Difference between revisions of "Succinate and rotenone"
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|description=Substrate supply by '''succinate''' (S) is the basis for electron input through Complex II into the [[mETS]]. Inhibition of [[Complex I]] by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of [[succinate dehydrogenase]]. | |description=Substrate supply by '''succinate''' (S) is the basis for electron input through Complex II into the [[mETS]]. Inhibition of [[Complex I]] by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of [[succinate dehydrogenase]]. | ||
|info=[[MiPNet11.09]], [[MiPNet12.11]] | |info=[[MiPNet11.09]], [[MiPNet12.11]] | ||
|type=Substrate ETS | |||
}} | |||
{{MitoPedia topics | |||
|mitopedia topic=Inhibitor, Substrate and metabolite | |||
|type=Substrate ETS | |type=Substrate ETS | ||
}} | }} | ||
Revision as of 14:39, 9 March 2011
- high-resolution terminology - matching measurements at high-resolution
Succinate and rotenone
Description
Substrate supply by succinate (S) is the basis for electron input through Complex II into the mETS. Inhibition of Complex I by rotenone (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of succinate dehydrogenase.
Abbreviation: S(Rot)
Reference: MiPNet11.09, MiPNet12.11
MitoPedia topics:
Inhibitor,
Substrate and metabolite
Labels:
Enzyme: Complex II; Succinate Dehydrogenase"Complex II; Succinate Dehydrogenase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property. Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Substrate; Glucose; TCA Cycle"Substrate; Glucose; TCA Cycle" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
