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LEAK respiration
Description
EAK respiration or LEAK oxygen flux L compensating for proton leak, proton slip, cation cycling and electron leak, is a dissipative component of respiration which is not available for performing biochemical work and thus related to heat production. LEAK respiration is measured in the LEAK state, in the presence of reducing substrate(s), but absence of ADP - abbreviated as L(n) (theoretically, absence of inorganic phosphate presents an alternative), or after enzymatic inhibition of the phosphorylation system, which can be reached with the use of oligomycin - abbreviated as L(Omy). The LEAK state is the non-phosphorylating resting state of intrinsic uncoupled or dyscoupled respiration when oxygen flux is maintained mainly to compensate for the proton leak at a high chemiosmotic potential, when ATP synthase is not active. In this non-phosphorylating resting state, the electrochemical proton gradient is increased to a maximum, exerting feedback control by depressing oxygen flux to a level determined mainly by the proton leak and the H+/O2 ratio. In this state of maximum protonmotive force, LEAK respiration, L, is higher than the LEAK component of OXPHOS capacity, P. The conditions for measurement and expression of respiration vary (oxygen flux in the LEAK state, JO2L, or oxygen flow, IO2L). If these conditions are defined and remain consistent within a given context, then the simple symbol L for respiratory rate can be used as a substitute for the more explicit expression for respiratory activity.
» MiPNet article
Abbreviation: L
Reference: BEC 2020.1, Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol
Contents
LEAK respiration: concept-linked terminology of respiratory states

Gnaiger E (2019) LEAK respiration: concept-linked terminology of respiratory states. Mitochondr Physiol Network 2019-01-24. |
» Gnaiger 2020 BEC MitoPathways
Abstract: Mitochondrial respiratory states have been defined originally by Chance and Williams (1955) as a sequence (from 1 to 5) of titrations and transitions in a respiratory protocol, including State 4 as a LEAK state of respiration obtained after exhaustion of the added ADP. The second state (State 2) is induced by addition of 'high ADP'. Confusion persists in the current literature as to the meaning of State 2, which can be resolved by a transition from a specific protocol-linked to a generalized concept-linked terminology.
• O2k-Network Lab: AT Innsbruck Gnaiger E
The LEAK state
- Respiration compensating for the proton leak is the main component of LEAK respiration. If proton leak were the only component involved, it would make sense to simply write leak respiration for the compensatory oxygen flux. Proton slip and cation cycling, however, are also involved to a larger or smaller extent to stimulate LEAK respiration. The upper case 'LEAK', therefore, should make us aware that this is more accurately considered as an acronym, and cannot be taken as a definitive delineation of the stimulatory mechanism in the LEAK state of respiration.
- Note: The distinction between LEAK- and ET capacity helps to clarify the important difference between physiologically uncoupled or pathologically dyscoupled respiration (LEAK) in contrast to noncoupled respiration (ET capacity).
- States and rates are distinguished: The LEAK state is a respiratory state, LEAK; whereas LEAK respiration L is a rate (Gnaiger 2019 MitoFit Preprint Arch).
Protocols for measurement of LEAK respiration
- The LEAK state can be induced experimentally in various ways, which may yield idential estimates of LEAK respiration, or may show deviations that help to critically assess the proper protocol to be applied in specific cases:
a) LEAK state with ATP
LEAK state with ATP: classical State 4 in isolated mitochondria), LEAK respiration L(T) after phosphorylation of ADP to ATP is completed, or when a high concentration of ATP is added in the absence of ADP (Gnaiger 2000 Proc Natl Acad Sci U S A).
- In contradiction to the original definition of State 2 (ROX), yet with reference to Chance and Williams (1956), 'State 2' has later been used for describing this functionally different LEAK state:
- ‘State 2: substrate added, respiration low due to lack of ADP. .. the controlled respiration prior to addition of ADP, which is strictly termed “state 2”, is functionally the same as state 4, and the latter term is usually used for both states’ (Nicholls & Ferguson 1992).
- Thus State 2 was re-defined as functionally the same as State 4. State 2 (Chance and Williams 1955, 1956), however, is substrate-limited residual oxygen consumption at high ADP (ROXD), whereas L(n) and L(T) (State 4) are LEAK respiration in the absence of adenylates, L(n) (no ADP, no ATP) or presence of ATP, L(T).
- To overcome the termonological confusion persisting in the scientific literature, the respiratory coupling states of LEAK respiration, OXPHOS capacity and ET capacity are distinguished from residual oxygen consumption (ROX; Gnaiger 2009).
b) LEAK state with oligomycin
LEAK state with oligomycin: rate L(Omy) (in isolated mitochondria or other mitochondrial preparations, and non-permeabilized cells).
c) LEAK state without adenylates
- LEAK state without adenylates: rate L(n) (in isolated mitochondria or other mitochondrial preparations, using a protocol different from the classical State 2-3-4 sequence).
- Sequential addition of (1) mitochondria, (2) ADP, and (3) reduced substrates is the basis of the original State 1-2-3 definitions of respiratory states (Chance and Williams 1955 part III, 1956), where State 2 is zero respiration or residual oxygen consumption in the absence of substrate. An alternative protocol is well established, as shown, e.g., by the classical Fig. 5A (Chance and Williams 1955 part I): 600 µM ADP is added after a state described as ‘Aerobic mitochondria plus succinate’. That state was never defined as ‘State 2’ by Brit Chance. Later Estabrook (1967) made this protocol more popular, with addition of substrate before any ADP or ATP was added.
- In this alternative protocol, a respiratory LEAK state is induced in isolated mitochondria, permeabilized tissues, or permeabilized cells, adding the mitochondrial preparation to respiration medium containing inorganic phosphate (State 1), then adding reduced substrate (no external adenylates). This second state (Estabrook 1967) is a non-phosphorylating LEAK state, with respiration L(n) (n for no adenylates; Gnaiger 2009), when substrate-saturated respiration compensates for the proton leak (mainly) in the absence of ADP.
State 4 versus State 2
Static head
- LEAK state - Static head
- State 4 is frequently referred to as 'static head' of isolated mitochondria. Equivalence requires testing, if at State 4 (in a protocol defined by Chance and Williams 1955) ATPase activity is actually zero, such that respiration at State 4 is not partially stimulated by partial recycling of ATP to ADP. In the latter case, State 4 respiration would be higher than LEAK respiration and thus higher than respiration at static head.
Keywords
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
- Bioblast links: Coupling control - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
Mitochondrial and cellular respiratory rates in coupling-control states
Respiratory rate | Definition | Icon | |
---|---|---|---|
OXPHOS capacity | P = P´-Rox | ![]() |
mt-preparations |
ROUTINE respiration | R = R´-Rox | ![]() |
living cells |
ET capacity | E = E´-Rox | ![]() |
» Level flow |
» Noncoupled respiration - Uncoupler | |||
LEAK respiration | L = L´-Rox | ![]() |
» Static head |
» LEAK state with ATP | |||
» LEAK state with oligomycin | |||
» LEAK state without adenylates | |||
Residual oxygen consumption Rox | L = L´-Rox | ![]() |
FCR | Definition | Icon | |
---|---|---|---|
L/P coupling-control ratio | L/P | ![]() |
» Respiratory acceptor control ratio, RCR = P/L |
L/R coupling-control ratio | L/R | ![]() | |
L/E coupling-control ratio | L/E | ![]() |
» Uncoupling-control ratio, UCR = E/L |
P/E control ratio | P/E | ![]() | |
R/E control ratio | R/E | ![]() | |
net P/E control ratio | (P-L)/E | ![]() | |
net R/E control ratio | (R-L)/E | ![]() |
Net, excess, and reserve capacities of respiration
Respiratory net rate | Definition | Icon |
---|---|---|
P-L net OXPHOS capacity | P-L | ![]() |
R-L net ROUTINE capacity | R-L | ![]() |
E-L net ET capacity | E-L | ![]() |
E-P excess capacity | E-P | ![]() |
E-R reserve capacity | E-R | ![]() |
Coupling-control efficiency | Definition | Icon | Canonical term | ||
---|---|---|---|---|---|
P-L control efficiency | jP-L | = (P-L)/P | = 1-L/P | ![]() |
P-L OXPHOS-flux control efficiency |
R-L control efficiency | jR-L | = (R-L)/R | = 1-L/R | ![]() |
R-L ROUTINE-flux control efficiency |
E-L coupling efficiency | jE-L | = (E-L)/E | = 1-L/E | ![]() |
E-L ET-coupling efficiency » Biochemical coupling efficiency |
E-P control efficiency | jE-P | = (E-P)/E | = 1-P/E | ![]() |
E-P ET-excess flux control efficiency |
E-R control efficiency | jE-R | = (E-R)/E | = 1-R/E | ![]() |
E-R ET-reserve flux control efficiency |
General
- » Basal respiration
- » Cell ergometry
- » Dyscoupled respiration
- » Dyscoupling
- » Electron leak
- » Electron-transfer-pathway state
- » Hyphenation
- » Oxidative phosphorylation
- » Oxygen flow
- » Oxygen flux
- » Permeabilized cells
- » Phosphorylation system
- » Proton leak
- » Proton slip
- » Respiratory state
- » Uncoupling
- Bioblast links: Uncoupling - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Specific
- » Artefacts by single dose uncoupling
- » ATP synthase
- » CCCP
- » Coupling-control protocol
- » DNP
- » Dyscoupled respiration
- » FCCP
- » Gnaiger 2019 MitoFit Preprint Arch
- » Is respiration uncoupled - noncoupled - dyscoupled?
- » Noncoupled respiration: Discussion
- » Uncoupler
- » Uncoupled respiration - see » Noncoupled respiration
- » Uncoupling proteins
- » Uncoupling protein 1
- » Uncoupler titrations - Optimum uncoupler concentration
- Specific
- Respiratory states and control ratios
- » Biochemical coupling efficiency
- » Coupling-control state
- » Electron-transfer-pathway state
- » Electron-transfer pathway
ET capacity
- » E-L coupling efficiency
- » Flux control efficiency
- » Flux control ratio
- » LEAK-control ratio
- » LEAK respiration
- » Noncoupled respiration
- » OXPHOS
- » OXPHOS capacity; » State 3
- » OXPHOS-control ratio, P/E ratio
- » Respiratory acceptor control ratio
- » ROUTINE-control ratio
- » ROUTINE respiration
- » ROUTINE state
- » State 3u
- » State 4
- » Uncoupling-control ratio UCR
- Respiratory states and control ratios
- General (alphabetical order)
- Other keyword lists
- Bioblast links: pH and protons - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- pH and protons
- » pH
- » hydrogen ion
- » proton
- » pH buffering capacity
- » proton flux
- » proton pump versus hydrogen ion pump
- » proton leak
- » proton slip
- » protonmotive force
- pH and protons
- O2k-pH
- » O2k-Catalogue: O2k-pH ISE-Module
- » O2k-Manual pH electrode: MiPNet23.15 O2k-pH ISE-Module
- » O2k-SOP: MiPNet08.16 pH calibration
- » File:PH-Calibration-List.xls
- » NextGen-O2k, ratiometric: Carboxy SNARF 1
- » NextGen-O2k, ratiometric: HPTS
- » pH calibration buffers
- O2k-pH
- O2k-Publications
- HRFR - general
- » O2k-Manual: MiPNet22.11 O2k-FluoRespirometer manual
- » O2k signals and output
- » O2k-SOP: MiPNet14.06 Instrumental O2 background
- » MiPNet19.18A O2k-Series G: Start
- » ESD
- » O2k configuration
- » O2k control
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- » O2k-Main Unit#O2k-Series
- » Titration-Injection microPump
- » Compare: O2k-TPP+_ISE-Module
- HRFR - general
References
Bioblast link | Reference | Year |
---|---|---|
Chance 1955 J Biol Chem-III | Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation: III. The steady state. J Biol Chem 217:409-27. | 1955 |
Chance 1955 J Biol Chem-I | Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J Biol Chem 217:383-93. | 1955 |
Chance 1956 Adv Enzymol Relat Subj Biochem | Chance B, Williams GR (1956) The respiratory chain and oxidative phosphorylation. Adv Enzymol Relat Subj Biochem 17:65-134. | 1956 |
Estabrook 1967 Methods Enzymol | Estabrook RW (1967) Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios. Methods Enzymol 10:41-7. | 1967 |
Gnaiger 1993 Hypoxia | Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In: Surviving hypoxia: Mechanisms of control and adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo:77-109. | 1993 |
Gnaiger 1993 Pure Appl Chem | Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65:1983-2002. | 1993 |
Gnaiger 2009 Int J Biochem Cell Biol | Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45. | 2009 |
Gnaiger 2019 MitoFit Preprint Arch | Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6. | 2019-08-30 |
BEC 2020.1 doi10.26124bec2020-0001.v1 | Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1. | 2020 |
- Caplan SR, Essig A (1983) Bioenergetics and linear nonequilibrium thermodynamics. The steady state. Harvard Univ. Press, Cambridge:435 pp.
- Nicholls DG, Ferguson SJ (2002) Bioenergetics 3. Academic Press, London:287 pp.
- Bioblast alert 2014(04)
- » List of publications: LEAK
Sort in ascending/descending order by a click on one of the small symbols in squares below. Default sorting: chronological. Empty fields appear first in ascending order.
