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From Bioblast
 YearReferenceCouplingPathwaysPreparationsSpecies;modelTissue;cell
Keeney 2009 Hum Gene Ther2009Keeney PM, Quigley CK, Dunham LD, Papageorge CM, Iyer S, Thomas RR, Schwarz KM, Trimmer PA, Khan SM, Portell FR, Bergquist KE, Bennett JP (2009) Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model. Hum Gene Ther 20:897-907.OXPHOS
LEAK
ROUTINE
ET
ROXIntact cellsHumanNervous system
Neuroblastoma
Hoeks 2008 FEBS Lett2008Hoeks J, Briedé JJ, de Vogel J, Schaart G, Nabben M, Moonen-Kornips E, Hesselink MK, Schrauwen P (2008) Mitochondrial function, content and ROS production in rat skeletal muscle: Effect of high-fat feeding. FEBS Lett 582:510-16.ROUTINE
OXPHOS
ET
F
NS
ROX
Isolated mitochondriaRatSkeletal muscle
Spacek 2008 Int J Biochem Cell Biol2008Spacek T, Santorová J, Zacharovová K, Berková Z, Hlavatá L, Saudek F, Jezek P (2008) Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential. Int J Biochem Cell Biol 40:1522-35.LEAK
ROUTINE
ET
ROXIntact cellsRatIslet cell;pancreas;thymus
Other cell lines
Gnaiger 2008 POS2008Gnaiger E (2008) Polarographic oxygen sensors, the oxygraph and high-resolution respirometry to assess mitochondrial function. In: Mitochondrial dysfunction in drug-induced toxicity (Dykens JA, Will Y, eds) John Wiley & Sons, Inc, Hoboken, NJ:327-52.LEAK
ROUTINE
ET
ROXPermeabilized cells
Permeabilized tissue
Intact cells
MouseBlood cells
Franciso 2007 Eur J Pharmacol2007Franciso R, Perez-Tomas R, Gimenez-Bonafe P, Soto-Cerrato V, Gimenez-Xavier P, Santiago A (2007) Mechanisms of prodigiosin cytotoxicity in human neuroblastoma cell lines. Eur J Pharmacol 572:111-9.ROUTINEIntact cellsHumanNeuroblastoma
Rodriguez-Juarez 2007 Biochem J2007Rodriguez-Juarez F, Aguirre E, Cadenas S (2007) Relative sensitivity of soluble guanylate cyclase and mitochondrial respiration to endogenous nitric oxide at physiological oxygen concentration. Biochem J 405:223-31.ROUTINEIntact cellsRatFibroblast
Cadenas 2006 Biochim Biophys Acta2006Aguirre E, Rodriguez-Juarez F, Gnaiger E, Cadenas S (2006) Measurement of the control of cellular respiration by nitric oxide under normoxia and hypoxia: instrumental comparison including high-resolution respirometry. Biochim Biophys Acta, EBEC Short Reports Suppl 14:136-7.ROUTINEEnzyme
Oxidase;biochemical oxidation
Intact cells
HumanHEK
Huetter 2006 Exp Gerontol2006Hütter E, Unterluggauer H, Garedew A, Jansen-Dürr P, Gnaiger E (2006) High-resolution respirometry - a modern tool in aging research. Exp Gerontol 41:103-9.ROUTINEIntact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Stadlmann 2006 Cell Biochem Biophys2006Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxidative phosphorylation but decreased mitochondrial respiratory capacity in IL-1ß treated human peritoneal mesothelial cells. Cell Biochem Biophys 44:179-86.ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Hervouet 2006 Biochem Biophys Res Commun2006Hervouet E, Pecina P, Demont J, Vojtíšková A, Simonnet H, Houštek J, Godinot C (2006) Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride. Biochem Biophys Res Commun 344:1086-93.ROUTINEIntact cellsHuman
Saccharomyces cerevisiae
Fungi
Ter Veld 2006 Pflugers Arch2006ter Veld F, Nicolay K, Jeneson JA (2006) Increased resistance to fatigue in creatine kinase deficient muscle is not due to improved contractile economy. Pflugers Arch 452:342-8. doi: 10.1007/s00424-005-0041-6ROUTINEIntact organMouseSkeletal muscle
Krumschnabel 2004 Aquat Toxicol2004Krumschnabel G, Nawaz M (2004) Acute toxicity of hexavalent chromium in isolated teleost hepatocytes. Aquat Toxicol 70:159-167.ROUTINEIntact cellsFishesLiver
Manzl 2004 J Exp Zool A2004Manzl C, Krumschnabel G, Schwarzbaum PJ, Chabicovsky M, Dallinger R (2004) Intracellular pH regulation in isolated hepatopancreas cells from the Roman snail (Helix pomatia). J Exp Zool A 301:75-84.ROUTINEIntact cellsMolluscs
Huetter 2004 Biochem J2004Hütter E, Renner K, Pfister G, Stöckl P, Jansen-Dürr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. https://doi.org/10.1042/BJ20040095LEAK
ROUTINE
ET
Intact cellsHumanFibroblast
