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| == Expand the full year == | | == Next == |
| <br/> [[Image:O2k-News icon.jpg|left|60px|Oroboros Ecosystem Agenda]] [[File:Expand.png|right|45px|Click on [Expand] or [Collapse]]] | | <br/> [[Image:O2k-News icon.jpg|left|60px|Oroboros Ecosystem Agenda]] [[File:Expand.png|right|45px|Click on [Expand] or [Collapse]]] |
| <div class="toccolours mw-collapsible mw-collapsed"> | | <div class="toccolours mw-collapsible mw-collapsed"> |
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| ::::::::[[Image:O2k-Workshops.jpg|60px|link=http://wiki.oroboros.at/index.php/Oroboros_Events |O2k-Workshops and Events]] '''[[O2k-Events#Next Oroboros Events - save the date |<u>Next Oroboros Events</u>]]''' | | ::::::::[[Image:O2k-Workshops.jpg|60px|link=http://wiki.oroboros.at/index.php/Oroboros_Events |O2k-Workshops and Events]] '''[[O2k-Events#Next Oroboros Events - save the date |<u>Next Oroboros Events</u>]]''' |
| ::::::::::::::::» '''[[MitoFit Open Seminars |<u>MitoFit Seminars Innsbruck</u>]]''' | | ::::::::::::::::» '''[[MitoFit Open Seminars |<u>MitoFit Seminars Innsbruck</u>]]''' |
| == Current alerts and Archive 2020 ==
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| {{Oroboros Ecosystem Agenda list}}
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| <br/> [[Image:O2k-Workshops.jpg|left|50px|Oroboros Calendar]] [[File:Expand.png|right|45px|Click on [Expand] or [Collapse]]]
| | == Alerts and Archive 2020 == |
| <div class="toccolours mw-collapsible mw-collapsed">
| | {{Oroboros Ecosystem Agenda list}} |
| :::'''<big>» Archive Oroboros Ecosystem Agenda </big>''' - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
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| <div class="mw-collapsible-content">
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| 2020 Week 1 '''The Oroboros team enjoys ''holidays'' from 2019 Dec 24 to 2020 Jan 06'''
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| {| style="width:95%;
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| |<div style="display: table; style="width: 95%; border-radius: 6px; background-color: #white; border: 1px solid #090982; margin: 0.5em 1em 0 1em; padding: 6px; box-shadow: 0px 0px 5px #090982;>
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| <table>
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| [[Image:Logo_OROBOROS_INSTRUMENTS.jpg|right|35px|link=http://wiki.oroboros.at/index.php/OROBOROS_INSTRUMENTS |Oroboros]]
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| :'''[[Oroboros picture of the month]]'''
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| <hr>
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| {| | |
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| [[File:Oroboros Winter.jpg|250px|Oroboros of the month]]
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| | ''' Season's Greetings'''
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| : Our office is closed until 2020-01-06.
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| : We wish you a Happy New Year 2020!
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| : Your Oroboros team
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| ::::::* the [[Oroboros_contact#Oroboros_Customer_Relations_Ninjas |Oroboros Customer Relations Ninjas]]
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| ::::::* the [[Oroboros_contact#Oroboros_Sales_Athletes |Oroboros Sales Athletes]]
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| ::::::* the [[Oroboros_contact#Oroboros_Bioenergetics_Adventurers |Oroboros Bioenergetics Adventurers]]
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| ::::::* the [[Oroboros_contact#Oroboros_Quality_Management_Angels |Oroboros Quality Management Angels]]
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| ::::::* the [[Oroboros_contact#Oroboros_Leadership_Group |Oroboros Leadership Group]]
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| |}
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| |}
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| *'''Jan-04 Sa'''
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| :::: [[Image:O2k-News icon.jpg|60px|link=https://wiki.oroboros.at/index.php/Oroboros_News | News]] The [[Oroboros Ecosystem Agenda 2020]] is launched as a signature of the [[Oroboros Ecosystem]].
