MitoEAGLE data: muscle: Difference between revisions

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:::: The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
:::: The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.


== WG2 Participants ==
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== WG3 Management ==
 
== WG2 Management ==


=== Tasks ===
=== Tasks ===

Revision as of 14:52, 27 April 2016


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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping


MitoEAGLE data: muscle



WG2

MITOEAGLE data repository in muscle and other tissues


MITOEAGLE Working Groups

WG2 Description

During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.

WG2 Participants

CountryCityContact
AustraliaMelbourneBishop David J
AustriaInnsbruckDoerrier Carolina
AustriaInnsbruckLaner Verena
AustriaInnsbruckGnaiger Erich
AustriaSalzburgMayr JA
BelgiumLeuvenBird Matthew
BelgiumLiegeVotion Dominique-Marie
BrazilSão PauloFerreira Julio Cesar B
BrazilJaboticabal, SPGarcia Geovana S
CanadaAntigonishKane Daniel A
CanadaRimouskiVandermeeren E
CanadaVancouverBoushel Robert C
CanadaEdmonton (Alberta)Lemieux Helene
CanadaRimouskiBlier Pierre U
CroatiaSplitMihanovic I
CroatiaZagrebSaric A
Czech RepublicPilsenMarkova Michaela
Czech RepublicPragueElkalaf Moustafa
Czech RepublicPilsenKuncova J
Czech RepublicPrague 10Krajcova Adela
Czech RepublicHradec KrálovéWaldauf P
DenmarkMalovHey-Mogensen M
DenmarkCopenhagen NMortensen OH
DenmarkCopenhagenGonzalez-Franquesa Alba
DenmarkHvidovreNehlin Jan O
DenmarkCopenhagenDela Flemming
DenmarkCopenhagenLarsen Steen
EstoniaTartuPaju Kalju
EstoniaTallinnKarro N
EstoniaTallinnPuurand Marju
EstoniaTallinnTruu Laura
EstoniaTallinnVendelin Marko
EstoniaTallinnKaambre Tuuli
EstoniaTallinnTepp Kersti
EstoniaTallinnAid-Vanakova Jekaterina
FinlandHelsinkiPirinen E
FinlandJyvaeskylaeLehti Maarit
FranceMontpellier Cedex 1Chabi Beatrice
FranceMontpellierCortade F
FranceGrenoble Cedex 9Schlattner Uwe
FranceParisPetit Patrice X
FranceParisVentura-Clapier R
FranceGrenoble cedex 9Dubouchaud Herve
FranceBordeaux cedexMourier A
FranceParisArmand Anne-Sophie
GermanyMunichJastroch M
GermanyRostockHaider F
GermanyLeipzigOst Mario
GermanyNuthetalKlaus S
GermanyBochumPlaten P
GermanyDuesseldorfRoden Michael
GermanyDuesseldorfJelenik T
GermanyBremerhavenMark Felix Christopher
GermanyColognePesta Dominik
GermanyKölnKimoloi Sammy
GermanyDüsseldorfGranata Cesare
GreeceAthensTrougakos Ioannis P
GreeceHeraklioSidiropoulou K
GreeceHeraklionTavernarakis Nektarios
IndiaHaryanaSharma Vipin
IrelandDublinO'Gorman Donal
IrelandSligoMurphy J
IrelandDublinPorter Richard K
IsraelRishon Le ZionHachmo Yafit
IsraelZrifinSova Marina
IsraelJerusalemSaada Reisch Ann
ItaliaUdineSalvadego Desy
ItalyPisaGastaldelli Amalia
ItalyMilanDe Palma Clara
ItalyNovaraReano Simone
ItalyMilanGiovarelli Matteo
ItalyRomeScatena Roberto
ItalyBolognaGenova Maria Luisa
JapanSapporoMaekawa S
JapanSapporoNambu H
JapanSapporoShirakawa R
LatviaRigaLiepins Edgars
LatviaRigaInashkina I
LatviaRigaKuka Janis
LatviaRigaZvejniece Liga
LuxembourgStrassenDevaux Yvan
MaltaMsidaVella Joanna
NetherlandsAmsterdamDe Goede Paul
NetherlandsMaastrichtHoeks Joris
NetherlandsWageningenKeijer Jaap
NetherlandsBT AmsterdamJaspers Richard T
NetherlandsMaastrichtVan Polanen N
NetherlandsMaastrichtGrevendonk L
NiederlandeER MasstrichtDe Theije C
NiederlandeER MasstrichtDe Wit-Verheggen V
NorwayOsloLund Jenny
NorwayUllevålHeiestad Christina
NorwayTromsoeAasum E
NorwayOsloTorp May-Kristin
NorwayTromsoeJansen Kirsten M
NorwayOsloEide L
NorwayOsloNikolic N
NorwayOsloRustan AC
NorwayBergenTronstad Karl Johan
NorwayTromsoeLarsen Terje S
