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From Bioblast
 YearReferenceCouplingPathwaysPreparationsSpecies;modelTissue;cell
Singhal 2017 Mol Biol Cell2017Singhal RK, Kruse C, Heidler J, Strecker V, Zwicker K, Düsterwald L, Westermann B, Herrmann JM, Wittig I, Rapaport D (2017) Coi1 is a novel assembly factor of the yeast complex III-complex IV supercomplex. Mol Biol Cell 28:2609-22.ROUTINE
ET
Isolated mitochondriaSaccharomyces cerevisiae
Beresewicz 2017 PLoS One2017Beresewicz M, Boratynska-Jasinska A, Charzewski L, Kawalec M, Kabzinska D, Kochanski A, Krzysko KA, Zablocka B (2017) The effect of a novel c.820C>T (Arg274Trp) mutation in the mitofusin 2 gene on fibroblast metabolism and clinical manifestation in a patient. PLoS One 12:0169999.LEAK
ET
ROUTINE
Intact cellsHumanFibroblast
Endothelial;epithelial;mesothelial cell
Seo 2017 Elife2017Seo AY, Lau PW, Feliciano D, Sengupta P, Gros MAL, Cinquin B, Larabell CA, Lippincott-Schwartz J (2017) AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation. Elife 6. pii: e21690.ROUTINESaccharomyces cerevisiae
Rohde 2017 Cell Death Differ2017Rohde K, Kleinesudeik L, Roesler S, Löwe O, Heidler J, Schröder K, Wittig I, Dröse S, Fulda S (2017) A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis. Cell Death Differ 24:83-97.LEAK
ROUTINE
ET
CIV
ROX
Intact cellsMouseFibroblast
Tegelberg 2017 Orphanet J Rare Dis2017Tegelberg S, Tomašić N, Kallijärvi J, Purhonen J, Elmér E, Lindberg E, Nord DG, Soller M, Lesko N, Wedell A, Bruhn H, Freyer C, Stranneheim H, Wibom R, Nennesmo I, Wredenberg A, Eklund EA, Fellman V (2017) Respiratory chain complex III deficiency due to mutated BCS1L: a novel phenotype with encephalomyopathy, partially phenocopied in a Bcs1l mutant mouse model. Orphanet J Rare Dis 12:73.LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
S
Permeabilized cellsHuman
Mouse
Blood cells
Platelet
Permer 2017 Bachelor Thesis2017Permer M (2017) Respirometrische Charakterisierung kryopräservierter HEK 239T Zellen. Bachelor Thesis 1-56.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
HEK
Lang 2017 Aging (Albany NY)2017Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP (2017) SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. Aging (Albany NY) 9:2163-89.LEAK
ET
ROUTINE
ROXIntact cellsHumanKidney
HEK
Ortega 2017 Biol Reprod2017Ortega MS, Wohlgemuth S, Tribulo P, Siqueira LG, Null DJ, Cole JB, Da Silva MV, Hansen PJ (2017) A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows. Biol Reprod 96:652-63.LEAK
ROUTINE
ET
ROXBovinesBlood cells
Xu 2017 J Hum Genet2017Xu B, Li X, Du M, Zhou C, Fang H, Lyu J, Yang Y (2017) Novel mutation of ND4 gene identified by targeted next-generation sequencing in patient with Leigh syndrome. J Hum Genet 62:291-7.LEAK
ROUTINE
Intact cellsHumanBlood cells
Platelet
Chang 2017 J Biol Chem2017Chang JS, Ha K (2017) An unexpected role for the transcriptional coactivator isoform NT-PGC-1α in the regulation of mitochondrial respiration in brown adipocytes. J Biol Chem 292:9958-66.LEAK
ET
ROUTINE
ROXIntact cellsMouseFat
Alves 2017 Free Radic Biol Med2017Alves de Souza CE, Alves de Souza HM, Stipp MC, Corso CR, Galindo CM, Cardoso CR, Dittrich RL, de Souza Ramos EA, Klassen G, Carlos RM, Correia Cadena SMS, Acco A (2017) Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats. Free Radic Biol Med 110:228-39.LEAK
ROUTINE
ROXRat
Blecha 2017 Free Radic Biol Med2017Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66.ROUTINE
OXPHOS
SIntact cellsEndothelial;epithelial;mesothelial cell
Yang 2017 Cell Death Dis2017Yang N, Weinfeld M, Lemieux H, Montpetit B, Goping IS (2017) Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis. Cell Death Dis 8:e2587.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
Saccharomyces cerevisiae
Human
Lymphocyte