Manzl 2004 Comp Biochem Physiol C Toxicol Pharmacol2004Manzl C, Krumschnabel G, Schwarzbaum PJ, Dallinger R (2004) Acute toxicity of cadmium and copper in hepatopancreas cells from the Roman snail (Helix pomatia). Comp Biochem Physiol C Toxicol Pharmacol 138:45-52.ROUTINEMolluscs
Pecina 2004 Am J Physiol Cell Physiol2004Pecina P, Gnaiger E, Zeman J, Pronicka E, Houstek J (2004) Decreased affinity to oxygen of cytochrome c oxidase in Leigh syndrome caused by SURF1 mutations. Am J Physiol Cell Physiol 287:C1384-8.ROUTINEIntact cellsHumanFibroblast
Kalbacova 2003 Cytometry2003Kalbácová M, Vrbacký M, Drahota Z, Melková Z (2003) Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry. Cytometry 52A:110-6.ROUTINEIntact cellsOther cell lines
Gnaiger 2003 Adv Exp Med Biol2003Gnaiger E (2003) Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. https://doi.org/10.1007/978-1-4419-8997-0_4ROUTINE
OXPHOS
N
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Oxidase;biochemical oxidation
Human
Rat
Heart
Liver
Endothelial;epithelial;mesothelial cell
Fibroblast
Vrbacky 2003 Physiol Res2003Vrbacký M, Krijt J, Drahota Z, Mĕlková Z (2003) Inhibitory effects of Bcl-2 on mitochondrial respiration. Physiol Res 52:545-54.ROUTINE
OXPHOS
ET
N
S
Intact cells
Permeabilized cells
Human
Other mammals
Endothelial;epithelial;mesothelial cell
Other cell lines
HeLa
Rissanen 2003 Aquat Toxicol2003Rissanen E, Krumschnabel G, Nikinmaa M (2003) Dehydroabietic acid, a major component of wood industry effluents, interferes with cellular energetics in rainbow trout hepatocytes. Aquat Toxicol 62:45-53.ROUTINEIntact cellsFishesLiver
Krumschnabel 2003 J Exp Biol2003Krumschnabel G, Gstir R, Manzl C, Prem C, Pafundo D, Schwarzbaum PJ (2003) Metabolic and ionic responses of trout hepatocytes to anisosmotic exposure. J Exp Biol 206:1799-1808.ROUTINEIntact cellsFishesLiver
Renner 2003 Biochim Biophys Acta2003Renner K, Amberger A, Konwalinka G, Gnaiger E (2003) Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta 1642:115-23.ROUTINE
ET
Permeabilized cells
Enzyme
Oxidase;biochemical oxidation
Intact cells
HumanBlood cells
Stadlmann 2002 Transplantation2002Stadlmann S, Rieger G, Amberger A, Kuznetsov AV, Margreiter R, Gnaiger E (2002) H2O2-mediated oxidative stress versus cold ischemia-reperfusion: mitochondrial respiratory defects in cultured human endothelial cells. Transplantation 74:1800-3.LEAK
ROUTINE
OXPHOS
N
S
CIV
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Huetter 2002 Mol Biol Rep2002Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7.ROUTINEROXIntact cellsHumanFibroblast
Renner 2002 Mol Biol Rep2002Renner K, Kofler R, Gnaiger E (2002) Mitochondrial function in glucocorticoid triggered T-ALL cells with transgenic Bcl-2 expression. Mol Biol Rep 29:97-101.ROUTINEIntact cellsHumanBlood cells
Steininger 2002 J Antimicrob Chemother2002Steininger C, Allerberger F, Gnaiger E (2002) Clinical significance of inhibition kinetics in Streptococcus pyogenes in response to penicillin. J Antimicrob Chemother 50:517-23. https://doi.org/10.1093/jac/dkf174ROUTINEIntact cellsEubacteria
Wieser 2001 Biochem J2001Wieser W, Krumschnabel G (2001) Hierarchies of ATP-consuming processes: direct compared with indirect measurements, and comparative aspects. Biochem J 355:389-395.ROUTINEIntact cellsHuman
Fishes
Liver
Krumschnabel 2001 J Exp Biol2001Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Regulation of intracellular pH in anoxia-tolerant and anoxia-intolerant teleost hepatocytes. J Exp Biol 204:3943-3951.ROUTINEIntact cellsFishesLiver
Krumschnabel 2001 Gen Comp Endocrinol2001Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Metabolic responses to epinephrine stimulation in goldfish hepatocytes: evidence for the presence of alpha-adrenoceptors. Gen Comp Endocrinol 121:205-213.ROUTINEIntact cellsFishesLiver
Chowdhury 2000 Clin Chim Acta2000Chowdhury SK, Drahota Z, Floryk D, Calda P, Houstek J (2000) Activities of mitochondrial oxidative phosphorylation enzymes in cultured amniocytes. Clin Chim Acta 298:157-73.LEAK
ROUTINE
OXPHOS
N
S
CIV
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Gnaiger 2000 Transpl Int2000Gnaiger E, Kuznetsov AV, Rieger G, Amberger A, Fuchs A, Stadlmann S, Eberl T, Margreiter R (2000) Mitochondrial defects by intracellular calcium overload versus endothelial cold ischemia/reperfusion injury. Transpl Int 13:S555-7.ROUTINE
