Willems PH

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Willems PH

MitoPedia topics: EAGLE

COST: Member

COST Mentor: Mentor

MC Substitute - Management Committee MitoEAGLE

Name	Willems Peter,
Institution	Radboud Institute for Molecular Life Sciences 286 Membrane Biochemistry Radboud university medical center
Address	, 6500 HB
City	Nijmegen
State/Province
Country	Netherlands
Email	[email protected]
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Publications

	Published	Reference
Noz 2019 J Am Heart Assoc	2019	Noz MP, Hartman YAW, Hopman MTE, Willems PHGM, Tack CJ, Joosten LAB, Netea MG, Thijssen DHJ, Riksen NP (2019) Sixteen-week physical activity intervention in subjects with increased cardiometabolic risk shifts innate immune function towards a less proinflammatory state. J Am Heart Assoc 8:e013764.
Cheng 2016 Nat Immunol	2016	Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG (2016) Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 17:406-13.
Koopman 2016 EMBO Mol Med	2016	Koopman WJ, Beyrath J, Fung CW, Koene S, Rodenburg RJ, Willems PH, Smeitink JA (2016) Mitochondrial disorders in children: toward development of small-molecule treatment strategies. EMBO Mol Med 8:311-27.
Iannetti 2016 Nat Protoc	2016	Iannetti EF, Smeitink JA, Beyrath J, Willems PH, Koopman WJ (2016) Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy. Nat Protoc 11:1693-710.
Willems 2015 Cell Metab	2015	Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJH (2015) Redox homeostasis and mitochondrial dynamics. Cell Metab 22:207-18.
Grefte 2015 Biochim Biophys Acta	2015	Grefte S, Wagenaars JA, Jansen R, Willems PH, Koopman WJ (2015) Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2. Biochim Biophys Acta 1853:1606-14.
Schirris 2015 Cell Metab	2015	Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG (2015) Statin-induced myopathy is associated with mitochondrial complex III inhibition. Cell Metab 22:399-407.
Schoeckel 2015 Cancer Metab	2015	Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, Hägebarth A, Willems PH, Kopitz C, Koopman WJ, Héroult M (2015) Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab 3:11.
Liemburg-Apers 2015 Biophys J	2015	Liemburg-Apers DC, Schirris TJ, Russel FG, Willems PH, Koopman WJ (2015) Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux. Biophys J 109:1372-86.
Blanchet 2015 Sci Rep	2015	Blanchet L, Smeitink JA, van Emst-de Vries SE, Vogels C, Pellegrini M, Jonckheere AI, Rodenburg RJ, Buydens LM, Beyrath J, Willems PH, Koopman WJ (2015) Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning. Sci Rep 5:8035.
Forkink 2014 Biochim Biophys Acta	2014	Forkink M, Manjeri GR, Liemburg-Apers DC, Nibbeling E, Blanchard M, Wojtala A, Smeitink JA, Wieckowski MR, Willems PH, Koopman WJ (2014) Mitochondrial hyperpolarization during chronic Complex I inhibition is sustained by low activity of Complex II, III, IV and V. Biochim Biophys Acta 1837:1247-56.
Cheng 2014 Science	2014	Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR6, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG (2014) mTOR- and HIF-1 α–mediated aerobic glycolysis as metabolic basis for trained immunity. Science 345:1250684.
Willems 2013 Antioxid Redox Signal	2013	Willems P, Wanschers BF, Esseling J, Szklarczyk R, Kudla U, Duarte I, Forkink M, Nooteboom M, Swarts H, Gloerich J, Nijtmans L, Koopman W, Huynen MA (2013) BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion. Antioxid Redox Signal 18:129-38.