Welker 2017 Thesis2017Welker L (2017) Metabolic and morphologic shifts in Neuro2a cells cultured in galactose medium. Master's Thesis p26.LEAK
ROUTINE
ET
Intact cellsMouse
Phillips 2017 Cancer Res2017Phillips CM, Zatarain JR, Nicholls ME, Porter C, Widen SG, Thanki K, Johnson P, Jawad MU, Moyer MP, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood TG, Druzhyna N, Szczesny B, Módis K1, Szabo C, Chao C, Hellmich MR. (2017) Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.. Cancer Res. 77(21):5741-5754.LEAK
ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Boutant 2017 EMBO J2017Boutant M, Kulkarni SS, Joffraud M, Ratajczak J, Valera-Alberni M, Combe R, Zorzano A, Cantó C (2017) Mfn2 is critical for brown adipose tissue thermogenic function. EMBO J 36:1543-58.ROUTINE
LEAK
OXPHOS
ET
ROX
N
S
NS
Intact cells
Homogenate
Isolated mitochondria
MouseFat
Fibroblast
Rodrigues-Silva 2017 J Neurooncol2017Rodrigues-Silva E, Siqueira-Santos ES, Ruas JS, Ignarro RS, Figueira TR, Rogério F, Castilho RF (2017) Evaluation of mitochondrial respiratory function in highly glycolytic glioma cells reveals low ADP phosphorylation in relation to oxidative capacity. 10.1007/s11060-017-2482-0LEAK
ROUTINE
OXPHOS
ET
N
ROX
Permeabilized cells
Isolated mitochondria
Intact cells
RatNervous system
Jang 2017 Biol Open2017Jang DH, Seeger SC, Grady ME, Shofer FC, Eckmann DM (2017) Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biol Open 6:1831-9.LEAK
ROUTINE
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Fibroblast
Jang 2017 Clin Toxicol (Phila)2017Jang DH, Kelly M, Hardy K, Lambert DS, Shofer FS, Eckmann DM (2017) A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clin Toxicol (Phila) 55:579-84.LEAK
ROUTINE
OXPHOS
ET
F
S
CIV
NS
ROX
Intact cellsBlood cells
Jezek 2017 Biochim Biophys Acta2017Ježek J, Engstová H, Ježek P (2017) Antioxidant mechanism of mitochondria-targeted plastoquinone SkQ1 is suppressed in aglycemic HepG2 cells dependent on oxidative phosphorylation. Biochim Biophys Acta 1858:750-62.ET
ROUTINE
ROXIntact cellsHumanLiver
Elmer 2017 US Patent2017Elmer E, Hansson MJ, Ehinger JK, Piel S, Moss S (2017) Succinate prodrugs for use in the treatment of lactic acidosis or drug-induced side-effects due to complex I-related impairment of mitochondrial oxidative phosphorylation. US Patent US20170100359 A1.LEAK
ROUTINE
OXPHOS
ET
S
ROX
Intact cellsHumanHeart
Blood cells
Fibroblast
Macrophage-derived
Platelet
Shuvo 2017 Can J Microbiol2017Shuvo SR, Kovaltchouk U, Zubaer A, Kumar A, Summers WAT, Donald LJ, Hausner G, Court DA (2017) Functional characterization of an N-terminally-truncated mitochondrial porin expressed in Neurospora crassa. Can J Microbiol 17:1-9.ROUTINEIsolated mitochondriaFungi
Cervoni 2017 J Exp Biol2017Cervoni MS, Cardoso-Júnior CAM, Craveiro G, Souza AO, Alberici LC, Hartfelder K (2017) Mitochondrial capacity, oxidative damage and hypoxia gene expression are associated with age-related division of labor in honey bee (Apis mellifera L.) workers. J Exp Biol 220:4035-46.LEAK
ROUTINE
OXPHOS
ET
N
ROX
Intact cells
Lopez 2017 PLOS ONE2017López A, Ortiz F, Doerrier C, Venegas C, Fernández-Ortiz M, Aranda P, Díaz-Casado ME, Fernández-Gil B, Barriocanal-Casado E, Escames G, López L, Acuña-Castroviejo D (2017) Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases. PLOS ONE 12:e0183090.LEAK
ROUTINE
OXPHOS
N
S
NS
Isolated mitochondriaMouse
Wu 2017 Sci Rep2017Wu LH, Chang SC, Fu TC, Huang CH, Wang JS (2017) High-intensity interval training improves mitochondrial function and suppresses thrombin generation in platelets undergoing hypoxic stress. Sci Rep 7:4191.LEAK
OXPHOS
ET
ROUTINE
N
NS
ROX
CIV
Permeabilized cells
Intact cells
HumanBlood cells
Platelet
Bernardinelli 2017 PLoS One2017Bernardinelli E, Costa R, Scantamburlo G, To J, Morabito R, Nofziger C, Doerrier C, Krumschnabel G, Paulmichl M, Dossena S (2017) Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death. PLoS One 12(6):e0179591.LEAK
