Difference between revisions of "Succinate and rotenone"
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|abbr=S(Rot) | |abbr=S(Rot) | ||
|description=Substrate supply by '''[[Succinate|succinate]]''' (S) is the basis for electron input through [[Complex II]] into the [[Electron transport system|mETS]]. Inhibition of [[Complex I]] by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of [[Oxaloacetate|oxaloacetate]] which is a potent inhibitor of [[succinate dehydrogenase]]. | |description=Substrate supply by '''[[Succinate|succinate]]''' (S) is the basis for electron input through [[Complex II]] into the [[Electron transport system|mETS]]. Inhibition of [[Complex I]] by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of [[Oxaloacetate|oxaloacetate]] which is a potent inhibitor of [[succinate dehydrogenase]]. | ||
|info=[ | |info=[[Gnaiger 2012 MitoPathways]] | ||
|type=Substrate ETS | |type=Substrate ETS | ||
}} | }} | ||
Revision as of 05:57, 7 July 2014
- high-resolution terminology - matching measurements at high-resolution
Succinate and rotenone
Description
Substrate supply by succinate (S) is the basis for electron input through Complex II into the mETS. Inhibition of Complex I by rotenone (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of succinate dehydrogenase.
Abbreviation: S(Rot)
Reference: Gnaiger 2012 MitoPathways
MitoPedia topics: Inhibitor, Substrate and metabolite
