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List of results

• Coenzyme A  + ('''Coenzyme A''' is a coenzyme playing an essential role in the [[tricarboxylic acid cycle]] (oxidation of [[pyruvate]] to [[acetyl-CoA]]) and [[fatty acid oxidation]]. CoA is a thiol that reacts with carboxylic acids to form CoA-activated thioesters.)
• Coenzyme Q  + ('''Coenzyme Q''' or ubiquinone (2,3-dimeth … '''Coenzyme Q''' or ubiquinone (2,3-dimethoxy-5-methyl-6-polyprenyl-1,4-benzoquinone) was discovered in 1957 by the group of Crane. It is a lipid composed of a benzoquinone ring with an isoprenoid side chain, two methoxy groups and one methyl group. The length of the isoprenoid chain varies depending on the species; for example, six isoprenoid units (CoQ₆) is the most commonly found CoQ in ''Saccharomyces cerevisiae'', eight units in ''Escherichia coli'' (CoQ₈), nine units in ''Caenorhabditis elegans'' and rodents (CoQ₉), ten units in humans (CoQ₁₀), and some species have more than one CoQ form, e.g. human and rodent mitochondria contain different proportions of CoQ₉ and CoQ₁₀. These redox compounds exist in three different forms: [[quinone]] (oxidized), [[quinol]] (reduced), and an intermediate [[semiquinone]].</br></br>''More details'' » '''[[Q-junction]]'''[Q-junction]]''')
• Comorbidity  + ('''Comorbidities''' are common in obesogen … '''Comorbidities''' are common in obesogenic lifestyle-induced early aging. These are preventable, non-communicable diseases with strong associations to obesity. In many studies, cause and effect in the sequence of onset of comorbidities remain elusive. Chronic degenerative diseases are commonly obesity-induced. The search for the link between obesity and the etiology of diverse preventable diseases lead to the hypothesis, that mitochondrial dysfunction is the common mechanism, summarized in the term 'mitObesity'.nism, summarized in the term 'mitObesity'.)
• Complex I  + ('''Complex I''', '''NADH:ubiquinone oxidor … '''Complex I''', '''NADH:ubiquinone oxidoreductase''' (EC 1.6.5.3), is an enzyme complex of the [[Electron transfer pathway]], a [[proton pump]] across the inner mt-membrane, responsible for electron transfer to [[ubiquinone]] from [[NADH]] formed in the mt-matrix. CI forms a [[supercomplex]] with [[Complex III]]. There is a widespread ambiguity on the 'lonely H⁺ (the lonely [[hydron]])' surrounding Complex I: [[Ambiguity crisis - NAD and H+ |CI ambiguities]].[[Ambiguity crisis - NAD and H+ |CI ambiguities]].)
• Complex III  + ('''Complex III''' or coenzyme Q : cytochro … '''Complex III''' or coenzyme Q : cytochrome c - oxidoreductase, sometimes also called the cytochrome ''bc''₁ complex is a complex of the [[electron transfer pathway]]. It catalyzes the reduction of cytochrome ''c'' by oxidation of [[coenzyme Q]] (CoQ) and the concomitant [[Proton pump|pumping of 4 protons]] from the cathodic (negative) mitochondrial matrix to the anodic (positive) intermembrane space.l matrix to the anodic (positive) intermembrane space.)
• Complex IV  + ('''Complex IV''' or '''cytochrome ''c'' ox … '''Complex IV''' or '''cytochrome ''c'' oxidase''' is the terminal oxidase of the mitochondrial [[electron transfer system]], reducing [[oxygen]] to [[water]], with reduced [[cytochrome c |cytochrome ''c'']] as a substrate. Concomitantly to that, CIV [[Proton pump|pumps protons]] against the electrochemical protonmotive force. CIV is frequently abbreviated as COX or CcO. It is the 'ferment' (Atmungsferment) of Otto Warburg, shown to be related to the cytochromes discovered by David Keilin.he cytochromes discovered by David Keilin.)