ROUTINE
ET
ROXIntact cellsHumanKidney
Bansal 2017 Environ Health Perspect2017Bansal A, Rashid C, Xin F, Li C, Polyak E, Duemler A, van der Meer T, Stefaniak M, Wajid S, Doliba N, Bartolomei MS, Simmons RA (2017) Sex- and dose-specific effects of maternal bisphenol A exposure on pancreatic islets of first- and second-generation adult mice offspring. Environ Health Perspect 125:097022.LEAK
ROUTINE
ET
ROXIntact cellsMouseIslet cell;pancreas;thymus
Da Silva 2017 Life Sci2017da Silva MH, Peçanha FLM, de Oliveira AM, da-Silva WS (2017) 4-Phenyl butyric acid increases particulate hexokinase activity and protects against ROS injury in L6 myotubes. Life Sci 179:98-102.ROUTINEIntact cellsRatSkeletal muscle
Other cell lines
Greenall 2017 Oncogenesis2017Greenall SA, Lim YC, Mitchell CB, Ensbey KS, Stringer BW, Wilding AL, O'Neill GM, McDonald KL, Gough DJ, Day BW, Johns TG (2017) Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma. Oncogenesis 6:e336.ROUTINEIntact cellsHumanNervous system
Canevarolo 2017 Thesis2017Canevarolo RR (2017) Resistência ao metotrexato está diretamente associada à concentração de glutationa em linhagens de leucemia linfoide aguda. Dissertation p159.LEAK
ROUTINE
ET
Intact cellsHumanMacrophage-derived
Kang 2017 Mol Cell2017Kang Y, Stroud DA, Baker MJ, De Souza DP, Frazier AE, Liem M, Tull D, Mathivanan S, McConville MJ, Thorburn DR, Ryan MT, Stojanovski D (2017) Sengers Syndrome-associated mitochondrial acylglycerol kinase is a subunit of the human TIM22 protein import complex. Mol Cell 67:457-70.ROUTINE
ET
Intact cellsHuman
Beresewicz 2017 PLOS ONE2017Beręsewicz M, Boratyńska-Jasińska A, Charzewski Ł, Kawalec M, Kabzińska D, Kochański A, Krzyśko KA, Zabłocka B (2017) The effect of a novel c.820C>T (Arg274Trp) mutation in the mitofusin 2 gene on fibroblast metabolism and clinical manifestation in a patient. PLOS ONE 12:e0169999.LEAK
ET
ROUTINE
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Frawley 2017 Chem Res Toxicol2017Frawley KL, Cronican AA, Pearce LL, Peterson J (2017) Sulfide toxicity and its modulation by nitric oxide in bovine pulmonary artery endothelial cells. Chem Res Toxicol 30:2100-9.ROUTINEIntact cellsBovinesEndothelial;epithelial;mesothelial cell
Goncalves 2017 J Cell Commun Signal2017Gonçalves R, Zamoner A, Zanatta L, Zanatta AP, Remor AP, da Luz Scheffer D, Latini A, Silva FR (2017) 1,25(OH)2 vitamin D3 signalling on immature rat Sertoli cells: gamma-glutamyl transpeptidase and glucose metabolism. J Cell Commun Signal 11:233-43.LEAK
ROUTINE
ET
ROXIntact cellsRatGenital
Ruiz 2017 Brain Pathol2017Ruiz M, Bégou M, Launay N, Ranea-Robles P, Bianchi P, López-Erauskin J, Morató L, Guilera C, Petit B, Vaurs-Barriere C, Guéret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A (2017) Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease. Brain Pathol 28:611-30.LEAK
ROUTINE
ET
ROXIntact cellsHuman
Mouse
Nervous system
Fibroblast
Ounpuu 2017 Biochim Biophys Acta2017Ounpuu L, Klepinin A, Pook M, Teino I, Peet N, Paju K, Tepp K, Chekulayev V, Shevchuk I, Koks S, Maimets T, Kaambre T (2017) 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochim Biophys Acta 1861:2146-54.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
CIV
Permeabilized cells
Intact cells
HumanStem cells
Zhou 2017 Oxid Med Cell Longev2017Zhou H, Nie K, Qiu R, Xiong J, Shao X, Wang B, Shen L, Lyu J, Fang H (2017) Generation and bioenergetic profiles of cybrids with east Asian mtDNA haplogroups. Oxid Med Cell Longev 2017:1062314.LEAK
ROUTINE
Intact cellsHuman
Scrima 2017 PLOS ONE2017Scrima R, Menga M, Pacelli C, Agriesti F, Cela O, Piccoli C, Cotoia A, De Gregorio A, Gefter JV, Cinnella G, Capitanio N (2017) Para-hydroxyphenylpyruvate inhibits the pro-inflammatory stimulation of macrophage preventing LPS-mediated nitro-oxidative unbalance and immunometabolic shift. PLOS ONE 12:e0188683.LEAK
