Difference between revisions of "Wrobeln 2017 Artif Cells Nanomed Biotechnol"
(Created page with "{{Publication |title=Wrobeln A, Schlüter KD, Linders J, Zähres M, Mayer C, Kirsch M, Ferenz KB (2017) Functionality of albumin-derived perfluorocarbon-based artificial oxyge...") |
|||
Line 10: | Line 10: | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area= | |area=mt-Medicine, Pharmacology;toxicology | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=Labels, 2019-10, | |additional=Labels, 2019-10, | ||
}} | }} |
Latest revision as of 15:35, 29 October 2019
Wrobeln A, Schlüter KD, Linders J, Zähres M, Mayer C, Kirsch M, Ferenz KB (2017) Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart. Artif Cells Nanomed Biotechnol 45:723-30. |
Wrobeln A, Schlueter KD, Linders J, Zaehres M, Mayer C, Kirsch M, Ferenz KB (2017) Artif Cells Nanomed Biotechnol
Abstract: The aim of this study was to prove whether albumin-derived perfluorocarbon-based nanoparticles (capsules) can operate as a novel artificial oxygen carrier in a rat Langendorff-heart perfusion model. Hearts perfused with capsules showed increased left ventricular pressure and rate pressure product compared to hearts perfused with pure Krebs-Henseleit (KH)-buffer. The capsules prevented the myocardium from functional fail when in their absence a noxious ischemia was observed. Capsules did not change rheological properties of KH-buffer and could repeatedly reload with oxygen. This albumin-derived perfluorocarbon-based artificial oxygen carrier preserved the function of rat hearts due to the transport of oxygen in a satisfactory manner. Because of these positive results, the functionality of the applied capsules should be verified in living animals. • Keywords: Langendorff-heart, Perfluorocarbon-based artificial oxygen carrier, Albumin, Blood substitutes, Nanocapsules, Perfluorodecalin • Bioblast editor: Plangger M
Labels: MiParea: mt-Medicine, Pharmacology;toxicology
HRR: Oxygraph-2k
Labels, 2019-10