Year | Reference | Coupling | Pathway | Preparation | Organism | Tissue;cell | |
---|---|---|---|---|---|---|---|
Knapp-Wilson 2021 bioRxiv | 2021 | Knapp-Wilson A, Pereira GC, Buzzard E, Richardson A, Corey RA, Neal C, Verkade P, Halestrap AP, Gold VAM, Kuwabara P, Collinson I (2021) Maintenance of complex I and respiratory super-complexes by NDUF-11 is essential for respiratory function, mitochondrial structure and health in C. elegans. bioRxiv doi: https://doi.org/10.1101/2021.01.06.425530. | LEAK OXPHOS | N S | Isolated mitochondria | Caenorhabditis elegans | |
Avram 2021 Int J Mol Sci | 2021 | Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E (2021) Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity. Int J Mol Sci 22:424. | ROUTINE ET LEAK | ROX | Intact cells | Human | Platelet |
MiPNet21.17 BloodCellsIsolation | 2020-10-22 | O2k-Protocols: Isolation of blood cells for HRR. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS ROX | Intact cells Permeabilized cells | Human | Blood cells Platelet |
Hassan 2020 MitoFit Preprint Arch | 2020-04-30 | Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. MitoFit Preprint Arch 2020.3 doi:10.26124/mitofit:200003. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | |
Lopez 2020 Function (Oxf) | 2020 | Lopez R, Marzban B, Gao X, Lauinger E, Van den Bergh F, Whitesall SE, Converso-Baran K, Burant CF, Michele DE, Beard DA (2020) Impaired myocardial energetics causes mechanical dysfunction in decompensated failing hearts. Function (Oxf) 1:zqaa018. | LEAK OXPHOS | F N | Isolated mitochondria | Rat | Heart |
Baxter 2020 Elife | 2020 | Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705. | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Mouse | Heart |
Stepanova 2020 Methods Cell Biol | 2020 | Stepanova Anna, Galkin Alexander (2020) Measurement of mitochondrial H2O2 production under varying O2 tensions. Methods Cell Biol 155:273-93. | LEAK OXPHOS | S N Gp | Isolated mitochondria | Mouse | Nervous system |
De Souza 2020 Heliyon | 2020 | De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. Heliyon 6:e03862. | LEAK ROUTINE ET | ROX | Intact cells | Human | Liver HeLa |
Davidson 2020 Circ Res | 2020 | Davidson MT, Grimsrud P, Lai L, Draper J, Fisher-Wellman KH, Narowski TM, Koves TR, Kelly DP, Muoio DM (2020) Extreme acetylation of the cardiac mitochondrial proteome does not promote heart failure. Circ Res 127:1094-108. | LEAK | F N | Isolated mitochondria | Mouse | Heart |
Dymkowska 2020 J Appl Toxicol | 2020 | Dymkowska D, Wrzosek A, Zabłocki K (2020) Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N-methyltransferase level in endothelial cells. J Appl Toxicol [Epub ahead of print]. | LEAK ET ROUTINE | Intact cells | Human | Endothelial;epithelial;mesothelial cell | |
Hayes 2020 Nutrients | 2020 | Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871. | LEAK ROUTINE OXPHOS ET | N S Gp CIV ROX | Permeabilized cells Intact cells | Human | HeLa |
Beninca 2020 J Med Genet | 2020 | Beninca C, Zanette V, Brischigliaro M, Johnson M, Reyes A, Valle DAD, Robinson AJ, Degiorgi A, Yeates A, Telles BA, Prudent J, Baruffini E, Santos ML, de Souza RL, Fernandez-Vizarra E, Whitworth A, Zeviani M (2020) Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features. J Med Genet [Epub ahead of print]. | LEAK ROUTINE ET | Intact cells | Human | Fibroblast | |
Larsen 2020 Cardiovasc Drugs Ther | 2020 | Larsen AH, Wiggers H, Dollerup OL, Jespersen NR, Hansson NH, Frøkiær J, Brøsen K, Nørrelund H, Bøtker HE, Møller N, Jessen N (2020) Metformin lowers body weight but fails to increase insulin sensitivity in chronic heart failure patients without diabetes: a randomized, double-blind, placebo-controlled study. Cardiovasc Drugs Ther [Epub ahead of print]. | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Kupats 2020 Oxid Med Cell Longev | 2020 | Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
Stankova 2020 Int J Mol Sci | 2020 | Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101. | LEAK OXPHOS | F N S Gp NS ROX | Homogenate | Mouse | Liver |
Sharma 2020 Integr Cancer Ther | 2020 | Sharma P, Singh S (2020) Combinatorial effect of DCA and let-7a on triple-negative MDA-MB-231 cells: A metabolic approach of treatment. Integr Cancer Ther 19:1534735420911437. | LEAK OXPHOS | N S | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
Rondot 2020 Thesis | 2020 | Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41. | LEAK OXPHOS | N S NS ROX | Permeabilized tissue | Hexapods | Skeletal muscle |
Assis-de-Lemos 2020 Curr Protoc Toxicol | 2020 | Assis-de-Lemos G, Ledur PF, Karmirian K, Rehen SK, Galina A (2020) A protocol to study mitochondrial function in human neural progenitors and iPSC-derived astrocytes. Curr Protoc Toxicol 85:e97. | LEAK ROUTINE ET | ROX | Intact cells | Human | Nervous system |
McCommis 2020 bioRxiv | 2020 | McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, Todd King M, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Ketogenic diet prevents heart failure from defective mitochondrial pyruvate metabolism. bioRxiv doi: https://doi.org/10.1101/2020.02.21.959635 . | LEAK OXPHOS | F N | Isolated mitochondria | Mouse | Heart |
Krabbendam 2020 Cell Death Dis | 2020 | Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM (2020) SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis 11:263. | LEAK OXPHOS | N S | Isolated mitochondria | Mouse | Nervous system |
Dawid 2020 Biochim Biophys Acta Bioenerg | 2020 | Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251. | LEAK ROUTINE OXPHOS ET | N S Gp NS ROX | Permeabilized cells Isolated mitochondria Intact cells | Human Mouse | Nervous system HEK |
Wei 2020 Hum Mutat | 2020 | Wei X, Du M, Li D, Wen S, Xie J, Li Y, Chen A, Zhang K, Xu P, Jia M, Wen C, Zhou H, Lyu J, Yang Y, Fang H (2020) Mutations in FASTKD2 are associated with mitochondrial disease with multi-OXPHOS deficiency. Hum Mutat 41:961-72. | LEAK ROUTINE | Intact cells | Human | Lymphocyte | |
Jayakumari 2020 J Diabetes | 2020 | Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55. | LEAK OXPHOS ET | F N S NS ROX | Isolated mitochondria | Human | Heart |
Franco 2020 bioRxiv | 2020 | Franco JLM, Genoula M, Corral D, Duette G, Ferreyra M, Maio M, Dolotowicz MB, Aparicio-Trejo OE, Patiño-Martínez E, Fuentes F, Soldan V, Moraña EJ, Palmero D, Ostrowski M, Schierloh P, Sánchez-Torres C, Hernández-Pando R, Pedraza-Chaverri J, Rombouts Y, Layre E, Hudrisier D, Vérollet C, Neyrolles O, Sasiain MC, Lugo-Villarino G, Balboa L (2020) Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity. bioRxiv doi: https://doi.org/10.1101/2020.03.23.001818 . | LEAK ROUTINE | N S CIV ROX | Intact cells | Human | Macrophage-derived |
Leguina-Ruzzi 2020 Biomolecules | 2020 | Leguina-Ruzzi A, Vodičková A, Holendová B, Pavluch V, Tauber J, Engstová H, Dlasková A, Ježek P (2020) Glucose-induced expression of DAPIT in pancreatic β-cells. Biomolecules 10:E1026. | LEAK ROUTINE ET | Intact cells | Rat | Islet cell;pancreas;thymus | |
Bose 2020 Aging Cell | 2020 | Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell [Epub ahead of print]. | LEAK OXPHOS | F N CIV NS ROX | Permeabilized tissue | Mouse | Heart |
Friederich-Persson 2020 Am J Physiol Renal Physiol | 2020 | Friederich-Persson M, Persson P (2020) Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats. Am J Physiol Renal Physiol 318:F683-88. | LEAK OXPHOS | N Gp | Isolated mitochondria | Rat | Kidney |
Alexopoulos 2020 Nat Commun | 2020 | Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL (2020) Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nat Commun 11:2397. | LEAK | N | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Liver Fat |
Lin 2020 Preprints | 2020 | Lin M, Fu T, Hsu C, Huang S, Lin Y, Wang J (2020) Cycling exercise training enhances mitochondrial bioenergetics of platelets in patients with peripheral arterial disease: a randomized controlled trial. Preprints 2020070567. | LEAK ROUTINE OXPHOS ET | F N S Gp NS ROX | Permeabilized cells Intact cells | Human | Platelet |
Palavicini 2020 JCI Insight | 2020 | Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Nervous system |
Padilla-Flores 2020 Biochem Biophys Res Commun | 2020 | Padilla-Flores T, Lopez-Gonzalez Z, Vaca L, Aparicio-Trejo OE, Briones-Herrera A, Riveros-Rosas H, Pedraza-Chaverri J, Leon-Aparicio D, Salvador C, Sampieri A, Escobar LI (2020) "Funny" channels in cardiac mitochondria modulate membrane potential and oxygen consumption. Biochem Biophys Res Commun 524:1030-36. | LEAK ROUTINE | ROX | Intact cells | Rat | Heart |
Keppner 2020 Thesis | 2020 | Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Blood cells |
Messner 2020 Thesis | 2020 | Messner M (2020) Sorafenib resistance of hepatocellular carcinoma. PhD Thesis 130. | LEAK ROUTINE ET | ROX | Intact cells | Human | Liver |
Gnaiger 2020 BEC MitoPathways | 2020 | Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2: 112 pp. doi:10.26124/bec:2020-0002. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS ROX | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria Intact cells | Human Mouse | Heart Skeletal muscle Fibroblast |
Hraoui 2020 J Exp Biol | 2020 | Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Molluscs | Lung;gill |
Andrade 2020 Nutr Metab Cardiovasc Dis | 2020 | Andrade D, Oliveira G, Menezes L, Nascimento AL, Carvalho S, Stumbo AC, Thole A, Garcia-Souza É, Moura A, Carvalho L, Cortez E (2020) Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice. Nutr Metab Cardiovasc Dis 30:151-61. | LEAK OXPHOS | F N NS | Permeabilized tissue | Mouse | Heart |
Silva Ferraz 2020 Biochem Pharmacol | 2020 | Silva Ferraz L, Torres da Costa R, Alves da Costa C, Augusto João Ribeiro C, Costa Arruda D, Stuchi Maria-Engler S, Rodrigues T (2020) Targeting mitochondria in melanoma: interplay between MAPK signaling pathway and mitochondrial dynamics . Biochem Pharmacol 178:114104. | LEAK ROUTINE ET | Intact cells | Human | Endothelial;epithelial;mesothelial cell | |
Agil 2020 J Clin Med | 2020 | Agil A, Chayah M, Visiedo L, Navarro-Alarcon M, Rodríguez Ferrer JM, Tassi M, Reiter RJ, Fernández-Vázquez G (2020) Melatonin improves mitochondrial dynamics and function in the kidney of Zücker diabetic fatty rats. J Clin Med 9:E2916. | LEAK OXPHOS | N S | Isolated mitochondria | Rat | Kidney |
Oliveira 2020 Anim Reprod | 2020 | Oliveira VS, Castro AJG, Domingues JT, Souza AZP, Scheffer DL, Latini A, Soares CHL, Van Der Kraak G, Silva FRMB (2020) A brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters sertoli cell secretion and mitochondrial activity. Anim Reprod 17:e20190116. | LEAK ROUTINE ET | ROX | Intact cells | Rat | Genital |
Nicolaisen 2020 FASEB J | 2020 | Nicolaisen TS, Klein AB, Dmytriyeva O, Lund J, Ingerslev LR, Fritzen AM, Carl CS, Lundsgaard AM, Frost M, Ma T, Schjerling P, Gerhart-Hines Z, Flamant F, Gauthier K, Larsen S, Richter EA, Kiens B, Clemmensen C (2020) Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure. FASEB J 34:15480-91. | LEAK OXPHOS | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Liu 2020 Cell Death Dis | 2020 | Liu YF, Zhu Juan-Juan, Yu Tian X, Liu Han, Zhang Tao, Zhang Yun-Peng, Xie Si-An, Zheng Ming, Kong Wei, Yao Wei-Juan, Pang Wei, Zhao Chuan-Rong, Tang Yuan-Jun, Zhou Jing (2020) Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis 11:35. | LEAK OXPHOS | N S CIV ROX | Permeabilized tissue | Mouse | Endothelial;epithelial;mesothelial cell |
Yurre 2020 Arq Bras Cardiol | 2020 | Yurre AR, Silva JDFD, Torres MKDS, Martins EL, Ramos IP, Silva WSFLD, Sarpa JDS, Guedes CCDS, Napoleão TH, Coelho LCBB, Paiva PMG, Medei E (2020) Evaluation of the cardiac effects of a water-soluble lectin (Wsmol) from Moringa oleifera seeds. Arq Bras Cardiol 114:1029-37. | LEAK OXPHOS | N NS ROX | Isolated mitochondria | Mouse | Heart |
Coppin 2020 Cell Death Dis | 2020 | Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360. | LEAK ROUTINE OXPHOS ET | N S Gp CIV NS ROX | Permeabilized cells Intact cells | Human | Islet cell;pancreas;thymus Endothelial;epithelial;mesothelial cell |
Brum 2020 Mol Neurobiol | 2020 | Brum EDS, Fialho MFP, Fischer SPM, Hartmann DD, Gonçalves DF, Scussel R, Machado-de-Ávila RA, Dalla Corte CL, Soares FAA, Oliveira SM (2020) Relevance of mitochondrial dysfunction in the reserpine-induced experimental fibromyalgia model. Mol Neurobiol 57:4202-17. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Nervous system |
Rebane-Klemm 2020 Cancers (Basel) | 2020 | Rebane-Klemm E, Truu L, Reinsalu L, Puurand M, Shevchuk I, Chekulayev V, Timohhina N, Tepp K, Bogovskaja J, Afanasjev V, Suurmaa K, Valvere V, Kaambre T (2020) Mitochondrial respiration in KRAS and BRAF mutated colorectal tumors and polyps. Cancers (Basel) 12:E815. | LEAK OXPHOS | N NS | Permeabilized tissue | Human | Endothelial;epithelial;mesothelial cell |
Fisher 2020 Placenta | 2020 | Fisher J, McKeating D, Pennell E, Cuffe J, Holland O, Perkins A (2020) Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta 82:1-4. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Human | Genital |
Souza da Silva 2020 Mol Neurobiol | 2020 | Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
Rocha 2020 Sci Adv | 2020 | Rocha AL, de Lima TI, de Souza GP, Corrêa RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, Dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA (2020) Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. Sci Adv 6:eabc6250. | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Fat |
Dawson 2020 Exp Gerontol | 2020 | Dawson NJ, Salmón P (2020) Age-related increase in mitochondrial quantity may mitigate a decline in mitochondrial quality in red blood cells from zebra finches (Taeniopygia guttata). Exp Gerontol 133:110883. | LEAK ROUTINE ET | ROX | Intact cells | Birds | Blood cells |
Dulac 2020 J Physiol | 2020 | Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol 598:3691-710. | LEAK OXPHOS | N NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Simard 2020 Metabolites | 2020 | Simard C, Lebel A, Allain EP, Touaibia M, Hebert-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in Drosophila melanogaster. Metabolites 109:E363. | LEAK OXPHOS ET | N S Gp NS ROX | Permeabilized tissue | Drosophila | |
Close 2020 Cells | 2020 | Close AF, Dadheech N, Lemieux H, Wang Q, Buteau J (2020) Disruption of beta-cell mitochondrial networks by the orphan nuclear receptor Nor1/Nr4a3. Cells 9:E168. | LEAK ROUTINE | N S CIV NS ROX | Permeabilized cells Intact cells | Rat | Islet cell;pancreas;thymus |
MitoEAGLE muscle 1 | 2020 | Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08 | LEAK OXPHOS ET | N NS S ROX | Permeabilized tissue | Human | Skeletal muscle |
Seitaj 2020 Cells | 2020 | Seitaj B, Maull F, Zhang L, Wüllner V, Wolf C, Schippers P, La Rovere R, Distler U, Tenzer S, Parys JB, Bultynck G, Methner A (2020) Transmembrane BAX inhibitor-1 motif containing protein 5 (TMBIM5) sustains mitochondrial structure, shape, and function by impacting the mitochondrial protein synthesis machinery. Cells 9:E2147. | LEAK ROUTINE ET | ROX | Intact cells | Human | Kidney |
Kline 2020 Nitric Oxide | 2020 | Kline JA, Puskarich MA, Pike JW, Zagorski J, Alves NJ (2020) Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism. Nitric Oxide 96:20-8. | LEAK ET | ROX | Intact cells | Human | Platelet Blood cells |
Schoepf 2020 Nat Commun | 2020 | Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. Nat Commun 11:1487. | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Permeabilized tissue | Human | Genital Other cell lines |
Buch 2020 FASEB J | 2020 | Buch BT, Halling JF, Ringholm S, Gudiksen A, Kjøbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70. | LEAK OXPHOS | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Courtes 2020 Brain Res Bull | 2020 | Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Rat | Nervous system |
McLaughlin 2020b Sci Rep | 2020 | McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599. | LEAK OXPHOS ET | F N S Gp CIV ROX | Isolated mitochondria | Mouse | Heart Liver Kidney Fat |
De-Souza 2020 J Biol Chem | 2020 | De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82. | LEAK OXPHOS | N Gp NS ROX | Isolated mitochondria Intact cells | Caenorhabditis elegans Saccharomyces cerevisiae | |
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Chausse 2020 Brain Behav Immun | 2020 | Chausse B, Lewen A, Poschet G, Kann O (2020) Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain Behav Immun 88:802-14. | LEAK OXPHOS | S | Permeabilized cells | Mouse | Nervous system |
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Janowska 2020 Toxicol In Vitro | 2020 | Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK (2020) Mitochondrial respiratory chain Complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug carbamate toxicity and treatment. Toxicol In Vitro 65:104794. | LEAK ROUTINE ET | N S NS ROX | Permeabilized cells Intact cells | Human | Platelet Blood cells |
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Aparicio-Trejo 2020 Free Radic Biol Med | 2020 | Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32. | LEAK OXPHOS | F N S ROX | Isolated mitochondria | Rat | Kidney |
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Hartmann 2020 Free Radic Res | 2020 | Hartmann DD, Gonçalves DF, Da Rosa PC, Martins RP, Courtes AA, Franco JL, A Soares FA, Puntel GO (2020) A single muscle contusion promotes an immediate alteration in mitochondrial bioenergetics response in skeletal muscle fibres with different metabolism. Free Radic Res 54:137-49. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Rat | Skeletal muscle |
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Mouithys-Mickalad 2020 Chem Biol Interact | 2020 | Mouithys-Mickalad A, Ceusters J, Charif M, El Moualij B, Schoumacher M, Plyte S, Franck T, Bettendorff L, Pirotte B, Serteyn D, de Tullio P (2020) Modulation of mitochondrial respiration rate and calcium-induced swelling by new cromakalim analogues. Chem Biol Interact 331:109272. | LEAK ROUTINE ET | ROX | Intact cells | Rat | Heart |
Evinova 2020 J Membr Biol | 2020 | Evinova A, Cizmarova B, Hatokova Z, Racay P (2020) High‑resolution respirometry in assessment of mitochondrial function in neuroblastoma SH‑SY5Y intact cells. J Membr Biol 253:129-36. | LEAK ROUTINE ET | N S ROX | Permeabilized cells Intact cells | Human | Neuroblastoma |
Baggio 2020 Neurotoxicology | 2020 | Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Zebrafish | Nervous system |
Fuchs 2020 J Funct Foods | 2020 | Fuchs C, Bakuradze T, Steinke R, Grewal R, Eckert GP, Richling E (2020) Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells. J Funct Foods 70:103988. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Liver |
Parker 2020 Thesis | 2020 | Parker EP (2020) The effect of isoleucine supplementation of peripheral blood mononuclear cell metabolism in subjects with type 2 diabetes. URS Thesis 31. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Blood cells |
Kanellopoulos 2020 Cell | 2020 | Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97. | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Drosophila | Nervous system Other cell lines |
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Wu 2020 Chemosphere | 2020 | Wu F, Sokolov EP, Dellwig O, Sokolova IM (2020) Season-dependent effects of ZnO nanoparticles and elevated temperature on bioenergetics of the blue mussel Mytilus edulis. Chemosphere 263:127780. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Molluscs | Other cell lines |