ROUTINE
ET
ROXIntact cellsHuman
Mouse
Endothelial;epithelial;mesothelial cell
Blood cells
Fibroblast
Macrophage-derived
Mantilla 2017 PLOS Pathog2017Mantilla BS, Marchese L, Casas-Sánchez A, Dyer NA, Ejeh N, Biran M, Bringaud F, Lehane MJ, Acosta-Serrano A, Silber AM (2017) Proline metabolism is essential for Trypanosoma brucei brucei survival in the tsetse vector. PLOS Pathog 13:e1006158.LEAK
OXPHOS
ET
ROUTINE
S
ROX
N
Permeabilized cells
Intact cells
Protists
Radenkovic 2017 Biochem Pharmacol2017Radenkovic F, Holland OJ, Vanderlelie JJ, Perkins AV (2017) Selective inhibition of endogenous antioxidants with Auranofin causes mitochondrial oxidative stress which can be countered by selenium supplementation. Biochem Pharmacol 146:42-52.ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanOther cell lines
Theisen 2017 Am J Med Genet A2017Theisen BE, Rumyantseva A, Cohen JS, Alcaraz WA, Shinde DN, Tang S, Srivastava S, Pevsner J, Trifunovic A, Fatemi A (2017) Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy. Am J Med Genet A 173:2505-10.LEAK
ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Saintas 2017 PLOS ONE2017Saintas E, Abrahams L, Ahmad GT, Ajakaiye AM, AlHumaidi AS, Ashmore-Harris C, Clark I, Dura UK, Fixmer CN, Ike-Morris C, Mato Prado M, Mccullough D, Mishra S, Schöler KM, Timur H, Williamson MD, Alatsatianos M, Bahsoun B, Blackburn E, Hogwood CE, Lithgow PE, Rowe M, Yiangou L, Rothweiler F, Cinatl J Jr, Zehner R, Baines AJ, Garrett MD, Gourlay CW, Griffin DK, Gullick WJ, Hargreaves E, Howard MJ, Lloyd DR, Rossman JS, Smales CM, Tsaousis AD, von der Haar T, Wass MN, Michaelis M (2017) Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS. PLOS ONE 12:e0172140.LEAK
ROUTINE
ET
Intact cellsHumanNervous system
Other cell lines
Favero 2017 Thesis2017Favero BC (2017) Efeitos da leucina sobre a via da mTOR e da miostatina em cultura celular de miotúbulos. Dissertation p55.LEAK
ROUTINE
ET
MouseSkeletal muscle
Cunha de Padua 2017 Carbohydr Polym2017Cunha de Padua MM, Suter Correia Cadena SM, de Oliveira Petkowicz CL, Martinez GR, Rodrigues Noleto G (2017) Toxicity of native and oxovanadium (IV/V) galactomannan complexes on HepG2 cells is related to impairment of mitochondrial functions. Carbohydr Polym 173:665-75.LEAK
ROUTINE
ET
ROXHumanLiver
Westerlund 2017 Pediatr Res2017Westerlund E, Marelsson SE, Ehinger JK, Sjövall F, Morota S, Åsander Frostner E, Oldfors A, Darin N, Lundgren J, Hansson MJ, Fellman V, Elmér E (2017) Oxygen consumption in platelets as an adjunct diagnostic method for pediatric mitochondrial disease. Pediatr Res 83:455-65.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Blood cells
Ortega-Dominguez 2017 Food Chem Toxicol2017Ortega-Domínguez B, Aparicio-Trejo OE, García-Arroyo FE, León-Contreras JC, Tapia E, Molina-Jijón E, Hernández-Pando R, Sánchez-Lozada LG, Barrera-Oviedo D, Pedraza-Chaverri J (2017) Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic. Food Chem Toxicol 107:373-85.LEAK
ROUTINE
OXPHOS
N
NS
Isolated mitochondria
Tueller 2017 Biochem Biophys Res Commun2017Tueller DJ, Harley JS, Hancock CR (2017) Effects of curcumin and ursolic acid on the mitochondrial coupling efficiency and hydrogen peroxide emission of intact skeletal myoblasts. Biochem Biophys Res Commun 492:368-72.LEAK
ROUTINE
OXPHOS
F
N
NS
ROX
Permeabilized cells
Intact cells
Skeletal muscle
Rezania 2017 Thromb Res2017Rezania S, Puskarich MA, Petrusca DN, Neto-Neves EM, Rondina MT, Kline JA (2017) Platelet hyperactivation, apoptosis and hypercoagulability in patients with acute pulmonary embolism. Thromb Res 155:106-15.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Platelet