• Ammonia solution concentrated  + ('''Concentrated ammonia solution''' (25 % … '''Concentrated ammonia solution''' (25 % - 30 % ammonium hydroxide solution, ammonia) is used for the service of the polarographic oxygen sensor OroboPOS. After opening the commercial solution, the concentration of ammonia may decline during storage and may render the ammonia stock ineffective for sensor service.</br></br>'''Source:''' A commercially available solution from a drugstore is sufficient for this cleaning purposere is sufficient for this cleaning purpose)
• Concentration  + ('''Concentration''' [mol·L<sup>-1< … '''Concentration''' [mol·L^-1] is a volume-specific quantity for diluted [[sample]]s s. In a concentration, the sample is expressed in a variety of [[format]]s: [[count]], amount, [[charge]], [[mass]], [[energy]]. In solution chemistry, amount concentration is [[amount of substance]] ''n''_B per volume ''V'' of the solution, ''c''_B = [B] = ''n''_B·''V''^-1 [mol·dm^-3] = [mol·L^-1]. The standard concentration, ''c''°, is defined as 1 mol·L^-1 = 1 M. [[Count]] concentration ''C_X'' = ''N_X''·''V''^-1 [x·L^-1] is the concentration of the number ''N_X'' of elementary entities ''X'', for which the less appropriate term 'number concentration' is used by [[Cohen 2008 IUPAC Green Book |IUPAC]]. If the sample is expressed as volume ''V''_s (''e.g.'', ''V''_O₂), then the 'volume-concentration' of ''V''_s in ''V'' is termed '[[volume fraction]]', ''Φ''_s = ''V''_s·''V''^-1 (''e.g.'', volume fraction of O₂ in dry air, ''Φ''_O₂) = 0.20946). [[Density]] is the mass concentration in a volume ''V''_S of pure sample S. </br></br>A ''change'' of concentration, d''c''_X, in isolated or closed [[system]]s at constant [[volume]] is due to internal transformations ([[advancement per volume]]) only. In closed compressible systems (with a gas phase), the concentration of the gas changes, when pressure-volume work is performed on the system. In open systems, a change of concentration can additionally be due to [[external flow]] across the system boundaries.flow]] across the system boundaries.)
• Connect to O2k - DatLab 7  + ('''Connect to O2k''' connects DatLab with … '''Connect to O2k''' connects DatLab with the O2k. Select the [[USB port]] (or [[Serial port]]) with the corresponding cable connecting your PC to the O2k. Select the subdirectory for saving the [[DatLab data file| DLD file]]. Then data recording starts with experimental time set at zero.starts with experimental time set at zero.)
• Coupled respiration  + ('''Coupled respiration''' drives oxidative … '''Coupled respiration''' drives oxidative phosphorylation of the diphosphate [[ADP]] to the triphosphate [[ATP]], mediated by proton pumps across the inner mitochondrial membrane. Intrinsically [[uncoupled respiration]], in contrast, does not lead to phosphorylation of ADP, despite of protons being pumped across the inner mt-membrane. Coupled respiration, therefore, is the coupled part of respiratory oxygen flux that pumps the fraction of protons across the inner mt-membrane which is utilized by the phosphorylation system to produce ATP from ADP and Pi. In the OXPHOS state, mitochondria are in a partially coupled state, and the corresponding coupled respiration is the [[free OXPHOS capacity]]. In the state of ROUTINE respiration, coupled respiration is the [[free ROUTINE activity]].[[free ROUTINE activity]].)

• Coupling-control efficiency  + ('''Coupling-control efficiencies''' are [[flux control efficiency |flux control efficiencies]] ''j_Z-Y'' at a constant [[ET-pathway competent state]].)
• Coupling-control ratio  + ('''Coupling-control ratios''' ''CCR'' are … '''Coupling-control ratios''' ''CCR'' are [[flux control ratio]]s ''FCR'' at a constant mitochondrial [[pathway-control state]]. In mitochondrial preparations, there are three well-defined coupling states of respiration: [[LEAK respiration]], [[OXPHOS]], and [[Electron transfer pathway |Electron-transfer-pathway state]] (ET state). In these states, the corresponding respirtory rates are symbolized as ''L'', ''P'', and ''E''. In living cells, the OXPHOS state cannot be induced, but in the [[ROUTINE]] state the respiration rate is ''R''. A reference rate ''Z'' is defined by taking ''Z'' as the maximum flux, i.e. flux ''E'' in the ET-state, such that the lower and upper limits of the ''CCR'' are defined as 0.0 and 1.0. Then there are two mitochondrial ''CCR'', [[L/E |''L/E'']] and [[P/E |''P/E'']], and two ''CCR'' for living cells, [[L/E |''L/E'']] and [[ROUTINE-control ratio |''R/E'']].[[ROUTINE-control ratio |''R/E'']].)
• Coupling-control state  + ('''Coupling-control states''' are defined … '''Coupling-control states''' are defined in [[mitochondrial preparations]] (isolated mitochondria, permeabilized cells, permeabilized tissues, homogenates) as [[LEAK respiration]], [[OXPHOS]], and [[ET-pathway |ET]] states, with corresponding respiration rates (''L, P, E'') in any [[electron-transfer-pathway state]] which is competent for electron transfer. These coupling states are induced by titration of ADP and uncouplers, and application of specific inhibitors of the [[phosphorylation pathway]]. In [[living cells]], the coupling-control states are [[LEAK respiration]], [[ROUTINE]], and [[ET pathway |ET]] states of respiration with corresponding rates ''L, R, E'', using membrane-permeable inhibitors of the [[phosphorylation system]] (e.g. [[oligomycin]]) and [[uncoupler]]s (e.g. [[CCCP]]). [[Coupling-control protocol]]s induce these coupling-control states sequentially at a constant [[electron-transfer-pathway state]].[[electron-transfer-pathway state]].)
• Creatine  + ('''Creatine''' is a nitrogenous organic acid that occurs naturally in vertebrates and helps primarily muscle cells to supply energy by increasing the formation of adenosine triphosphate ([[ATP]]).)