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| :::: [[Image:Gentle-Science_Ganesha.jpg|60px|link=http://www.bioblast.at/index.php/Gentle_Science|Gentle Science]] [https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)33170-8/fulltext?dgcid=raven_jbs_etoc_email 2020: a critical year for women, gender equity, and health - a Lancet Editorial]
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| ::::* One month ago
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| {| style="width:95%;
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| |<div style="display: table; style="width: 95%; border-radius: 6px; background-color: white; border: 1px solid #090982; margin: 0.5em 1em 0 1em; padding: 6px; box-shadow: 0px 0px 5px #090982;>
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| <table>
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| [[Image:Logo_OROBOROS_INSTRUMENTS.jpg|right|35px|link=http://wiki.oroboros.at/index.php/OROBOROS_INSTRUMENTS |Oroboros]]
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| :: '''NextGen-O2k SME2 coaching Orily Pratt part 2'''
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| <hr>
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| {|
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| |[[File:2019-12-04 Coaching with Orily Pratt.jpg|left|250px|MitoFit Guest Seminar]] On '''December 03/04''' the second part of the '''SME phase 2 Coaching for the [[NextGen-O2k]] project''' with '''Orily Pratt''' (Tel Aviv, IL) took place in Innsbruck.
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| <br/>
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| <br/>
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| :»Wednesday, 4th of December; Oroboros Instruments, Schoepfstrasse 18, MiPArt, Innsbruck, Austria.
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| |}
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| |}
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| 2020 Week 2
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| *'''Jan-07 Tu''' The Oroboros Office opens in the New Year 2020
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| [[File:EBEClogo2022.jpg|right|300px|right|link=EBEC22 Innsbruck AT]]
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| ::::* From the '''Austrian Bioenergetics Group''' to '''Mitochondrial Physiology and Bioenergetics DACH''' (D: Germany; A: Austria; CH: Switzerland)
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| :::::: [[EBEC22 Innsbruck AT |EBEC22 - the 22nd European Bioenergetics Conference]] will be held in Innsbruck (2022, Aug 22-27). We would like to invite several Austrian colleagues to join the ''EBEC22 National Scientific Committee''. This provides an excellent opportunity to establish an ''Austrian Bioenergetics Group'' towards and beyond EBEC22. We hope that this topic will be discussed at the forthcoming [[1st Myocardial Function Symposium 2020 Graz AT]], and further at the [[MitoEAGLE Summit Obergurgl 2020]]. Please, contact the organizer of EBEC22 - [email protected] | |
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| * '''Jan-08 We'''
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| :::: [[File:MitoPedia.jpg|60px|MitoPedia]] '''[[Force]]''' and '''[[Energy]]''': this we all need in the New Year - and '''MitoPedia''' may help to clarify the difference.
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| :::: [[Image:Quality.png|left|60px|link=http://wiki.oroboros.at/index.php/MitoPedia:_Oroboros_QM |Quality]]
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| * '''Jan-09 Th'''
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| [[File:MITOEAGLE-representation.jpg|right|200px|link=http://www.mitoeagle.org/index.php/MitoEAGLE|COST Action MitoEAGLE]]
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| ::::* Planning the [[MitoEAGLE Summit Obergurgl 2020]]
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| :::::: Members of the [[Management Committee MitoEAGLE]] and [[MitoEAGLE Working Groups |Working Group Leaders]]: please submit your suggestions for [[MitoEAGLE Summit Obergurgl 2020]]:
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| ::::::# Suggested type and title of your personal presentation, according to the MoU and final MitoEAGLE output
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| ::::::# Suggested scientists (titles) for presentations, according to the MoU
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| * '''Jan-10 Fr'''
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| ::::» <big>'''[[1st Myocardial Function Symposium 2020 Graz AT]]'''</big>
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| ::::* 14:45 Novel technologies for mitochondria and cell research (Gnaiger, Innsbruck, AUT)
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| * '''Jan-11 Sa''' - [[1st Myocardial Function Symposium 2020 Graz AT]]
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| * '''Jan-12 So'''
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| ::::* One month ago
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| {| style="width:95%;
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| |<div style="display: table; style="width: 95%; border-radius: 6px; background-color: white; border: 1px solid #090982; margin: 0.5em 1em 0 1em; padding: 6px; box-shadow: 0px 0px 5px #090982;>
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| <table>
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| [[Image:Logo_OROBOROS_INSTRUMENTS.jpg|right|35px|link=http://wiki.oroboros.at/index.php/OROBOROS_INSTRUMENTS |Oroboros]]
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| :: '''Cluster Awards 2019'''
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| <hr>
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| {|
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| |[[File:Cluster Awards 2019.jpg|right|500px|Cluster Awards 2019]]
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| On December 12<sup>th</sup>, the '''Cluster Awards 2019''' were presented for the best Tyrolean innovations of the year. We are thrilled to be the recipient in the '''Life Sciences Cluster''' for our EU Horizon 2020-funded '''[[NextGen-O2k |NextGen-O2k project]]'''.