Pfeiffer 2017 Free Radic Biol Med2017Pfeiffer A, Schneider J, Bueno D, Dolga A, Voss TD, Lewerenz J, Wüllner V, Methner A (2017) Bcl-xL knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity. Free Radic Biol Med 112:350-9.LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
Permeabilized cellsMouseFibroblast
Profilo 2017 Biochim Biophys Acta2017Profilo E, Peña-Altamira LE, Corricelli M, Castegna A, Danese A, Agrimi G, Petralla S, Giannuzzi G, Porcelli V, Sbano L, Viscomi C, Massenzio F, Palmieri EM, Giorgi C, Fiermonte G, Virgili M, Palmieri L, Zeviani M, Pinton P, Monti B, Palmieri F, Lasorsa FM (2017) Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells. Biochim Biophys Acta 1863:1422-35.LEAK
ET
ROUTINE
ROXIntact cellsMouseNervous system
Other cell lines
Neuroblastoma
Cunha 2017 Int J Biol Macromol2017Cunha de Padua MM, Suter Correia Cadena SM, de Oliveira Petkowicz CL, Martinez GR, Rodrigues Noleto G (2017) Galactomannan from Schizolobium amazonicum seed and its sulfated derivatives impair metabolism in HepG2 cells. Int J Biol Macromol 101:64-473.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Schaefer 2017 Neurophotonics2017Schaefer PM, Hilpert D, Niederschweiberer M, Neuhauser L, Kalinina S, Calzia E, Rueck A, von Einem B, von Arnim CAF (2017) Mitochondrial matrix pH as a decisive factor in neurometabolic imaging. Neurophotonics 4:045004.ROUTINE
ET
CIV
ROX
Kidney
HEK
Nogueira 2017 Free Radic Biol Med2017Nogueira NP, Saraiva FMS, Oliveira MP, Mendonca APM, Inacio JDF, Almeida-Amaral EE, Menna-Barreto RF, Laranja GAT, Lopes Torres EJ, Oliveira MF, Paes MC (2017) Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production. Free Radic Biol Med 108:183-91.LEAK
ROUTINE
OXPHOS
ET
SIntact organism
Permeabilized cells
Protists
Zeidler 2017 J Biol Chem2017Zeidler JD, Fernandes-Siqueira LO, Carvalho AS, Cararo-Lopes E, Dias MH, Ketzer LA, Galina A, Da Poian AT (2017) Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria. J Biol Chem 292:14176-87.LEAK
ROUTINE
ET
F
N
ROX
Intact cellsMouse
Xiong 2017 J Am Heart Assoc2017Xiong S, Wang B, Lin S, Zhang H, Li Y, Wei X, Cui Y, Wei X, Lu Z, Gao P, Li L, Zhao Z, Liu D, Zhu Z (2017) Activation of transient receptor potential melastatin subtype 8 attenuates cold-induced hypertension through ameliorating vascular mitochondrial dysfunction. J Am Heart Assoc 6. pii: e005495.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
MouseEndothelial;epithelial;mesothelial cell
Zholobenko 2017 PLOS ONE2017Zholobenko AV, Mouithys-Mickalad A, Dostal Z, Serteyn D, Modriansky M (2017) On the causes and consequences of the uncoupler-like effects of quercetin and dehydrosilybin in H9c2 cells. PLOS ONE 12:e0185691.LEAK
OXPHOS
ET
ROUTINE
F
N
S
NS
ROX
Permeabilized cells
Intact cells
RatHeart
Morrow 2017 Proc Natl Acad Sci U S A2017Morrow RM, Picard M, Derbeneva O, Leipzig J, McManus MJ, Gouspillou G, Barbat-Artigas S, Dos Santos C, Hepple RT, Murdock DG, Wallace DC (2017) Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity. Proc Natl Acad Sci U S A 114:2705-10.ROUTINE
OXPHOS
LEAK
N
NS
ROX
Other combinations
Permeabilized tissueSkeletal muscle
Bombaca 2017 Free Radic Biol Med2017Bombaça ACS, Dias FA, Ennes-Vidal V, Garcia-Gomes ADS, Sorgine MHF, d'Avila-Levy CM, Menna-Barreto RFS (2017) Hydrogen peroxide resistance in Strigomonas culicis: Effects on mitochondrial functionality and Aedes aegypti interaction. Free Radic Biol Med 113:255-66.ROUTINECIV
ROX
Intact cellsProtists
Sidlauskas 2017 Neurosci Lett2017Sidlauskas K, Sidlauskiene R, Li N, Liobikas J (2017) 5-Hydroxy-1,4-naphthalenedione exerts anticancer effects on glioma cells through interaction with the mitochondrial electron transport chain. Neurosci Lett 639:207-14.OXPHOS
LEAK
ROUTINE
ET
N
S
Intact cells
Permeabilized cells
RatNervous system
Other cell lines
Holland 2017 Placenta2017Holland OJ, Hickey AJR, Alvsaker A, Moran S, Hedges C, Chamley LW, Perkins AV (2017) Changes in mitochondrial respiration in the human placenta over gestation. Placenta 57:102-12.LEAK