Makrecka-Kuka 2020 Sci Rep | 2020 | Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. Sci Rep 10:21595. | LEAK OXPHOS | N S NS ROX | Permeabilized cells | Mouse | Endothelial;epithelial;mesothelial cell |
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Li Puma 2020 Am J Physiol Regul Integr Comp Physiol | 2020 | Li Puma Lance C, Hedges Michael, Heckman Joseph M, Mathias Alissa B, Engstrom Madison R, Brown Abigail B, Chicco Adam J (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:R972-80. | LEAK OXPHOS | N NS | Permeabilized tissue Homogenate Isolated mitochondria | Mouse | Heart Skeletal muscle |
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Battaglia 2020 Cell Death Dis | 2020 | Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM (2020) Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004. | LEAK OXPHOS ET | N S CIV NS ROX | Intact cells | Rat | Nervous system |
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McLaughlin 2020 Sci Rep | 2020 | McLaughlin KL, Kew KA, McClung JM, Fisher-Wellman KH (2020) Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase. Sci Rep 10:3603. | LEAK | F N S | Isolated mitochondria | Mouse | Heart Skeletal muscle |
Zussman 2020 J Autoimmun | 2020 | Zussman R, Xu LY, Damani T, Groom KM, Chen Q, Seers B, Viall CA, Chamley LW, Hickey A (2020) Antiphospholipid antibodies can specifically target placental mitochondria and induce ROS production. J Autoimmun 111:102437. | LEAK ET | N S Gp CIV NS ROX | Permeabilized tissue | Human | Genital |
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Zhang 2020 Chemosphere | 2020 | Zhang Y, Li Y, Feng Q, Shao M, Yuan F, Liu F (2020) Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in Musca domestica larvae. Chemosphere 248:126009. | LEAK OXPHOS | N S ROX | Isolated mitochondria | Hexapods | |
Peres de Oliveira 2020 Proteome Sci | 2020 | Peres de Oliveira A, Basei FL, Slepicka PF, de Castro Ferezin C, Melo-Hanchuk TD, de Souza EE, Lima TI, Dos Santos VT, Mendes D, Silveira LR, Menck CFM, Kobarg J (2020) NEK10 interactome and depletion reveal new roles in mitochondria. Proteome Sci 18:4. | LEAK ROUTINE ET | Intact cells | Human | HeLa | |
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Owiredu 2020 Am J Physiol Cell Physiol | 2020 | Owiredu S, Ranganathan A, Eckmann DM, Shofer FS, Hardy K, Lambert DS, Kelly M, Jang DH (2020) Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide poisoned individuals. Am J Physiol Cell Physiol 319:C129-35. | LEAK ROUTINE ET | S CIV ROX | Permeabilized cells Intact cells | Human | Blood cells |
Pajuelo 2020 Cells | 2020 | Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:443. | LEAK OXPHOS ET | N S Gp CIV NS ROX | Permeabilized cells | Human | HEK |
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Al-Azab 2020 FEBS J | 2020 | Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104. | LEAK ROUTINE OXPHOS ET | N ROX | Permeabilized cells Intact cells | Human | Other cell lines |
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Schleier 2020 J Cardiovasc Transl Res | 2020 | Schleier Y, Moreno-Loaiza O, López Alarcón MM, Lopes Martins EG, Braga BC, Ramos IP, Galina A, Medei EH (2020) NOD mice recapitulate the cardiac disturbances observed in type 1 diabetes. J Cardiovasc Transl Res [Epub ahead of print]. | LEAK OXPHOS | N NS ROX | Isolated mitochondria | Mouse | Heart |
Hoffmann 2020 J Clin Endocrinol Metab | 2020 | Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Frambach 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727. | LEAK OXPHOS | F N S Gp CIV Other combinations ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Carvalho 2020 BMC Nutr | 2020 | Carvalho E, Adams SH, Boersheim E, Blackburn ML, Ono-Moore KD, Cotter M, Bowlin AK, Yeruva L (2020) Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. BMC Nutr 6:13. | LEAK OXPHOS | N NS ROX | Permeabilized tissue | Pig | Liver |
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Silva-Rodrigues 2020 Free Radic Biol Med | 2020 | Silva-Rodrigues T, De-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A (2020) Hyperglycemia in a Type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med [Epub ahead of print]. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Rat | Nervous system |
Gnad 2020 Cell Metab | 2020 | Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A (2020) Adenosine/A2B receptor signaling ameliorates the effects of aging and counteracts obesity. Cell Metab 32:56-70.e7. | LEAK OXPHOS ET | N S | Permeabilized tissue | Mouse | Skeletal muscle |
Alahmad 2020 EMBO Mol Med | 2020 | Alahmad A, Nasca A, Heidler J, Thompson K, Oláhová M, Legati A, Lamantea E, Meisterknecht J, Spagnolo M, He L, Alameer S, Hakami F, Almehdar A, Ardissone A, Alston CL, McFarland R, Wittig I, Ghezzi D, Taylor RW (2020) Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I. EMBO Mol Med [Epub ahead of print]. | LEAK ROUTINE ET | ROX | Intact cells | Human | Fibroblast |
Ajime 2020 Nicotine Tob Res | 2020 | Ajime TT, Serré J, Wüst RCI, Messa GAM, Poffé C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G (2020) Two weeks smoking cessation reverses cigarette smoke-induced skeletal muscle atrophy and mitochondrial dysfunction in mice. Nicotine Tob Res [Epub ahead of print]. | LEAK ET | S | Permeabilized tissue | Mouse | Skeletal muscle |
Roy Chowdhury 2020 Cancers (Basel) | 2020 | Roy Chowdhury S, Bouchard EDJ, Saleh R, Nugent Z, Peltier C, Mejia E, Hou S, McFall C, Squires M, Hewitt D, Davidson L, Shen GX, Johnston JB, Doucette C, Hatch GM, Fernyhough P, Marshall A, Gibson SB, Dawe DE, Banerji V (2020) Mitochondrial respiration correlates with prognostic markers in chronic lymphocytic leukemia and Is normalized by ibrutinib treatment. Cancers (Basel) 12:E650. | LEAK ET | ROX | Intact cells | Human | Lymphocyte |
Weber 2020 FASEB J | 2020 | Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, Sebastián D, Soler-Vázquez MC, Montironi C, Recalde S, Fucho R, Calderón-Domínguez M, Mir JF, Bartrons R, Escola-Gil JC, Sánchez-Infantes D, Zorzano A, Llorente-Cortes V, Casals N, Valentí V, Frühbeck G, Herrero L, Serra D (2020) Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB J [Epub ahead of print]. | LEAK OXPHOS | N NS | Isolated mitochondria | Mouse | Liver |
Vanweert 2020 J Clin Endocrinol Metab | 2020 | Vanweert F, de Ligt M, Hoeks J, Hesselink MKC, Schrauwen P, Phielix E (2020) Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. J Clin Endocrinol Metab [Epub ahead of print]. | LEAK OXPHOS ET | F N | Permeabilized tissue | Human | Skeletal muscle |
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Gvozdjakova 2020 Diagnostics (Basel) | 2020 | Gvozdjakova Anna, Sumbalova Zuzana, Kucharska Jarmila, Komlosi Maria, Rausova Zuzana, Vancova Olga, Szamosova Monika, Mojto Viliam(2020) Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:E176. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Platelet |
Brunetta 2020 J Physiol | 2020 | Brunetta HS, Politis-Barber V, Petrick HL, Dennis KMJH, Kirsh AJ, Barbeau PA, Nunes EA, Holloway GP (2020) Nitrate attenuates HFD-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission. J Physiol 598:3357-71. | LEAK OXPHOS | N NS | Permeabilized tissue | Mouse | Fat |
Boardman 2020 Am J Physiol Heart Circ Physiol | 2020 | Boardman NT, Pedersen TM, Rossvoll L, Hafstad AD, Aasum E (2020) Diet-induced obese mouse hearts tolerate an acute high fatty acid exposure that also increases ischemic tolerance. Am J Physiol Heart Circ Physiol 319:H682-93. | LEAK OXPHOS | F N | Isolated mitochondria | Mouse | Heart |
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Grewal 2020 Exp Neurol | 2020 | Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Neuroblastoma |
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Kapser-Fischer 2020 Thesis | 2020 | Kapser-Fischer IP (2020) Dietary interventions in C57BL/6 mice and their interplay with selected metabolic and genetic parameters. PhD Thesis 120. | LEAK OXPHOS | Homogenate | Mouse | Fat | |
Bhaskaran 2020 Aging Cell | 2020 | Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225. | LEAK OXPHOS | N S CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
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Magnesa 2020 Thesis | 2020 | Magnesa B (2020) Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effect in obese subjects and bed rest effect in healthy subjects. PhD Thesis 81. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Cipullo 2020 Nucleic Acids Res | 2020 | Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J (2020) Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Res [Epub ahead of print]. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | HEK |
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Mohsin 2020 Arch Biochem Biophys | 2020 | Mohsin AA, Thompson J, Hu Y, Hollander J, Lesnefsky EJ, Chen Q (2020) Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299. | LEAK OXPHOS | N S | Permeabilized cells | Rat | Skeletal muscle |
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Hingst 2020 Mol Metab | 2020 | Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP (2020) Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 40:101028. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Mouse | Skeletal muscle |
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Macedo 2020 FASEB J | 2020 | Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J [Epub ahead of print]. | LEAK OXPHOS | F N CIV ROX | Intact organism Isolated mitochondria | Caenorhabditis elegans | |
Avila-Rojas 2020 Food Chem Toxicol | 2020 | Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Rat | Kidney |
Purhonen 2020 Nat Commun | 2020 | Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Mouse | Liver Kidney |
Yadav 2020 Cell Death Dis | 2020 | Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186. | LEAK OXPHOS ET | N CIV NS ROX | Permeabilized cells | Human | Heart Stem cells |
Allen 2020 Thesis | 2020 | Allen FM (2020) Mitochondrial metabolism elucidated by rapid fractionation from tissue. PhD Thesis 298. | LEAK ET | S | Isolated mitochondria | Mouse Rat | Heart Liver |
Seo 2020 J Clin Med | 2020 | Seo DY, Heo JW, No MH, Yoo SZ, Ko JR, Park DH, Kang JH, Kim CJ, Jung SJ, Han J, Kwak HB (2020) Exercise training protects against atorvastatin-induced skeletal muscle dysfunction and mitochondrial dysfunction in the skeletal muscle of rats. J Clin Med 9:E2292. | LEAK OXPHOS | N | Permeabilized tissue | Rat | Skeletal muscle |
Risiglione 2020 Int J Mol Sci | 2020 | Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP+ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Neuroblastoma |
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Ugarteburu 2020 J Clin Med | 2020 | Ugarteburu O, Sánchez-Vilés M, Ramos J, Barcos-Rodríguez T, Garrabou G, García-Villoria J, Ribes A, Tort F (2020) Physiopathological bases of the disease caused by HACE1 mutations: alterations in autophagy, mitophagy and oxidative stress response. J Clin Med 9:E913. | LEAK ROUTINE ET | ROX | Intact cells | Human | Fibroblast |
Pham 2020 Eur J Appl Physiol | 2020 | Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69. | LEAK OXPHOS ET | N CIV NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Visavadiya 2020 Mol Cell Biochem | 2020 | Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem [Epub ahead of print]. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Liver |
Wen 2020 Biomedicines | 2020 | Wen JJ, Cummins CB, Williams TP, Radhakrishnan RS (2020) The genetic evidence of burn-induced cardiac mitochondrial metabolism dysfunction . Biomedicines 8:E566. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Rat | Heart |
Doig 2020 Skelet Muscle | 2020 | Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Boel 2020 J Exp Biol | 2020 | Boël M, Romestaing C, Duchamp C, Veyrunes F, Renaud S, Roussel D, Voituron Y (2020) Improved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals. J Exp Biol 223:jeb215558. | LEAK ET | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Falcao-Tebas 2020 J Physiol | 2020 | Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol [Epub ahead of print]. | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Rat | Skeletal muscle |
Russell 2020 Nutrients | 2020 | Russell JS, Griffith TA, Naghipour S, Vider J, Du Toit EF, Patel HH, Peart JN, Headrick JP (2020) Dietary α-linolenic acid counters cardioprotective dysfunction in diabetic mice: unconventional PUFA protection. Nutrients 12:E2679. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
Krajcova 2020 PLOS ONE | 2020 | Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142. | LEAK OXPHOS ET | N S NS ROX | Homogenate Isolated mitochondria | Human | Heart |
Anderson 2020 Cells | 2020 | Anderson Vulczak, de Oliveira Souza Anderson, Ferrari Gustavo Duarte, Caleiro Seixas Azzolini Ana Elisa, Pereira-da-Silva Gabriela, Alberici Luciane Carla (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:628. | LEAK OXPHOS ET | N ROX | Permeabilized tissue | Mouse | |
Chabi 2019 MitoFit Preprint Arch EA | 2019-10-10 | Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MitoEAGLE.0001. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Gnaiger 2019 MitoFit Preprint Arch | 2019-08-30 | Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6. | LEAK OXPHOS ET | F N S Gp DQ CIV NS Other combinations ROX | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | ||
Doerrier 2019 MitoFit Preprint Arch EA | 2019-07-04 | Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0009. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
MiPNet18.05 Amplex-Mouse-heart | 2019-06-24 | O2k-Fluorometry: HRR and H2O2 production in mouse cardiac tissue homogenate. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
MiPNet20.13 Safranin mt-membranepotential | 2019-06-24 | O2k-FluoRespirometry: HRR and simultaneous determination of mt-membrane potential with safranin or TMRM. | LEAK ET | S ROX | Homogenate | Mouse | Nervous system |
MiPNet20.14 AmplexRed H2O2-production | 2019-06-24 | O2k-FluoRespirometry: HRR and simultaneous determination of H2O2 production with Amplex UltraRed. | LEAK OXPHOS ET | S | Isolated mitochondria | Mouse | Heart |
Schoepf 2019 MitoFit Preprint Arch | 2019-06-11 | Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Eichelbrönner I, Sorn P, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2019) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature. MitoFit Preprint Arch doi:10.26124/mitofit:190003. - 2020-03-20 Published in »Nature Communications 11:1487« | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Genital |
Boardman 2019 Can J Physiol Pharmacol | 2019 | Boardman NT, Falck AT, Lund T, Chu X, Martin-Armas M, Norvik JV, Jenssen TG, Ytrehus K (2019) Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress. Can J Physiol Pharmacol 98:139-46. | LEAK OXPHOS | N | Isolated mitochondria | Rat | Heart |
Lau 2019 Comp Biochem Physiol B Biochem Mol Biol | 2019 | Lau GY, Milsom WK, Richards JG, Pamenter ME (2019) Heart mitochondria from naked mole-rats (Heterocephalus glaber) are more coupled, but similarly susceptible to anoxia-reoxygenation stress than in laboratory mice (Mus musculus). Comp Biochem Physiol B Biochem Mol Biol 240:110375. | LEAK OXPHOS ET | N S | Isolated mitochondria | Mouse Other mammals | Heart |
Gregg 2019 J Biol Chem | 2019 | Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at Complex I in pancreatic β-cells. J Biol Chem 294:4656-66. | OXPHOS ET LEAK | N S NS ROX | Permeabilized tissue | Mouse | Islet cell;pancreas;thymus |
McManus 2019 Cell Metab | 2019 | McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC (2019) Mitochondrial DNA variation dictates expressivity and progression of nuclear DNA mutations causing cardiomyopathy. Cell Metab 29:78-90. | LEAK OXPHOS | N ROX | Isolated mitochondria | Mouse | Heart |
McMurray 2019 FASEB J | 2019 | McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME (2019) Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J 33:13515-26. | LEAK OXPHOS | F N S CIV ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Ng 2019 J Biol Chem | 2019 | Ng J, Kaur H, Collier T, Chang K, Brooks AES, Allison JR, Brimble MA, Hickey A, Birch NP (2019) Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic. J Biol Chem 294:8806-18. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Neuroblastoma |
Karusheva 2019 Am J Clin Nutr | 2019 | Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bódis K, Bärenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Müssig K, Szendroedi J, Roden M (2019) Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial. Am J Clin Nutr 110:1098-107. | LEAK OXPHOS ET | F N NS ROX | Permeabilized tissue Isolated mitochondria | Human | Skeletal muscle |
Bittel 2019 Diabetologia | 2019 | Bittel AJ, Bittel DC, Mittendorfer B, Patterson BW, Okunade AL, Yoshino J, Porter LC, Abumrad NA, Reeds DN, Cade WT (2019) A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes. Diabetologia 63:611-23. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
Petrick 2019 Biochem J | 2019 | Petrick HL, Holloway GP (2019) High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to L-carnitine. Biochem J 476:547-58. | OXPHOS LEAK | F N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Teh 2019 Mol Cancer Ther | 2019 | Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705. | LEAK ROUTINE OXPHOS ET | N S DQ ROX | Intact cells Permeabilized cells Permeabilized tissue | Human Mouse | Other cell lines |
Detaille 2019 PLoS One | 2019 | Detaille D, Pasdois P, Sémont A, Dos Santos P, Diolez P (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One 14:e0216385. | LEAK OXPHOS | N S NS ROX | Isolated mitochondria | Rat | Heart |
Benoist 2019 Sci Rep | 2019 | Benoist L, Chadet S, Genet T, Lefort C, Heraud A, Danila MD, Muntean DM, Baron C, Angoulvant D, Babuty D, Bourguignon T, Ivanes F (2019) Stimulation of P2Y11 receptor protects human cardiomyocytes against hypoxia/reoxygenation injury and involves PKCε signaling pathway. Sci Rep 9:11613. | LEAK ROUTINE ET | ROX | Intact cells | Human | Heart |
Latham 2019 J Anim Sci | 2019 | Latham CM, Fenger CK, White SH (2019) Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses. J Anim Sci [Epub ahead of print]. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Horse | Skeletal muscle |
Kluckova 2019 FASEB J | 2019 | Kluckova K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA (2019) Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function. FASEB J 34:303-315. | LEAK ROUTINE OXPHOS ET | F N NS ROX | Permeabilized cells Intact cells | Mouse | Nervous system |
Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol | 2019 | Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21. | OXPHOS ET LEAK | N S Gp CIV NS ROX | Permeabilized tissue | Other invertebrates | Skeletal muscle |
Anderson 2019 Acta Neuropathol | 2019 | Anderson CJ, Bredvik K, Burstein SR, Davis C, Meadows SM, Dash J, Case L, Milner TA, Kawamata H, Zuberi A, Piersigilli A, Lutz C, Manfredi G (2019) ALS/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response. Acta Neuropathol 138:103-21. | LEAK | N S | Isolated mitochondria | Mouse | Heart |
Braganza 2019 JCI Insight | 2019 | Braganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248. | LEAK OXPHOS ET ROUTINE | N NS | Permeabilized tissue Intact cells | Human | Skeletal muscle Blood cells Platelet |
Mayer 2019 Lipids | 2019 | Mayer K, Sommer N, Hache K, Hecker A, Reiche S, Schneck E, Weissmann N, Seeger W, Hecker M (2019) Resolvin E1 improves mitochondrial function in human alveolar epithelial cells during severe inflammation. Lipids 54:53-65. | LEAK ROUTINE ET | ROX | Intact cells | Human | Lung;gill Endothelial;epithelial;mesothelial cell Other cell lines |