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| '''Life Sciences'''
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| ::: Oroboros Instruments GmbH, Innsbruck: "NextGen-O2k"
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| '''Renewable Energies'''
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| ::: Heliotherm Wärmepumpentechnik GmbH, Langkampfen: "Invisible Heatpump"
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| '''Forest and wood'''
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| ::: Holzbau Unterrainer GmbH, Ainet: "Radius wood - production of curved cross laminated timber elements"
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| '''Information Technologies'''
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| ::: Lo.La Peak Solutions GmbH, Trins: "LO.LA Safety - Digital Safety Management in Ski Resorts"
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| '''Mechatronics''': ALPEX Technologies GmbH, Mils: "EVEREST 4.0"
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| '''Wellness''': Organoid Technologies GmbH, Flow: "natural sauna surfaces made of hay"
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| » More details (in German): '''[https://www.standort-tirol.at/page.cfm?vpath=newsroom/news&genericpageid=26328 Standortagentur Tirol]'''.
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| <div style="text-align: right; direction: ltr; margin-left: 1em;">Photo © Standortagentur Tirol</div>
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| |}
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| |}
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| 2020 Week 3
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| *'''Jan-13 Mo'''
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| *'''Jan-14 Tu'''
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| ::::* Circular ITC Grants for [[2020 PaduaMuscleDays Padova IT]], [[6th EU-Cardioprotection Meeting 2020 Riga LV]] and [[36th Congress Czech Nutrition Society 2020 Hradec Kralove CZ]] - [https://wiki.oroboros.at/images/a/af/ITC_Newsletter.pdf pdf]
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| *'''Jan-15 We'''
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| ::::[[Image:O2k-Publications.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]] '''Statistical evaluation on replica in [[HRR]] with permeabilized skeletal muscle fibers'''
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| :::::: - from the O2k-Network: [[AU Melbourne Stepto NK]]
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| ::::::* Jacques M, Kuang J, Bishop DJ, Yan X, Alvarez-Romero J, Munson F, Garnham A, Papadimitriou I, Voisin S, Eynon N (2019) Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study. FASEB J [Epub ahead of print]. - [[Jacques 2020 FASEB J |»Bioblast link«]]
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| *'''Jan-16 Th'''
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| ::::[[File:MitoPedia.jpg|60px|MitoPedia]] '''[[Oxygen flux]]''' - which SI units should be used?
