Oxaloacetate

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Bioblasts - Richard Altmann and MiPArt by Odra Noel
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MitoPedia

Oxaloacetate

Description

Oxaloacetic acid

Oxaloacetic acid, C4H4O5, occurs under physiological conditions as the anion oxaloacetate2-, Oa. Oxaloacetate is formed from malate by MDH. Oa reacts with acetyl-CoA through citrate synthase to form citrate, or with glutamate through transaminase to form oxoglutarate and aspartate. Oa transport is restricted across the inner mt-membrane of various tissues. Oa is a potent inhibitor of succinate dehydrogenase.

Abbreviation: Oa

Reference: Gnaiger 2020 BEC MitoPathways


MitoPedia topics: Substrate and metabolite