Difference between revisions of "Succinate and rotenone"
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{{MitoPedia | {{MitoPedia | ||
|abbr=S(Rot) | |abbr=S(Rot) | ||
|description=Substrate supply by '''succinate''' (S) is the basis for electron input through Complex II into the [[Electron transport system|mETS]]. Inhibition of [[Complex I]] by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of [[succinate dehydrogenase]]. | |description=Substrate supply by '''[[Succinate|succinate]]''' (S) is the basis for electron input through Complex II into the [[Electron transport system|mETS]]. Inhibition of [[Complex I]] by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of [[succinate dehydrogenase]]. | ||
|info=[[MiPNet11.09]], [[MiPNet12.11]] | |info=[[MiPNet11.09]], [[MiPNet12.11]] | ||
|type=Substrate ETS | |type=Substrate ETS | ||
Revision as of 12:21, 16 May 2012
- high-resolution terminology - matching measurements at high-resolution
Succinate and rotenone
Description
Substrate supply by succinate (S) is the basis for electron input through Complex II into the mETS. Inhibition of Complex I by rotenone (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of succinate dehydrogenase.
Abbreviation: S(Rot)
Reference: MiPNet11.09, MiPNet12.11
MitoPedia topics:
Inhibitor,
Substrate and metabolite