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| ::::[[File:MitoPedia.jpg|60px|MitoPedia]] Did you ever think that units for body mass could be an issue? » '''[[Body mass]]'''
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| *'''Jan-17 Fr'''
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| ::::[[Image:O2k-close.jpg|60px|link=http://wiki.oroboros.at/index.php/About_Oroboros |About Oroboros]] <big>'''HRR</big> - high-resolution respirometry and oxygen kinetics''' 10 years ago: '''Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 2010'''. - [[Scandurra_2010_Adv_Exp_Med_Biol |»Bioblast link«]]
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| :::: [[Image:TRANSMIT Acronym.jpg|60px|TRANSMIT]] <big>'''[[TRANSMIT Symposium 2020 Brussels BE]]'''</big>
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| *'''Jan-18 Sa''' - [[TRANSMIT Symposium 2020 Brussels BE]]
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| ::::[[Image:O2k-Publications.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]] '''Mitochondrial respiration is oxygen-dependent in human cardiac homogenate preparations'''
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| :::::: - from the O2k-Network: [[CZ Prague Krajcova A]]
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| ::::::* Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142. - [[Krajcova 2020 PLOS ONE |»Bioblast link«]]
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| 2020 Week 4
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| *'''Jan-20 Mo'''
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| :::: [[Image:O2k-Workshops.png|70px|O2k-Workshops|link=O2k-Events#Next_O2k-Workshops]] [[MiPNet25.03 IOC144 Innsbruck AT |<big>'''IOC144 Innsbruck AT'''</big>]] - O2k-Coaching Days ''fully booked''
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| *'''Jan-21 Tu''' - [[MiPNet25.03 IOC144 Innsbruck AT |IOC144 Innsbruck AT]]
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| ::::* Mr Hai Wu (CEO of [[CN Beijing Huawei |Huawei]], Oroboros distributor in China) and Dr. Rupert Ecker (CEO of [https://www.tissuegnostics.com/en/TissueGnostics Vienna TissueGnostics]) join the O2k-Coaching Days for extending collaborative projects.
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| *'''Jan-22 We''' - [[MiPNet25.03 IOC144 Innsbruck AT |IOC144 Innsbruck AT]]
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| *'''Jan-23 Th''' - [[MitoFit_Open_Seminars|MitoFit Open Seminar]] - [[Gnaiger E|Erich Gnaiger]]: An improved index of obesity versus BMI - an issue of mitObesity and gender medicine in our modern world's obesogenic environment.
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| *'''Jan-24 Fr'''
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| ::::* Further circulars to invited speakers for submission of tentative titles for oral and poster presentations - [[MitoEAGLE Summit Obergurgl 2020]]
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| :::: [[Image:O2k-Support.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Open_Support |O2k-Open Support]] [[File:Blue-info.png|40px|Info: improve]] '''Do you write the serial number of the polarographic oxygen sensor (POS) in the ‘O2k configuration’ window?'''
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| ::::::: Including the POS serial number in the ´O2k configuration´ window is important to keep a track record of the sensors used according to the O2k. This will be especially helpful if troubleshooting is needed. ''Further details'' » [[O2k configuration]]
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| :::: [[Image:O2k-Support.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Open_Support |O2k-Open Support]] [[File:Red-loss of data.png|40px|Warning: loss of data]] '''Do you perform O2k-Chamber volume calibration?'''
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| ::::::: The volume calibration is essential to ensure that the chamber volume is correctly calibrated to its standard volume of 2 mL (or 0.5 mL for the [[O2k-sV-Module]]). ''Further details'' » [[O2k-Chamber MitoPedia]]
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| :::: [[Image:O2k-Support.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Open_Support |O2k-Open Support]] [[File:Yellow-take care.png|40px|Take care]] '''Do you use the correct O<sub>2</sub> solubility factor (F<sub>M</sub>) in the ‘O2 calibration’ window in DatLab?
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| ::::::: The O<sub>2</sub> solubility factor varies according to the medium used and influences the air calibration. ''Further details'' » [[Oxygen solubility factor]]
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| 2020 Week 5
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| *'''Jan-27 Mo'''
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| :::: [[Image:O2k-Workshops.png|70px|O2k-Workshops|link=O2k-Events#Next_O2k-Workshops]] [[MiPNet25.06 IOC145 Innsbruck AT |<big>'''IOC145 Innsbruck AT'''</big>]] - O2k-Coaching Days ''fully booked''
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| :::: DSL-Seminar, 16:00
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| :::::: [[Gnaiger E]]: mitObesity: compromised mitochondrial fitness in degenerative comorbidities of early aging.
