Template:SUIT-010 O2 ce-pce D050

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MitoPedia: SUIT

Steps and respiratory states

Ce1;ce2Rot;ce3S(p);ce3S;ce4D;ce4c;1Dig;2Ama.png

Step State Pathway Q-junction Comment - Events (E) and Marks (M)
ce1 ROUTINE ce1
  • ROUTINE respiration in the physiological coupling state R. Externally added permeable substrates could contribute to this respiratory state.
ce2Rot ROX ce1;ce2Rot
ce3S(p) S S ce1;ce2Rot;ce3S(p)
ce3S S S CII ce1;ce2Rot;ce3S(p);ce3S
ce4D SP S CII ce1;ce2Rot;ce3S(p);ce3S;ce4D
ce4c SP S CII ce1;ce2Rot;ce3S(p);ce3S;ce4D;ce4c
  • Succinate, S ( type S-pathway to Q).
  • Addition of cytochrome c yields a test for integrity of the mtOM. Stimulation by added cytochrome c would indicate an injury of the mtOM and limitation of respiration in the preceding state without added c due to loss of cytochrome c. Typically, cytochrome c is added immediately after the earliest ADP-activation step (P, OXPHOS-capacity with saturating [ADP]).
  • OXPHOS capacity, P (with saturating [ADP]), active OXPHOS state.
1Dig SP S CII ce1;ce2Rot;ce3S(p);ce3S;ce4D;ce4c;1Dig



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