User talk:Beno Marija/MitO2 Kit Produktseite: Difference between revisions
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{{Product | {{Product | ||
|description= Cell permeable compound - | |description=Cell permeable compound - Mito-CII-Kit, 2 vials; 1 vial of NV118 (25 mg) + 1 vial of NV161 (10 mg) | ||
|product id= | |product id=60200-01 | ||
|product type=O2k | |product type=O2k | ||
|info=[[ | |info=[[Image:MitoPedia.jpg|left|60px|link=http://www.bioblast.at/index.php/MitoPedia:_DatLab |MitoPedia: Mito-CII]] [[MitoPedia: Mito-CII]] | ||
|product image= | |product image= | ||
}} | }} | ||
__TOC__ | __TOC__ | ||
Compounds | Compounds | ||
== Cell permeable | == Cell permeable compounds NV118 and NV161 - Mito-CII-Kit == | ||
=== Preparation === | |||
::::* The prodrug NV118 is dissolved in DMSO to 1M concentration and stored in aliquots at -20. | |||
::::* The prodrug NV161 is dissolved in DMSO to 1M concentration and stored in aliquots at -20. | |||
{{Publication | {{Publication | ||
|title=[[Image:O2k-Protocols.jpg|right|80px|link=http://wiki.oroboros.at/index.php/O2k-Protocols|O2k-Protocols]] Cell permeable compound - | |title=[[Image:O2k-Protocols.jpg|right|80px|link=http://wiki.oroboros.at/index.php/O2k-Protocols|O2k-Protocols]] Cell permeable compound - Mito-CII-Kit. | ||
|info=[[File:PDF.jpg|100px|link=http://wiki.oroboros.at/images/c/c8/MiPNet22.10_MiR05-Kit.pdf |Bioblast pdf]] » [http://wiki.oroboros.at/index.php/File:MiPNet22.10_MiR05-Kit.pdf Versions] | |info=[[File:PDF.jpg|100px|link=http://wiki.oroboros.at/images/c/c8/MiPNet22.10_MiR05-Kit.pdf |Bioblast pdf]] » [http://wiki.oroboros.at/index.php/File:MiPNet22.10_MiR05-Kit.pdf Versions] | ||
|authors=Oroboros | |authors=Oroboros | ||
|year=2019-03-01 | |year=2019-03-01 | ||
|journal=Mitochondr Physiol Network | |journal=Mitochondr Physiol Network | ||
|abstract=Gnaiger E, Laner V, Passrugger M, NeuroVive Pharmaceutical AB (2019) cell permeable compound - | |abstract=Gnaiger E, Bastos A, Laner V, Passrugger M, NeuroVive Pharmaceutical AB (2019) cell permeable compound - Mito-CII-Kit. Mitochondr Physiol Network 24.03(01):1-2. | ||
(##) The cell permeable compound | (##) The cell permeable compound Mito-CII-Kit is the first generation of NeuroVive Pharmaceutical AB's succinate/malonate prodrugs and was developed to stimulate and inhibit Complex II of the respiratory electron transfer system in intact cells, and will expand the toolbox for evaluating the role of mitochondria in disease. | ||
:» Product: [[Oroboros O2k]], [[Oroboros O2k-Catalogue | O2k-Catalogue]] | :» Product: [[Oroboros O2k]], [[Oroboros O2k-Catalogue | O2k-Catalogue]] | ||
|keywords= | |keywords=Mito-CII-Kit | ||
|mipnetlab=AT_Innsbruck_Oroboros, NeuroVive | |mipnetlab=AT_Innsbruck_Oroboros, NeuroVive | ||
}} | }} | ||
== Compounds of | == Compounds of Mito-CII-Kit == | ||
:::: The | :::: The Mito-CII-Kit is composed of equal quantities of the following Compounds: | ||
::::* '''[[ | ::::* '''Cell permeable compound [[NV118]]''' | ||
::::: Description: Succinate prodrug: C<sub>10</sub>H<sub>14</sub>O<sub>8</sub>, Molecular weight 262,2g.mol<sup>-1</sup> | ::::: Description: Succinate prodrug: C<sub>10</sub>H<sub>14</sub>O<sub>8</sub>, Molecular weight 262,2g.mol<sup>-1</sup> | ||
