Residual endogenous substrates

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Residual endogenous substrates


Ren.png Oxygen consumption due to residual endogenous substrates. Ren is the respiration in the REN state. It is due to oxidative reactions in mt-preparations incubated without addition of fuel substrates in the absence or presence of ADP (in the presence of ADP to stimulate the consumption of endogenous fuel substrates: State 2). Ren values may be used as technical replicates when obtained from the same mt-preparation in different protocols.

Ren may be higher than Rox. Correspondingly, Q and NAD are not fully oxidized in the REN state compared to the ROX state.

In previous editions (including Gnaiger 2020 BEC MitoPathways), the REN state was not distinguished from the ROX state. However, in novel applications (Q-Module and NADH-Module), a distinction of these states is necessary. Care must be taken when assuming Ren as a substitute of Rox correction of mitochondrial respiration.

Abbreviation: REN, Ren

Reference: BEC 2020.1, Electron-transfer-pathway state, Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol, Komlodi 2021 BEC Q


Bioblast linkReferenceYear
Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45.
Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2.
Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1.
Keilin D (1929) Cytochrome and respiratory enzymes. Proc R Soc London Ser B 104:206-52.1929
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MitoPedia concepts: Respiratory state, Recommended 

MitoPedia topics: EAGLE 

Labels: MiParea: Respiration 

Pathway: REN"REN" is not in the list (F, N, S, Gp, DQ, CIV, NS, Other combinations, ROX) of allowed values for the "Pathways" property.  HRR: Theory 

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