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| :::::: Univ.-Klinik für Visceral-, Transplantations- u. Thoraxchirurgie, Surgery building, 12th floor, north, seminar room
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| *'''Jan-28 Tu''' - [[MiPNet25.06 IOC145 Innsbruck AT |IOC145 Innsbruck AT]]
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| ::::[[Image:O2k-Publications.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]] '''Mitochondrial respiration of blood cells and cardiovascular disease'''
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| :::::: - from the O2k-Network: [[FR Strasbourg Zoll J]]
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| ::::::* Alfatni A, Riou M, Charles AL, Meyer A, Barnig C, Andres E, Lejay A, Talha S, Geny B (2020) Peripheral blood mononuclear cells and platelets mitochondrial dysfunction, oxidative stress, and circulating mtDNA in cardiovascular diseases. J Clin Med 9 pii:E311. - [[Alfatni 2020 J Clin Med |»Bioblast link«]]
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| *'''Jan-29 We''' - [[MiPNet25.06 IOC145 Innsbruck AT |IOC145 Innsbruck AT]]
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| *'''Jan-30 Th''' - [[MitoFit_Open_Seminars|MitoFit Open Seminar]] - [[Karabatsiakis_A|Alexander Karabatsiakis]]: Targeting the reversibility of mitochondrial changes in bioenergetics and biogenesis in Major Depressive Disorder by clinical routine antidepressant treatment.
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| :::: [[Image:O2k-Support.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Open_Support |O2k-Open Support]] [[File:Yellow-take care.png|40px|Take care]] '''Do you check the O<sub>2</sub> flux at the end of the air calibration with the O2k-chamber closed?'''
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| ::::::: In DatLab 7.4, instrumental DL-Protocols guide you automatically towards closing the O2k-chamber after air calibration, to monitor "O<sub>2</sub> slope neg." (negative) as a test of any biological contamination which would increase oxygen consumption in the absence of a biological sample. ''Further details in'' [[MitoPedia: DatLab |MitoPedia]]: [[Oxygen calibration - DatLab]]
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| :::: [[Image:O2k-Support.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Open_Support |O2k-Open Support]] [[File:Blue-info.png|40px|Info: improve]] '''Do you set mark ‘R1’ and complete the air calibration correctly?'''
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| ::::::: Your air calibration is not effective until you set mark ‘R1’ andclick on <span style="background:lightgrey">Calibrate and copy to clipboard</span style> in the <span style="background:lightgrey">O2 calibration</span style> window. ''Further details in'' [[MitoPedia: DatLab |MitoPedia]]: [[Oxygen calibration - DatLab]]
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|
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| ::::* '''Open Innovation''' in the NextGen-O2k software development DatLab 8. Here is a summary of [[MitoPedia: DatLab |MitoPedia]] pages including [[:Category:DatLab 8 perspectives |'''DatLab 8 perspectives''']]
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| *'''Jan-31 Fr'''
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| ::::* Deadline for [[APS2020_Chicago_US|APS2020]] Abstract submission for poster presentation.'''
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| ::::* [[2020 PaduaMuscleDays Padova IT |Call for EJTM Communications]] - deadline for manuscript submissions
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| ::::* Registration deadline for [[6th EU-Cardioprotection Meeting 2020 Riga LV]]
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| :::: [[Image:O2k-Support.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Open_Support |O2k-Open Support]][[File:Yellow-take care.png|40px|Take care]] '''Reproducibility committment in high-resolution respirometry: quality control in oxygen calibration'''
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| ::::::: In the DatLab 7.4 software, new instrumental DL-Protocols guide the user automatically step-by-step, to calibrate the instrument accurately. Reproducibility is monitored and documented when following user-friendly standard operating procedures (SOP). ''Further details in'' [[MitoPedia: DatLab |MitoPedia]]: »[[Oxygen calibration - DatLab]]
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| 2020 Week 6
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| *'''Feb-03 Mo'''
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| :::[[File:FFG-logo.png|150px|FFG]] '''<big>»Official start of the FFG funded project [[MitoKIN|'''MitoKIN''']]</big>'''
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| ::::[[Image:O2k-Publications.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]] '''Blood cell mitochondrial function does not provide a general substitute for muscle biopsies'''
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| :::::: - from the O2k-Network: [[US AR Little Rock Boersheim E]]
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| ::::::* Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Boersheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512. - [[Rose 2019 Am J Physiol Endocrinol Metab |»Bioblast link«]]
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| ::::* Do you know that the Oroboros O2k can also be used to study the mitochondrial dark respiration of microalgae and its response to climate change impact in the ocean? One of our customers, [https://wiki.oroboros.at/index.php/Tremblay_N Dr Nelly Tremblay] is using for the first time the [[SUIT-022]] protocol to study alternative oxidases in the marine model organism ''Phaeodactylum tricornutum''.
