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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
| Country | City | Contact |
|---|---|---|
| Australia | Melbourne | Bishop David J |
| Austria | Innsbruck | Gnaiger Erich |
| Austria | Salzburg | Mayr JA |
| Austria | Innsbruck | Doerrier Carolina |
| Austria | Innsbruck | Laner Verena |
| Belgium | Leuven | Bird Matthew |
| Belgium | Liege | Votion Dominique-Marie |
| Brazil | São Paulo | Ferreira Julio Cesar B |
| Brazil | Jaboticabal, SP | Garcia Geovana S |
| Canada | Edmonton (Alberta) | Lemieux Helene |
| Canada | Rimouski | Vandermeeren E |
| Canada | Antigonish | Kane Daniel A |
| Canada | Rimouski | Blier Pierre U |
| Canada | Vancouver | Boushel Robert C |
| Croatia | Split | Mihanovic I |
| Croatia | Zagreb | Saric A |
| Czech Republic | Pilsen | Markova Michaela |
| Czech Republic | Prague 10 | Krajcova Adela |
| Czech Republic | Prague | Elkalaf Moustafa |
| Czech Republic | Pilsen | Kuncova J |
| Czech Republic | Hradec Králové | Waldauf P |
| Denmark | Copenhagen N | Mortensen OH |
| Denmark | Copenhagen | Dela Flemming |
| Denmark | Hvidovre | Nehlin Jan O |
| Denmark | Copenhagen | Larsen Steen |
| Denmark | Copenhagen | Gonzalez-Franquesa Alba |
| Denmark | Malov | Hey-Mogensen M |
| Estonia | Tallinn | Karro N |
| Estonia | Tallinn | Truu Laura |
| Estonia | Tartu | Paju Kalju |
| Estonia | Tallinn | Kaambre Tuuli |
| Estonia | Tallinn | Tepp Kersti |
| Estonia | Tallinn | Vendelin Marko |
| Estonia | Tallinn | Puurand Marju |
| Estonia | Tallinn | Aid-Vanakova Jekaterina |
| Finland | Jyvaeskylae | Lehti Maarit |
| Finland | Helsinki | Pirinen E |
| France | Bordeaux cedex | Mourier A |
| France | Grenoble Cedex 9 | Schlattner Uwe |
| France | Montpellier | Cortade F |
| France | Montpellier Cedex 1 | Chabi Beatrice |
| France | Paris | Armand Anne-Sophie |
| France | Paris | Petit Patrice X |
| France | Paris | Ventura-Clapier R |
| France | Grenoble cedex 9 | Dubouchaud Herve |
| Germany | Leipzig | Ost Mario |
| Germany | Cologne | Pesta Dominik |
| Germany | Köln | Kimoloi Sammy |
| Germany | Rostock | Haider F |
| Germany | Nuthetal | Klaus S |
| Germany | Munich | Jastroch M |
| Germany | Bremerhaven | Mark Felix Christopher |
| Germany | Bochum | Platen P |
| Germany | Düsseldorf | Granata Cesare |
| Germany | Duesseldorf | Roden Michael |
| Germany | Duesseldorf | Jelenik T |
| Greece | Heraklio | Sidiropoulou K |
| Greece | Athens | Trougakos Ioannis P |
| Greece | Heraklion | Tavernarakis Nektarios |
| India | Haryana | Sharma Vipin |
| Ireland | Dublin | O'Gorman Donal |
| Ireland | Dublin | Porter Richard K |
| Ireland | Sligo | Murphy J |
| Israel | Rishon Le Zion | Hachmo Yafit |
| Israel | Zrifin | Sova Marina |
| Israel | Jerusalem | Saada Reisch Ann |
| Italia | Udine | Salvadego Desy |
| Italy | Bologna | Genova Maria Luisa |
| Italy | Rome | Scatena Roberto |
| Italy | Milan | De Palma Clara |
| Italy | Pisa | Gastaldelli Amalia |
| Italy | Milan | Giovarelli Matteo |
| Italy | Novara | Reano Simone |
| Japan | Sapporo | Shirakawa R |
| Japan | Sapporo | Nambu H |
| Japan | Sapporo | Maekawa S |
| Latvia | Riga | Inashkina I |
| Latvia | Riga | Kuka Janis |
| Latvia | Riga | Zvejniece Liga |
| Latvia | Riga | Liepins Edgars |
| Luxembourg | Strassen | Devaux Yvan |
| Malta | Msida | Vella Joanna |
| Netherlands | Maastricht | Hoeks Joris |
| Netherlands | Maastricht | Grevendonk L |
| Netherlands | Wageningen | Keijer Jaap |
| Netherlands | Amsterdam | De Goede Paul |
| Netherlands | Maastricht | Van Polanen N |
| Netherlands | BT Amsterdam | Jaspers Richard T |
| Niederlande | ER Masstricht | De Theije C |
| Niederlande | ER Masstricht | De Wit-Verheggen V |
| Norway | Ullevål | Heiestad Christina |
| Norway | Oslo | Lund Jenny |
| Norway | Oslo | Rustan AC |
| Norway | Oslo | Eide L |
| Norway | Bergen | Tronstad Karl Johan |
| Norway | Oslo | Torp May-Kristin |