ROUTINE
OXPHOS
F
N
CIV
NS
ROX
Permeabilized cells
Intact cells
Genital
Porter 2017 Adipocyte2017Porter C (2017) Quantification of UCP1 function in human brown adipose tissue. Adipocyte 6:167-74.LEAK
ROUTINE
OXPHOS
ET
Permeabilized tissue
Isolated mitochondria
Intact cells
Fat
Wang 2017 J Am Heart Assoc2017Wang B, Xiong S, Lin S, Xia W, Li Q, Zhao Z, Wei X, Lu Z, Wei X, Gao P, Liu D, Zhu Z (2017) Enhanced mitochondrial transient receptor potential channel, canonical type 3-mediated calcium handling in the vasculature from hypertensive rats. J Am Heart Assoc 6. pii: e005812.ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsRatEndothelial;epithelial;mesothelial cell
McFarlane 2017 Am J Physiol Regul Integr Comp Physiol2017McFarlane SV, Mathers KE, Staples JF (2017) Reversible temperature-dependent differences in brown adipose tissue respiration during torpor in a mammalian hibernator. Am J Physiol Regul Integr Comp Physiol 312:R434-42.LEAK
ROUTINE
OXPHOS
F
N
Isolated mitochondria
Intact cells
Other mammalsFat
Dechandt 2017 J Bioenerg Biomembr2017Dechandt CRP, Zuccolotto-Dos-Reis FH, Teodoro BG, Fernandes AMAP, Eberlin MN, Kettelhut IC, Curti C, Alberici LC (2017) Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Biomembr 49:399-411.LEAK
ROUTINE
ET
F
N
ROX
Permeabilized cells
Intact cells
RatLiver
Comelli 2017 J Bioenerg Biomembr2017Comelli M, Pretis I, Buso A, Mavelli I (2017) Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status. J Bioenerg Biomembr 50:33-52.LEAK
ROUTINE
OXPHOS
ET
N
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanNervous system
Cigliano 2017 Mol Neurobiol2017Cigliano L, Spagnuolo MS, Crescenzo R, Cancelliere R, Iannotta L, Mazzoli A, Liverini G, Iossa S (2017) Short-term fructose feeding induces inflammation and oxidative stress in the hippocampus of young and adult rats. Mol Neurobiol 55:2869-83.ROUTINECIV
Other combinations
Homogenate
Intact cells
RatNervous system
Other cell lines
Rodolphi 2017 Thesis2017Rodolphi MS (2017) Efeitos da nandrolona e da ceftriaxona na homeostasia glutamatérgica: uma busca por mecanismos interativos entre astrócitos e neurônios envolvidos no comportamento agressivo. Dissertation p58.ROUTINE
OXPHOS
S
CIV
ROX
HomogenateMouseNervous system
Djordjevic 2017 Neuroscience2017Djordjevic J, Thomson E, Chowdhury SR, Snow WM, Perez C, Wong TP, Fernyhough P, Albensi BC (2017) Brain region- and sex-specific alterations in mitochondrial function and NF-κB signaling in the TgCRND8 mouse model of Alzheimer's disease. Neuroscience 361:81-92.ROUTINE
OXPHOS
ET
N
S
ROX
Isolated mitochondriaMouseNervous system
Li 2017 Oxid Med Cell Longev2017Li CJ, Chen PK, Sun LY, Pang CY (2017) Enhancement of mitochondrial transfer by antioxidants in human mesenchymal stem cells. Oxid Med Cell Longev 2017:8510805.ET
LEAK
ROUTINE
ROXIntact cellsHumanFat
Pino 2017 Int J Obes (Lond)2017Pino MF, Divoux A, Simmonds AV, Smith SR, Sparks LM (2017) Investigating the effects of Orexin-A on thermogenesis in human deep neck brown adipose tissue. Int J Obes (Lond) 41:1646-53.LEAK
ROUTINE
Intact cellsHumanFat
De Carvalho 2017 Sci Rep2017de Carvalho AETS, Bassaneze V, Forni MF, Keusseyan AA, Kowaltowski AJ, Krieger JE (2017) Early postnatal cardiomyocyte proliferation requires high oxidative energy metabolism. Sci Rep 7:15434.ROUTINEIntact cellsRatHeart
Uzhachenko 2017 Aging (Albany NY)2017Uzhachenko R, Boyd K, Olivares-Villagomez D, Zhu Y, Goodwin JS, Rana T, Shanker A, Tan WJ, Bondar T, Medzhitov R, Ivanova AV (2017) Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis. Aging (Albany NY) 9:627-49.LEAK
ET
ROUTINE
ROXIntact cellsMouseKidney
Endothelial;epithelial;mesothelial cell
Fibroblast
MiPNet21.14 Reference sample HRR2016-10-19
O2k-Protocols

Development of a reference sample for HRR.

LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanHEK
MiPNet21.12 Comparison mt respiration media2016-10-18
O2k-Protocols

O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.

LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanHEK
MiPNet08.09 CellRespiration2016-08-11
O2k-Procedures contents

High-resolution respirometry and coupling-control protocol with living cells: ROUTINE, LEAK, ET-pathway, ROX.

LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
Lymphocyte
MiPNet10.04 CellRespiration2016-08-08
O2k-Protocols

An experiment with high-resolution respirometry: coupling control in cell respiration.

LEAK
ROUTINE
ET
ROXIntact cellsMouseBlood cells
Barth 2016 Thesis2016Barth C (2016) Effekte einer intermittierenden Hyperoxie auf die mitochondriale Atmung in Alveolarmakrophagen. Dissertation p69.LEAK
ROUTINE
OXPHOS
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
MouseLung;gill
Macrophage-derived
Stier 2016 Methods Ecol Evol2016Stier A, Romestaing C, Schull Q, Lefol E, Robin JP, Roussel D, Bize P (2016) How to measure mitochondrial function in birds using red blood cells: a case study in the king penguin and perspectives in ecology and evolution. Methods Ecol Evol doi:10.1111/2041-210X.12724.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Permeabilized tissue
Intact cells
BirdsSkeletal muscle
Blood cells
Jang 2016 Clin Toxicol (Phila)2016Jang DH, Shofer FS, Weiss SL, Becker LB (2016) Impairment of mitochondrial respiration following ex vivo cyanide exposure in peripheral blood mononuclear cells. Clin Toxicol (Phila) 54:303-7.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Lymphocyte
Lesage 2016 Am J Hum Genet2016Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T, Maurage CA, Sahbatou M, Liebau S, Ding J, Bilgic B, Emre M, Erginel-Unaltuna N, Guven G, Tison F, Tranchant C, Vidailhet M, Corvol JC, Krack P, Leutenegger AL, Nalls MA, Hernandez DG, Heutink P, Gibbs JR, Hardy J, Wood NW, Gasser T, Durr A, Deleuze JF, Tazir M, Destée A, Lohmann E, Kabashi E, Singleton A, Corti O, Brice A (2016) Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-Dependent Mitophagy. Am J Hum Genet 98:500-13.LEAK
ROUTINE
ET
ROXIntact cellsOther mammalsKidney
Other cell lines
Svenkrtova 2016 Biogerontology2016Svenkrtova A, Belicova L, Volejnikova A, Sigler K, Jazwinski SM, Pichova A (2016) Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality. Biogerontology 17:395-408.ROUTINECIV
ROX
Intact cellsSaccharomyces cerevisiae
Zhunussova 2016 PLOS ONE2016Zhunussova A, Vitol EA, Polyak B, Tuleukhanov S, Brooks AD, Sensenig R, Friedman G, Orynbayeva Z (2016) Mitochondria-mediated anticancer effects of non-thermal atmospheric plasma. PLOS ONE 11:e0156818.LEAK
ROUTINE
ET
Intact cellsHumanGenital
Other cell lines
Nauta 2016 Thesis2016Nauta TD (2016) HIF-2α regulates in vitro neovascularization during hypoxia. Doctoral Dissertation p206.LEAK
ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Davuluri 2016 J Physiol2016Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60.LEAK
ROUTINE
ET
ROXIntact cellsMouseSkeletal muscle
Other cell lines
Holandino 2016 Bioelectrochemistry2016Holandino C, Teixeira CA, de Oliveira FA, Barbosa GM, Siqueira CM, Messeder DJ, de Aguiar FS, da Veiga VF, Girard-Dias W, Miranda K, Galina A, Capella MA, Morales MM (2016) Direct electric current treatment modifies mitochondrial function and lipid body content in the A549 cancer cell line. Bioelectrochemistry 111:83-92.LEAK
ROUTINE
ET
ROXIntact cellsHumanLung;gill
Other cell lines
Anand 2016 PLOS ONE2016Anand R, Strecker V, Urbach J, Wittig I, Reichert AS (2016) Mic13 is essential for formation of crista junctions in mammalian cells. PLOS ONE 11:e0160258.LEAK
ROUTINE
OXPHOS
ET
N
CIV
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HEK
Liu 2016 Apoptosis2016Liu X, Gao RW, Li M, Si CF, He YP, Wang M, Yang Y, Zheng QY, Wang CY (2016) The ROS derived mitochondrial respiration not from NADPH oxidase plays key role in Celastrol against angiotensin II-mediated HepG2 cell proliferation. Apoptosis 21:1315-26.ROUTINEIntact cellsHumanLiver