OXPHOS
Permeabilized cells
Oxidase;biochemical oxidation
Intact cells
HumanEndothelial;epithelial;mesothelial cell
HUVEC
Steurer 1999 Transplant Proc1999Steurer W, Stadlmann S, Roberts K, Fischer M, Margreiter R, Gnaiger E (1999) Quality assessment of isolated pancreatic rat islets by high-resolution respirometry. Transplant Proc 31:650.ROUTINEIntact cellsRatIslet cell;pancreas;thymus
Guan 1999 J Biotechnol1999Guan YH, Kemp RB (1999) Detection of the changing substrate requirements of cultured animal cells by stoichiometric growth equations validated by enthalpy balances. J Biotechnol 69:95-114.ROUTINEIntact cellsCHO
Macrophage-derived
Krumschnabel 1999 Comp Biochem Physiol C Pharmacol Toxicol Endocrinol1999Krumschnabel G, Schwarzbaum PJ, Wieser W (1999) Energetics of trout hepatocytes during A23187-induced disruption of Ca2+ homeostasis. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 124:187-195.ROUTINEIntact cellsFishesLiver
Guan 1999 Cytotechnol1999Guan YH, Kemp RB (1999) On-line heat flux measurements improve the culture medium for the growth and productivity of genetically engineered CHO cells. Cytotechnol 30:107-20.ROUTINEIntact cellsCHO
Gnaiger 1998 BTK-HRR1998Gnaiger E, Kuznetsov AV, Lassnig B, Fuchs A, Reck M, Renner K, Stadlmann S, Rieger G, Margreiter R (1998) High-resolution respirometry. Optimum permeabilization of the cell membrane by digitonin. In BioThermoKinetics in the Post Genomic Era (Larsson C, Pahlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:89-95.ROUTINE
OXPHOS
SPermeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
HUVEC
Gnaiger 1998 J Exp Biol1998Gnaiger E, Lassnig B, Kuznetsov AV, Rieger G, Margreiter R (1998) Mitochondrial oxygen affinity, respiratory flux control, and excess capacity of cytochrome c oxidase. https://doi.org/10.1242/jeb.201.8.1129ROUTINE
OXPHOS
N
S
CIV
Isolated mitochondria
Enzyme
Oxidase;biochemical oxidation
Intact cells
Human
Rat
Heart
Liver
Endothelial;epithelial;mesothelial cell
HUVEC
Kidane 1997 J Thermal Anal1997Kidane AH, Guan Y, Evans PM, Kaderbhai MA, Kemp RB (1997) Comparison of heat flux in wild-type and genetically-engineered Chinese hamster ovary cells. J Thermal Anal 49: 771-783.ROUTINEIntact cellsOther mammalsCHO
Krumschnabel 1997 J Comp Physiol B1997Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1997) Acute and chronic effects of temperature, and of nutritional state, on ion homeostasis and energy metabolism in teleost hepatocytes. J Comp Physiol B 167:280-6.ROUTINEIntact cellsFishesLiver
Steinlechner-Maran 1997 Transplantation1997Steinlechner-Maran R, Eberl T, Kunc M, Schröcksnadel H, Margreiter R, Gnaiger E (1997) Respiratory defect as an early event in preservation/reoxygenation injury in endothelial cells. Transplantation 63:136-42.ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Krumschnabel 1996 Am J Physiol1996Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1996) Membrane-metabolic coupling and ion homeostasis in anoxia-tolerant and anoxia-intolerant hepatocytes. Am J Physiol 270:R614-620.ROUTINEIntact cellsFishes
Steinlechner-Maran 1996 Am J Physiol Cell Physiol1996Steinlechner-Maran R, Eberl T, Kunc M, Margreiter R, Gnaiger E (1996) Oxygen dependence of respiration in coupled and uncoupled endothelial cells. Am J Physiol Cell Physiol 271:C2053-61. https://doi.org/10.1152/ajpcell.1996.271.6.C2053ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Gnaiger 1995 Springer1995Gnaiger E (1995) Zelluläre und mitochondriale Adaptationsvorgänge bei Hypoxie. Springer, Berlin, Heidelberg In: Erich Rügheimer (Eds.), Respiratorische Therapie nach operativen Eingriffen:3-16. https://doi.org/10.1007/978-3-642-78399-9_1ROUTINEHuman
Gnaiger 1995 J Bioenerg Biomembr1995Gnaiger E, Steinlechner-Maran R, Méndez G, Eberl T, Margreiter R (1995) Control of mitochondrial and cellular respiration by oxygen. https://doi.org/10.1007/BF02111656LEAK
ROUTINE
OXPHOS
N
S
Isolated mitochondria
Intact cells
Human
Rat
Liver
Endothelial;epithelial;mesothelial cell
HUVEC
Kemp 1994 BTK-2261994
BTK1994