| Norway | Tromsoe | Larsen Terje S |
| Norway | Tromsoe | Jansen Kirsten M |
| Norway | Tromsoe | Aasum E |
| Norway | Oslo | Nikolic N |
| Norway | Tromsoe | Schots Pauke C |
| Poland | Lodz | Labieniec-Watala Magdalena |
| Poland | Warsaw | Dymkowska Dorota |
| Poland | Warsaw | Sek Aleksandra |
| Poland | Warsaw | Kampa Rafal Pawel |
| Poland | Lodz | Watala Cezary |
| Portugal | Porto | Magalhaes Jose |
| Portugal | Coimbra | Pereira Susana P |
| Portugal | Coimbra | Palmeira Carlos |
| Portugal | Porto | Beleza Jorge |
| Portugal | Cantanhede | Martins Joao D |
| Portugal | Coimbra | Carvalho Eugenia |
| Portugal | Coimbra | Martins Marques T |
| Portugal | Cantanhede | Ferreira LL |
| Portugal | Porto | Coxito Pedro |
| Romania | Timisoara | Lighezan R |
| Romania | Timisoara | Muntean Danina M |
| Singapore | Singapore | Hausenloy Derek J |
| Slovakia | Bratislava | Ukropcova B |
| Slovakia | Bratislava | Maderova D |
| Slovakia | Bratislava | Nemec Michal |
| Slovakia | Bratislava | Ukropec J |
| Slovakia | Bratislava | Sumbalova Zuzana |
| Slovenia | Ljubljana | Pirkmajer Sergej |
| Slovenia | Ljubljana | Dolinar K |
| Slovenia | Ljubljana | Mars T |
| South Africa | Smith James | |
| Spain | Barcelona | Guitart M |
| Spain | Barcelona | De la Torre Lara J |
| Spain | Sevilla | Bustos Matilde |
| Spain | Granada | Lopez Garcia Luis Carlos |
| Spain | Barcelona | Batlle M |
| Spain | Armilla (Granada) | Fernandez-Ortiz Marisol |
| Spain | Madrid | Cadenas S |
| Spain | Madrid | Moran M |
| Spain | Barcelona | Sebastian D |
| Spain | Barcelona | Garcia-Roves Pablo Miguel |
| Spain | Barcelona | Zorzano Antonio |
| Spain | Barcelona | Catalan M |
| Spain | Armilla (Granada) | Acuna-Castroviejo Dario |
| Spain | Barcelona | Gama Perez Pau |
| Spain | Armilla, Granada | Escames Germaine |
| Spain | A Coruña | Blanco FJ |
| Sweden | Stockholm | Cardinale Daniele A |
| Sweden | Linköping | Fontes-Oliveira CC |
| Switzerland | Lausanne | Weger M |
| Switzerland | Lausanne | Zalachoras I |
| Switzerland | Lausanne | Gebara E |
| Switzerland | Bern | Nuoffer Jean-Marc |
| Switzerland | Lausanne | Morato Fornaguera L |
| Switzerland | Lausanne | Sandi Carmen |
| The Netherlands | BT Amsterdam | Wuest Rob CI |
| The Netherlands | Wageningen | Van der Ende Miranda |
| Turkey | Ankara | Tuncay Erkan |
| USA | Baton Rouge | Irving Brian A |
| USA | Orlando | Coen Paul M |
| USA | Torrance | Rossiter Harry B |
| USA | Fort Collins | Chicco Adam J |
| USA | Boca Raton | Khamoui Andy V |
| USA | Colorado Springs | Jacobs RA |
| USA | Baton Rouge | Axelrod Christopher L |
| USA | Norfolk | Lai Nicola |
| USA | Seattle | Marcinek DJ |
| USA | Gainesville | Hepple Russell T |
| USA | Chicago | Dayanidhi Sudarshan |
| USA | Baltimore | Fang Evandro F |
| USA | Orlando | Distefano Giovanna |
| USA | Fairbanks | O'Brien Kristin |
| USA | Ann Arbor | Beard Daniel A |
| USA | Baltimore | Gonzalez-Freire Marta |
| USA | College Station | White-Springer Sarah H |
| USA | Little Rock | Porter Craig |
| USA | St Louis | Welch R |
| USA | Gainesville | Wohlgemuth Stephanie E |
| USA | Gainesville | Neyroud D |
| USA | College Station | Latham C |
| United Kingdom | Cambridge | Murray Andrew James |
| United Kingdom | London | Szabadkai Gyorgy |
| United Kingdom | Birmingham | Thakker A |
| United Kingdom | Leeds | Boyle JP |
| United Kingdom | Manchester | Giakoumaki I |
| United Kingdom | Nottingham | Chakrabarti Lisa |
| United Kingdom | Birmingham | Ashcroft S |
| United Kingdom | Oxford | Makrecka-Kuka Marina |
| United Kingdom | Birmingham | Joanisse S |
| United Kingdom | Loughborough | Ebanks Brad |
| United Kingdom | Plymouth, Devon | McKenna Helen T |
| United Kingdom | Birmingham | Garten Antje |
| United Kingdom | Cambridge | Shiroma Jonathan G |
| United Kingdom | Brighton | Moore Anthony L |
| United States | Providence | Siamwala J |
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap
