointest Liver Physiol2023Pereyra AS, McLaughlin KL, Buddo KA, Ellis JM (2023) Medium-chain fatty acid oxidation is independent of L-carnitine in liver and kidney but not in heart and skeletal muscle. https://doi.org/10.1152/ajpgi.00105.2023Heart
Skeletal muscle
Liver
Kidney
Mouse
Frangos 2023 J Biol Chem2023Frangos SM, DesOrmeaux GJ, Holloway GP (2023) Acidosis attenuates CPT-I supported bioenergetics as a potential mechanism limiting lipid oxidation. https://doi.org/10.1016/j.jbc.2023.105079Skeletal muscleMouse
Pinho 2023 Eur J Clin Invest2023Pinho ACO, Santos D, Oliveira PJ, Leal EC, Carvalho E (2023) Real-time OXPHOS capacity analysis in wounded skin from diabetic mice: A pilot study. https://doi.org/10.1111/eci.14128Mouse
Ismaeel 2023 Physiol Rep2023Ismaeel A, Valentino TR, Burke B, Goh J, Saliu TP, Albathi F, Owen A, McCarthy JJ, Wen Y (2023) Acetate and succinate benefit host muscle energetics as exercise-associated post-biotics. https://doi.org/10.14814/phy2.15848Skeletal muscleMouse
Bellissimo 2023 Exp Physiol2023Bellissimo CA, Castellani LN, Finch MS, Murugathasan M, Gandhi S, Sweeney G, Abdul-Sater AA, MacPherson REK, Perry CGR (2023) Memory impairment in the D2.mdx mouse model of Duchenne muscular dystrophy is prevented by the adiponectin receptor agonist ALY688. https://doi.org/10.1113/ep091274Nervous systemMouse
Zhang 2023 Nat Commun2023Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C (2023) ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury. https://doi.org/10.1038/s41467-023-43439-0LiverMouse
Bodis 2023 Diabetes Obes Metab2023Bódis K, Breuer S, Crepzia-Pevzner A, Zaharia OP, Schön M, Saatmann N, Altenhofen D, Springer C, Szendroedi J, Wagner R, Al-Hasani H, Roden M, Pesta D, Chadt A (2023) Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high-fat diet-fed mouse model. https://doi.org/10.1111/dom.15322FatMouse
Batterson 2023 Physiol Rep2023Batterson PM, McGowan EM, Borowik AK, Kinter MT, Miller BF, Newsom SA, Robinson MM (2023) High-fat diet increases electron transfer flavoprotein synthesis and lipid respiration in skeletal muscle during exercise training in female mice. https://doi.org/10.14814/phy2.15840Skeletal muscleMouse
Donnelly 2023 MitoFit2023Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion AC, Matera A, Tavernari D, Zanou N, Kayser B, Gnaiger E, Place N (2023) Functional hypoxia reduces mitochondrial calcium uptake. MitoFit Preprints 2023.2. https://doi.org/10.26124/mitofit:2023-00022024-11-17 published in Redox Biol.Skeletal muscle
Heart
Nervous system
Other cell lines
Human
Mouse
Vilas-Boas 2023 J Biol Chem2023Vilas-Boas EA, Cabral-Costa JV, Ramos VM, Caldeira da Silva CC, Kowaltowski AJ (2023) Goldilocks calcium concentrations and the regulation of oxidative phosphorylation: too much, too little, or just right. https://doi.org/10.1016/j.jbc.2023.102904LiverMouse
Wu 2023 Int Immunopharmacol2023Wu F, Zhang YT, Teng F, Li HH, Guo SB (2023) S100a8/a9 contributes to sepsis-induced cardiomyopathy by activating ERK1/2-Drp1-mediated mitochondrial fission and respiratory dysfunction. https://doi.org/10.1016/j.intimp.2023.109716HeartMouse
Dominguez-Lopez 2023 Neuropharmacology2023Dominguez-Lopez S, Ahn B, Sataranatarajan K, Ranjit R, Premkumar P, Van Remmen H, Beckstead MJ (2023) Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione. https://doi.org/10.1016/j.neuropharm.2023.109436Nervous systemMouse
Mahmoud 2023 Pharmacol Res2023Mahmoud AM, Kostrzewa M, Marolda V, Cerasuolo M, Maccarinelli F, Coltrini D, Rezzola S, Giacomini A, Mollica MP, Motta A, Paris D, Zorzano A, Marzo VD, Ronca R, Ligresti A (2023) Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer. https://doi.org/10.1016/j.phrs.2023.106683Endothelial;epithelial;mesothelial cellMouse
Kim 2023 bioRxiv2023Kim Y, Li C, Gu C, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Fang Y, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM (2023) MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy. https://doi.org/10.1101/2023.01.10.523171Endothelial;epithelial;mesothelial cellMouse
Kyriazis 2023 Res Sq2023Kyriazis G, Serrano J, Boyd J, Mason C, Smith K, Karolyi K, Kondo S, Brown I, Maurya S, Meshram N, Serna V, Gilger J, Branch D, Gardell S, Baskin K, Ayala J, Pratley R, Goodpaster B, Coen P (2023) The TAS1R2 sweet taste receptor regulates skeletal muscle mass and fitness. https://doi.org/10.21203/rs.3.rs-2475555/v1Skeletal muscleMouse
Bahire 2023 Mitochondrion2023Bahire KL, Maļuhins R, Bello F, Freitag SV, Jeļisejevs I, Gile R, Upīte J, Plesnila N, Jansone B (2023) Hemispheric analysis of mitochondrial complex I and II activity in the mouse model of ischemia-reperfusion-induced injury. https://doi.org/10.1016/j.mito.2023.02.005Nervous systemMouse
Duran-Gueell 2023 FASEB J2023Duran-Güell M, Garrabou G, Flores-Costa R, Casulleras M, López-Vicario C, Zhang IW, Cantó-Santos J, Contreras BJ, Sánchez-Rodríguez MB, Romero-Grimaldo B, Horrillo R, Costa M, Arroyo V, Clària J (2023) Essential role for albumin in preserving liver cells from TNFα-induced mitochondrial injury. https://doi.org/10.1096/fj.202201526rLiverMouse
Szulik 2023 Basic Res Cardiol2023Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O'Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin S (2023) SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation. https://doi.org/10.1007/s00395-023-00991-6HeartMouse
Leduc-Gaudet 2023 Nat Commun2023Leduc-Gaudet JP, Franco-Romero A, Cefis M, Moamer A, Broering FE, Milan G, Sartori R, Chaffer TJ, Dulac M, Marcangeli V, Mayaki D, Huck L, Shams A, Morais JA, Duchesne E, Lochmuller H, Sandri M, Hussain SNA, Gouspillou G (2023) MYTHO is a novel regulator of skeletal muscle autophagy and integrity. https://doi.org/10.1038/s41467-023-36817-1Skeletal muscleMouse
Vamesu 2023 JCI Insight2023Vamesu BM, Nicola T, Li R, Hazra S, Matalon S, Kaminski N, Ambalavanan N, Kandasamy J (2023) Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function. https://doi.org/10.1172/jci.insight.160697Lung;gillMouse
Temelie 2023 Int J Mol Sci2023Temelie M, Talpur R, Dominguez-Prieto M, Dantas Silva A, Cenusa C, Craciun L, Savu DI, Moisoi N (2023) Impaired integrated stress response and mitochondrial integrity modulate genotoxic stress impact and lower the threshold for immune signalling. https://doi.org/10.3390/ijms24065891FibroblastMouse
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