Kappler 2019 Am J Physiol Endocrinol Metab | 2019 | Kappler L, Hoene M, Hu C, von Toerne C, Li J, Bleher D, Hoffmann C, Böhm A, Kollipara L, Zischka H, Königsrainer A, Häring HU, Peter A, Xu G, Sickmann A, Hauck SM, Weigert C, Lehmann R (2019) Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints. Am J Physiol Endocrinol Metab 317:E374-E387. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue Isolated mitochondria | Human Mouse | Skeletal muscle Liver |
Perry 2019 J Mol Cell Cardiol | 2019 | Perry JB, Davis GN, Allen ME, Makrecka-Kuka M, Dambrova M, Grange RW, Shaikh SR, Brown DA (2019) Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J Mol Cell Cardiol 135:160-171. | LEAK OXPHOS | N S ROX | Isolated mitochondria Permeabilized cells | Rat | Heart |
Dilberger 2019 Oxid Med Cell Longev | 2019 | Dilberger B, Baumanns S, Schmitt F, Schmiedl T, Hardt M, Wenzel U, Eckert GP (2019) Mitochondrial oxidative stress impairs energy metabolism and reduces stress resistance and longevity of C. elegans. Oxid Med Cell Longev 2019:6840540. | LEAK ROUTINE ET | N S CIV NS | Isolated mitochondria | Caenorhabditis elegans | |
Bettinazzi 2019 Proc Biol Sci | 2019 | Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S (2019) Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria. Proc Biol Sci 286:20182708. | LEAK OXPHOS ET | N Gp CIV NS ROX | Permeabilized cells | Molluscs | Lung;gill Genital |
Tetsi 2019 Antioxidants (Basel) | 2019 | Tetsi L, Charles AL, Georg I, Goupilleau F, Lejay A, Talha S, Maumy-Bertrand M, Lugnier C, Geny B (2019) Effect of the phosphodiesterase 5 inhibitor sildenafil on ischemia-reperfusion-induced muscle mitochondrial dysfunction and oxidative stress. Antioxidants (Basel) 8:E93. | LEAK OXPHOS | N CIV NS | Permeabilized tissue | Mouse | Skeletal muscle |
Rose 2019 Am J Physiol Endocrinol Metab | 2019 | Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized cells Permeabilized tissue Intact cells | Human | Skeletal muscle Blood cells Platelet |
Noz 2019 J Am Heart Assoc | 2019 | Noz MP, Hartman YAW, Hopman MTE, Willems PHGM, Tack CJ, Joosten LAB, Netea MG, Thijssen DHJ, Riksen NP (2019) Sixteen-week physical activity intervention in subjects with increased cardiometabolic risk shifts innate immune function towards a less proinflammatory state. J Am Heart Assoc 8:e013764. | LEAK ET | ROX | Intact cells | Human | Blood cells |
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Rojas-Morales 2019 Free Radic Biol Med | 2019 | Rojas-Morales P, León-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jiménez-Osorio AS, González-Reyes S, Marquina- Castillo B, Hernández-Pando R, Barrera-Oviedo D, Sánchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med 135:60-67. | LEAK OXPHOS | N | Isolated mitochondria | Rat | Kidney |
Ma 2019 Biochem Biophys Res Commun | 2019 | Ma T, Lin S, Wang B, Wang Q, Xia W, Zhang H, Cui Y, He C, Wu H, Sun F, Zhao Z, Gao P, Zhu Z, Liu D (2019) TRPC3 deficiency attenuates high salt-induced cardiac hypertrophy by alleviating cardiac mitochondrial dysfunction. Biochem Biophys Res Commun 519:674-81. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Heart |
Hafen 2019 J Appl Physiol (1985) | 2019 | Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) 127:47-57. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Cecatto 2019 Mitochondrion | 2019 | Cecatto C, Amaral AU, Wajner A, Wajner SM, Castilho RF, Wajner M (2019) Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats. Mitochondrion 50:1-13. | LEAK OXPHOS ET | N S | Permeabilized cells Isolated mitochondria | Rat | Liver Other cell lines |
Wang 2019 Free Radic Biol Med | 2019 | Wang SQ, Yang XY, Cui SX, Gao ZH, Qu XJ (2019) Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer. Free Radic Biol Med 134:87-98. | OXPHOS LEAK | Isolated mitochondria | Mouse | Heart Liver Endothelial;epithelial;mesothelial cell | |
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Cecatto 2019 Toxicol In Vitro | 2019 | Cecatto C, Amaral AU, Roginski AC, Castilho RF, Wajner M (2019) Impairment of mitochondrial bioenergetics and permeability transition induction caused by major long-chain fatty acids accumulating in VLCAD deficiency in skeletal muscle as potential pathomechanisms of myopathy. Toxicol In Vitro 62:104665. | LEAK OXPHOS ET | N S | Permeabilized tissue Isolated mitochondria | Rat | Skeletal muscle |
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Thome 2019 Am J Physiol Cell Physiol | 2019 | Thome T, Salyers ZR, Kumar RA, Hahn D, Berru FN, Ferreira LF, Scali ST, Ryan TE (2019) Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol 317:C701-13. | LEAK ROUTINE OXPHOS ET | N NS ROX | Isolated mitochondria Intact cells | Mouse | Skeletal muscle |
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Aguilar 2019 Cell Rep | 2019 | Aguilar E, Esteves P, Sancerni T, Lenoir V, Aparicio T, Bouillaud F, Dentin R, Prip-Buus C, Ricquier D, Pecqueur C, Guilmeau S, Alves-Guerra MC (2019) UCP2 deficiency increases colon tumorigenesis by promoting lipid synthesis and depleting NADPH for antioxidant defenses. Cell Rep 28:2306-16. | LEAK OXPHOS | N | Homogenate | Mouse | Endothelial;epithelial;mesothelial cell |
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Devaux 2019 J Exp Biol | 2019 | Devaux JBL, Hickey AJR, Renshaw GMC (2019) Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia/reoxygenation. J Exp Biol 222:jeb191353. | LEAK ROUTINE OXPHOS ET | N S NS | Homogenate | Fishes | Nervous system |
Lerchner 2019 Anal Bioanal Chem | 2019 | Lerchner J, Sartori MR, Volpe POL, Lander N, Mertens F, Vercesi AE (2019) Direct determination of anaerobe contributions to the energy metabolism of Trypanosoma cruzi by chip calorimetry. Anal Bioanal Chem 411:3763-68. | LEAK OXPHOS ET | ROX | Intact cells | Protists | |
Dechandt 2019 Front Neurol | 2019 | Dechandt CRP, Ferrari GD, Dos Santos JR, de Oliveira JAC, da Silva-Jr RMP, Cunha AOS, Garcia-Cairasco N, Alberici LC (2019) Energy metabolism and redox state in brains of wistar audiogenic rats, a genetic model of epilepsy. Front Neurol 10:1007. | LEAK OXPHOS ET | N ROX | Permeabilized tissue | Rat | Nervous system |
Veyrat-Durebex 2019 Mol Neurobiol | 2019 | Veyrat-Durebex C, Bris C, Codron P, Bocca C, Chupin S, Corcia P, Vourc'h P, Hergesheimer R, Cassereau J, Funalot B, Andres CR, Lenaers G, Couratier P, Reynier P, Blasco H (2019) Metabo-lipidomics of fibroblasts and mitochondrial-endoplasmic reticulum extracts from ALS patients shows alterations in purine, pyrimidine, energetic, and phospholipid metabolisms. Mol Neurobiol 56:5780-91. | LEAK ET ROUTINE | ROX | Intact cells | Human | Fibroblast |
Fang 2019 Nat Commun | 2019 | Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA (2019) NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nat Commun 10:5284. | LEAK OXPHOS | F N S CIV ROX | Homogenate | Mouse | Heart Nervous system Liver |
Desmoulins 2019 Mol Metab | 2019 | Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C (2019) Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab 20:166-77. | OXPHOS ET LEAK | N NS | Homogenate | Rat | Nervous system |
Zhang 2019 Redox Biol | 2019 | Zhang Y, Bharathi SS, Beck ME, Goetzman ES (2019) The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide. Redox Biol 26:101253. | LEAK OXPHOS | N NS F | Isolated mitochondria | Mouse | Liver |
Cruz-Gregorio 2019 Biomolecules | 2019 | Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Coronado-Martinez I, Pedraza-Chaverri J, Lizano M (2019) E6 oncoproteins from high-risk human papillomavirus induce mitochondrial metabolism in a head and neck squamous cell carcinoma model. Biomolecules 9:E351. | LEAK ROUTINE | CIV ROX | Intact cells | Human | Endothelial;epithelial;mesothelial cell |
Diebold 2019 Nat Metab | 2019 | Diebold LP, Gil HJ, Gao P, Martinez CA, Weinberg SE, Chandel NS (2019) Mitochondrial Complex III is necessary for endothelial cell proliferation during angiogenesis. Nat Metab 1:158–71. | LEAK ROUTINE | ROX | Intact cells | Human | HUVEC |
Campos 2019 Thesis | 2019 | Campos DF (2019) Os peixes amazônicos vivem perto dos seus limites térmicos? O efeito das mudanças climáticas sobre a ecofisiologia de peixes de Igarapé da Amazônia Central. PhD Thesis 106. | LEAK OXPHOS ET | N S CIV NS ROX | Intact cells | Fishes | Lung;gill |
Berru 2019 Sci Rep | 2019 | Berru FN, Gray SE, Thome T, Kumar RA, Salyers ZR, Coleman M, Dennis Le, O'Malley K, Ferreira LF, Berceli SA, Scali ST, Ryan TE (2019) Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics. Sci Rep 9:15547. | LEAK OXPHOS | N S CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Monteiro 2019 J Bioenerg Biomembr | 2019 | Monteiro J, Assis-de-Lemos G, de-Souza-Ferreira E, Marques AM, Neves GA, Silveira MS, Galina A (2019) Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. J Bioenerg Biomembr 52:1-15. | LEAK OXPHOS | N S NS ROX | Isolated mitochondria | Mouse | Nervous system |
Lefranc 2019 Hypertension | 2019 | Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A (2019) MR (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity. Hypertension 73:458-68. | OXPHOS LEAK | N | Isolated mitochondria | Mouse | Fat |
Bousseau 2019 FASEB J | 2019 | Bousseau S, Marchand M, Soleti R, Vergori L, Hilairet G, Recoquillon S, Le Mao M, Gueguen N, Khiati S, Clarion L, Bakalara N, Martinez MC, Germain S, Lenaers G, Andriantsitohaina R (2019) Phostine 3.1a as a pharmacological compound with antiangiogenic properties against diseases with excess vascularization. FASEB J 33:5864-75. | LEAK ET | ROX | Intact cells | Human | Endothelial;epithelial;mesothelial cell |
Stepanova 2019 Antioxid Redox Signal | 2019 | Stepanova Anna, Sosunov S, Niatsetskaya Z, Konrad Csaba, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin Alexander (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal 31:608-22. | LEAK OXPHOS | N NS | Isolated mitochondria | Mouse | Nervous system |
Grauso 2019 Sci Rep | 2019 | Grauso M, Lan A, Andriamihaja M, Bouillaud F, Blachier F (2019) Hyperosmolar environment and intestinal epithelial cells: impact on mitochondrial oxygen consumption, proliferation, and barrier function in vitro. Sci Rep 9:11360. | LEAK ROUTINE OXPHOS ET | N NS | Permeabilized cells Intact cells | Human | Endothelial;epithelial;mesothelial cell Other cell lines |
Tomasic 2019 Biochim Biophys Acta Mol Basis Dis | 2019 | Tomašić N, Kotarsky H, de Oliveira Figueiredo R, Hansson E, Mörgelin M, Tomašić I, Kallijärvi J, Elmér E, Jauhiainen M, Eklund EA, Fellman V (2019) Fasting reveals largely intact systemic lipid mobilization mechanisms in respiratory chain complex III deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165573. | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Liver |
Krycer 2019 J Biol Chem | 2019 | Krycer JR, Elkington SD, Diaz-Vegas A, Cooke KC, Burchfield JG, Fisher-Wellman KH, Cooney GJ, Fazakerley DJ, James DE (2019) Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes. J Biol Chem 295:99-110. | LEAK ET | ROX | Intact cells | Rat | Fat |
Larsen 2019 Appl Physiol Nutr Metab | 2019 | Larsen S, Dandanell S, Kristensen KB, Jørgensen SD, Dela F, Helge JW (2019) Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans. Appl Physiol Nutr Metab 44:958-64. | OXPHOS ET LEAK | N NS | Permeabilized tissue | Human | Skeletal muscle |
Weinstein 2019 bioRxiv | 2019 | Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 . | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Other cell lines Lymphocyte |
Miranda Mendonca 2019 Neurochem Int | 2019 | Miranda Mendonça AP, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF, da Silva Fragoso VM (2019) Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. Neurochem Int 126:210-17. | LEAK OXPHOS ET | N CIV ROX | Permeabilized tissue | Mouse | Nervous system |
Belosludtsev 2019 Biochim Biophys Acta Biomembr | 2019 | Belosludtsev KN, Belosludtseva NV, Talanov EY, Tenkov KS, Starinets VS, Agafonov AV, Pavlik LL, Dubinin MV (2019) Effect of bedaquiline on the functions of rat liver mitochondria. Biochim Biophys Acta Biomembr 1861:288-97. | LEAK OXPHOS | N S NS | Isolated mitochondria | Rat | Liver |
Turnbull 2019 Am J Physiol Cell Physiol | 2019 | Turnbull PC, Hughes MC, Perry CGR (2019) The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione. Am J Physiol Cell Physiol 317:C1278-88. | LEAK OXPHOS | N | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
Nunes 2019 Oxid Med Cell Longev | 2019 | Nunes MEM, Schimith LE, da Costa-Silva DG, Lopes AR, Leandro LP, Martins IK, de Mello RS, Hartmann DD, de Carvalho NR, Carvalho da Rosa P, Trevisan R, Di Giulio RT, Posser T, Franco JL (2019) Acute exposure to permethrin modulates behavioral functions, redox, and bioenergetics parameters and induces DNA damage and cell death in larval zebrafish. Oxid Med Cell Longev 2019:9149203. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Homogenate | Zebrafish | |
Madlala 2019 Integr Food Nutr Metab | 2019 | Madlala HP, Maarman GJ, Ojuka E (2019) Fructose impairs mitochondrial respiration and substrate utilization in hepatocytes via the enzyme, glutamate oxaloacetate transaminase. Integr Food Nutr Metab doi: 10.15761/IFNM.1000228. | LEAK OXPHOS ET | N CIV ROX | Permeabilized cells | Human | Liver |
Ahn 2019 J Cachexia Sarcopenia Muscle | 2019 | Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia Sarcopenia Muscle 10:411-28. | OXPHOS LEAK | N S CIV NS ROX | Isolated mitochondria | Mouse | Skeletal muscle |
Gaviraghi 2019 Anal Biochem | 2019 | Gaviraghi A, Oliveira MF (2019) A method for assessing mitochondrial physiology using mechanically permeabilized flight muscle of Aedes aegypti mosquitoes. Anal Biochem 576:33-41. | LEAK OXPHOS ET | N Gp CIV ROX | Permeabilized tissue | Hexapods | Skeletal muscle |
Azevedo 2019 Food Chem Toxicol | 2019 | Azevedo LF, Porto Dechandt CR, Cristina de Souza Rocha C, Hornos Carneiro MF, Alberici LC, Barbosa F Jr (2019) Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats. Food Chem Toxicol 132:110694. | LEAK OXPHOS ET | N S ROX | Permeabilized tissue | Rat | Liver |
Cornacchia 2019 Cell Stem Cell | 2019 | Cornacchia D, Zhang C, Zimmer B, Chung SY, Fan Y, Soliman MA, Tchieu J, Chambers SM, Shah H, Paull D, Konrad C, Vincendeau M, Noggle SA, Manfredi G, Finley LWS, Cross JR, Betel D, Studer L (2019) Lipid deprivation induces a stable, naive-to-primed intermediate state of pluripotency in human PSCs. Cell Stem Cell 25:120-36. | LEAK ET | N CIV | Intact cells | Human | Stem cells |
Hunter 2019 J Appl Physiol | 2019 | Hunter GR, Moellering DR, Windham ST, Mathis SL, Bamman MM, Fisher G (2019) Relationship between V̇o2peak, cycle economy, and mitochondrial respiration in untrained/trained. J Appl Physiol 127:1562-8. | LEAK OXPHOS | F N | Permeabilized tissue | Human | Skeletal muscle |
Bundgaard 2019 Sci Rep | 2019 | Bundgaard A, James AM, Gruszczyk AV, Martin J, Murphy MP, Fago A (2019) Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury. Sci Rep 9:2850. | LEAK OXPHOS | S | Isolated mitochondria | Mouse Reptiles | Heart |
Catalao 2019 Brain Res | 2019 | Catalão CHR, Souza AO, Santos-Júnior NN, da Silva SC, da Costa LHA, Alberici LC, Rocha MJA, da Silva Lopes L (2019) Kaolin-induced hydrocephalus causes acetylcholinesterase activity dysfunction following hypothalamic damage in infant rats. Brain Res 1724:146408. | LEAK OXPHOS ET | N ROX | Homogenate | Rat | Nervous system |
McCoin 2019 Am J Physiol Endocrinol Metab | 2019 | McCoin CS, Von Schulze A, Allen J, Fuller KN, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn Ii GW, Shankar K, Morris EM, Thyfault JP (2019) Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. Am J Physiol Endocrinol Metab 317:E298-E311. | LEAK OXPHOS ET | F N NS | Isolated mitochondria | Mouse | Liver |
Shuvo 2019 J Bioenerg Biomembr | 2019 | Shuvo SR, Wiens LM, Subramaniam S, Treberg JR, Court DA (2019) Increased reactive oxygen species production and maintenance of membrane potential in VDAC-less Neurospora crassa mitochondria. J Bioenerg Biomembr 51:341-54. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Fungi | |
Diao 2019 Brain Res | 2019 | Diao X, Zhou Z, Xiang W, Jiang Y, Tian N, Tang X, Chen S, Wen J, Chen M, Liu K, Li Q, Liao R (2019) Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction. Brain Res 1727:146514. | LEAK OXPHOS ET | N | Isolated mitochondria | Mouse | Nervous system |
Malyala 2019 PLoS Comput Biol | 2019 | Malyala S, Zhang Y, Strubbe JO, Bazil JN (2019) Calcium phosphate precipitation inhibits mitochondrial energy metabolism. PLoS Comput Biol 15:e1006719. | OXPHOS LEAK | N S | Isolated mitochondria | Guinea pig | Heart |
Oses 2019 Epilepsy Res | 2019 | Oses JP, Müller AP, Strogulski NR, Moreira JD, Böhmer AE, Hansel G, Carteri RB, Busnello JV, Kopczynski A, Rodolphi MS, Souza DO, Portela LV (2019) Sustained elevation of cerebrospinal fluid glucose and lactate after a single seizure does not parallel with mitochondria energy production. Epilepsy Res 152:35-41. | LEAK OXPHOS ROUTINE | N CIV NS | Homogenate | Rat | Nervous system |
Goldberg 2019 Biochem J | 2019 | Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2019) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37. | LEAK ET | F N S NS Other combinations ROX | Isolated mitochondria | Mouse | Heart |
Esteves 2019 Oncogene | 2019 | Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R (2019) Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene 39:617-36. | LEAK ROUTINE OXPHOS ET | N ROX | Permeabilized cells Intact cells | Human | Endothelial;epithelial;mesothelial cell |
Datzmann 2019 Pharmacol Res | 2019 | Datzmann T, Hoffmann A, McCook O, Merz T, Wachter U, Preuss J, Vettorazzi S, Calzia E, Gröger M, Kohn F, Schmid A, Denoix N, Radermacher P, Wepler M (2019) Effects of sodium thiosulfate (Na2S2O3) during resuscitation from hemorrhagic shock in swine with preexisting atherosclerosis. Pharmacol Res 151:104536. | LEAK OXPHOS | N NS | Homogenate | Pig | Heart Liver Kidney |
Driescher 2019 Heliyon | 2019 | Driescher N, Joseph DE, Human VR, Ojuka E, Cour M, Hadebe N, Bester D, Marnewick JL, Lecour S, Lochner A, Essop MF (2019) The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 5:e01357. | LEAK OXPHOS ET | F N CIV ROX | Permeabilized tissue | Rat | Heart |
Silva Ramos 2019 PLoS Genet | 2019 | Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085. | LEAK OXPHOS ET | N S Gp | Permeabilized cells Isolated mitochondria | Mouse | Heart Fibroblast |
Repp 2019 Thesis | 2019 | Repp BM (2019) Identification and verification of novel disease-causing genes and therapy options for patients with mitochondrial disorders – Focus on ACAD9. PhD Thesis 178. | LEAK OXPHOS | N S CIV ROX | Permeabilized cells | Human | HEK |
Oakey 2019 Wellcome Open Res | 2019 | Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG (2019) Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion. Wellcome Open Res 3:147. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Skeletal muscle |
Glombik 2019 Neurotox Res | 2019 | Głombik K, Detka J, Góralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Rat | Nervous system |
Kunz 2019 Am J Physiol Endocrinol Metab | 2019 | Kunz HE, Dasari S, Lanza IR (2019) EPA and DHA elicit distinct transcriptional responses to high-fat feeding in skeletal muscle and liver. Am J Physiol Endocrinol Metab 317:E460-E472. | LEAK OXPHOS | F N S NS ROX | Isolated mitochondria | Mouse | Skeletal muscle Liver |
Kolleritsch 2019 Cardiovasc Res | 2019 | Kolleritsch S, Kien B, Schoiswohl G, Diwoky C, Schreiber R, Heier C, Maresch LK, Schweiger M, Eichmann TO, Stryeck S, Krenn P, Tomin T, Kolb D, Rülicke T, Hoefler G, Wolinski H, Madl T, Birner-Gruenberger R, Haemmerle G (2019) Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice. Cardiovasc Res 116:339-52. | LEAK OXPHOS | N | Homogenate | Mouse | Heart |