::::: Aliquots per 25 mg | ::::: Aliquots per 25 mg | ||
::::* '''[[ | ::::* '''Cell permeable compound [[NV161]]''' | ||
::::: Description: Malonate prodrug: C<sub>9</sub>H<sub>12</sub>O<sub>8</sub>, Molecular weight 248,2g.mol<sup>-1</sup> | ::::: Description: Malonate prodrug: C<sub>9</sub>H<sub>12</sub>O<sub>8</sub>, Molecular weight 248,2g.mol<sup>-1</sup> | ||
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::::* Reference: | ::::* Reference: | ||
:::::: Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency. Nat Commun 7:12317. [[Ehinger 2016 Nat Commun|»Bioblast link«]] - Original publication introducing | :::::: Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency. Nat Commun 7:12317. [[Ehinger 2016 Nat Commun|»Bioblast link«]] - Original publication introducing Mito-CII. | ||
== Expiry date of Mito-CII-Kit compounds (according to NeuroVive) == | |||
Before preparation: | |||
::::* 3 years in -80° C | |||
::::* 1 year in -20° C | |||
Prepared: | |||
::::* In DMSO solution | |||
::::::* at room temperature: 24 hours. | |||
::::::* at -20° C: for weeks | |||
::::* | CAS-Numbers: | ||
::::* | ::::* NV-118: 1592635-33-0 | ||
::::* NV-161: 1432752-62-9 | |||
Latest revision as of 14:16, 22 March 2019
User talk:Beno Marija/MitO2 Kit Produktseite
Description | Cell permeable compound - Mito-CII-Kit, 2 vials; 1 vial of NV118 (25 mg) + 1 vial of NV161 (10 mg) |
---|---|
Product ID | 60200-01 |
Type | O2k |
Link | MitoPedia: Mito-CII |
Image |
Compounds
Cell permeable compounds NV118 and NV161 - Mito-CII-Kit
Preparation
- The prodrug NV118 is dissolved in DMSO to 1M concentration and stored in aliquots at -20.
- The prodrug NV161 is dissolved in DMSO to 1M concentration and stored in aliquots at -20.
Cell permeable compound - Mito-CII-Kit. |
» » Versions
Oroboros (2019-03-01) Mitochondr Physiol Network
Abstract: Gnaiger E, Bastos A, Laner V, Passrugger M, NeuroVive Pharmaceutical AB (2019) cell permeable compound - Mito-CII-Kit. Mitochondr Physiol Network 24.03(01):1-2.
(##) The cell permeable compound Mito-CII-Kit is the first generation of NeuroVive Pharmaceutical AB's succinate/malonate prodrugs and was developed to stimulate and inhibit Complex II of the respiratory electron transfer system in intact cells, and will expand the toolbox for evaluating the role of mitochondria in disease.
- » Product: Oroboros O2k, O2k-Catalogue
• Keywords: Mito-CII-Kit
• O2k-Network Lab: AT_Innsbruck_Oroboros, NeuroVive
Compounds of Mito-CII-Kit
- The Mito-CII-Kit is composed of equal quantities of the following Compounds:
- Cell permeable compound NV118
- Description: Succinate prodrug: C10H14O8, Molecular weight 262,2g.mol-1
- Aliquots per 25 mg
- Cell permeable compound NV161
- Description: Malonate prodrug: C9H12O8, Molecular weight 248,2g.mol-1
- Aliquots per 10 mg
- Reference:
- Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency. Nat Commun 7:12317. »Bioblast link« - Original publication introducing Mito-CII.
Expiry date of Mito-CII-Kit compounds (according to NeuroVive)
Before preparation:
- 3 years in -80° C
- 1 year in -20° C
Prepared:
- In DMSO solution
- at room temperature: 24 hours.
- at -20° C: for weeks
CAS-Numbers:
- NV-118: 1592635-33-0
- NV-161: 1432752-62-9
Labels: MiParea: Instruments;methods
HRR: O2k-Protocol
O2k-chemicals and media