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• Gnaiger 2018 MiP2018
  ...r Erich.jpg|90px|left|Erich Gnaiger]] Mitochondrial respiratory control by fuel substrates and specific inhibitors of respiratory enzymes: Building blocks ...ture I aim at providing (''1'') a historical account of the development of substrate-uncoupler-inhibitor-titration (SUIT) protocols to address defined PCS, as a
  6 KB (827 words) - 11:51, 3 November 2018
• Kamath 2010
  ..., Krieglstein J, Kowluru A. (2010) Regulation of glucose-and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in p ...on, additional studies are needed to precisely identify the phosphoprotein substrate(s) for PHP in the cascade of events leading to nutrient-induced insulin sec
  2 KB (317 words) - 10:51, 21 November 2012
• Kamath 2010 Am J Physiol Endocrinol Metab
  ..., Krieglstein J, Kowluru A (2010) Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in p ...on, additional studies are needed to precisely identify the phosphoprotein substrate(s) for PHP in the cascade of events leading to nutrient-induced insulin sec
  2 KB (341 words) - 15:08, 26 May 2015
• Gnaiger 2017 Abstract EUROMIT2017 Cologne
  ...a compensatory or adaptive metabolic reprogramming and shift of preferred substrate utilization. Combining the flexibility of cell culture models and tissue sa
  4 KB (491 words) - 19:17, 10 January 2022
• Forbes 2018 Nat Rev Nephrol
  ...ors including mutations in genes that impact mitochondrial function and/or substrate delivery may also be important risk factors for DKD. Hence, we postulate th
  2 KB (247 words) - 20:08, 14 September 2023
• Q-pools
  ...ne in aerobic [[mitochondrial preparations]] incubated without [[CHNO-fuel substrate]]s. Intermediate redox states of Q_ra are sensitive to pathway co ...ia and partially reduced in aerobic mt-preparations incubated without CHNO-fuel substrates || || 1, 2, 3
  5 KB (698 words) - 21:19, 3 April 2021
• Sumbalova 2014 Abstract MiP2014
  ...n multiple types of mitochondria revealed that malate, a substrate used to fuel CI-linked respiration, inhibits CII-linked (succinate+rotenone; coupled and ...be suggestive of a higher involvement of SDH in respiration with CI-linked substrate combinations. Indeed, this involvement, as determined by inhibition of SDH
  4 KB (587 words) - 13:46, 5 January 2023
• Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT
  ...easured using high-resolution respirometry (O2k, Oroboros Instruments) and substrate-uncoupler-inhibitor titration (SUIT) protocols developed specifically for t ...s a central role in the maintenance of mitochondrial respiration as a fuel substrate.
  4 KB (479 words) - 18:55, 10 January 2022
• Coupling/pathway control diagram
  ...a transition is induced between two [[coupling-control state]]s. If ''X'' (fuel substrates, e.g. pyruvate and succinate, or [[Electron transfer pathway]] i
  2 KB (240 words) - 20:03, 1 January 2021
• Alan 2023 MiP2023
  ...lebrand Domain-containing Protein 8 (Vwa8) in mitochondrial morphology and substrate preference. ...th the organization of membrane protein complexes as well as mitochondrial substrate preference1. <br>
  3 KB (437 words) - 16:44, 12 July 2023
• Bastos Sant'Anna Silva 2019 Life Sciences Meeting 2019 Innsbruck AT
  ...red using High-Resolution FluoRespirometry (O2k, Oroboros Instruments) and substrate-uncoupler-inhibitor titration (SUIT) protocols developed specifically for t ...s a central role in the maintenance of mitochondrial respiration as a fuel substrate.
  3 KB (465 words) - 19:11, 10 January 2022
• Rustan 2017 Abstract MITOEAGLE Barcelona
  ...s of the myotubes, and how these processes can be measured using efficient fuel handling systems. ...ous or subsequent capture of the ¹⁴CO₂ produced. The substrate oxidation assay is a novel variant of previously described experimental app
  4 KB (536 words) - 14:31, 12 January 2018
• Lin 2017 FASEB J
  ...high-resolution respirometry Oroboros Oxygraph-2k (O2k). The mitochondrial substrate-uncoupler-inhibitor titration (SUIT) protocol was used to determine mitocho ...cific mitochondrial respiration is likely associated with the differential fuel metabolism and contractile properties of muscle fibers.
  3 KB (361 words) - 17:32, 25 February 2020
• Hand 2012 Abstract Bioblast
  ...ence of a diffusible inhibitor. Similar patterns are seen with Complex II substrate alone (succinate), which supports a much higher OXPHOS capacity than that o
  5 KB (683 words) - 11:16, 8 June 2020
• Zhang 2020 Intensive Care Med Exp
  ...anz C, Hellmann A, Mizaikoff B, Radermacher P, Hartmann C (2020) Metabolic substrate utilization in stress-induced immune cells. Intensive Care Med Exp 8:28. ...rom glucose, other sources, such as fatty acids and glutamine, are able to fuel the TCA cycle. Rising evidence has shown that cellular metabolism has a dir
  2 KB (281 words) - 14:40, 19 January 2021
• Categories of SUIT protocols
  ...IT protocols''' group [[MitoPedia: SUIT |SUIT protocols]] according to all substrate types involved in a protocol (F, N, S, Gp), independent of the sequence of ...tocol, the categories of SUIT protocols reduce this diversity to a list of substrate types involved.
  5 KB (673 words) - 16:25, 3 June 2020
• Electron-transfer-pathway state
  ...ogenous substrates and addition to the mitochondrial respiration medium of fuel substrates (CHNO) activating specific mitochondrial pathways, and possibly ...mitochondrial [[SUIT protocols]]. Mitochondrial pathways are stimulated by fuel substrates (CHNO) feeding electrons into the [[Electron transfer pathway]]
  15 KB (1,913 words) - 19:27, 25 August 2023
• SUIT-003 O2 ce-pce D018
  ...d, the addition of [[pyruvate]] is recommended to provide an external fuel substrate.
  2 KB (309 words) - 23:56, 12 April 2021
• Bastos Sant'Anna Silva 2018 MiPschool Tromso C4
  ...easured using high-resolution respirometry (O2k, Oroboros Instruments) and substrate-uncoupler-inhibitor titration (SUIT) protocols developed specifically for t ...s a central role in the maintenance of mitochondrial respiration as a fuel substrate.
  5 KB (637 words) - 19:10, 10 January 2022
• Schulte 1992 J Exp Biol
  ...s may limit the rate at which white muscle mitochondria can produce ATP to fuel glycogenesis in situ. It is postulated that the high [ATP]/[ADP]f ratios ar |topics=Aerobic glycolysis, ADP, ATP, AMP, PCr;Cr, pH, Phosphate, Substrate
  2 KB (309 words) - 09:13, 9 November 2016

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