Other cell lines
Bastow 2016 J Cell Sci2016Bastow EL, Peswani AR, Tarrant DS, Pentland DR, Chen X, Morgan A, Staniforth GL, Tullet JM, Rowe ML, Howard MJ, Tuite MF, Gourlay CW (2016) New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis. J Cell Sci 129:4118-29.LEAK
ROUTINE
ET
ROXIntact cellsSaccharomyces cerevisiae
Puskarich 2016 J Crit Care2016Puskarich MA, Kline JA, Watts JA, Shirey K, Hosler J, Jones AE (2016) Early alterations in platelet mitochondrial function are associated with survival and organ failure in patients with septic shock. J Crit Care 31:63-7.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Platelet
Oliveira 2016 PLOS ONE2016Oliveira MP, Correa Soares JB, Oliveira MF (2016) Sexual preferences in nutrient utilization regulate oxygen consumption and reactive oxygen species generation in Schistosoma mansoni: potential implications for parasite redox biology. PLOS ONE 11:e0158429.LEAK
ROUTINE
F
ROX
Intact organismOther invertebrates
Heimer 2016 Am J Hum Genet2016Heimer G, Kerätär JM, Riley LG, Balasubramaniam S, Eyal E, Pietikäinen LP, Hiltunen JK, Marek-Yagel D, Hamada J, Gregory A, Rogers C, Hogarth P, Nance MA, Shalva N, Veber A, Tzadok M, Nissenkorn A, Tonduti D, Renaldo F, Kraoua I, Panteghini C, Valletta L, Garavaglia B, Cowley MJ, Gayevskiy V, Roscioli T, Silberstein JM, Hoffmann C, Raas-Rothschild A, Tiranti V, Anikster Y, Christodoulou J, Kastaniotis AJ, Ben-Zeev B, Hayflick SJ (2016) MECR mutations cause childhood-onset dystonia and optic atrophy, a mitochondrial fatty acid synthesis disorder. Am J Hum Genet 99:1229-44.LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Sanchez-Calvo 2016 PLOS ONE2016Sánchez-Calvo B, Cassina A, Rios N, Peluffo G, Boggia J, Radi R, Rubbo H, Trostchansky A (2016) Nitro-arachidonic acid prevents Angiotensin II-induced mitochondrial dysfunction in a cell line of kidney proximal tubular cells. PLOS ONE 11:e0150459.LEAK
ROUTINE
ET
ROXIntact cellsHumanKidney
Other cell lines
Birkenmeier 2016 Int J Cancer2016Birkenmeier Katrin, Droese Stefan, Wittig Ilka, Winkelmann Ria, Kaefer Viktoria, Doering Claudia, Hartmann Sylvia, Wenz Tina, Reichert Andreas S, Brandt Ulrich, Hansmann Martin‐Leo (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
HeLa
Macrophage-derived
Wos 2016 Arch Biochem Biophys2016Woś M, Szczepanowska J, Pikuła S, Tylki-Szymańska A, Zabłocki K, Bandorowicz-Pikuła J (2016) Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease. Arch Biochem Biophys 593:50-9.LEAK
ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Jang 2016 J Intensive Care Med2016Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med 32:86-94.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Lymphocyte
McFarlane 2016 Thesis2016McFarlane SV (2016) Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Dissertation p74.LEAK
ROUTINE
OXPHOS
ET
F
N
Isolated mitochondria
Intact cells
Other mammalsFat
Cacabelos 2016 Acta Neuropathol Commun2016Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Intact cells
MouseNervous system
Other cell lines
Ehinger 2016 Mov Disord2016Ehinger JK, Morota S, Hansson MJ, Gesine P, Elmér E (2016) Mitochondrial respiratory function in peripheral blood cells from Huntington’s disease patients. Mov Disord doi:10.1002/mdc3.12308.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Lymphocyte
Platelet
Scrima 2016 Biochim Biophys Acta2016Scrima R, Cela O, Merla G, Augello B, Rubino R, Quarato G, Fugetto S, Menga M, Fuhr L, Relógio A, Piccoli C, Mazzoccoli G, Capitanio N (2016) Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay. Biochim Biophys Acta 1857:1344-51.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Endothelial;epithelial;mesothelial cell
Other cell lines
Fibroblast
Peruzzo 2016 Cell Cycle2016Peruzzo P, Comelli M, Di Giorgio E, Franforte E, Mavelli I, Brancolini C (2016) Transformation by different oncogenes relies on specific metabolic adaptations. Cell Cycle 15:2656-68.LEAK
ROUTINE
ET
ROXIntact cellsMouseFibroblast