Langley 2019 Biochim Biophys Acta Mol Basis Dis | 2019 | Langley MR, Yoon H, Kim HN, Choi CI, Simon W, Kleppe L, Lanza IR, LeBrasseur NK, Matveyenko A, Scarisbrick IA (2019) High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system. Biochim Biophys Acta Mol Basis Dis 1866:165630. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Mouse | Nervous system |
Rutai 2019 Shock | 2019 | Rutai A, Fejes R, Juhász L, Tallósy SP, Poles MZ, Földesi I, Mészáros AT, Szabó A, Boros M, Kaszaki J (2019) Endothelin A and B receptors: Potential pargets for microcirculatory-mitochondrial therapy in experimental sepsis. Shock 54:87-95. | LEAK OXPHOS | N S ROX | Homogenate | Rat | Liver |
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Qaed 2019 Oxid Med Cell Longev | 2019 | Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z (2019) Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxid Med Cell Longev 2019:6521218. | LEAK OXPHOS ET ROUTINE | N S NS ROX | Homogenate Isolated mitochondria Permeabilized cells Intact cells | Rat | Heart |
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Macedo 2019 Biochim Biophys Acta Mol Cell Biol Lipids | 2019 | Macedo F, Martins GL, Luévano-Martínez LA, Viana GM, Riske KA, Inague A, Yoshinaga MY, Aguilaniu H, Miyamoto S, Glezer I, da Cunha FM (2019) Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans. Biochim Biophys Acta Mol Cell Biol Lipids 1865:158539. | LEAK OXPHOS | N CIV NS | Isolated mitochondria | Caenorhabditis elegans | |
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Manfredini 2019 Clin Sci (Lond) | 2019 | Manfredini A, Constantino L, Pinto MC, Michels M, Burger H, Kist LW, Silva MC, Gomes LM, Dominguini D, Steckert A, Simioni C, Bogo M, Streck E, Barichello T, de Quevedo J, Singer M, Ritter C, Dal-Pizzol F (2019) Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model. Clin Sci (Lond) 133:1993-2004. | LEAK OXPHOS | N NS | Permeabilized tissue | Rat | Nervous system |
Halling 2019 Am J Physiol Endocrinol Metab | 2019 | Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Miranda-Silva 2019 Acta Physiologica | 2019 | Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Intact organ Permeabilized tissue Isolated mitochondria | Rat | Heart |
Svensson 2019 Am J Physiol Endocrinol Metab | 2019 | Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S (2019) Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab 318:E145-51. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Zhao 2019 Basic Res Cardiol | 2019 | Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Intact cells Permeabilized cells | Rat | Heart Fibroblast |
De-Souza-Ferreira 2019 J Neurochem | 2019 | de-Souza-Ferreira E, Rios-Neto IM, Martins EL, Galina A (2019) Mitochondria-coupled glucose phosphorylation develops after birth to modulate H2O2 release and calcium handling in rat brain. J Neurochem 149:624-40. | LEAK OXPHOS ET | N Gp CIV NS | Isolated mitochondria | Rat | Nervous system |
Scavuzzo 2019 J Neurophysiol | 2019 | Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35. | LEAK OXPHOS | N S CIV NS ROX | Homogenate | Rat | Nervous system |
Mejia 2019 Reprod Biol Endocrinol | 2019 | Mejia JF, Hirschi KM, Tsai KYF, Long MG, Tullis BC, Bitter EEK, Bikman BT, Reynolds PR, Arroyo JA (2019) Differential placental ceramide levels during gestational diabetes mellitus (GDM). Reprod Biol Endocrinol 17:81. | LEAK OXPHOS ET | N NS | Permeabilized cells | Human | Genital |
Zhang 2019 Nephron | 2019 | Zhang R, Wang X, Gao Q, Jiang H, Zhang S, Lu M, Liu F, Xue X (2019) Taurine supplementation reverses diabetes-induced podocytes injury via modulation of the CSE/TRPC6 axis and improvement of mitochondrial function. Nephron 144:84-95. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Intact cells Permeabilized cells | Mouse | Kidney |
Rajendran 2019 EMBO Mol Med | 2019 | Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J (2019) Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11:e9456. | LEAK OXPHOS ET | N S CIV NS | Isolated mitochondria | Mouse | Liver Kidney Heart |
Callegari 2019 J Mol Biol | 2019 | Callegari S, Müller T, Schulz C, Lenz C, Jans DC, Wissel M, Opazo F, Rizzoli SO, Jakobs S, Urlaub H, Rehling P, Deckers M (2019) A MICOS-TIM22 association promotes carrier import into human mitochondria. J Mol Biol 431:2835-51. | LEAK ET ROUTINE | Intact cells | Human | HEK | |
Bouitbir 2019 Toxicology | 2019 | Bouitbir J, Alshaikhali A, Panajatovic MV, Abegg VF, Paech F, Krähenbühl S (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib. Toxicology 426:152281. | LEAK OXPHOS | N S CIV NS ROX | Permeabilized cells Permeabilized tissue | Rat Mouse | Heart |
Dollerup 2019 J Physiol | 2019 | Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Skrivergaard 2019 Viruses | 2019 | Skrivergaard S, Jensen MS, Rolander TB, Nguyen TBN, Bundgaard A, Nejsum LN, Martensen PM (2019) The cellular localization of the p42 and p46 oligoadenylate synthetase 1 isoforms and their impact on mitochondrial respiration. Viruses 11:E1122. | LEAK ROUTINE OXPHOS ET | N S ROX | Permeabilized cells Intact cells | Human | Other cell lines HeLa |
Ruegsegger 2019 FASEB J | 2019 | Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS (2019) Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J 33:4458-72. | LEAK OXPHOS | N NS ROX | Isolated mitochondria | Mouse | Nervous system |
Cormier 2019 Sci Rep | 2019 | Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster. Sci Rep 9:4531. | LEAK OXPHOS ET | N Gp NS ROX CIV | Permeabilized tissue | Drosophila | Skeletal muscle |
Courtes 2019 Biomed Pharmacother | 2019 | Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca2+-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111:1438-46. | OXPHOS LEAK | N S NS ROX | Isolated mitochondria | Rat | Liver |
Krylova 2019 Mitochondrion | 2019 | Krylova TD, Sheremet NL, Tabakov VY, Lyamzaev KG, Itkis YS, Tsygankova PG, Andreeva NA, Shmelkova MS, Nevinitsyna TA, Kadyshev VV, Zakharova EY (2019) Three rare pathogenic mtDNA substitutions in LHON patients with low heteroplasmy. Mitochondrion 50:139-144. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Fibroblast |
Wessels 2019 Obesity (Silver Spring) | 2019 | Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T (2019) Adipose mitochondrial respiratory capacity in obesity is impaired independently of glycemic status of tissue donors. Obesity (Silver Spring) 27:756-66. | LEAK OXPHOS ET | N NS ROX | Permeabilized cells | Human | Fat |
Havird 2019 Mitochondrion | 2019 | Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11. | LEAK OXPHOS | N S CIV NS ROX | Isolated mitochondria | Plants | |
Ederle 2019 J Clin Med | 2019 | Ederle C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B (2019) Mitochondrial function in peripheral blood mononuclear cells (PBMC) is enhanced, together with increased reactive oxygen species, in severe asthmatic patients in exacerbation. J Clin Med 8:E1613. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Blood cells |
Kharechkina 2019 Biochim Biophys Acta Gen Subj | 2019 | Kharechkina ES, Nikiforova AB, Teplova VV, Odinokova IV, Krestinina OV, Baburina YL, Kruglova SA, Kruglov AG (2019) Regulation of permeability transition pore opening in mitochondria by external NAD(H). Biochim Biophys Acta Gen Subj 1863:771-83. | LEAK OXPHOS ET | S | Isolated mitochondria | Rat | Liver |
Sundstroem 2019 Acta Neuropathol Commun | 2019 | Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55. | ET LEAK | N S NS ROX | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
Dall 2019 J Biol Chem | 2019 | Dall M, Trammell SAJ, Asping M, Hassing AS, Agerholm M, Vienberg SG, Gillum MP, Larsen S, Treebak JT (2019) Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity. J Biol Chem 294:13304-26. | LEAK OXPHOS ET | F N S | Intact cells | Mouse | Liver |
Viana 2019 Sci Rep | 2019 | Viana LR, Tobar N, Busanello ENB, Marques AC, de Oliveira AG, Lima TI, Machado G, Castelucci BG, Ramos CD, Brunetto SQ, Silveira LR, Vercesi AE, Consonni SR, Gomes-Marcondes MCC (2019) Leucine-rich diet induces a shift in tumour metabolism from glycolytic towards oxidative phosphorylation, reducing glucose consumption and metastasis in Walker-256 tumour-bearing rats. Sci Rep 9:15529. | LEAK OXPHOS | N | Permeabilized tissue | Rat | Endothelial;epithelial;mesothelial cell |
Rudler 2019 Sci Adv | 2019 | Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A (2019) Fidelity of translation initiation is required for coordinated respiratory complex assembly. Sci Adv 5:eaay2118. | LEAK OXPHOS ET | N S | Isolated mitochondria | Mouse | Heart |
Flis 2019 Int J Mol Sci | 2019 | Flis DJ, Dzik K, Kaczor JJ, Cieminski K, Halon-Golabek M, Antosiewicz J, Wieckowski MR, Ziolkowski W (2019) Swim training modulates mouse skeletal muscle energy metabolism and ameliorates reduction in grip strength in a mouse model of amyotrophic lateral sclerosis. Int J Mol Sci 20:E233. | LEAK OXPHOS | N | Isolated mitochondria | Mouse | Skeletal muscle |
Lewis 2019 Am J Physiol Regul Integr Comp Physiol | 2019 | Lewis MT, Kasper JD, Bazil JN, Frisbee JC, Wiseman RW (2019) Skeletal muscle energetics are compromised only during high-intensity contractions in the Goto-Kakizaki rat model of type 2 diabetes. Am J Physiol Regul Integr Comp Physiol 317:R356-68. | LEAK OXPHOS | F N | Isolated mitochondria | Rat | Skeletal muscle |
Lauridsen 2019 Mitochondrion | 2019 | Lauridsen PE, Rasmussen LJ, Desler C (2019) Mitochondrial oxidative phosphorylation capacity of cryopreserved cells. Mitochondrion 47:47-53. | LEAK ROUTINE ET | ROX | Intact cells | Human | Other cell lines |
Zhang 2019 Biochem Biophys Res Commun | 2019 | Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW (2019) Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun 514:386-92. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Mouse | Liver |
Wolf 2019 Cells | 2019 | Wolf C, Zimmermann R, Thaher O, Bueno D, Wüllner V, Schäfer MKE, Albrecht P, Methner A (2019) The Charcot-Marie tooth disease mutation R94Q in MFN2 decreases ATP production but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289. | LEAK ROUTINE ET OXPHOS | ROX N NS | Intact cells Permeabilized cells | Mouse | Fibroblast |
Rawat 2019 J Mol Biol | 2019 | Rawat S, Anusha V, Jha M, Sreedurgalakshmi K, Raychaudhuri S (2019) Aggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells. J Mol Biol 431:996-1015. | OXPHOS LEAK | N S CIV ROX | Permeabilized cells | Mouse | Nervous system Other cell lines |
Fiorenza 2019 FASEB J | 2019 | Fiorenza M, Lemminger AK, Marker M, Eibye K, Iaia FM, Bangsbo J, Hostrup M (2019) High-intensity exercise training enhances mitochondrial oxidative phosphorylation efficiency in a temperature-dependent manner in human skeletal muscle: implications for exercise performance. FASEB J 33:8976-89. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Kumar 2019 Free Radic Biol Med | 2019 | Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99. | LEAK ROUTINE OXPHOS ET | F N S DQ CIV NS ROX | Permeabilized cells Permeabilized tissue Intact cells | Mouse | Skeletal muscle |
Fernando 2019 Exp Gerontol | 2019 | Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Shirakawa 2019 Sci Rep | 2019 | Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T, Maekawa S, Nambu H, Katayama T, Fukushima A, Saito A, Ishimori N, Dela F, Kinugawa S, Anzai T (2019) Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. Sci Rep 9:14709. | LEAK OXPHOS ET | N S NS | Permeabilized cells | Human | Blood cells |
Esselun 2019 Oxid Med Cell Longev | 2019 | Esselun C, Bruns B, Hagl S, Grewal R, Eckert GP (2019) Differential effects of silibinin A on mitochondrial function in neuronal PC12 and HepG2 liver cells. Oxid Med Cell Longev 2019:1652609. | LEAK OXPHOS ET | N S CIV NS | Permeabilized cells | Human Rat | Nervous system Liver |
Gonzalez-Mariscal 2019 FASEB J | 2019 | González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Monteiro 2019 Thesis | 2019 | Monteiro ARB (2019) Effects of resistance training on mitochondrial function and gene expression of UCP-3 in muscles of ovariectomized rats. Dissertation 82. | LEAK OXPHOS ET | N | Permeabilized tissue | Rat | Skeletal muscle |
Kopinski 2019 Proc Natl Acad Sci U S A | 2019 | Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC (2019) Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci U S A 116:16028-35. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Human | Other cell lines |
Ejarque 2019 Int J Obes (Lond) | 2019 | Ejarque M, Ceperuelo-Mallafré V, Serena C, Maymo-Masip E, Duran X, Díaz-Ramos A, Millan-Scheiding M, Núñez-Álvarez Y, Núñez-Roa C, Gama P, Garcia-Roves PM, Peinado MA, Gimble JM, Zorzano A, Vendrell J, Fernández-Veledo S (2019) Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells. Int J Obes (Lond) 43:1256-68. | LEAK ROUTINE ET | Intact cells | Human | Fat | |
Havird 2019 Philos Trans R Soc Lond B Biol Sci | 2019 | Havird JC, Shah AA, Chicco AJ (2019) Powerhouses in the cold: mitochondrial function during thermal acclimation in montane mayflies. Philos Trans R Soc Lond B Biol Sci 375:20190181. | LEAK OXPHOS | N NS | Isolated mitochondria | Hexapods | |
Altinok 2019 J Cell Physiol | 2019 | Altinok O, Poggio JL, Stein DE, Bowne WB, Shieh AC, Snyder NW, Orynbayeva Z (2019) Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria. J Cell Physiol 235:2569-81. | LEAK OXPHOS | N S | Isolated mitochondria | Human | Other cell lines |
Bertolini 2019 MBio | 2019 | Bertolini MS, Chiurillo MA, Lander N, Vercesi AE, Docampo R (2019) MICU1 and MICU2 play an essential role in mitochondrial Ca2+ uptake, growth, and infectivity of the human pathogen Trypanosoma cruzi. MBio 10:e00348-19. | LEAK OXPHOS ET | Permeabilized cells | Protists | ||
Ling 2019 Am J Clin Nutr | 2019 | Ling Y, Carayol J, Galusca B, Canto C, Montaurier C, Matone A, Vassallo I, Minehira K, Alexandre V, Cominetti O, Núñez Galindo A, Corthésy J, Dayon L, Charpagne A, Métairon S, Raymond F, Descombes P, Casteillo F, Peoc'h M, Palaghiu R, Féasson L, Boirie Y, Estour B, Hager J, Germain N, Gheldof N (2019) Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue. Am J Clin Nutr 110:605-16. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Human | Skeletal muscle Fat |
Tarpey 2019 J Biol Chem | 2019 | Tarpey MD, Amorese AJ, Balestrieri NP, Fisher-Wellman KH, Spangenburg EE (2019) Doxorubicin causes lesions in the electron transport system of skeletal muscle mitochondria that are associated with a loss of contractile function. J Biol Chem 294:19709-22. | LEAK ET | F N S CIV | Permeabilized tissue Isolated mitochondria | Mouse | Skeletal muscle |
McBride 2019 Arch Biochem Biophys | 2019 | McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48. | LEAK OXPHOS | F N CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Carteri 2019 Toxicol Lett | 2019 | Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Mouse | Nervous system |
Reyes-Fermin 2019 Antioxidants (Basel) | 2019 | Reyes-Fermín LM, Avila-Rojas SH, Aparicio-Trejo OE, Tapia E, Rivero I, Pedraza-Chaverri J (2019) The protective effect of alpha-mangostin against cisplatin-induced cell death in LLC-PK1 cells is associated to mitochondrial function preservation. Antioxidants (Basel) 8:E133. | LEAK ROUTINE ET | CIV ROX | Intact cells | Pig | Kidney |
Svab 2019 Neurochem Res | 2019 | Svab G, Doczi J, Gerencser AA, Ambrus A, Gallyas F, Sümegi B, Tretter L (2019) The mitochondrial targets of neuroprotective drug vinpocetine on primary neuron cultures, brain capillary endothelial cells, synaptosomes, and brain mitochondria. Neurochem Res 44:2435-47. | LEAK OXPHOS ET | N S | Isolated mitochondria Intact cells | Guinea pig | Nervous system |
Nambu 2019 Eur J Pharmacol | 2019 | Nambu H, Takada S, Fukushima A, Matsumoto J, Kakutani N, Maekawa S, Shirakawa R, Nakano I, Furihata T, Katayama T, Yamanashi K, Obata Y, Saito A, Yokota T, Kinugawa S (2019) Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure. Eur J Pharmacol 866:172810. | LEAK OXPHOS | F N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Paradis 2019 Antioxidants (Basel) | 2019 | Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B (2019) Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle. Antioxidants (Basel) 8:E168. | LEAK OXPHOS | N S CIV | Permeabilized tissue | Mouse | Skeletal muscle |
Bahhir 2019 PLoS Genet | 2019 | Bahhir D, Yalgin C, Ots L, Jaervinen S, George J, Naudi A, Krama T, Krams I, Tamm M, Andjelkovic A, Dufour E, Gonzalez de Cozar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Joers P (2019) Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. PLoS Genet 15:e1008410. | LEAK OXPHOS | N Gp CIV ROX | Homogenate | Drosophila | |
Penniman 2019 Mol Metab | 2019 | Penniman CM, Suarez Beltran PA, Bhardwaj G, Junck TL, Jena J, Poro K, Hirshman MF, Goodyear LJ, O'Neill BT (2019) Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity. Mol Metab 30:203-220. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue Isolated mitochondria | Mouse | Skeletal muscle |
Kladnicka 2019 Physiol Res | 2019 | Kladnická I, Čedíková M, Kripnerová M, Dvořáková J, Kohoutová M, Tůma Z, Müllerová D, Kuncová J (2019) Mitochondrial respiration of adipocytes differentiating from human mesenchymal stem cells derived from adipose tissue. Physiol Res 68:287-96. | LEAK ROUTINE ET | ROX | Intact cells | Human | Fat Stem cells |
Kakimoto 2019 PLoS One | 2019 | Kakimoto PA, Chausse B, Caldeira da Silva CC, Donato Júnior J, Kowaltowski AJ (2019) Resilient hepatic mitochondrial function and lack of iNOS dependence in diet-induced insulin resistance. PLoS One 14:e0211733. | LEAK OXPHOS | F NS | Isolated mitochondria | Mouse | Liver |
Holsgrove 2019 Thesis | 2019 | Holsgrove A (2019) The effect of temperature on cardiac energetics in the rainbow trout, Onchorhynchus mykiss. Phd Thesis 166. | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Fishes | Heart |
Dlaskova 2019 Biochim Biophys Acta Bioenerg | 2019 | Dlasková A, Špaček T, Engstová H, Špačková J, Schröfel A, Holendová B, Smolková K, Plecitá-Hlavatá L, Ježek P (2019) Mitochondrial cristae narrowing upon higher 2-oxoglutarate load. Biochim Biophys Acta Bioenerg 1860:659-78. | LEAK ET | N ROX | Intact cells | Human | Liver |
Martines 2019 Sci Rep | 2019 | Martines AMF, Gerding A, Stolle S, Vieira-Lara MA, Wolters JC, Jurdzinski A, Bongiovanni L, de Bruin A, van der Vlies P, van der Vries G, Bloks VW, Derks TGJ, Reijngoud DJ, Bakker BM (2019) Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice. Sci Rep 9:14539. | LEAK OXPHOS | F N | Isolated mitochondria | Mouse | Liver |
Gratl 2019 Eur J Vasc Endovasc Surg | 2019 | Gratl A, Frese J, Speichinger F, Pesta D, Frech A, Omran S, Greiner A (2019) Regeneration of mitochondrial function in gastrocnemius muscle in peripheral arterial disease after successful revascularisation. Eur J Vasc Endovasc Surg 59:109-15. | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
Scheiber 2019 Exp Mol Med | 2019 | Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, Westenfeld R, Szendroedi J (2019) High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure. Exp Mol Med 51:16. | LEAK OXPHOS ET | F N NS | Permeabilized tissue Isolated mitochondria | Human | Heart |
Pedrotti 2019 Sci Adv | 2019 | Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Intact cells | Mouse | Fat |
... further results |
- » Abstracts: LEAK
Sort in ascending/descending order by a click on one of the small symbols in squares below.
