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Goodpaster Bret H

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BEC 2020.1 Mitochondrial physiology
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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Goodpaster Bret H

MitoPedia topics: EAGLE 

COST: Member COST WG1: WG1

Name Goodpaster Bret H, Prof., PhD.

Director and Senior Investigator

at Translational Research Institute for Metabolism


at Sanford Burnham Prebys Medical Discovery Institute at Lake Nona

Institution Translational Research Institute for Metabolism and Diabetes,

Florida Hospital & Sanford Burnham Prebys, US

Address 301 East Princeton Street, 32804
City Orlando
State/Province Florida (FL)
Country USA
Email [email protected]
Weblink Goodpaster at Sanford/Burham Institute
O2k-Network Lab US FL Orlando Goodpaster BH

Labels: Field of research: Basic, Clinical  Topics: Exercise and muscle metabolism 



Doerrier 2020 PaduaMuscleDays Poster2020Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays.
Doerrier 2019 MiP20192019
Carolina Doerrier
Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers.
Kramer 2019 Abstract IOC1412019Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02.
Doerrier 2018 MiP2018c2018
Carolina Doerrier
Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.
Coen 2017 Abstract MITOEAGLE Barcelona2017
To bring MitoEAGLE and MoTrPAC together.
Distefano 2017 MiPschool Obergurgl2017
Giovanna Distefano
Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects.
Doerrier 2017 MiP2017 WG22017
Carolina Anneliese Doerrier
Upper limit of OXPHOS capacity in permeabilized myofibers: effect of oxygen, ADP and blebbistatin in MiR05Cr and Buffer Z.
Goodpaster 2016 Abstract MitoFit Science Camp 20162016The molecular transducers of physical activity consortium (MoTrPAC) and MitoEAGLE: exercise effects on mitochondria.
Goodpaster 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Goodpaster 2015 Fatty Acid Oxidation O2k-Network Discussion Forum
Zhang 2015 Abstract MiPschool Greenville 20152015Skeletal muscle NAMPT overexpression prevents mitochondrial dysfunction during hindlimb unloading induced muscle atrophy.
Coen 2014 Abstract MiP20142014Exercise improves insulin sensitivity and muscle mitochondrial respiration following Roux-en-Y gastric bypass surgery.
DeLany 2013 TOS2013Skeletal muscle mitochondrial respiration is lower in African American compared to Caucasian women and is associated with resting metabolic rate and cardiorespiratory fitness.
Distefano 2012 Abstract IOC682012Distefano G, Dube JJ, Helbling NL, Ritov VB, Stefanovic-Racic M, Toledo FGS, Ng J, Goodpaster BH, Coen PM (2012) Human skeletal muscle mitochondria respiration: The influence of aging, adiposity and aerobic fitness. MiPNet17.08.


  • We love our O2k. We have performed measurements in more than 300 muscle biopsies to date, and Paul Coen and I just got a paper accepted in Journal of Gerontology highlighting the measurements related to function in the elderly (2012-10-05).


        • Benefits for COST and for the COST Action MitoEAGLE and for COST International Partner Countries
The TRI-MD is a is a joint venture between Florida Hospital and Sanford-Burnham Medical Research Institute that is dedicated to the study of obesity, metabolism, diabetes, and the metabolic origins of cardiovascular disease.
Our groupโ€™s research program is in part focused on skeletal muscle mitochondrial energetics in the context of aging, obesity and exercise. Over the past 10 years we have conducted over 1000 respirometry assays in human muscle and so we are in an excellent position to support the scientific mission of the COST Action MitoEAGLE. In addition, we are keen to share our experience in human permeabilized muscle fiber bundle preparation. To this end we feel that our contribution may best benefit the scientific goal of Working Group #2.
In summary, we are keen to join and contribute to the important scientific mission of the Horizon 2020 COST Action CA15203 MitoEAGLE.

Participated at