• Curcumin  + ('''Curcumin''' has been shown to possess s … '''Curcumin''' has been shown to possess significant anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant and anti-infective effects. The protective effects of curcumin on rat heart mitochondrial injuries induced by in vitro anoxia–reoxygenation were evaluated by [http://www.ncbi.nlm.nih.gov/pubmed/23984717 Xu et al 2013]. It was found that curcumin added before anoxia or immediately prior to reoxygenation exhibited remarkable protective effects against anoxia–reoxygenation induced oxidative damage to mitochondria. induced oxidative damage to mitochondria.)
• Electric current  + ('''Current''' or electric [[flow]] … '''Current''' or electric [[flow]] ''I''_el is the [[advancement]] of [[charge]] per unit of time, expressed in the SI base unit [[ampere]] [C·s^-1 = A]. Electrons or ions are the current-carrying [[motive entity |motive entities]] of electric flow. Electrons e^- are negatively charged subatomic particles carrying 'negative electricity' with a mass that is about 1/1700 of the smallest particle — the proton — carrying 'positive electricity' (Thompson 1906). Correspondingly the [[velocity]] of electrons is much higher than that of protons or any other (larger) ion. Current is the velocity ''v'' of paticles times the number of motive charges. Therefore, electron current ''I''_e^- is of a different nature from electric current ''I''_el''χ'' carried by all species ''i'' of ions ''X_i'' (cations and anions) summarized as ''χ'' = Σ(''z_i''·''X_i''). Whereas ''I''_e^- is the net translocation of electrons moving forwards and backwards, ''I''_el''χ'' is the net translocation of charges carried by different cations and anions. In contrast, ion current ''I''_elX of a specific ion X is the partial translocation of charges carried by net translocation of ion X only. If cation current ''I''_elX⁺ is antagonized entirely by counterion current ''I''_elY^- as the process of antiport, then the electric current ''I''_el''χ'' is zero. The (net) electric current in a compartmental system is driven by the electric force Δ_el''F''_p⁺ or electric potential difference Δ''Ψ''_p⁺, whereas a compensated ion/counterion antiport current is insensitive to the electric potential difference.tal system is driven by the electric force Δ_el''F''_p⁺ or electric potential difference Δ''Ψ''_p⁺, whereas a compensated ion/counterion antiport current is insensitive to the electric potential difference.)
• Cuvettes  + ('''Cuvettes''' are used in [[fluorometry]] … '''Cuvettes''' are used in [[fluorometry]] and [[transmission spectrophotometry]] to contain the samples. Use of the term 'cells' for cuvettes is discouraged, to avoid confusion with 'living cells'. Traditionally cuvettes have a square cross-section (10 x 10 mm). For many applications they are made of transparent plastic. Glass cells are used where samples may contain plastic solvents, and for some applications requiring measurements below 300 nm, quartz glass or high purity fused silica cuvettes may be necessary.ty fused silica cuvettes may be necessary.)
• Cyanide  + ('''Cyanide''' (usually added as KCN) is a competitive inhibitor of [[Complex_IV| cytochcrome ''c'' oxidase (CIV)]]. Inhibition is reversed by pyruvate and high oxygen levels.)
• Cyclic voltammetry - DatLab  + ('''Cyclic voltammetry''')
• Cyclic voltammetry  + ('''Cyclic voltammetry''' (CV) is a type of … '''Cyclic voltammetry''' (CV) is a type of electrochemical measurement which is applied with the [[Q-Module]] as quality control to </br>(''1'') determine the oxidation and reduction peak potentials of [[Coenzyme Q]] in the specific experimental condition, (2) check the quality of the [[Q-Sensor]], and (''3'') test the interference of chemicals used in the HRR assay with the Q-Sensor. In CV, the [[Q-Sensor]] with the [[three-electrode system]] is used to obtain information about the analyte ([[Coenzyme Q|CoQ]]) by measuring the current (''I'') as the electric potential (''V'') between two of the electrodes is varied. In CV the electric potential between the glassy carbon (GC) and the Ag/AgCl reference electrode changes linearly versus time in cyclical phases, while the current is detected between GC and platinum electrode (Pt). The detected current is plotted versus the applied voltage to obtain the typical cyclic voltammogram trace (Figure 1). The presence of substances that are oxidized/reduced will result in current between GC and Pt, which can be seen as characteristic peaks in the voltammogram at a defined potential. The oxidation or the reduction peak potential values are used to set the GC (integrated into the [[Q-Sensor]]) for a separate experiment to measure the [[Q redox state]] of a biological sample. The oxidation and reduction peak potentials can be influenced by 1) the respiration medium, 2) the type of [[Coenzyme Q | CoQ]], 3) the polarization window, 4) the scan speed, 5) the number of cycles, 6) the concentration of the analyte (CoQ), and 7) the initial polarization voltage. <be></br>:::-''See'': [[MiPNet24.12 NextGen-O2k: Q-Module]].</br>:::::[[MiPNet24.16 DatLab8.0: CV-Module]][[MiPNet24.16 DatLab8.0: CV-Module]])