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Triethyltin bromide
Description
Triethyltin bromide (TET) is a lipophilic [1] inhibitor of the mitochondrial ATPase [2] which is used to induce LEAK state in intact cells of Saccharomyces cerevisiae.
Linear Formula: (C2H5)3SnBr
Synonym: Bromotriethylstannane
References
- Aguilaniu H, Gustafsson L, Rigoulet M, Nyström T (2001) Protein oxidation in G0 cells of Saccharomyces cerevisiae depends on the state rather than rate of respiration and is enhanced in pos9 but not yap1 mutants. J Biol Chem 276:35396-404. Bioblast Link
- Cain K, Griffiths DE (1977) Studies of energy-linked reactions. Localization of the site of action of trialkyltin in yeast mitochondria. Biochem J 162:575-80. [http://www.biochemj.org/content/162/3/575.full-text.pdf Open Access
- Also see: Sundaram V, Petkova MI, Pujol-Carrion N, Boada J, de la Torre-Ruiz MA (2015) Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival. Mol Microbiol 97:93-109. Bioblast Link]]
Abbreviation: TET
MitoPedia concepts:
Respiratory state
MitoPedia methods:
Respirometry
MitoPedia topics: Enzyme, Inhibitor
Contributed by Kandolf G 2016-02-08
