Difference between revisions of "Oxoglutarate"
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{{MitoPedia | {{MitoPedia | ||
|abbr=Og | |abbr=Og | ||
|description=2-Oxoglutarate is a product of [[isocitrate dehydrogenase]] (IDH) in the [[TCA cycle]], and is | |description=2-'''Oxoglutarate''' (alpha-ketoglutarate) is formed from isocitrate as a product of [[isocitrate dehydrogenase]] (IDH) in the [[TCA cycle]], and is a substrate of [[oxoglutarate dehydrogenase]] (OgDH). The 2-oxoglutarate carrier exchanges malate<sup>2-</sup> for 2-oxoglutarate<sup>2-</sup> as part of the [[malate-aspartate shuttle]]. In the cytosol, oxoglutarate+aspartate are transaminated to form oxaloacetate+glutamate. Cytosolic malate dehydrogenase converts oxaloacetate+NADH to malate. | ||
|info=[[MiPNet11.04]] | |info=[[MiPNet11.04]] | ||
|type=Enzyme | |type=Enzyme | ||
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|discipline=Mitochondrial Physiology | |discipline=Mitochondrial Physiology | ||
|enzymes=TCA Cycle and Matrix Dehydrogenases, Inner mtMembrane Transporter | |enzymes=TCA Cycle and Matrix Dehydrogenases, Inner mtMembrane Transporter | ||
|topics=Substrate; Glucose; TCA Cycle | |||
|type=Enzyme | |||
}} | }} | ||
Revision as of 21:39, 16 October 2010
- high-resolution terminology - matching measurements at high-resolution
Oxoglutarate
Description
2-Oxoglutarate (alpha-ketoglutarate) is formed from isocitrate as a product of isocitrate dehydrogenase (IDH) in the TCA cycle, and is a substrate of oxoglutarate dehydrogenase (OgDH). The 2-oxoglutarate carrier exchanges malate2- for 2-oxoglutarate2- as part of the malate-aspartate shuttle. In the cytosol, oxoglutarate+aspartate are transaminated to form oxaloacetate+glutamate. Cytosolic malate dehydrogenase converts oxaloacetate+NADH to malate.
Abbreviation: Og
Reference: MiPNet11.04
Labels:
Enzyme: TCA Cycle and Matrix Dehydrogenases"TCA Cycle and Matrix Dehydrogenases" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property., Inner mtMembrane Transporter"Inner mtMembrane Transporter" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property. Regulation: Substrate; Glucose; TCA Cycle"Substrate; Glucose; TCA Cycle" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