Year | Reference | Coupling | Pathway | Preparation | Organism | Tissue;cell | |
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Doerrier 2020 PaduaMuscleDays Poster | 2020 | Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human Mouse | Skeletal muscle |
Goncalves Debora 2019 MiPschool Coimbra | 2019 | Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Drosophila | |
Van der Ende 2019 MiPschool Coimbra | 2019 | Mitochondrial respiration in muscle tissue of colon cancer patients. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Cardoso 2019 MiP2019 | 2019 | Effects of glucose concentration in cell culture media on hepatocellular carcinoma HuH7 cells evaluated by high-resolution respirometry. | LEAK ROUTINE ET | ROX | Intact cells | Human | Liver |
Kramer 2019 Abstract IOC141 | 2019 | Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02. | LEAK OXPHOS ET | N CIV NS ROX | Human | Skeletal muscle | |
Garcia-Roves 2019 MiPschool Coimbra | 2019 | Generating reference values on mitochondrial respiration in permeabilized muscle fibers. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Minuzzi 2019 MiPschool Coimbra | 2019 | A pilot study on mitochondrial function of mouse skin using high-resolution respirometry. | LEAK OXPHOS ET | F N S | Permeabilized tissue | Mouse | Endothelial;epithelial;mesothelial cell |
Betiu 2019 MiP2019 | 2019 | Cell-permeable succinate improves amiodarone-induced mitochondrial Complex I and II inhibition in human platelets. | LEAK ET | ROX | Permeabilized cells Intact cells | Human | Platelet |
Timohhina 2019 MiP2019 | 2019 | Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells. | LEAK OXPHOS ET | ROX | Human | Endothelial;epithelial;mesothelial cell | |
Garcia 2019 MiPschool Coimbra | 2019 | Functional interactions between the Drosophila melanogaster mitochondrial glycerol-3-phosphate dehydrogenase and a xenotopically expressed alternative oxidase. | LEAK OXPHOS | N Gp | Drosophila | ||
Sumbalova 2019a MiP2019 | 2019 | Platelet mitochondrial function, coenzyme Q10, and oxidative stress in patients with chronic kidney diseases. | LEAK OXPHOS | F N S Gp CIV NS ROX | Intact cells | Human | Platelet |
Chabi 2019 MiP2019 | 2019 | Generating reference values on mitochondrial respiration in permeabilized muscle fibers. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Kandel 2019 Biophys J | 2019 | Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley Jr AW, Dash RK (2019) Calcium stimulation of mitochondrial respiration is substrate dependent and tissue specific. Biophys J. | LEAK OXPHOS | F N S | Isolated mitochondria | Rat | Heart Kidney |
Aid-Vanakova 2019 MiP2019 | 2019 | Adaptation of muscle OXPHOS in developing glucose intolerance - Wfs1 mice model. | LEAK OXPHOS | N S | Mouse | Skeletal muscle Heart | |
Beleza 2019 MiPschool Coimbra | 2019 | Gestational exercise counteracts the deleterious consequences imposed by diabetes mellitus developed during pregnancy on 16 weeks old male offspring liver mitochondrial function. | LEAK OXPHOS | N S | Rat | Liver | |
Sumbalova 2019b MiP2019 | 2019 | The decline of mitochondrial respiration in isolated platelets after short-term storage. | LEAK OXPHOS | F N S Gp CIV NS ROX | Intact cells | Human | Platelet |
Doerrier 2019 MiP2019 | 2019 | Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. | LEAK ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Lelcu 2019 MiP2019 | 2019 | Assessment of platelet respiration in blood malignancies: a pilot study in children and adults. | LEAK OXPHOS ET | N NS ROX | Permeabilized cells | Human | Platelet |
Evinova 2019 MiPschool Coimbra | 2019 | High resolution respirometry of neuroblastoma SK-N-SH and SH-SY 5Y cell lines. | LEAK ROUTINE ET | N | Intact cells | Human | Neuroblastoma |
Hatokova 2019 MiPschool Coimbra | 2019 | Influence the passage number on a respiration of SH-SY 5Y cells. | LEAK ROUTINE ET | Intact cells | Human | Neuroblastoma | |
Lemieux 2019a MiP2019 | 2019 | Partial prevention of oxidative stress damage to mitochondria with photobiomodulation. | LEAK OXPHOS ET | N S CIV NS | Other invertebrates | ||
Dominguez-Amorocho 2019 MiP2019 | 2019 | Role of Sirtuin 1/3 in CD4+ T cells activation and differentiation in obese and transplanted animals. | LEAK ET OXPHOS | ROX | Mouse | Lymphocyte | |
Acuna-Castroviejo 2018 MiP2018 | 2018 | Mitochondria, melatonin, and neuroinflammation in Parkinson's disease. Acuna-Castroviejo_Presentation | LEAK OXPHOS | N | Mouse | Nervous system | |
Gnaiger 2018 AussieMit | 2018 | Komlodi Timea, Sobotka Ondrej, Doerrier Carolina, Gnaiger Erich (2018) Mitochondrial H2O2 production is low under tissue normoxia but high at in-vitro air-level oxygen pressure - comparison of LEAK and OXPHOS states. AussieMit 2018 Melbourne AU. | LEAK ROUTINE OXPHOS | NS | Isolated mitochondria Intact cells | Mouse Saccharomyces cerevisiae | Heart Nervous system |
Doerrier 2018 EBEC2018 | 2018 | Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system Blood cells HEK Platelet |
Bovard 2018 IOC134 | 2018 | Integrative determinants of oxygen uptake and biomolecular markers of exercise training. | LEAK | Human | Skeletal muscle | ||
Garcia-Souza 2018 Life Sciences Meeting 2018 Innsbruck AT | 2018 | A respirometric cell viability test for peripheral-blood mononuclear cells and platelets. | LEAK ROUTINE ET | S | Intact cells | Human | Blood cells Platelet |
Kovalev 2018 EMBS | 2018 | Kovalev A, Sokolova I, Sukhotin A (2018) Allometry of mitochondrial respiration in mussels. EMBS. | LEAK OXPHOS ET | CIV | Isolated mitochondria | Molluscs | Liver Islet cell;pancreas;thymus |
Nemec 2018 MiP2018 | 2018 | Aerobic/strength exercise intervention modulates skeletal muscle mitochondrial function in seniors. | LEAK | F N NS Other combinations | Permeabilized tissue | Human | Skeletal muscle |
Gnaiger 2018 MiPschool Tromso A1 | 2018 | Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control. | LEAK ET OXPHOS | F N S Gp DQ CIV NS Other combinations | |||
Han 2018 MiP2018 | 2018 | Mitochondrial functional changes elicited by a single near-infrared (670nm) exposure. Han_Presentation | LEAK ROUTINE ET | Human | Kidney HEK | ||
Krajcova 2018 ICO134 | 2018 | Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Human | Skeletal muscle |
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT | 2018 | pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells | Human | HEK Kidney |
Li 2018 IBEC | 2018 | Li C, Li N, Zhang Y (2018) UPRmt and mitophagy are selectively activated depending on muscle fiber types in insulin resistant rats. IBEC. | LEAK OXPHOS | Rat | Skeletal muscle | ||
Evinova 2018 MiP2018 | 2018 | High-resolution respirometry of neuroblastoma SH-SY 5Y cell line. | LEAK ROUTINE ET | Intact cells | Human | Other cell lines Neuroblastoma | |
Harper 2018 MiPschool Tromso D1 | 2018 | OXPHOS efficiency in skeletal and cardiac muscles: Proton leaks, ROS and glutathione redox. | LEAK | Heart Skeletal muscle | |||
Meszaros 2018 EBEC2018 | 2018 | Tissue- and substrate-specific patterns in the oxygen kinetics of mitochondrial respiration. | LEAK OXPHOS ET | N | Isolated mitochondria | Mouse | Heart Nervous system Liver |
Doerrier 2018 ESCI2018 | 2018 | High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease | LEAK ROUTINE OXPHOS ET | F N S Gp ROX CIV | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | Human Mouse | Heart Skeletal muscle Nervous system Blood cells HEK |
Doerrier 2018 MiP2018a | 2018 | Inter-laboratory harmonization of protocols for mitochondrial function evaluation in permeabilized muscle fibers. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Kuka 2018 MiP2018 | 2018 | The discovery of methyl-GBB - acylcarnitine lowering as an effective strategy to treat cardiometabolic diseases. | LEAK OXPHOS | Rat | Heart | ||
Bastos Sant'Anna Silva 2018 MiPschool Tromso C4 | 2018 | Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function. | LEAK ROUTINE OXPHOS ET | S ROX | Intact cells | Human | Genital |
Avram 2018 MiP2018 | 2018 | Cell-permeable succinate bypasses statin-induced mitochondrial complex I inhibition in human platelets. Avram_Presentation | LEAK ET | S | Permeabilized cells Intact cells | Human | Platelet |
Ravasz 2018 Abstract The evolving concept of mitochondria | 2018 | Vast pools of endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondria. | LEAK OXPHOS | N | Isolated mitochondria | Mouse | Liver |
Pchelin 2018 IOC130 | 2018 | Activation of heterodimeric receptor to erythropoietin with its agonist CdEPO regulates brain mitochondrial bioenergetics after local acute ischemia/reperfusion in C57BL/6 mice. | LEAK | N | Isolated mitochondria | Mouse | Nervous system |
Doerrier 2018 MiP2018c | 2018 | Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Meszaros 2018 Mt Med Hinxton | 2018 | High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments. | LEAK OXPHOS ET | N CIV NS | Isolated mitochondria | Mouse | Heart Nervous system Liver |
McMaster 2018 Am J Obstet Gynecol | 2018 | Preeclampsia is associated with placental mitochondrial dysfunction. | LEAK ROUTINE OXPHOS ET | N | Isolated mitochondria | Human | |
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT | 2018 | Cellular succinate transport and mitochondrial respiratory function in prostate cancer. | ROUTINE LEAK OXPHOS ET | S ROX | Permeabilized cells Intact cells | Human | HEK Genital |
Garipi 2018 MiPschool Tromso E2 | 2018 | Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS production | LEAK ROUTINE OXPHOS ET | CIV NS ROX | Permeabilized cells Permeabilized tissue | Human | Endothelial;epithelial;mesothelial cell Other cell lines |
Gnaiger 2018 EBEC2018 | 2018 | The protonmotive force under pressure: an isomorphic analysis. | LEAK | ||||
Komlodi 2018 AussieMit | 2018 | Komlodi T, Hunger M, Moore AL, Gnaiger E (2018) Electron transfer at the Q-junction: new perspectives from combined measurement of mitochondrial O2 flux, H2O2 flux, and coenzyme Q redox state. AussieMit 2018 Melbourne AU. | LEAK OXPHOS | S Gp | Isolated mitochondria | Mouse | Nervous system |
Komlodi 2018 EBEC2018 | 2018 | Electron supply to the Q-junction: assessment of mitochondrial respiration, H2O2 flux and the redox state of the Q-pool. | LEAK OXPHOS | S Gp | Isolated mitochondria | Mouse | Nervous system |
Porter 2018 MiP2018b | 2018 | Skeletal muscle mitochondrial thermogenesis in hypermetabolic humans. | LEAK OXPHOS | ||||
Schoepf 2018 33rd Annual EAU Congress Copenhagen | 2018 | Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue. | LEAK OXPHOS ET | F N NS Other combinations ROX | Permeabilized cells Permeabilized tissue | Human | Genital |
Sobotka 2018 MiP2018 | 2018 | Measurement of ROS production under hypoxia and unexpected methodological pitfalls of Amplex UltraRed assay. | LEAK OXPHOS | Isolated mitochondria | Mouse Saccharomyces cerevisiae | Heart Nervous system | |
Krajcova 2018 MiPschool Tromso E2 | 2018 | High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. | LEAK OXPHOS ET | N NS ROX | Homogenate | Human | Heart |
Gnaiger 2017 MiPschool A1 | 2017 | Elemental steps towards understanding mitochondrial core energy metabolism: coupling control. | LEAK ROUTINE OXPHOS ET | ROX | Intact cells Permeabilized cells Permeabilized tissue Isolated mitochondria | ||
Meszaros 2017 MiP2017 | 2017 | Mitochondrial oxygen kinetics as a sensitive diagnostic tool to determine apparent cytochrome c oxidase excess capacity. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Mouse | Nervous system Liver Kidney |
Keppner 2017 MiPschool Obergurgl | 2017 | Different respiratory states to determine LEAK and uncoupled respiration in the SUIT protocol: effect and consequences. | LEAK OXPHOS ET | N NS | Permeabilized cells | Blood cells | |
Doerrier 2017 MiP2017 C1 | 2017 | Effects of warm ischemia on cardiac mitochondria to detect specific targets by high-resolution respirometry (HRR) | LEAK ET | F N S CIV NS | Isolated mitochondria | Mouse | Heart |
Nogueras 2017 MiPschool Obergurgl | 2017 | Mitochondrial dysfunction in peripheral blood mononuclear cells from multiple sclerosis patients. | LEAK ROUTINE ET | ROX | Intact cells | Blood cells | |
Ukropec 2017 MITOEAGLE Obergurgl | 2017 | Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment? | LEAK OXPHOS ET | F N S Gp NS | Permeabilized cells | Skeletal muscle | |
Markova 2017 MiP2017 | 2017 | Porcine sepsis and associated myocardial depression. | LEAK OXPHOS | N S CIV NS ROX | Pig | Heart | |
Hartmann 2017 Abstract MITOEAGLE Barcelona | 2017 | Mitochondrial respiration of isolated peripheral blood mononuclear cells in an experimental porcine brain injury model. | LEAK ROUTINE ET | Intact cells | Human Pig | Blood cells | |
Gnaiger 2017 Abstract MitoEAGLE Barcelona | 2017 | Quality first: a paradigm shift in mt-respiratory control towards global connection. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Human Mouse | Heart Genital |
Gasparrini 2017 MiPschool Obergurgl | 2017 | Anti-inflammatory effects of strawberry and honey extracts in RAW 264.7 macrophages stressed with LPS. | LEAK | ROX | Mouse | Macrophage-derived | |
Doerrier 2017 MiPschool C2 | 2017 | Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system HEK |
Calabria 2017 MiP2017 | 2017 | Age and frailty related changes in PBMCs mitochondrial function and whole body physiology. | LEAK ET | S | Permeabilized cells | Human | Blood cells |
Siewiera 2017 MiPschool Obergurgl | 2017 | Blood platelets as bioenergetic markers of brain damage in STZ-diabetes. | LEAK ROUTINE ET | Intact cells | Rat | Blood cells Platelet | |
Gnaiger 2017 MiP2017 | 2017 | Gnaiger E (2017) Protonmotive force and chemiosmotic pressure: a generalization of non-ohmic flux control of the proton leak. MiP2017. | LEAK | ||||
Juhasz 2017 MiPschool Obergurgl | 2017 | Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats. | LEAK OXPHOS | N S | Homogenate | Rat | Liver |
Chabi 2017 MITOEAGLE Obergurgl | 2017 | Optimization of permeabilized fibers preparation for mitochondrial respiration measurements using Design of Experiments methodology. | LEAK | NS | Permeabilized tissue | Mouse | Skeletal muscle |
Michalak 2017 MiP2017 | 2017 | The effect of anticoagulants on mitochondrial respiration in intact peripheral blood mononuclear cells. | LEAK ROUTINE ET | ROX | Intact cells | Human | Blood cells |
Michalak 2017 Abstract MITOEAGLE Barcelona | 2017 | Mitochonrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes. | LEAK ROUTINE OXPHOS ET | ROX | Intact cells | Human | Blood cells |
Doerrier 2017 Abstract MitoEAGLE Barcelona | 2017 | SUIT reference protocol for comparative mitochondrial physiology. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system HEK |
Giampieri 2017 MiPschool Obergurgl | 2017 | Strawberry extract protects human dermal fibroblasts against oxidative stress and improves mitochondrial functionality. | LEAK | ROX | Fibroblast | ||
Lin 2017 FASEB J | 2017 | Mitochondrial respiration is fiber-type specific in skeletal muscles. | LEAK ROUTINE | N NS | Permeabilized tissue | Rat | Skeletal muscle |
Karavyraki 2017 MiPschool Obergurgl | 2017 | Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells. | LEAK | ROX | Intact cells | Human | |
Krajcova 2017 MITOEAGLE Obergurgl | 2017 | Developing a method of assessing mitochondrial functions in homogenates of human heart muscle. | LEAK OXPHOS ET | N NS | Homogenate | Human | |
Irving 2017 MiP2017 | 2017 | Impact of acute exercise on PBMC respiratory function and methodological considerations. | LEAK ROUTINE OXPHOS ET | N NS ROX | Blood cells | ||
Hellgren 2017 MiPschool Obergurgl | 2017 | Effect of prenatal hypoxia on adult mitochondrial respiration and ROS production. | LEAK ROUTINE ET | N | Homogenate | Mouse | Heart |
Cizmarova 2017 MiP2017 | 2017 | PBMC cryopreservation and evaluation for functional mitochondrial diagnosis. | LEAK ROUTINE ET | Intact cells | Human | Blood cells | |
Rybacka-Mossakowska 2017 MiP2017 | 2017 | Mitochondrial respiration in intact peripheral blood mononuclear cells in multiple sclerosis patients. | LEAK ROUTINE ET | ROX | Intact cells | Human | Blood cells |