Kemp RB, Hoare S, Schmalfeldt M, Bridge ChMC, Evansa PM, Gnaiger E (1994) A thermochemical study of the producion of lactate by glutaminolysis and glycolysis in mouse macrophage hybridoma cells. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:226-31.

ROUTINEIntact cellsMouseMacrophage-derived
Krumschnabel 1994 J Exp Biol1994Krumschnabel G, Malle S, Schwarzbaum PJ, Wieser W (1994) Glycolytic function in goldfish hepatocytes at different temperatures: relevance for Na+ pump activity and protein synthesis. J Exp Biol 193:285-90.ROUTINEIntact cellsFishesLiver
Eberl 1994 BTK-2881994
BTK1994

Eberl T, Steinlechner R, Salvenmoser W, Abendstein B, Rhomberg M, Schröcksnadel H, Schmid T, Gnaiger E, Margreiter R (1994) Endothelial cell cultures as a model for organ preservation studies. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:288-93.

ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Krumschnabel 1994 Physiol Zool1994Krumschnabel G, Schwarzbaum PJ, Wieser W (1994) Coupling of energy supply and energy demand in isolated goldfish hepatocytes. Physiol Zool 67:438-448.ROUTINEIntact cellsFishesLiver
Knoblechner 1994 BTK-2941994
BTK1994

Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E (1994) The effect of 2-chlorodeoxy-adenosine on endogenous respiration of a human lymphoma cell line (U-937). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:294-6.

ROUTINEIntact cellsHumanBlood cells
SteinlechnerMaran 1994 BTK-2831994
BTK1994

Steinlechner-Maran R, Eberl T, Margreiter R, Gnaiger E (1994) Oxygen dependence of cellular respiration in endothelial cells: A sensitive toxicological test. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:283-7.

ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Krumschnabel 1994 Experientia1994Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-5.ROUTINEIntact cellsFishesLiver
Buck 1993 Am J Physiol Regul Integr Comp Physiol1993Buck LT, Hochachka PW, Schön A, Gnaiger E (1993) Microcalorimetric measurement of reversible metabolic suppression induced by anoxia in isolated hepatocytes. Am J Physiol Regul Integr Comp Physiol 265:R1014-9.LEAK
ROUTINE
Intact cellsReptilesLiver
Gnaiger 1992 Funct Ecol1992Gnaiger E (1992) Optimum efficiency of energy transformation and the evolution of catabolic pathways. Funct Ecol 6:234-41.ROUTINE
OXPHOS
Isolated mitochondriaRatLiver