Breuer 2013 Neurobiol Dis	2013	Breuer ME, Koopman WJ, Koene S, Nooteboom M, Rodenburg RJ, Willems PH, Smeitink JA (2013) The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases. Neurobiol Dis 51:27-34. https://doi.org/10.1016/j.nbd.2012.03.007
Distelmaier 2012 Antioxid Redox Signal	2012	Distelmaier F, Valsecchi F, Forkink M, van Emst-de Vries S, Swarts HG, Rodenburg RJ, Verwiel ET, Smeitink JA, Willems PH, Koopman WJ (2012) Trolox-sensitive reactive oxygen species regulate mitochondrial morphology, oxidative phosphorylation and cytosolic calcium handling in healthy cells. Antioxid Redox Signal 17:1657-69.
Koopman 2012 N Engl J Med	2012	Koopman WJ, Willems PH, Smeitink JA (2012) Monogenic mitochondrial disorders. N Engl J Med 366:1132-41.
Dieteren 2011 Proc Natl Acad Sci U S A	2011	Dieteren CE, Gielen SC, Nijtmans LG, Smeitink JA, Swarts HG, Brock R, Willems PH, Koopman WJ (2011) Solute diffusion is hindered in the mitochondrial matrix. Proc Natl Acad Sci U S A 108:8657-62.
Heeman 2011 J Cell Sci	2011	Heeman B, Van den Haute C, Aelvoet SA, Valsecchi F, Rodenburg RJ, Reumers V, Debyser Z, Callewaert G, Koopman WJ, Willems PH, Baekelandt V (2011) Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. J Cell Sci 124:1115-25.
Koene 2011 J Inherit Metab Dis	2011	Koene S, Willems PH, Roestenberg P, Koopman WJ, Smeitink JA (2011) Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency. J Inherit Metab Dis 34:293-307. https://doi.org/10.1007/s10545-009-9005-x
Koopman 2010 Antioxid Redox Signal	2010	Koopman WJ, Nijtmans LG, Dieteren CE, Roestenberg P, Valsecchi F, Smeitink JA, Willems PH (2010) Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation. Antioxid Redox Signal 12:1431-70.
Distelmaier 2009 Brain	2009	Distelmaier F, Koopman WJ, van den Heuvel LP, Rodenburg RJ, Mayatepek E, Willems PH, Smeitink JA (2009) Mitochondrial Complex I deficiency: from organelle dysfunction to clinical disease. Brain 132:833-42.
Eisenberg 2008 Hum Mol Genet	2008	Eisenberg I, Novershtern N, Itzhaki Z, Becker-Cohen M, Sadeh M, Willems PH, Friedman N, Koopman WJ, Mitrani-Rosenbaum S (2008) Mitochondrial processes are impaired in hereditary inclusion body myopathy. Hum Mol Genet 17:3663-74.
Mortiboys 2008 Ann Neurol	2008	Mortiboys H, Thomas KJ, Koopman WJ, Klaffke S, Abou-Sleiman P, Olpin S, Wood NW, Willems PH, Smeitink JA, Cookson MR, Bandmann O (2008) Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol 64:555-65.

Abstracts

	Published	Reference
Foriel 2015 Abstract MiP2015	2015	Drosophila as a model to study therapeutic approaches for mitochondrial diseases.
Iannetti 2015 Abstract MiP2015	2015	High-Content Screening of mitochondrial morphofunction in living cells.
Koopman 2015 Abstract MiP2015	2015	Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux.
Wagenaars 2014 Abstract IOC 2014-04 Schroecken	2014	Wagenaars J, Willems PHGM, Koopman WJ (2014) Oxygen consumption in OXPHOS-deficient cells. Mitochondr Physiol Network 19.02.
Wojtala 2014 Abstract MiP2014	2014	Proteomic analysis of mitochondrial Complex I deficient mouse model - impact of Complex I deficiency on p66Shc-Ser36 phosphorylation pathway in NDUFS4^-/- mouse tissues.
Grefte 2014 Abstract MiP2014	2014	Myotube formation does not require mitochondrial ATP production but is inhibited by rotenone via the Rho-associated, coiled-coil containing protein kinase II.
Koopman 2014 Abstract MiP2014	2014	Redox regulation of mitochondrial dynamics and function.