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| *'''Feb-04 Tu'''
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| :::: [[Image:NextGenO2k logo.jpg|70px|O2k-Workshops|link=O2k-Events#Next_O2k-Workshops]] [[MiPNet25.10 IOC and Distributor engagement Tokyo JP |'''MiPNet25.10 IOC and Distributor engagement Tokyo JP''']]
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| :::: [[File:O2k-brief.png|50px|link=https://wiki.oroboros.at/images/7/7b/Cronin_2018_Nature_O2k-brief.pdf|O2k-brief]] '''Cronin''' (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature - '''Lymphocytes''', '''Cancer''' - [http://wiki.oroboros.at/index.php/O2k-brief O2k-brief repository]
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| *'''Feb-05 We''' - [[MiPNet25.10 IOC and Distributor engagement Tokyo JP]]
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| ::::[[Image:O2k-Publications.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]] '''Aerobic and resistance training address central defects and peripheral comorbidities in Alzheimer’s disease'''
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| :::::: - from the O2k-Network: [[US FL Boca Raton Khamoui AV]]
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| ::::::* Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Diseases 2020:Article ID 5919501. - [[Pena 2020 Int J Chronic Dis |»Bioblast link«]]
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| *'''Feb-06 Th''' - [[MiPNet25.10 IOC and Distributor engagement Tokyo JP]]
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| :::: '''MitoFit Open Seminar'''
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| :::::* 16:00-16:30 [[Beleza J|Jorge Beleza]]: Exercise performed during pregnancy as a preventive tool against transgenerational development of diabetes mellitus and NAFLD in the offspring. The role of epigenetic-mediated mechanisms. [[Media:MitoFitOpenSeminar_JorgeBeleza_20200206.pdf|»Abstract«]]
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| :::::* 16:30-17:00 [[Pereira R|Rita Pereira]]: The Handball4Health Project : A community-based intervention programme
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| *'''Feb-07 Fr''' - [[MiPNet25.10 IOC and Distributor engagement Tokyo JP]]
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| 2020 Week 7
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| *'''Feb-10 Mo'''
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| ::::* '''Early Bird Registration Deadline''' for [[ESSR 2020 Innsbruck AT]]
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| *'''Feb-11 Tu'''
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| *'''Feb-12 We'''
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| :::: [[File:MitoPedia.jpg|60px|MitoPedia]] What do metformin, melatonin and other bioactive mitObesity compounds have in common? » '''[[MitObesity drugs]]'''
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| :::: [[Image:O2k-Feedback.jpg|left|60px|link=http://wiki.oroboros.at/index.php/O2k-Feedback |O2k-Feedback]] ''I had a very pleasant experience at the work shop. I thank you and all the team members for devoting their time for us and teaching each step in a systematic manner.'' - '''[[Gayathri Narayanappa]]''' participaing in [[MiPNet25.03 IOC144 Innsbruck AT]]
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| *'''Feb-13 Th'''
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|
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| *'''Feb-14 Fr'''
| | ::::::::::::::::::::::<big>» [[Archive Oroboros Ecosystem Agenda 2020]]</big> |