NorwayTromsoeSchots Pauke C
PolandLodzWatala Cezary
PolandLodzLabieniec-Watala Magdalena
PolandWarsawSek Aleksandra
PolandWarsawDymkowska Dorota
PolandWarsawKampa Rafal Pawel
PortugalCantanhedeFerreira LL
PortugalCoimbraCarvalho Eugenia
PortugalCantanhedeMartins Joao D
PortugalPortoCoxito Pedro
PortugalCoimbraPereira Susana P
PortugalCoimbraMartins Marques T
PortugalPortoBeleza Jorge
PortugalPortoMagalhaes Jose
PortugalCoimbraPalmeira Carlos
RomaniaTimisoaraMuntean Danina M
RomaniaTimisoaraLighezan R
SingaporeSingaporeHausenloy Derek J
SlovakiaBratislavaNemec Michal
SlovakiaBratislavaUkropec J
SlovakiaBratislavaUkropcova B
SlovakiaBratislavaMaderova D
SlovakiaBratislavaSumbalova Zuzana
SloveniaLjubljanaPirkmajer Sergej
SloveniaLjubljanaMars T
SloveniaLjubljanaDolinar K
South AfricaSmith James
SpainArmilla, GranadaEscames Germaine
SpainArmilla (Granada)Acuna-Castroviejo Dario
SpainBarcelonaZorzano Antonio
SpainSevillaBustos Matilde
SpainBarcelonaGarcia-Roves Pablo Miguel
SpainArmilla (Granada)Fernandez-Ortiz Marisol
SpainMadridCadenas S
SpainA CoruñaBlanco FJ
SpainMadridMoran M
SpainBarcelonaSebastian D
SpainBarcelonaCatalan M
SpainBarcelonaGama Perez Pau
SpainBarcelonaBatlle M
SpainBarcelonaDe la Torre Lara J
SpainBarcelonaGuitart M
SpainGranadaLopez Garcia Luis Carlos
SwedenStockholmCardinale Daniele A
SwedenLinköpingFontes-Oliveira CC
SwitzerlandLausanneWeger M
SwitzerlandLausanneGebara E
SwitzerlandBernNuoffer Jean-Marc
SwitzerlandLausanneSandi Carmen
SwitzerlandLausanneMorato Fornaguera L
SwitzerlandLausanneZalachoras I
The NetherlandsBT AmsterdamWuest Rob CI
The NetherlandsWageningenVan der Ende Miranda
TurkeyAnkaraTuncay Erkan
USABaton RougeAxelrod Christopher L
USAGainesvilleHepple Russell T
USAChicagoDayanidhi Sudarshan
USACollege StationWhite-Springer Sarah H
USABaltimoreFang Evandro F
USATorranceRossiter Harry B
USAGainesvilleWohlgemuth Stephanie E
USABoca RatonKhamoui Andy V
USANorfolkLai Nicola
USACollege StationLatham C
USAFort CollinsChicco Adam J
USAAnn ArborBeard Daniel A
USAFairbanksO'Brien Kristin
USASt LouisWelch R
USABaton RougeIrving Brian A
USAOrlandoCoen Paul M
USAGainesvilleNeyroud D
USAColorado SpringsJacobs RA
USALittle RockPorter Craig
USAOrlandoDistefano Giovanna
USABaltimoreGonzalez-Freire Marta
United KingdomBirminghamGarten Antje
United KingdomManchesterGiakoumaki I
United KingdomCambridgeShiroma Jonathan G
United KingdomLoughboroughEbanks Brad
United KingdomNottinghamChakrabarti Lisa
United KingdomLeedsBoyle JP
United KingdomOxfordMakrecka-Kuka Marina
United KingdomBirminghamJoanisse S
United KingdomBrightonMoore Anthony L
United KingdomLondonSzabadkai Gyorgy
United KingdomCambridgeMurray Andrew James
United KingdomPlymouth, DevonMcKenna Helen T
United KingdomBirminghamThakker A
United KingdomBirminghamAshcroft S
United StatesProvidenceSiamwala J


WG2 Management

Tasks

  1. Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
  2. Collection and indexing of the data sets as required for statistical analysis.
  3. Discussion of procedures, protocols and general guidelines.
  4. Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
  5. Opening of the database to the research public for data search and moderated entry of new data sets.


Milestones

  1. Call for data report delivered.
  2. Data sets entered in standardized format.
  3. Summary, interpretation and discussion of data for review.


Deliverables

  1. A MITOEAGLE database on muscle tissue from humans and model organisms.
  2. A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
  3. Draft of review manuscript.


Projects in progress

» MiPMap

Next steps

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