Amick 2017 MiPschool Obergurgl | 2017 | Bioenergetic profiling of mitochondria isolated from three distinct brain regions relevant to AD pathology in non-human primates. | LEAK OXPHOS | F N | Isolated mitochondria | Other mammals | Nervous system |
Afrin 2017 MiPschool Obergurgl | 2017 | Induction of mitochondrial dysfunction by Manuka honey as a strategy for prevention of colon cancer in vitro model: a rising role on reactive oxygen species, apoptosis, and cell metabolism. | LEAK | ROX | |||
Nemec 2017 MiP2017 | 2017 | Three-month exercise modulates skeletal muscle mitochondria function in patients with mild cognitive impairment. | LEAK | N NS | Permeabilized tissue | Human | Skeletal muscle |
Chowdhury 2017 Blood | 2017 | Importance of mitochondrial metabolism as a selective therapeutic approach in chronic lymphocytic leukemia patients. | LEAK | ROX | Intact cells | Human | Lymphocyte |
Komlodi 2017 MiPschool Obergurgl | 2017 | Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H2O2 production. | LEAK OXPHOS | N S Gp Other combinations ROX | Isolated mitochondria | Mouse | Nervous system |
Bento 2017 MITOEAGLE Obergurgl | 2017 | Isolation of human urine-derived stem cells for mitochondrial function profile assessment. | LEAK ET | ROX | Intact cells | Human | Stem cells |
Iyer 2017 MiP2017 | 2017 | Bioenergetic profiling of patient derived human fibroblasts for mitochondrial diseases. Iyer_Presentation | LEAK ROUTINE | Human | Fibroblast | ||
Distefano 2017 MiPschool Obergurgl | 2017 | Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects. | LEAK OXPHOS ET | F NS | Permeabilized tissue | Human | Skeletal muscle |
Han 2017 MiP2017 | 2017 | Metabolic syndrome differentially impacts the retina and underlying retinal pigment epithelium cells. | LEAK OXPHOS | S CIV NS | Rat | Nervous system | |
Markova 2017 MiPschool Obergurgl | 2017 | Mitochondrial respiration in the rat left heart ventricle after inhibition of pyruvate dehydrogenase kinase. | LEAK OXPHOS | N S CIV NS ROX | Homogenate | Rat | Heart |
MitoFit Open Seminar 2017-07-14 | 2017 |
Innsbruck AT, 2017 Jul 14. MitoFit Open Seminar on immune cell bioenergetics. Investigating the role of mitochondria in healthy and psychopathological aging. | LEAK ROUTINE ET | Intact cells | Human | Blood cells | |
Siewiera 2017 MiP2017 | 2017 | Changes in blood platelet and brain mitochondrial respiration during short and long-lasting STZ-induced diabetes. | LEAK ET | N | Homogenate Intact cells | Rat | Nervous system Blood cells Platelet |
Reboredo-Rodriguez 2017 MiPschool Obergurgl | 2017 | Protective effect of a polyphenol-rich strawberry extract on oxidative and endoplasmic reticulum stresses in HepG2 cell line. | LEAK ET | ROX | Human | Liver | |
Waldauf 2017 MITOEAGLE Obergurgl | 2017 | Effect of propofol on energy metabolism in an in vitro model of human skeletal muscle homogenates. | LEAK OXPHOS ET | F N S CIV NS | Homogenate | Human | Skeletal muscle |
Komlodi 2017 MiP2017 | 2017 | H2O2 production under hypoxia in brain and heart mitochondria: does O2 concentration matter? | LEAK OXPHOS | N NS | Isolated mitochondria | Mouse | Heart Nervous system |
O'Brien 2017 Abstract IOC122 | 2017 | PPARα independent effects of nitrate supplementation on skeletal muscle mitochondrial function in hypoxia. | LEAK OXPHOS | F | Mouse | Skeletal muscle | |
Doerrier 2017 MiP2017 WG2 | 2017 | Upper limit of OXPHOS capacity in permeabilized myofibers: effect of oxygen, ADP and blebbistatin in MiR05Cr and Buffer Z. | LEAK OXPHOS ET | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Meszaros 2017 MiPschool Obergurgl | 2017 | (Very) High-resolution respirometry – a deep dive into oxygen dependence of mitochondrial respiration. | LEAK OXPHOS | N S | Isolated mitochondria | Mouse | Liver Nervous system Kidney |
Krylova 2017 MiPschool Obergurgl | 2017 | High-resolution respirometry in diagnostic of mitochondrial complex I deficiency. | LEAK ROUTINE ET | N S | Intact cells Permeabilized cells | Endothelial;epithelial;mesothelial cell Fibroblast | |
Kovalcikova 2017 MiP2017 | 2017 | Mitochondrial protein TMEM70: key role in the biogenesis of ATP synthase verified in a mouse knockout model. | LEAK OXPHOS | Mouse | Heart Liver | ||
Komlodi 2017 Abstract MITOEAGLE Barcelona | 2017 | Succinate dehydrogenase regulation via oxaloacetate in brain mitochondria. | OXPHOS LEAK ET | N S | Isolated mitochondria Homogenate | Guinea pig Mouse | Nervous system Kidney Heart Liver |
Hoel 2017 MiPschool Obergurgl | 2017 | A study on mitochondrial stress responses due to OXPHOS inhibition. | LEAK | ROX | Human | Nervous system | |
Krumschnabel 2016b Abstract MitoFit Science Camp 2016 | 2016 | O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry. | LEAK OXPHOS ET | N S NS ROX | Human | Kidney HEK | |
Herminghaus 2016 Abstract MitoFit Science Camp 2016 | 2016 | Sterile laparotomy time-dependently modulates hepatic but not colonic mitochondrial function similar to moderate abdominal sepsis. | LEAK OXPHOS | N NS | Rat | Liver Endothelial;epithelial;mesothelial cell | |
Laner 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
Sumbalova 2016b Abstract MitoFit Science Camp 2016 | 2016 | Human blood cells: isolation and HRR. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Intact cells | Human | Blood cells Lymphocyte Platelet |
Bezuidenhout 2016b Abstract MitoFit Science Camp 2016 | 2016 | Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers. | LEAK OXPHOS ET | N S ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Madlala 2016 Abstract MitoFit Science Camp 2016 | 2016 | Fructose-induced defects in selected mitochondrial enzymes is detected by respirometry using glutamate&malate but not pyruvate&malate substrates. | LEAK OXPHOS ET | N | Permeabilized cells | Human | Liver |
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck | 2016 | Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry. | LEAK OXPHOS ET | F N S Gp CIV ROX | Isolated mitochondria | Mouse | Heart |
Sobotka 2016 Abstract IOC116 | 2016 | Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11 | LEAK OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Isolated mitochondria | Rat | Liver |
Lamberti 2016 Abstract MitoFit Science Camp 2016 | 2016 | Development of a reference sample for HRR. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Human | Kidney HEK | |
Krajcova 2016 Abstract MitoFit Science Camp 2016 | 2016 | Mitochondrial pathogenesis of propofol infusion syndrome in an in vitro model of human skeletal muscle. | LEAK ET | F | Homogenate | Human | Skeletal muscle |
Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Mitochondrial function in primary prostate cancer. | LEAK OXPHOS ET | N S Other combinations | Permeabilized tissue | Human | |
Sparagna 2016 Abstract IOC109 | 2016 | Sparagna GC (2016) Measuring cardiac mitochondrial function in pediatric patients before and after implantation of a left ventricular assist device. Mitochondr Physiol Network 21.01. | LEAK OXPHOS | N S NS | Human | Heart | |
Cecatto 2016 Abstract IOC116 | 2016 | Cecatto C, Silva JC, Wajner A, Godoy KS, Ribeiro, RT, Amaral AU, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver. Mitochondr Physiol Network 21.11 | LEAK OXPHOS ET | F N CIV Other combinations | Permeabilized tissue Isolated mitochondria | Rat | Nervous system Liver |
Krumschnabel 2016a Abstract MitoFit Science Camp 2016 | 2016 | O2k-Protocols: Mitochondrial preparations for HRR. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate Isolated mitochondria | Mouse | Heart |
Calzia 2016 Abstract MitoFit Science Camp 2016 | 2016 | Mitochondrial respiration shows tissue- and strain-specific aging in short- and long-lived N. furzeri strains. | LEAK OXPHOS ET | NS | Fishes | Heart Skeletal muscle Nervous system Liver | |
Volani 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Effects of systemic iron perturbations on mitochondrial activity and on cellular metabolism in vivo. | LEAK ROUTINE OXPHOS ET | N S | Homogenate | Mouse | Liver |
Gnaiger 2016 Abstract UMDF2016 | 2016 | Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. | LEAK OXPHOS ET | F N NS | Permeabilized cells Permeabilized tissue | Human | Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast |
Doerrier 2016 Abstract MitoFit Science Camp 2016 | 2016 | Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS ROX | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | Human Mouse | Heart Blood cells HEK Platelet |
Davies 2016 Abstract Proceedings of The Physiological Society | 2016 | Development of mitochondrial function in the cortex and cerebellum of the ovine fetus. | LEAK OXPHOS | N S NS | Homogenate | Bovines | Nervous system |
Volani 2016 Abstract MitoFit Science Camp 2016 | 2016 | Effects of iron imbalances on mitochondrial activity in mouse liver homogenate and permabilized rat PBMCs. | LEAK OXPHOS ET | N S | Homogenate | Mouse Rat | Liver Blood cells Lymphocyte |
Chicco 2016b Abstract MitoFit Science Camp 2016 | 2016 | OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m. | LEAK OXPHOS ET | F N | Permeabilized tissue | Human | Skeletal muscle |
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry. | LEAK OXPHOS ET | F N S NS ROX | Mouse | Nervous system | |
Laner 2016 Abstract MitoFit Science Camp 2016 | 2016 | OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
Sumbalova 2015 Abstract MiP2015 | 2015 | High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods. | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Nervous system |
Ali 2015 Abstract MiPschool Cape Town 2015 | 2015 | Early gender-related dimorphism in heart and brain mitochondria function and ROS dynamics. | LEAK OXPHOS ET | Mouse | Heart Nervous system | ||
Laner 2015 Abstract MiPschool Cape Town 2015 | 2015 | The Oroboros Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. | LEAK ROUTINE OXPHOS ET | N S NS | Isolated mitochondria Intact cells | Mouse Saccharomyces cerevisiae | Heart |
Sleiman 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration in sequential biospies from skeletal muscles during hemorrhagic shock and over the course of 48h of reperfusion in pigs. | LEAK OXPHOS ET | N S | Homogenate | Pig | Skeletal muscle |
Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | LEAK OXPHOS | F N | Permeabilized tissue | Mouse | Skeletal muscle |
Blecha 2015 Abstract MiP2015 | 2015 | Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells. | LEAK ET | ROX | |||
Laner 2015 Abstract MiP2015 | 2015 | Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
Dyrstad 2015 Abstract MiPschool London 2015 | 2015 | Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells. | LEAK ROUTINE ET | N ROX | Human | Endothelial;epithelial;mesothelial cell Other cell lines | |
Ost 2015 Abstract IOC100 | 2015 | Ost M (2015) “Mitokines” and the organismal role of mitochondrial function in energy homeostasis & metabolism. Mitochondr Physiol Network 20.01. | LEAK OXPHOS | Permeabilized tissue | Mouse | Skeletal muscle Fibroblast | |
Weidgang 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration in homogenized biopsies from kidney, liver, heart and diaphragm from mice after blunt thoracic trauma and hemorrhagic shock. Effects of a novel hydrogen sulfide donor AP39. | LEAK OXPHOS ET | N S | Homogenate | Mouse | Heart Skeletal muscle Liver Kidney |
Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | LEAK OXPHOS ET | F | Permeabilized tissue | Human Rat | Skeletal muscle |
Calzia 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise. | LEAK OXPHOS ET | N S ROX | Human | Skeletal muscle | |
Salin 2015 Abstract MiP2015 | 2015 | Individual variation in whole-organism performance is related to mitochondrial properties at high temperatures. | LEAK | Fishes | Skeletal muscle Liver | ||
Sheldon 2015 Abstract MiPschool Greenville 2015 | 2015 | eNOS is required to preserve hepatic mitochondrial function in western diet-induced nonalcoholic fatty liver disease. | LEAK OXPHOS ET | N NS | Mouse | Liver | |
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II | 2015 | On coupling control of mitochondrial respiration. What is wrong with the RCR? | LEAK ROUTINE OXPHOS ET | N S ROX | |||
Devaux 2015 Abstract MiP2015 | 2015 | Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression. | LEAK OXPHOS ET | N S | Homogenate | Fishes | Nervous system |
Van Dyk 2015 Abstract MiPschool Cape Town 2015 | 2015 | Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer. | LEAK ROUTINE ET | N ROX | Isolated mitochondria | Human | Other cell lines Fibroblast |
Gnaiger 2015 Abstract MiP2015 | 2015 | Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry. | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Intact cells | Human | HEK |
Galina 2015 Abstract MiP2015 | 2015 | High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles. | LEAK | N S ROX | Permeabilized tissue | Rat | Skeletal muscle |
Doerrier 2015 Abstract MiPschool Greenville 2015 | 2015 | "Succinate paradox" study by high resolution respirometry combined with fluorometry and spectrofluorometry: NextGen-O2k. | LEAK OXPHOS | S | Isolated mitochondria | Mouse | Heart |
Maarman 2015 Abstract MiPschool Cape Town 2015 | 2015 | Characterisation of mitochondrial function in a model of pulmonary hypertension-induced right ventricular failure. | LEAK OXPHOS | N S NS | Isolated mitochondria | Rat | Heart |
Doerrier 2015 Abstract MiP2015 | 2015 | Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function. | LEAK OXPHOS | S | Isolated mitochondria | Mouse | Heart |
Smenes 2015 Abstract IOC100 | 2015 | Smenes BT, Baekkerud FH, Hassel E, Wohlwend M, Slagsvold KH, Rognmo O, Wahba A (2015) Mitochondrial function in patients exercising prior to coronary surgery – A single blinded randomized controlled trial. Mitochondr Physiol Network 20.01. | LEAK ROUTINE ET | N S | Human | Skeletal muscle | |
Karabatsiakis 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder. | LEAK ROUTINE OXPHOS ET | ROX | Human | Blood cells | |
Funk 2015 Abstract MiPschool Greenville 2015 | 2015 | Isolated mitochondria from liver and brain of long-lived growth hormone receptor gene disrupted mice demonstrate reduced respiration rates. | LEAK OXPHOS | Isolated mitochondria | Mouse | Nervous system Liver | |
Ojuka 2015 Abstract MiPschool Cape Town 2015 | 2015 | Use of malate or carnitine as co-substrates for assessment of fatty acid oxidation. | LEAK OXPHOS ET | Permeabilized cells Permeabilized tissue Isolated mitochondria | |||
Renshaw 2015 Abstract MiP2015 | 2015 | Mitochondrial responses to thermal stress: is the ability to withstand anoxia-induced stress associated with cross-tolerance to thermal stress? | LEAK OXPHOS ET | N S | Homogenate | Fishes | Nervous system |
Gnaiger 2015 Abstract MiPschool Cape Town 2015 | 2015 | The functional design of the electron transfer system (ETS) and mitochondrial respiratory control. | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | ||
Ali 2015 Abstract MiP2015 | 2015 | Mitochondrial function and ROS homeostasis in young mouse heart and brain: the sex factor! | LEAK OXPHOS ET | Homogenate | Mouse | Heart Nervous system | |
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human Mouse | Skeletal muscle |
Rutkai 2015 Abstract MiPschool Greenville 2015 | 2015 | Sex-differences in mitochondrial respiration is mediated by nitric oxide in rat cerebral arteries. | LEAK ROUTINE ET | Rat | Endothelial;epithelial;mesothelial cell | ||
Power 2014 Abstract MiP2014 | 2014 | The hot heart: cardiac mitochondrial energetics during hyperthermia. | LEAK OXPHOS | Isolated mitochondria | Rat | Heart | |
Herminghaus 2014 Abstract MiP2014 | 2014 | Severity of polymicrobial sepsis modulates mitochondrial function in rat liver. | LEAK OXPHOS | N S | Isolated mitochondria | Rat | Liver |
Laner 2014 Abstract MiP2014 | 2014 | Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers. | LEAK ROUTINE OXPHOS ET | N NS | Permeabilized tissue | Dog | Skeletal muscle |
Schoepf 2014 Abstract MiP2014 | 2014 | OXPHOS analysis in small prostate biopsies. | LEAK OXPHOS ET | N S CIV NS | Permeabilized tissue | Human | Genital |
Jezek 2014 Abstract MiP2014 | 2014 | Mitochondrial cristae morphology changes: from Hackenbrock to hypoxia. | LEAK OXPHOS | Isolated mitochondria | Other cell lines | ||
Paes 2014 Abstract IOC 2014-04 Schroecken | 2014 | Paes MC, Saraiva FMS, Nogueira NP, Laranja GAT, Coelho MGP, Oliveira MF (2014) Heme increases mitochondrial membrane potential and ROS production in Trypanosoma cruzi epimastigotes. Mitochondr Physiol Network 19.02. | LEAK OXPHOS ET | S Other combinations | Permeabilized cells Oxidase;biochemical oxidation | Protists | |
Karabatsiakis 2014 Abstract IOC96 | 2014 | Karabatsiakis A (2014) Consequences of depression on respiratory activity in peripheral blood mononuclear cells. Mitochondr Physiol Network 19.11. | LEAK ROUTINE ET | Intact cells | Human | Blood cells Lymphocyte | |
Sparks 2014 Abstract MiP2014 | 2014 | NAMPT remodels substrate metabolism in skeletal muscle. | LEAK OXPHOS | N S | Permeabilized tissue | Mouse | Skeletal muscle |
Krumschnabel 2014 Abstract MiP2014 | 2014 | Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
Mendonca 2014 Abstract IOC 2014-04 Schroecken | 2014 | Mendonca AP, Rodrigues MF, Amoedo ND, Oliveira MF (2014) Effects of iron on mitochondrial physiology of central nervous system cell lines. Mitochondr Physiol Network 19.02. | LEAK OXPHOS ET | Nervous system Other cell lines Neuroblastoma | |||
Volodina 2014 Abstract MiP2014 | 2014 | Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Rat | Liver |
Lai 2014 Abstract1 MiP2014 | 2014 | Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle. | LEAK OXPHOS | N | Isolated mitochondria | Rat Dog | Heart Skeletal muscle Fibroblast |
Alberici 2014 Abstract MiP2014 | 2014 | Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism. | LEAK ROUTINE ET | Intact cells | Rat | Skeletal muscle | |
Doerrier 2014 Abstract SECF | 2014 | Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Isolated mitochondria | Mouse | Heart |
Zorzano 2014 Abstract MiP2014 | 2014 | Metabolic implications of mitofusin 2 dysfunction. | LEAK OXPHOS | Mouse | Skeletal muscle | ||
Bristot 2014 Abstract MiP2014 | 2014 | High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations. | LEAK OXPHOS | Intact cells | Human | Fibroblast | |
El-Bacha 2014 Abstract MiP2014 | 2014 | Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells. | LEAK ROUTINE ET | Intact cells | Human | Liver | |
Porter 2014 Abstract IOC95 | 2014 | Porter C (2014) The impact of resistance exercise training on skeletal muscle mitochondrial respiration in healthy young adults. Mitochondr Physiol Network 19.10 | LEAK OXPHOS ET | Permeabilized tissue | Human | Skeletal muscle | |
Volska 2013 Abstract MiP2013 | 2013 | Volska K, Makrecka-Kuka M, Svalbe B, Dambrova M (2013) The inhibitor of L-carnitine biosynthesis protects brain mitochondria against anoxia-reoxygenation injury. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | N | Isolated mitochondria | Rat | Nervous system |
Hickey 2013 Abstract MiP2013 | 2013 | Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S CIV NS | Permeabilized tissue | Other mammals Fishes | Heart |
Quistorff 2013 Abstract MiP2013 | 2013 | Quistorff B (2013) With type 2 diabetes mitochondrial dysfunction develops earlier in liver than in skeletal muscle. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | F S Other combinations | Rat | Skeletal muscle Liver | |
Gnaiger 2013 Abstract Mito2013 | 2013 | Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
Amoedo 2013 Abstract MiP2013 | 2013 | Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S ROX | Permeabilized cells Enzyme Intact cells | Mouse | Endothelial;epithelial;mesothelial cell Other cell lines |
Korzeniewski 2013 Abstract MiP2013 | 2013 | Korzeniewski B (2013) Regulation of oxidative phosphorylation during work transitions in different tissues results from its kinetic properties. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | Heart Skeletal muscle | |||
Krumschnabel 2013 Abstract MiP2013 | 2013 | Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse Fishes | Heart Nervous system Liver |
Gnaiger 2013 Abstract MiP2013 | 2013 | Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibers from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
Cavalcanti de Albuquerque 2013 Abstract MiP2013 | 2013 | Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S Gp NS ROX | Intact organism Permeabilized tissue | Rat | Skeletal muscle |
Irving 2013 Abstract MiP2013 | 2013 | Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N NS | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Liver Fat |
Rodrigues 2013 Abstract MiP2013 | 2013 | Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08. | LEAK ROUTINE ET | ROX | Intact cells | Genital | |
Borutaite 2013 Abstract MiP2013 | 2013 | Borutaite V, Jablonskiene G, Arandarcikaite O (2013) Mitochondrial response to heart and brain ischemia. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | N S | Isolated mitochondria | Pig Rat | Heart Nervous system |
Kotwica 2013 Abstract MiP2013 | 2013 | Kotwica AO, Horscroft JA, Murray AJ(2013) Mitochondrial respiration in heart and soleus of ob/ob mice. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | F N S | Permeabilized tissue | Mouse | Heart Skeletal muscle |
Pecina 2013 Abstract MiP2013 | 2013 | Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S Gp NS Other combinations ROX | Permeabilized cells Homogenate | Human | Blood cells Lymphocyte |
Hendricks 2013 Abstract MiP2013 | 2013 | Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S NS | Intact cells Permeabilized cells Isolated mitochondria | Mouse | Nervous system |
Garcia-Roves 2013 Abstract MiP2013 | 2013 | Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S CIV NS | Permeabilized cells Permeabilized tissue Homogenate | Mouse | Skeletal muscle Nervous system Liver Islet cell;pancreas;thymus Fat |
DeLany 2013 TOS | 2013 | Skeletal muscle mitochondrial respiration is lower in African American compared to Caucasian women and is associated with resting metabolic rate and cardiorespiratory fitness. | LEAK OXPHOS | Permeabilized tissue | Human | Skeletal muscle | |
Galina 2013 Abstract MiP2013 | 2013 | Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S | Permeabilized cells Isolated mitochondria Enzyme Intact cells | Rat | Skeletal muscle Nervous system Liver Other cell lines |
Salin 2013 Abstract MiP2013 | 2013 | Salin K, Luquet E, Rey B, Roussel D, Voituron Y (2013) Mitochondrial functioning, a proximate mechanism underlying the pace-of- life? Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | S CIV | Isolated mitochondria Enzyme Oxidase;biochemical oxidation | Other mammals Amphibians | Liver |
Calzia 2013 Abstract MiP2013 | 2013 | Calzia E, Wagner K, Wagner F, Groeger M, Matallo J, McCook O, Wachter U, Vogt J, Radermacher P (2013) Studying mitochondrial effects of sulfide. Does the species matter? Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | Pig Mouse | Liver | ||
Oliveira MF 2013 Abstract MiP2013 | 2013 | Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV ROX | Intact organism Intact organ Permeabilized cells Permeabilized tissue Homogenate Intact cells | Human Drosophila Hexapods Other invertebrates | Skeletal muscle Neuroblastoma |
Garcia-Souza 2013 Abstract IOC80 | 2013 | Garcia-Souza LF (2013) Thrombin trigger mitochondrial functional remodeling in human platelets. Mitochondr Physiol Network 18.09. | LEAK ROUTINE ET | Intact cells | Human | Blood cells | |
Gomez Rodriguez 2013 Abstract IOC75 | 2013 | Gomez Rodriguez A (2013) ß-adrenergic receptor signaling interruption with two β-blockers (atenolol or nebivolol) can modify different oxidative stress related parameters linked to longevity in mouse liver. Mitochondr Physiol Network 18.03. | LEAK | Isolated mitochondria | Mouse | Liver | |
Jezek 2013 Abstract MiP2013 | 2013 | Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S ROX | Isolated mitochondria Intact cells | Mouse | Lung;gill Islet cell;pancreas;thymus |
Kressig 2013 Abstract IOC79 | 2013 | Kressig F (2013) et al. Mechanism of increased pulmonary vascular remodeling in UCP2 k/o mice. Mitochondr Physiol Network 18.07 | LEAK | Permeabilized cells Isolated mitochondria | Mouse | Lung;gill Other cell lines | |
Slinde 2013 Abstract MiP2013 | 2013 | Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N ROX | Permeabilized tissue Isolated mitochondria | Other mammals Fishes | Heart Liver Blood cells |
Chicco 2013 Abstract MiP2013 | 2013 | Chicco AJ, Le CH, Schlater A, Kanatous S (2013) Comparative muscle mitochondrial physiology of the northern elephant seal. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N Other combinations | Permeabilized tissue | Human Other mammals | Skeletal muscle |
Palm 2013 Abstract MiP2013 | 2013 | Palm F, Hansell P, Friederich-Persson M (2013) Role of mitochondrial function for the onset and progression of kidney disease. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | Intact organ Intact cells Isolated mitochondria | Mouse Rat | Kidney | |
Laner 2013 ASMRM | 2013 | Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The Oroboros O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
Hand 2013 Abstract MiP2013 | 2013 | Hand SC, Patil Y (2013) Defense against ATP depletion during the energy-limited state of diapause. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S | Intact organism Homogenate Isolated mitochondria Enzyme | Artemia Crustaceans | |
Skulachev 2013 Abstract MiP2013 | 2013 | Skulachev VP (2013) SkQ1, the first mitochondria-targeted medicine available in drugstores. Mitochondr Physiol Network 18.08. | LEAK ET | Intact organism Isolated mitochondria SMP Intact cells | Human Mouse Horse Dog Rabbit Fishes Other invertebrates Fungi Plants | Heart Skeletal muscle Nervous system Kidney Islet cell;pancreas;thymus Other cell lines HeLa Fibroblast Stem cells | |
Camacho-Pereira 2013 Abstract IOC75 | 2013 | Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03. | LEAK ROUTINE OXPHOS ET | N S NS | Intact cells Permeabilized cells Isolated mitochondria | Mouse | Liver HEK Macrophage-derived |
Szibor 2013 Abstract MiP2013 | 2013 | Szibor M, Heidler J, Gizatullina Z, Salwig I, Dhandapani PK, Wittig I, Rustin P (2013) Expression of Ciona intestinalis alternative oxidase in mouse. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | ROX | Isolated mitochondria Oxidase;biochemical oxidation | Mouse | Heart Skeletal muscle Nervous system Liver Lung;gill |
Dzialowski 2013 Abstract MiP2013 | 2013 | Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S NS | Intact organism Permeabilized tissue | Birds | Skeletal muscle |
Pichaud 2013 Abstract MiP2013 | 2013 | Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S Gp CIV NS ROX | Permeabilized tissue | Drosophila Hexapods | Skeletal muscle |
Gnaiger 2013 Abstract ASMRM | 2013 | Gnaiger E(2013) Loss of mitochondrial competence and degenerative disease: cause and effect. Abstract ASMRM-Seoul. | LEAK OXPHOS | Human | |||
Shabalina 2013 Abstract IOC79 | 2013 | Shabalina IG (2013) Enhanced Complex I but low Complex II substrate-derived ROS production rates in mice, prematurely aging due to enhanced mitochondrial DNA mutation rate. Mitochondr Physiol Network 18.07 | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Heart Skeletal muscle Liver |
Schulte 2013 Abstract MiP2013 | 2013 | Chung DJ, Schulte PM, Richards JG (2013) The effect of low-temperature acclimation on mitochondrial function in the common killifish (Fundulus heteroclitus), a top-down elasticity analysis. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | Isolated mitochondria | Fishes | Liver | |
Scott 2013 Abstract MiP2013 | 2013 | Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | Isolated mitochondria Enzyme | Other mammals Birds | Skeletal muscle | |
Menze 2013 Abstract MiP2013 | 2013 | Menze MA, Marunde MA, Samarajeewa DA, Anderson J, Li S, Hand SC (2013) Group1 LEA protein ameliorates inhibition of mitochondrial respiration in Drosophila melanogaster Kc167 cells and isolated mitochondria. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS | N | Intact organism Intact cells Permeabilized cells Isolated mitochondria Enzyme | Drosophila Artemia Crustaceans Hexapods | Other cell lines CHO HEK Macrophage-derived |
Mark 2012 Abstract Bioblast | 2012 | Mark FC, Strobel A, Poertner HO (2012) Ocean warming and acidification – when fish mitochondria turn sour. Mitochondr Physiol Network 17.12. | LEAK ROUTINE OXPHOS | N S CIV NS | Permeabilized tissue Isolated mitochondria | Fishes | Heart Liver |
Horscroft 2012 Abstract IOC72 | 2012 | Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13. | LEAK OXPHOS ET | N NS | Human | Skeletal muscle | |
Rodrigues 2012 Abstract IOC72 | 2012 | Rodrigues MF, Amoedo ND, Rumjanek FD (2012) Studies of bioenergetics alterations in breast cancer lines induced by sodium butyrate. Mitochondr Physiol Network 17.13. | LEAK ROUTINE ET | ||||
Kamath 2012 Abstract IOC72 | 2012 | Kamath VG, Lizenby ZJ, Adusumilli VRKR, Hsiung CH, McKee EE (2012) Measuring mitochondrial OXPHOS as a nucleoside reverse transcriptase inhibitor induced cardiac toxicity endpoint. Mitochondr Physiol Network 17.13. | LEAK OXPHOS ET | Isolated mitochondria | Rat | ||
Doerrier 2012 Abstract Bioblast | 2012 | Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Mouse | Heart |
Hepple 2012 Abstract Bioblast | 2012 | Hepple RT, Picard M, Taivassalo T (2012) Is latent mitochondrial dysfunction in aging muscle exposed through mitochondrial isolation? Mitochondr Physiol Network 17.12. | LEAK OXPHOS | Permeabilized tissue Isolated mitochondria | Skeletal muscle | ||
Amoedo 2012 Abstract Bioblast | 2012 | Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12. | LEAK ROUTINE OXPHOS ET | S | Intact cells | Mouse | Other cell lines |
Harper 2012 Abstract Bioblast | 2012 | Harper ME, Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, Van IJcken W Frank Grosveld F, Dekemp RA, Boushel RC, Rudnicki MA (2012) Metabolic effects of microRNA-133 and its antagomir in mice. Mitochondr Physiol Network 17.12. | LEAK | Intact organism Permeabilized cells | Mouse | Skeletal muscle Fat | |
Horvath 2012 Abstract Bioblast | 2012 | Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
Albertini 2012 Abstract Bioblast | 2012 | Albertini E, Koziel R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Mitochondr Physiol Network 17.12. | LEAK ROUTINE ET | Intact cells | Endothelial;epithelial;mesothelial cell HUVEC | ||
Labieniec-Watala 2012 Abstract Bioblast | 2012 | Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse Rat | Heart Liver Fibroblast |
Dzialowski 2012 Abstract IOC72 | 2012 | Dzialowski EM, Sirsat T, Goy S (2012) T3: Does it really make the alligator go “Tick, Tock”? Mitochondr Physiol Network 17.13. | LEAK OXPHOS | N S NS | Isolated mitochondria | Reptiles | Heart Skeletal muscle |
Jacobs 2012 Abstract Bioblast | 2012 | Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | F N S NS | Permeabilized cells | Human | Skeletal muscle |
Towheed 2012 Abstract IOC72 | 2012 | Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13. | LEAK ROUTINE OXPHOS ET | N S NS | Intact organism Permeabilized tissue | Drosophila Hexapods | |
Sumbalova 2011 Abstract Mitochondrial Medicine | 2011 | Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
Pesta 2011Abstract Mitochondrial Medicine-Training | 2011 | Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Gnaiger 2011 Abstract SMRM-Hyderabad | 2011 | Gnaiger E, Wright-Paradis C, Sondergaard H, Calbet J, Damsgaard R, Munck-Andersen T, Saltin B, Boushel RC (2011) Conserved mitochondrial coupling and adaptive substrate control in Inuit and Caucasians: Acclimatization to active life styles in the Arctic winter. Abstract SMRM-Hyderabad. | LEAK OXPHOS | Human | |||
Pesta 2010 MiP Abstract | 2010 | Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010. | LEAK OXPHOS ET | F N S NS | Human | ||
Borutaite MiP2010 | 2010 | Borutaite V, Cizas P, Morkuniene R, Budvytyte R (2010) Effect of beta amyloid oligomers on neuronal viability and mitochondrial functions. | LEAK | Isolated mitochondria | Rat | Nervous system |
MitoPedia concepts:
Respiratory state,
SUIT state,
Recommended
MitoPedia methods:
Respirometry
MitoPedia topics:
EAGLE
Labels:
Regulation: Coupling efficiency;uncoupling
Coupling state: LEAK, ET
HRR: Theory